Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase lambda

Gene

POLL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195).8 Publications

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).6 Publications

Cofactori

Mn2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei312Schiff-base intermediate with DNA1 Publication1
Binding sitei386dCTPCombined sources1 Publication1
Metal bindingi427ManganeseCombined sources1 Publication1
Metal bindingi429ManganeseCombined sources1 Publication1
Metal bindingi490ManganeseCombined sources1 Publication1
Binding sitei513dCTPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi417 – 420dCTP bindingCombined sources1 Publication4
Nucleotide bindingi426 – 429dCTP bindingCombined sources1 Publication4

GO - Molecular functioni

  • 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
  • DNA binding Source: UniProtKB
  • DNA-directed DNA polymerase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication, DNA synthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDAi4.2.99.B1 2681
ReactomeiR-HSA-5693571 Nonhomologous End-Joining (NHEJ)
SABIO-RKiQ9UGP5

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase lambdaCurated (EC:2.7.7.76 Publications, EC:4.2.99.-2 Publications)
Short name:
Pol LambdaCurated
Alternative name(s):
DNA polymerase beta-21 Publication
Short name:
Pol beta21 Publication
DNA polymerase kappa1 Publication
Gene namesi
Name:POLLImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000166169.16
HGNCiHGNC:9184 POLL
MIMi606343 gene
neXtProtiNX_Q9UGP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi312K → A: Reduces dRP lyase activity by over 90%. 1 Publication1
Mutagenesisi427D → A: Loss of polymerase activity; when associated with A-429. 1 Publication1
Mutagenesisi429D → A: Loss of polymerase activity; when associated with A-427. 1 Publication1
Mutagenesisi505Y → A: No effect on polymerase activity. Reduces terminal transferase activities. 1 Publication1
Mutagenesisi506F → G or R: Strongly reduces polymerase and terminal transferase activities. 1 Publication1

Organism-specific databases

DisGeNETi27343
OpenTargetsiENSG00000166169
PharmGKBiPA33504

Chemistry databases

ChEMBLiCHEMBL5367

Polymorphism and mutation databases

BioMutaiPOLL
DMDMi17367126

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187831 – 575DNA polymerase lambdaAdd BLAST575

Proteomic databases

EPDiQ9UGP5
PaxDbiQ9UGP5
PeptideAtlasiQ9UGP5
PRIDEiQ9UGP5
ProteomicsDBi84253

PTM databases

iPTMnetiQ9UGP5
PhosphoSitePlusiQ9UGP5

Expressioni

Tissue specificityi

Expressed in a number of tissues. Abundant in testis.

Gene expression databases

BgeeiENSG00000166169 Expressed in 198 organ(s), highest expression level in body of pancreas
CleanExiHS_POLL
ExpressionAtlasiQ9UGP5 baseline and differential
GenevisibleiQ9UGP5 HS

Organism-specific databases

HPAiHPA066704

Interactioni

Subunit structurei

Binds PCNA.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi118155, 45 interactors
DIPiDIP-48999N
IntActiQ9UGP5, 38 interactors
MINTiQ9UGP5
STRINGi9606.ENSP00000299206

Chemistry databases

BindingDBiQ9UGP5

Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UGP5
SMRiQ9UGP5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UGP5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 132BRCTPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 279DNA binding1 PublicationAdd BLAST15
Regioni345 – 348DNA binding1 Publication4
Regioni420 – 429Involved in primer bindingBy similarity10
Regioni466 – 505DNA binding1 PublicationAdd BLAST40

Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

eggNOGiKOG2534 Eukaryota
COG1796 LUCA
GeneTreeiENSGT00530000063002
HOGENOMiHOG000007787
HOVERGENiHBG002788
InParanoidiQ9UGP5
KOiK03512
OMAiKYLGVCQ
OrthoDBiEOG091G03V5
PhylomeDBiQ9UGP5
TreeFamiTF103011

