UniProtKB - Q9UGP5 (DPOLL_HUMAN)
Protein
DNA polymerase lambda
Gene
POLL
Organism
Homo sapiens (Human)
Status
Functioni
DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195).8 Publications
Catalytic activityi
- EC:2.7.7.76 Publications
Cofactori
Mn2+1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 312 | Schiff-base intermediate with DNA1 Publication | 1 | |
Binding sitei | 386 | dCTPCombined sources1 Publication | 1 | |
Metal bindingi | 427 | ManganeseCombined sources1 Publication | 1 | |
Metal bindingi | 429 | ManganeseCombined sources1 Publication | 1 | |
Metal bindingi | 490 | ManganeseCombined sources1 Publication | 1 | |
Binding sitei | 513 | dCTPCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 417 – 420 | dCTP bindingCombined sources1 Publication | 4 | |
Nucleotide bindingi | 426 – 429 | dCTP bindingCombined sources1 Publication | 4 |
GO - Molecular functioni
- 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-directed DNA polymerase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- base-excision repair, gap-filling Source: UniProtKB
- DNA biosynthetic process Source: UniProtKB
- DNA replication Source: UniProtKB
- double-strand break repair via homologous recombination Source: UniProtKB
- double-strand break repair via nonhomologous end joining Source: UniProtKB
- nucleotide-excision repair Source: UniProtKB
- somatic hypermutation of immunoglobulin genes Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repair, DNA replication, DNA synthesis |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BRENDAi | 4.2.99.B1, 2681 |
PathwayCommonsi | Q9UGP5 |
Reactomei | R-HSA-5693571, Nonhomologous End-Joining (NHEJ) |
SABIO-RKi | Q9UGP5 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:POLLImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166169.16 |
HGNCi | HGNC:9184, POLL |
MIMi | 606343, gene |
neXtProti | NX_Q9UGP5 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 312 | K → A: Reduces dRP lyase activity by over 90%. 1 Publication | 1 | |
Mutagenesisi | 427 | D → A: Loss of polymerase activity; when associated with A-429. 1 Publication | 1 | |
Mutagenesisi | 429 | D → A: Loss of polymerase activity; when associated with A-427. 1 Publication | 1 | |
Mutagenesisi | 505 | Y → A: No effect on polymerase activity. Reduces terminal transferase activities. 1 Publication | 1 | |
Mutagenesisi | 506 | F → G or R: Strongly reduces polymerase and terminal transferase activities. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 27343 |
OpenTargetsi | ENSG00000166169 |
PharmGKBi | PA33504 |
Miscellaneous databases
Pharosi | Q9UGP5, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5367 |
Polymorphism and mutation databases
BioMutai | POLL |
DMDMi | 17367126 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218783 | 1 – 575 | DNA polymerase lambdaAdd BLAST | 575 |
Proteomic databases
EPDi | Q9UGP5 |
jPOSTi | Q9UGP5 |
MassIVEi | Q9UGP5 |
PaxDbi | Q9UGP5 |
PeptideAtlasi | Q9UGP5 |
PRIDEi | Q9UGP5 |
ProteomicsDBi | 79002 84253 [Q9UGP5-1] |
PTM databases
iPTMneti | Q9UGP5 |
PhosphoSitePlusi | Q9UGP5 |
Expressioni
Tissue specificityi
Expressed in a number of tissues. Abundant in testis.
Gene expression databases
Bgeei | ENSG00000166169, Expressed in body of pancreas and 212 other tissues |
ExpressionAtlasi | Q9UGP5, baseline and differential |
Genevisiblei | Q9UGP5, HS |
Organism-specific databases
HPAi | ENSG00000166169, Low tissue specificity |
Interactioni
Subunit structurei
Binds PCNA.
