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UniProtKB - Q9UGP5 (DPOLL_HUMAN)

Entry version 202 (02 Jun 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

DNA polymerase lambda

Gene

POLL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240).

Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195).

Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240).

Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195).

Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195).

8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei312Schiff-base intermediate with DNA1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei386dCTPCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi427ManganeseCombined sources1 Publication1
Metal bindingi429ManganeseCombined sources1 Publication1
Metal bindingi490ManganeseCombined sources1 Publication1
Binding sitei513dCTPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi417 – 420dCTP bindingCombined sources1 Publication4
Nucleotide bindingi426 – 429dCTP bindingCombined sources1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication, DNA synthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.2.99.B1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UGP5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5693571, Nonhomologous End-Joining (NHEJ)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9UGP5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase lambdaCurated (EC:2.7.7.76 Publications, EC:4.2.99.-2 Publications)
Short name:
Pol LambdaCurated
Alternative name(s):
DNA polymerase beta-21 Publication
Short name:
Pol beta21 Publication
DNA polymerase kappa1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9184, POLL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606343, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UGP5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166169.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi312K → A: Reduces dRP lyase activity by over 90%. 1 Publication1
Mutagenesisi427D → A: Loss of polymerase activity; when associated with A-429. 1 Publication1
Mutagenesisi429D → A: Loss of polymerase activity; when associated with A-427. 1 Publication1
Mutagenesisi505Y → A: No effect on polymerase activity. Reduces terminal transferase activities. 1 Publication1
Mutagenesisi506F → G or R: Strongly reduces polymerase and terminal transferase activities. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		27343

Open Targets

More...OpenTargetsi		ENSG00000166169

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33504

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UGP5, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5367

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POLL

Domain mapping of disease mutations (DMDM)

More...DMDMi		17367126

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187831 – 575DNA polymerase lambdaAdd BLAST575

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UGP5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UGP5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UGP5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UGP5

PeptideAtlas

More...PeptideAtlasi		Q9UGP5

PRoteomics IDEntifications database

More...PRIDEi		Q9UGP5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79002
84253 [Q9UGP5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UGP5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UGP5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a number of tissues. Abundant in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166169, Expressed in body of pancreas and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UGP5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UGP5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166169, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PCNA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118155, 64 interactors

Database of interacting proteins

More...DIPi		DIP-48999N

Protein interaction database and analysis system

More...IntActi		Q9UGP5, 41 interactors

Molecular INTeraction database

More...MINTi		Q9UGP5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359181

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9UGP5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UGP5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9UGP5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UGP5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UGP5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 132BRCTPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni161 – 205DisorderedSequence analysisAdd BLAST45
Regioni265 – 279DNA binding1 PublicationAdd BLAST15
Regioni345 – 348DNA binding1 Publication4
Regioni420 – 429Involved in primer bindingBy similarity10
Regioni466 – 505DNA binding1 PublicationAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi165 – 179Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2534, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158515

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UGP5

Identification of Orthologs from Complete Genome Data

More...OMAi		VKTAQMW

Database of Orthologous Groups

More...OrthoDBi		1328151at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UGP5

TreeFam database of animal gene trees

More...TreeFami		TF103011

Family and domain databases

Conserved Domains Database

More...CDDi		cd00141, NT_POLXc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR002008, DNA_pol_X_beta-like
IPR043519, NT_sf
IPR029398, PolB_thumb