Family and domain databases

CDDicd00141 NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR002054 DNA-dir_DNA_pol_X
IPR019843 DNA_pol-X_BS
IPR010996 DNA_pol_b-like_N
IPR028207 DNA_pol_B_palm_palm
IPR018944 DNA_pol_lambd_fingers_domain
IPR027421 DNA_pol_lamdba_lyase_dom_sf
IPR037160 DNA_Pol_thumb_sf
IPR022312 DNA_pol_X
IPR002008 DNA_pol_X_beta-like
IPR029398 PolB_thumb
PfamiView protein in Pfam
PF14792 DNA_pol_B_palm, 1 hit
PF14791 DNA_pol_B_thumb, 1 hit
PF10391 DNA_pol_lambd_f, 1 hit
PF14716 HHH_8, 1 hit
PRINTSiPR00869 DNAPOLX
PR00870 DNAPOLXBETA
SMARTiView protein in SMART
SM00483 POLXc, 1 hit
SUPFAMiSSF47802 SSF47802, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00522 DNA_POLYMERASE_X, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR
60 70 80 90 100
TGIGRARAEL FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL
110 120 130 140 150
PQLPPGAQLV KSAWLSLCLQ ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD
160 170 180 190 200
ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ KAKEAPNTQA QPISDDEASD
210 220 230 240 250
GEETQVSAAD LEALISGHYP TSLEGDCEPS PAPAVLDKWV CAQPSSQKAT
260 270 280 290 300
NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC
310 320 330 340 350
SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ
360 370 380 390 400
MWYQQGFRSL EDIRSQASLT TQQAIGLKHY SDFLERMPRE EATEIEQTVQ
410 420 430 440 450
KAAQAFNSGL LCVACGSYRR GKATCGDVDV LITHPDGRSH RGIFSRLLDS
460 470 480 490 500
LRQEGFLTDD LVSQEENGQQ QKYLGVCRLP GPGRRHRRLD IIVVPYSEFA
510 520 530 540 550
CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT HGCKVGPGRV
560 570
LPTPTEKDVF RLLGLPYREP AERDW
Length:575
Mass (Da):63,482
Last modified:May 1, 2000 - v1
Checksum:iFD9196A1C94923C4
GO
Isoform 2 (identifier: Q9UGP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDPRGILKAFPKRQKIHADASS → MLMHHQKYLQRFLGGKREKKQK
     23-297: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,839
Checksum:iB67B993D5EC4A47C
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9HBN3Q9HBN3_HUMAN
DNA polymerase lambda
POLL hCG_23002
248Annotation score:
Q5JQP3Q5JQP3_HUMAN
DNA polymerase lambda
POLL
218Annotation score:
Q5JQP2Q5JQP2_HUMAN
DNA polymerase lambda
POLL
470Annotation score:
Q5JQP4Q5JQP4_HUMAN
DNA polymerase lambda
POLL
298Annotation score:
Q5JQP8Q5JQP8_HUMAN
DNA polymerase lambda
POLL hCG_23002
487Annotation score:
Q5JQP0Q5JQP0_HUMAN
DNA polymerase lambda
POLL
188Annotation score:
Q5JQN9Q5JQN9_HUMAN
DNA polymerase lambda
POLL
334Annotation score:
Q5JQP7Q5JQP7_HUMAN
DNA polymerase lambda
POLL
151Annotation score:
Q5JQP1Q5JQP1_HUMAN
DNA polymerase lambda
POLL
268Annotation score:

Sequence cautioni

The sequence BAB14050 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138Y → C in AAG22519 (PubMed:10887191).Curated1
Sequence conflicti298E → G in AAH68529 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020268221T → P. Corresponds to variant dbSNP:rs3730463Ensembl.1
Natural variantiVAR_020269438R → W Changed DNA polymerase activity characterized by decreased fidelity and unchanged polymerization capacity; changed function in DNA double-strand break repair by non-homologous end joining and homologous recombination; no effect on 5'-deoxyribose-5-phosphate lyase activity. 3 PublicationsCorresponds to variant dbSNP:rs3730477Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565401 – 22MDPRG…ADASS → MLMHHQKYLQRFLGGKREKK QK in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_05654123 – 297Missing in isoform 2. 1 PublicationAdd BLAST275

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131890 mRNA Translation: CAB65074.1
AF161019 mRNA Translation: AAF27541.1
AF283478 mRNA Translation: AAG22519.1
AF525924 Genomic DNA Translation: AAM77696.1
AL627424 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49759.1
CH471066 Genomic DNA Translation: EAW49760.1
CH471066 Genomic DNA Translation: EAW49766.1
CH471066 Genomic DNA Translation: EAW49768.1
BC003548 mRNA Translation: AAH03548.2
BC068529 mRNA Translation: AAH68529.1
AK022476 mRNA Translation: BAB14050.1 Different initiation.
CCDSiCCDS7513.1 [Q9UGP5-1]
CCDS76332.1 [Q9UGP5-2]
RefSeqiNP_001167555.1, NM_001174084.1 [Q9UGP5-1]
NP_001167556.1, NM_001174085.1
NP_001295311.1, NM_001308382.1 [Q9UGP5-2]
NP_037406.1, NM_013274.3 [Q9UGP5-1]
XP_006717840.1, XM_006717777.1 [Q9UGP5-2]
XP_011537953.1, XM_011539651.1 [Q9UGP5-1]
UniGeneiHs.523230