1 PublicationBinary interactionsi
Hide detailsIsoform 2 [Q9UGP5-2]
Protein-protein interaction databases
BioGRIDi | 118155, 62 interactors |
DIPi | DIP-48999N |
IntActi | Q9UGP5, 41 interactors |
MINTi | Q9UGP5 |
STRINGi | 9606.ENSP00000359181 |
Chemistry databases
BindingDBi | Q9UGP5 |
Miscellaneous databases
RNActi | Q9UGP5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9UGP5 |
SMRi | Q9UGP5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UGP5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 132 | BRCTPROSITE-ProRule annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 265 – 279 | DNA binding1 PublicationAdd BLAST | 15 | |
Regioni | 345 – 348 | DNA binding1 Publication | 4 | |
Regioni | 420 – 429 | Involved in primer bindingBy similarity | 10 | |
Regioni | 466 – 505 | DNA binding1 PublicationAdd BLAST | 40 |
Sequence similaritiesi
Belongs to the DNA polymerase type-X family.Curated
Phylogenomic databases
eggNOGi | KOG2534, Eukaryota |
GeneTreei | ENSGT00940000158515 |
InParanoidi | Q9UGP5 |
OMAi | VKTAQMW |
OrthoDBi | 1328151at2759 |
PhylomeDBi | Q9UGP5 |
TreeFami | TF103011 |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.30.460.10, 1 hit 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR010996, DNA_pol_b-like_N IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR027421, DNA_pol_lamdba_lyase_dom_sf IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR002008, DNA_pol_X_beta-like IPR043519, NT_sf IPR029398, PolB_thumb |
Pfami | View protein in Pfam PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit PF14716, HHH_8, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00870, DNAPOLXBETA |
SMARTi | View protein in SMART SM00483, POLXc, 1 hit |
SUPFAMi | SSF47802, SSF47802, 1 hit SSF52113, SSF52113, 1 hit SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS00522, DNA_POLYMERASE_X, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UGP5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR
60 70 80 90 100
TGIGRARAEL FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL
110 120 130 140 150
PQLPPGAQLV KSAWLSLCLQ ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD
160 170 180 190 200
ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ KAKEAPNTQA QPISDDEASD
210 220 230 240 250
GEETQVSAAD LEALISGHYP TSLEGDCEPS PAPAVLDKWV CAQPSSQKAT
260 270 280 290 300
NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC
310 320 330 340 350
SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ
360 370 380 390 400
MWYQQGFRSL EDIRSQASLT TQQAIGLKHY SDFLERMPRE EATEIEQTVQ
410 420 430 440 450
KAAQAFNSGL LCVACGSYRR GKATCGDVDV LITHPDGRSH RGIFSRLLDS
460 470 480 490 500
LRQEGFLTDD LVSQEENGQQ QKYLGVCRLP GPGRRHRRLD IIVVPYSEFA
510 520 530 540 550
CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT HGCKVGPGRV
560 570
LPTPTEKDVF RLLGLPYREP AERDW
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JQP2 | Q5JQP2_HUMAN | DNA polymerase | POLL | 470 | Annotation score: | ||
Q5JQP8 | Q5JQP8_HUMAN | DNA polymerase | POLL hCG_23002 | 487 | Annotation score: | ||
Q9HBN3 | Q9HBN3_HUMAN | DNA polymerase | POLL hCG_23002 | 248 | Annotation score: | ||