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00869, DNAPOLX
PR00870, DNAPOLXBETA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00483, POLXc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47802, SSF47802, 1 hit
SSF52113, SSF52113, 1 hit
SSF81301, SSF81301, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50172, BRCT, 1 hit
PS00522, DNA_POLYMERASE_X, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR 
        60         70         80         90        100
TGIGRARAEL FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL 
       110        120        130        140        150
PQLPPGAQLV KSAWLSLCLQ ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD 
       160        170        180        190        200
ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ KAKEAPNTQA QPISDDEASD 
       210        220        230        240        250
GEETQVSAAD LEALISGHYP TSLEGDCEPS PAPAVLDKWV CAQPSSQKAT 
       260        270        280        290        300
NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC 
       310        320        330        340        350
SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ 
       360        370        380        390        400
MWYQQGFRSL EDIRSQASLT TQQAIGLKHY SDFLERMPRE EATEIEQTVQ 
       410        420        430        440        450
KAAQAFNSGL LCVACGSYRR GKATCGDVDV LITHPDGRSH RGIFSRLLDS 
       460        470        480        490        500
LRQEGFLTDD LVSQEENGQQ QKYLGVCRLP GPGRRHRRLD IIVVPYSEFA 
       510        520        530        540        550
CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT HGCKVGPGRV 
       560        570 
LPTPTEKDVF RLLGLPYREP AERDW
Length:575
Mass (Da):63,482
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD9196A1C94923C4
GO
Isoform 2 (identifier: Q9UGP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDPRGILKAFPKRQKIHADASS → MLMHHQKYLQRFLGGKREKKQK
     23-297: Missing.

Show »
Length:300
Mass (Da):33,839
Checksum:iB67B993D5EC4A47C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JQP8Q5JQP8_HUMAN
DNA polymerase
POLL hCG_23002
487Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JQP2Q5JQP2_HUMAN
DNA polymerase
POLL
470Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9HBN3Q9HBN3_HUMAN
DNA polymerase
POLL hCG_23002
248Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JQP4Q5JQP4_HUMAN
DNA polymerase
POLL
298Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JQP3Q5JQP3_HUMAN
DNA polymerase
POLL
218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JQN9Q5JQN9_HUMAN
DNA polymerase lambda
POLL
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JQP0Q5JQP0_HUMAN
DNA polymerase lambda
POLL
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JQP1Q5JQP1_HUMAN
DNA polymerase lambda
POLL
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JQP7Q5JQP7_HUMAN
DNA polymerase lambda
POLL
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14050 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138Y → C in AAG22519 (PubMed:10887191).Curated1
Sequence conflicti298E → G in AAH68529 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020268221T → P. Corresponds to variant dbSNP:rs3730463Ensembl.1
Natural variantiVAR_020269438R → W Changed DNA polymerase activity characterized by decreased fidelity and unchanged polymerization capacity; changed function in DNA double-strand break repair by non-homologous end joining and homologous recombination; no effect on 5'-deoxyribose-5-phosphate lyase activity. 3 PublicationsCorresponds to variant dbSNP:rs3730477Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565401 – 22MDPRG…ADASS → MLMHHQKYLQRFLGGKREKK QK in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_05654123 – 297Missing in isoform 2. 1 PublicationAdd BLAST275

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ131890 mRNA Translation: CAB65074.1
AF161019 mRNA Translation: AAF27541.1
AF283478 mRNA Translation: AAG22519.1
AF525924 Genomic DNA Translation: AAM77696.1
AL627424 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49759.1
CH471066 Genomic DNA Translation: EAW49760.1
CH471066 Genomic DNA Translation: EAW49766.1
CH471066 Genomic DNA Translation: EAW49768.1
BC003548 mRNA Translation: AAH03548.2
BC068529 mRNA Translation: AAH68529.1
AK022476 mRNA Translation: BAB14050.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7513.1 [Q9UGP5-1]
CCDS76332.1 [Q9UGP5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001167555.1, NM_001174084.1 [Q9UGP5-1]
NP_001167556.1, NM_001174085.1
NP_001295311.1, NM_001308382.1 [Q9UGP5-2]
NP_037406.1, NM_013274.3 [Q9UGP5-1]
XP_006717840.1, XM_006717777.1 [Q9UGP5-2]
XP_011537953.1, XM_011539651.1 [Q9UGP5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000299206; ENSP00000299206; ENSG00000166169 [Q9UGP5-1]
ENST00000370162; ENSP00000359181; ENSG00000166169 [Q9UGP5-1]
ENST00000370169; ENSP00000359188; ENSG00000166169 [Q9UGP5-1]
ENST00000628479; ENSP00000485885; ENSG00000166169 [Q9UGP5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27343