Genome annotation databases

EnsembliENST00000299206; ENSP00000299206; ENSG00000166169 [Q9UGP5-1]
ENST00000370162; ENSP00000359181; ENSG00000166169 [Q9UGP5-1]
ENST00000370169; ENSP00000359188; ENSG00000166169 [Q9UGP5-1]
ENST00000628479; ENSP00000485885; ENSG00000166169 [Q9UGP5-2]
GeneIDi27343
KEGGihsa:27343
UCSCiuc001ktg.2 human [Q9UGP5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131890 mRNA Translation: CAB65074.1
AF161019 mRNA Translation: AAF27541.1
AF283478 mRNA Translation: AAG22519.1
AF525924 Genomic DNA Translation: AAM77696.1
AL627424 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49759.1
CH471066 Genomic DNA Translation: EAW49760.1
CH471066 Genomic DNA Translation: EAW49766.1
CH471066 Genomic DNA Translation: EAW49768.1
BC003548 mRNA Translation: AAH03548.2
BC068529 mRNA Translation: AAH68529.1
AK022476 mRNA Translation: BAB14050.1 Different initiation.
CCDSiCCDS7513.1 [Q9UGP5-1]
CCDS76332.1 [Q9UGP5-2]
RefSeqiNP_001167555.1, NM_001174084.1 [Q9UGP5-1]
NP_001167556.1, NM_001174085.1
NP_001295311.1, NM_001308382.1 [Q9UGP5-2]
NP_037406.1, NM_013274.3 [Q9UGP5-1]
XP_006717840.1, XM_006717777.1 [Q9UGP5-2]
XP_011537953.1, XM_011539651.1 [Q9UGP5-1]
UniGeneiHs.523230

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NZPNMR-A242-327[»]
1RZTX-ray2.10A/E/I/M245-575[»]
1XSLX-ray2.30A/E/I/M242-575[»]
1XSNX-ray1.95A242-575[»]
1XSPX-ray2.20A242-575[»]
2BCQX-ray1.65A242-575[»]
2BCRX-ray1.75A242-575[»]
2BCSX-ray2.20A242-575[»]
2BCUX-ray2.20A242-575[»]
2BCVX-ray2.00A242-575[»]
2GWSX-ray2.40A/E/I/M242-575[»]
2JW5NMR-A34-135[»]
2PFNX-ray1.90A242-575[»]
2PFOX-ray2.00A242-575[»]
2PFPX-ray2.10A242-575[»]
2PFQX-ray2.10A242-575[»]
3C5FX-ray2.25A/B242-575[»]
3C5GX-ray2.20A/B242-575[»]
3HW8X-ray1.95A242-575[»]
3HWTX-ray1.95A242-575[»]
3HX0X-ray3.00A/F/K/P242-575[»]
3MDAX-ray2.03A252-575[»]
3MDCX-ray2.00A252-575[»]
3MGHX-ray2.40A/C242-575[»]
3MGIX-ray2.60A242-575[»]
3PMLX-ray2.60A/B242-575[»]
3PMNX-ray2.20A242-575[»]
3PNCX-ray2.00A242-575[»]
3UPQX-ray1.95A242-575[»]
3UQ0X-ray2.14A242-575[»]
3UQ2X-ray2.25A242-575[»]
4FO6X-ray2.01A242-575[»]
4K4GX-ray2.15A/E/I/M245-575[»]
4K4HX-ray2.10A/E/I/M245-575[»]
4K4IX-ray2.25A/E/I/M245-575[»]
4X5VX-ray2.15A251-575[»]
4XA5X-ray1.90A251-575[»]
4XQ8X-ray2.80A/B242-575[»]
4XRHX-ray3.00A/B242-575[»]
4XUSX-ray2.40A251-575[»]
5CA7X-ray2.52A/B242-575[»]
5CB1X-ray3.30A/B250-575[»]
5CHGX-ray2.90A/B242-575[»]
5CJ7X-ray2.90A/B242-575[»]
5CP2X-ray2.36A/B242-575[»]
5CR0X-ray2.75A/B242-575[»]
5CWRX-ray2.50A/B250-575[»]
5DDMX-ray2.80A/B242-575[»]
5DDYX-ray3.36A/C/E/G242-575[»]
5DKWX-ray2.69A/B249-575[»]
5IIIX-ray1.80A242-575[»]
5IIJX-ray1.72A242-575[»]
5IIKX-ray1.98A242-575[»]
5IILX-ray1.96A242-575[»]
5IIMX-ray1.94A242-575[»]
5IINX-ray2.15A242-575[»]
5IIOX-ray2.08A/E/I/M242-575[»]
5W4GX-ray2.04A4-32[»]
ProteinModelPortaliQ9UGP5
SMRiQ9UGP5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118155, 45 interactors
DIPiDIP-48999N
IntActiQ9UGP5, 38 interactors
MINTiQ9UGP5
STRINGi9606.ENSP00000299206