Q5JQP3 | Q5JQP3_HUMAN | DNA polymerase | POLL | 218 | Annotation score: | ||
Q5JQP4 | Q5JQP4_HUMAN | DNA polymerase | POLL | 298 | Annotation score: | ||
Q5JQN9 | Q5JQN9_HUMAN | DNA polymerase lambda | POLL | 334 | Annotation score: | ||
Q5JQP0 | Q5JQP0_HUMAN | DNA polymerase lambda | POLL | 188 | Annotation score: | ||
Q5JQP1 | Q5JQP1_HUMAN | DNA polymerase lambda | POLL | 268 | Annotation score: | ||
Q5JQP7 | Q5JQP7_HUMAN | DNA polymerase lambda | POLL | 151 | Annotation score: |
Sequence cautioni
The sequence BAB14050 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 138 | Y → C in AAG22519 (PubMed:10887191).Curated | 1 | |
Sequence conflicti | 298 | E → G in AAH68529 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020268 | 221 | T → P. Corresponds to variant dbSNP:rs3730463Ensembl. | 1 | |
Natural variantiVAR_020269 | 438 | R → W Changed DNA polymerase activity characterized by decreased fidelity and unchanged polymerization capacity; changed function in DNA double-strand break repair by non-homologous end joining and homologous recombination; no effect on 5'-deoxyribose-5-phosphate lyase activity. 3 PublicationsCorresponds to variant dbSNP:rs3730477Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056540 | 1 – 22 | MDPRG…ADASS → MLMHHQKYLQRFLGGKREKK QK in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_056541 | 23 – 297 | Missing in isoform 2. 1 PublicationAdd BLAST | 275 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ131890 mRNA Translation: CAB65074.1 AF161019 mRNA Translation: AAF27541.1 AF283478 mRNA Translation: AAG22519.1 AF525924 Genomic DNA Translation: AAM77696.1 AL627424 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49759.1 CH471066 Genomic DNA Translation: EAW49760.1 CH471066 Genomic DNA Translation: EAW49766.1 CH471066 Genomic DNA Translation: EAW49768.1 BC003548 mRNA Translation: AAH03548.2 BC068529 mRNA Translation: AAH68529.1 AK022476 mRNA Translation: BAB14050.1 Different initiation. |
CCDSi | CCDS7513.1 [Q9UGP5-1] CCDS76332.1 [Q9UGP5-2] |
RefSeqi | NP_001167555.1, NM_001174084.1 [Q9UGP5-1] NP_001167556.1, NM_001174085.1 NP_001295311.1, NM_001308382.1 [Q9UGP5-2] NP_037406.1, NM_013274.3 [Q9UGP5-1] XP_006717840.1, XM_006717777.1 [Q9UGP5-2] XP_011537953.1, XM_011539651.1 [Q9UGP5-1] |
Genome annotation databases
Ensembli | ENST00000299206; ENSP00000299206; ENSG00000166169 [Q9UGP5-1] ENST00000370162; ENSP00000359181; ENSG00000166169 [Q9UGP5-1] ENST00000370169; ENSP00000359188; ENSG00000166169 [Q9UGP5-1] ENST00000628479; ENSP00000485885; ENSG00000166169 [Q9UGP5-2] |
GeneIDi | 27343 |
KEGGi | hsa:27343 |
UCSCi | uc001ktg.2, human [Q9UGP5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ131890 mRNA Translation: CAB65074.1 AF161019 mRNA Translation: AAF27541.1 AF283478 mRNA Translation: AAG22519.1 AF525924 Genomic DNA Translation: AAM77696.1 AL627424 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49759.1 CH471066 Genomic DNA Translation: EAW49760.1 CH471066 Genomic DNA Translation: EAW49766.1 CH471066 Genomic DNA Translation: EAW49768.1 BC003548 mRNA Translation: AAH03548.2 BC068529 mRNA Translation: AAH68529.1 AK022476 mRNA Translation: BAB14050.1 Different initiation. |