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27343

UCSC genome browser

More...UCSCi		uc001ktg.2, human [Q9UGP5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131890 mRNA Translation: CAB65074.1
AF161019 mRNA Translation: AAF27541.1
AF283478 mRNA Translation: AAG22519.1
AF525924 Genomic DNA Translation: AAM77696.1
AL627424 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49759.1
CH471066 Genomic DNA Translation: EAW49760.1
CH471066 Genomic DNA Translation: EAW49766.1
CH471066 Genomic DNA Translation: EAW49768.1
BC003548 mRNA Translation: AAH03548.2
BC068529 mRNA Translation: AAH68529.1
AK022476 mRNA Translation: BAB14050.1 Different initiation.
CCDSiCCDS7513.1 [Q9UGP5-1]
CCDS76332.1 [Q9UGP5-2]
RefSeqiNP_001167555.1, NM_001174084.1 [Q9UGP5-1]
NP_001167556.1, NM_001174085.1
NP_001295311.1, NM_001308382.1 [Q9UGP5-2]
NP_037406.1, NM_013274.3 [Q9UGP5-1]
XP_006717840.1, XM_006717777.1 [Q9UGP5-2]
XP_011537953.1, XM_011539651.1 [Q9UGP5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NZPNMR-A242-327[»]
1RZTX-ray2.10A/E/I/M245-575[»]
1XSLX-ray2.30A/E/I/M242-575[»]
1XSNX-ray1.95A242-575[»]
1XSPX-ray2.20A242-575[»]
2BCQX-ray1.65A242-575[»]
2BCRX-ray1.75A242-575[»]
2BCSX-ray2.20A242-575[»]
2BCUX-ray2.20A242-575[»]
2BCVX-ray2.00A242-575[»]
2GWSX-ray2.40A/E/I/M242-575[»]
2JW5NMR-A34-135[»]
2PFNX-ray1.90A242-575[»]
2PFOX-ray2.00A242-575[»]
2PFPX-ray2.10A242-575[»]
2PFQX-ray2.10A242-575[»]
3C5FX-ray2.25A/B242-575[»]
3C5GX-ray2.20A/B242-575[»]
3HW8X-ray1.95A242-575[»]
3HWTX-ray1.95A242-575[»]
3HX0X-ray3.00A/F/K/P242-575[»]
3MDAX-ray2.03A252-575[»]
3MDCX-ray2.00A252-575[»]
3MGHX-ray2.40A/C242-575[»]
3MGIX-ray2.60A242-575[»]
3PMLX-ray2.60A/B242-575[»]
3PMNX-ray2.20A242-575[»]
3PNCX-ray2.00A242-575[»]
3UPQX-ray1.95A242-575[»]
3UQ0X-ray2.14A242-575[»]
3UQ2X-ray2.25A242-575[»]
4FO6X-ray2.01A242-575[»]
4K4GX-ray2.15A/E/I/M245-575[»]
4K4HX-ray2.10A/E/I/M245-575[»]
4K4IX-ray2.25A/E/I/M245-575[»]
4X5VX-ray2.15A251-575[»]
4XA5X-ray1.90A251-575[»]
4XQ8X-ray2.80A/B242-575[»]
4XRHX-ray3.00A/B242-575[»]
4XUSX-ray2.40A251-575[»]
5CA7X-ray2.52A/B242-575[»]
5CB1X-ray3.30A/B250-575[»]
5CHGX-ray2.90A/B242-575[»]
5CJ7X-ray2.90A/B242-575[»]
5CP2X-ray2.36A/B242-575[»]
5CR0X-ray2.75A/B242-575[»]
5CWRX-ray2.50A/B250-575[»]
5DDMX-ray2.80A/B242-575[»]
5DDYX-ray3.36A/C/E/G242-575[»]
5DKWX-ray2.69A/B249-575[»]
5IIIX-ray1.80A242-575[»]
5IIJX-ray1.72A242-575[»]
5IIKX-ray1.98A242-575[»]
5IILX-ray1.96A242-575[»]
5IIMX-ray1.94A242-575[»]
5IINX-ray2.15A242-575[»]
5IIOX-ray2.08A/E/I/M242-575[»]
5W4GX-ray2.04A4-32[»]
BMRBiQ9UGP5
SMRiQ9UGP5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118155, 64 interactors
DIPiDIP-48999N
IntActiQ9UGP5, 41 interactors
MINTiQ9UGP5
STRINGi9606.ENSP00000359181