Chemistry databases

BindingDBiQ9UGP5
ChEMBLiCHEMBL5367

PTM databases

iPTMnetiQ9UGP5
PhosphoSitePlusiQ9UGP5

Polymorphism and mutation databases

BioMutaiPOLL
DMDMi17367126

Proteomic databases

EPDiQ9UGP5
PaxDbiQ9UGP5
PeptideAtlasiQ9UGP5
PRIDEiQ9UGP5
ProteomicsDBi84253

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299206; ENSP00000299206; ENSG00000166169 [Q9UGP5-1]
ENST00000370162; ENSP00000359181; ENSG00000166169 [Q9UGP5-1]
ENST00000370169; ENSP00000359188; ENSG00000166169 [Q9UGP5-1]
ENST00000628479; ENSP00000485885; ENSG00000166169 [Q9UGP5-2]
GeneIDi27343
KEGGihsa:27343
UCSCiuc001ktg.2 human [Q9UGP5-1]

Organism-specific databases

CTDi27343
DisGeNETi27343
EuPathDBiHostDB:ENSG00000166169.16
GeneCardsiPOLL
HGNCiHGNC:9184 POLL
HPAiHPA066704
MIMi606343 gene
neXtProtiNX_Q9UGP5
OpenTargetsiENSG00000166169
PharmGKBiPA33504
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2534 Eukaryota
COG1796 LUCA
GeneTreeiENSGT00530000063002
HOGENOMiHOG000007787
HOVERGENiHBG002788
InParanoidiQ9UGP5
KOiK03512
OMAiKYLGVCQ
OrthoDBiEOG091G03V5
PhylomeDBiQ9UGP5
TreeFamiTF103011

Enzyme and pathway databases

BRENDAi4.2.99.B1 2681
ReactomeiR-HSA-5693571 Nonhomologous End-Joining (NHEJ)
SABIO-RKiQ9UGP5

Miscellaneous databases

ChiTaRSiPOLL human
EvolutionaryTraceiQ9UGP5
GeneWikiiDNA_polymerase_lambda
GenomeRNAii27343
PROiPR:Q9UGP5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166169 Expressed in 198 organ(s), highest expression level in body of pancreas
CleanExiHS_POLL
ExpressionAtlasiQ9UGP5 baseline and differential
GenevisibleiQ9UGP5 HS

Family and domain databases

CDDicd00141 NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR002054 DNA-dir_DNA_pol_X
IPR019843 DNA_pol-X_BS
IPR010996 DNA_pol_b-like_N
IPR028207 DNA_pol_B_palm_palm
IPR018944 DNA_pol_lambd_fingers_domain
IPR027421 DNA_pol_lamdba_lyase_dom_sf
IPR037160 DNA_Pol_thumb_sf
IPR022312 DNA_pol_X
IPR002008 DNA_pol_X_beta-like
IPR029398 PolB_thumb
PfamiView protein in Pfam
PF14792 DNA_pol_B_palm, 1 hit
PF14791 DNA_pol_B_thumb, 1 hit
PF10391 DNA_pol_lambd_f, 1 hit
PF14716 HHH_8, 1 hit
PRINTSiPR00869 DNAPOLX
PR00870 DNAPOLXBETA
SMARTiView protein in SMART
SM00483 POLXc, 1 hit
SUPFAMiSSF47802 SSF47802, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00522 DNA_POLYMERASE_X, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPOLL_HUMAN
AccessioniPrimary (citable) accession number: Q9UGP5
Secondary accession number(s): D3DR76
, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again