CCDSi | CCDS7513.1 [Q9UGP5-1] CCDS76332.1 [Q9UGP5-2] |
RefSeqi | NP_001167555.1, NM_001174084.1 [Q9UGP5-1] NP_001167556.1, NM_001174085.1 NP_001295311.1, NM_001308382.1 [Q9UGP5-2] NP_037406.1, NM_013274.3 [Q9UGP5-1] XP_006717840.1, XM_006717777.1 [Q9UGP5-2] XP_011537953.1, XM_011539651.1 [Q9UGP5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NZP | NMR | - | A | 242-327 | [»] | |
1RZT | X-ray | 2.10 | A/E/I/M | 245-575 | [»] | |
1XSL | X-ray | 2.30 | A/E/I/M | 242-575 | [»] | |
1XSN | X-ray | 1.95 | A | 242-575 | [»] | |
1XSP | X-ray | 2.20 | A | 242-575 | [»] | |
2BCQ | X-ray | 1.65 | A | 242-575 | [»] | |
2BCR | X-ray | 1.75 | A | 242-575 | [»] | |
2BCS | X-ray | 2.20 | A | 242-575 | [»] | |
2BCU | X-ray | 2.20 | A | 242-575 | [»] | |
2BCV | X-ray | 2.00 | A | 242-575 | [»] | |
2GWS | X-ray | 2.40 | A/E/I/M | 242-575 | [»] | |
2JW5 | NMR | - | A | 34-135 | [»] | |
2PFN | X-ray | 1.90 | A | 242-575 | [»] | |
2PFO | X-ray | 2.00 | A | 242-575 | [»] | |
2PFP | X-ray | 2.10 | A | 242-575 | [»] | |
2PFQ | X-ray | 2.10 | A | 242-575 | [»] | |
3C5F | X-ray | 2.25 | A/B | 242-575 | [»] | |
3C5G | X-ray | 2.20 | A/B | 242-575 | [»] | |
3HW8 | X-ray | 1.95 | A | 242-575 | [»] | |
3HWT | X-ray | 1.95 | A | 242-575 | [»] | |
3HX0 | X-ray | 3.00 | A/F/K/P | 242-575 | [»] | |
3MDA | X-ray | 2.03 | A | 252-575 | [»] | |
3MDC | X-ray | 2.00 | A | 252-575 | [»] | |
3MGH | X-ray | 2.40 | A/C | 242-575 | [»] | |
3MGI | X-ray | 2.60 | A | 242-575 | [»] | |
3PML | X-ray | 2.60 | A/B | 242-575 | [»] | |
3PMN | X-ray | 2.20 | A | 242-575 | [»] | |
3PNC | X-ray | 2.00 | A | 242-575 | [»] | |
3UPQ | X-ray | 1.95 | A | 242-575 | [»] | |
3UQ0 | X-ray | 2.14 | A | 242-575 | [»] | |
3UQ2 | X-ray | 2.25 | A | 242-575 | [»] | |
4FO6 | X-ray | 2.01 | A | 242-575 | [»] | |
4K4G | X-ray | 2.15 | A/E/I/M | 245-575 | [»] | |
4K4H | X-ray | 2.10 | A/E/I/M | 245-575 | [»] | |
4K4I | X-ray | 2.25 | A/E/I/M | 245-575 | [»] | |
4X5V | X-ray | 2.15 | A | 251-575 | [»] | |
4XA5 | X-ray | 1.90 | A | 251-575 | [»] | |
4XQ8 | X-ray | 2.80 | A/B | 242-575 | [»] | |
4XRH | X-ray | 3.00 | A/B | 242-575 | [»] | |
4XUS | X-ray | 2.40 | A | 251-575 | [»] | |
5CA7 | X-ray | 2.52 | A/B | 242-575 | [»] | |
5CB1 | X-ray | 3.30 | A/B | 250-575 | [»] | |
5CHG | X-ray | 2.90 | A/B | 242-575 | [»] | |
5CJ7 | X-ray | 2.90 | A/B | 242-575 | [»] | |
5CP2 | X-ray | 2.36 | A/B | 242-575 | [»] | |
5CR0 | X-ray | 2.75 | A/B | 242-575 | [»] | |
5CWR | X-ray | 2.50 | A/B | 250-575 | [»] | |
5DDM | X-ray | 2.80 | A/B | 242-575 | [»] | |
5DDY | X-ray | 3.36 | A/C/E/G | 242-575 | [»] | |
5DKW | X-ray | 2.69 | A/B | 249-575 | [»] | |
5III | X-ray | 1.80 | A | 242-575 | [»] | |
5IIJ | X-ray | 1.72 | A | 242-575 | [»] | |
5IIK | X-ray | 1.98 | A | 242-575 | [»] | |
5IIL | X-ray | 1.96 | A | 242-575 | [»] | |
5IIM | X-ray | 1.94 | A | 242-575 | [»] | |
5IIN | X-ray | 2.15 | A | 242-575 | [»] | |
5IIO | X-ray | 2.08 | A/E/I/M | 242-575 | [»] | |
5W4G | X-ray | 2.04 | A | 4-32 | [»] | |
BMRBi | Q9UGP5 | |||||