Chemistry databases

BindingDBiQ9UGP5
ChEMBLiCHEMBL5367

PTM databases

iPTMnetiQ9UGP5
PhosphoSitePlusiQ9UGP5

Genetic variation databases

BioMutaiPOLL
DMDMi17367126

Proteomic databases

EPDiQ9UGP5
jPOSTiQ9UGP5
MassIVEiQ9UGP5
PaxDbiQ9UGP5
PeptideAtlasiQ9UGP5
PRIDEiQ9UGP5
ProteomicsDBi79002
84253 [Q9UGP5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31295, 238 antibodies

The DNASU plasmid repository

More...DNASUi		27343

Genome annotation databases

EnsembliENST00000299206; ENSP00000299206; ENSG00000166169 [Q9UGP5-1]
ENST00000370162; ENSP00000359181; ENSG00000166169 [Q9UGP5-1]
ENST00000370169; ENSP00000359188; ENSG00000166169 [Q9UGP5-1]
ENST00000628479; ENSP00000485885; ENSG00000166169 [Q9UGP5-2]
GeneIDi27343
KEGGihsa:27343
UCSCiuc001ktg.2, human [Q9UGP5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27343
DisGeNETi27343

GeneCards: human genes, protein and diseases

More...GeneCardsi		POLL
HGNCiHGNC:9184, POLL
HPAiENSG00000166169, Low tissue specificity
MIMi606343, gene
neXtProtiNX_Q9UGP5
OpenTargetsiENSG00000166169
PharmGKBiPA33504
VEuPathDBiHostDB:ENSG00000166169.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2534, Eukaryota
GeneTreeiENSGT00940000158515
InParanoidiQ9UGP5
OMAiVKTAQMW
OrthoDBi1328151at2759
PhylomeDBiQ9UGP5
TreeFamiTF103011

Enzyme and pathway databases

BRENDAi4.2.99.B1, 2681
PathwayCommonsiQ9UGP5
ReactomeiR-HSA-5693571, Nonhomologous End-Joining (NHEJ)
SABIO-RKiQ9UGP5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27343, 5 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POLL, human
EvolutionaryTraceiQ9UGP5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DNA_polymerase_lambda

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27343
PharosiQ9UGP5, Tbio

Protein Ontology

More...PROi		PR:Q9UGP5
RNActiQ9UGP5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166169, Expressed in body of pancreas and 213 other tissues
ExpressionAtlasiQ9UGP5, baseline and differential
GenevisibleiQ9UGP5, HS

Family and domain databases

CDDicd00141, NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR002008, DNA_pol_X_beta-like
IPR043519, NT_sf
IPR029398, PolB_thumb
PfamiView protein in Pfam
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit
PRINTSiPR00869, DNAPOLX
PR00870, DNAPOLXBETA
SMARTiView protein in SMART
SM00483, POLXc, 1 hit
SUPFAMiSSF47802, SSF47802, 1 hit
SSF52113, SSF52113, 1 hit
SSF81301, SSF81301, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit
PS00522, DNA_POLYMERASE_X, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOLL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGP5
Secondary accession number(s): D3DR76
, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 202 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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