SMRi | Q9UGP5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118155, 62 interactors |
DIPi | DIP-48999N |
IntActi | Q9UGP5, 41 interactors |
MINTi | Q9UGP5 |
STRINGi | 9606.ENSP00000359181 |
Chemistry databases
BindingDBi | Q9UGP5 |
ChEMBLi | CHEMBL5367 |
PTM databases
iPTMneti | Q9UGP5 |
PhosphoSitePlusi | Q9UGP5 |
Polymorphism and mutation databases
BioMutai | POLL |
DMDMi | 17367126 |
Proteomic databases
EPDi | Q9UGP5 |
jPOSTi | Q9UGP5 |
MassIVEi | Q9UGP5 |
PaxDbi | Q9UGP5 |
PeptideAtlasi | Q9UGP5 |
PRIDEi | Q9UGP5 |
ProteomicsDBi | 79002 84253 [Q9UGP5-1] |
Protocols and materials databases
Antibodypediai | 31295, 229 antibodies |
Genome annotation databases
Ensembli | ENST00000299206; ENSP00000299206; ENSG00000166169 [Q9UGP5-1] ENST00000370162; ENSP00000359181; ENSG00000166169 [Q9UGP5-1] ENST00000370169; ENSP00000359188; ENSG00000166169 [Q9UGP5-1] ENST00000628479; ENSP00000485885; ENSG00000166169 [Q9UGP5-2] |
GeneIDi | 27343 |
KEGGi | hsa:27343 |
UCSCi | uc001ktg.2, human [Q9UGP5-1] |
Organism-specific databases
CTDi | 27343 |
DisGeNETi | 27343 |
EuPathDBi | HostDB:ENSG00000166169.16 |
GeneCardsi | POLL |
HGNCi | HGNC:9184, POLL |
HPAi | ENSG00000166169, Low tissue specificity |
MIMi | 606343, gene |
neXtProti | NX_Q9UGP5 |
OpenTargetsi | ENSG00000166169 |
PharmGKBi | PA33504 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2534, Eukaryota |
GeneTreei | ENSGT00940000158515 |
InParanoidi | Q9UGP5 |
OMAi | VKTAQMW |
OrthoDBi | 1328151at2759 |
PhylomeDBi | Q9UGP5 |
TreeFami | TF103011 |
Enzyme and pathway databases
BRENDAi | 4.2.99.B1, 2681 |
PathwayCommonsi | Q9UGP5 |
Reactomei | R-HSA-5693571, Nonhomologous End-Joining (NHEJ) |
SABIO-RKi | Q9UGP5 |
Miscellaneous databases
BioGRID-ORCSi | 27343, 3 hits in 847 CRISPR screens |
ChiTaRSi | POLL, human |
EvolutionaryTracei | Q9UGP5 |
GeneWikii | DNA_polymerase_lambda |
GenomeRNAii | 27343 |
Pharosi | Q9UGP5, Tbio |
PROi | PR:Q9UGP5 |
RNActi | Q9UGP5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166169, Expressed in body of pancreas and 212 other tissues |
ExpressionAtlasi | Q9UGP5, baseline and differential |
Genevisiblei | Q9UGP5, HS |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.30.460.10, 1 hit 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR010996, DNA_pol_b-like_N IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR027421, DNA_pol_lamdba_lyase_dom_sf IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR002008, DNA_pol_X_beta-like IPR043519, NT_sf IPR029398, PolB_thumb |
Pfami | View protein in Pfam PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit PF14716, HHH_8, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00870, DNAPOLXBETA |
SMARTi | View protein in SMART SM00483, POLXc, 1 hit |
SUPFAMi | SSF47802, SSF47802, 1 hit SSF52113, SSF52113, 1 hit SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS00522, DNA_POLYMERASE_X, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DPOLL_HUMAN | |
Accessioni | Q9UGP5Primary (citable) accession number: Q9UGP5 Secondary accession number(s): D3DR76 Q9HB35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations