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Protein

CMRF35-like molecule 8

Gene

CD300A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 8
Short name:
CLM-8
Alternative name(s):
CD300 antigen-like family member A
CMRF-35-H9
Short name:
CMRF35-H9
CMRF35-H
IRC1/IRC2
Immunoglobulin superfamily member 12
Short name:
IgSF12
Inhibitory receptor protein 60
Short name:
IRp60
NK inhibitory receptor
CD_antigen: CD300a
Gene namesi
Name:CD300A
Synonyms:CMRF35H, IGSF12
ORF Names:HSPC083
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167851.13
HGNCiHGNC:19319 CD300A
MIMi606790 gene
neXtProtiNX_Q9UGN4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 180ExtracellularSequence analysisAdd BLAST163
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 299CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11314
OpenTargetsiENSG00000167851
PharmGKBiPA142672149

Polymorphism and mutation databases

BioMutaiCD300A
DMDMi126302534

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001468218 – 299CMRF35-like molecule 8Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 103PROSITE-ProRule annotation
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei293PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine.2 Publications
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UGN4
PeptideAtlasiQ9UGN4
PRIDEiQ9UGN4
ProteomicsDBi84246
84247 [Q9UGN4-2]
84248 [Q9UGN4-3]
84249 [Q9UGN4-4]
TopDownProteomicsiQ9UGN4-1 [Q9UGN4-1]

PTM databases

iPTMnetiQ9UGN4
PhosphoSitePlusiQ9UGN4

Expressioni

Tissue specificityi

Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.3 Publications

Gene expression databases

BgeeiENSG00000167851 Expressed in 167 organ(s), highest expression level in blood
CleanExiHS_CD300A
ExpressionAtlasiQ9UGN4 baseline and differential
GenevisibleiQ9UGN4 HS

Organism-specific databases

HPAiHPA011645

Interactioni

Subunit structurei

Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT38O760153EBI-10320732,EBI-1047263

Protein-protein interaction databases

BioGridi116445, 2 interactors
IntActiQ9UGN4, 7 interactors
STRINGi9606.ENSP00000353259

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UGN4
SMRiQ9UGN4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UGN4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 123Ig-like V-typeAdd BLAST105

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXT8 Eukaryota
ENOG410ZH9V LUCA
GeneTreeiENSGT00470000042273
HOVERGENiHBG100050
InParanoidiQ9UGN4
KOiK06719
OMAiLWVPGCF
OrthoDBiEOG091G0RAD
PhylomeDBiQ9UGN4
TreeFamiTF334441

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGN4-1) [UniParc]FASTAAdd to basket
Also known as: IRC1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLPWALLLL WVPGCFALSK CRTVAGPVGG SLSVQCPYEK EHRTLNKYWC
60 70 80 90 100
RPPQIFLCDK IVETKGSAGK RNGRVSIRDS PANLSFTVTL ENLTEEDAGT
110 120 130 140 150
YWCGVDTPWL RDFHDPVVEV EVSVFPASTS MTPASITAAK TSTITTAFPP
160 170 180 190 200
VSSTTLFAVG ATHSASIQEE TEEVVNSQLP LLLSLLALLL LLLVGASLLA
210 220 230 240 250
WRMFQKWIKA GDHSELSQNP KQAATQSELH YANLELLMWP LQEKPAPPRE
260 270 280 290
VEVEYSTVAS PREELHYASV VFDSNTNRIA AQRPREEEPD SDYSVIRKT
Length:299
Mass (Da):33,201
Last modified:February 20, 2007 - v2
Checksum:i978461DA87E86269
GO
Isoform 2 (identifier: Q9UGN4-2) [UniParc]FASTAAdd to basket
Also known as: IRC1c

The sequence of this isoform differs from the canonical sequence as follows:
     14-126: Missing.

Show »
Length:186
Mass (Da):20,640
Checksum:i00D5E9379190EEEE
GO
Isoform 3 (identifier: Q9UGN4-3) [UniParc]FASTAAdd to basket
Also known as: IRC1b

The sequence of this isoform differs from the canonical sequence as follows:
     14-209: Missing.

Show »
Length:103
Mass (Da):11,870
Checksum:iB65239E9760E47AB
GO
Isoform 4 (identifier: Q9UGN4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-126: Missing.
     223-258: Missing.

Show »
Length:150
Mass (Da):16,517
Checksum:iED357EBD18A30FF0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QKQ4J3QKQ4_HUMAN
CMRF35-like molecule 8
CD300A
169Annotation score:

Sequence cautioni

The sequence AAF28906 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAF28906 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29VG → W in AAD01646 (PubMed:9701027).Curated2
Sequence conflicti28 – 29VG → W in AAF89957 (PubMed:10746781).Curated2
Sequence conflicti39E → Q in AAF89957 (PubMed:10746781).Curated1
Sequence conflicti189L → M in AAF28906 (Ref. 5) Curated1
Sequence conflicti193L → M in AAF28906 (Ref. 5) Curated1
Sequence conflicti209K → KWIK in AAD01646 (PubMed:9701027).Curated1
Sequence conflicti260S → F in AAF28906 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030797111R → Q2 PublicationsCorresponds to variant dbSNP:rs2272111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01055814 – 209Missing in isoform 3. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_01055914 – 126Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST113
Alternative sequenceiVSP_041246223 – 258Missing in isoform 4. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238323 mRNA Translation: CAB66145.1
AJ010101 mRNA Translation: CAB52291.1
AJ010102 mRNA Translation: CAB52292.1
AJ010103 mRNA Translation: CAB52293.1
AJ224864 mRNA Translation: CAB55347.1
AF020314 mRNA Translation: AAD01646.1
AF176991
, AF176985, AF176986, AF176987, AF176988, AF176989, AF176990 Genomic DNA Translation: AAF89957.1
AF161346 mRNA Translation: AAF28906.1 Sequence problems.
AC079325 Genomic DNA No translation available.
BC032352 mRNA Translation: AAH32352.1
CCDSiCCDS32720.1 [Q9UGN4-1]
CCDS58590.1 [Q9UGN4-2]
CCDS82196.1 [Q9UGN4-4]
RefSeqiNP_001243770.1, NM_001256841.1 [Q9UGN4-2]
NP_001317386.1, NM_001330457.1 [Q9UGN4-4]
NP_009192.2, NM_007261.3 [Q9UGN4-1]
UniGeneiHs.9688

Genome annotation databases

EnsembliENST00000310828; ENSP00000308188; ENSG00000167851 [Q9UGN4-2]
ENST00000360141; ENSP00000353259; ENSG00000167851 [Q9UGN4-1]
ENST00000361933; ENSP00000354564; ENSG00000167851 [Q9UGN4-3]
ENST00000392625; ENSP00000376401; ENSG00000167851 [Q9UGN4-4]
GeneIDi11314
KEGGihsa:11314
UCSCiuc002jkv.5 human [Q9UGN4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238323 mRNA Translation: CAB66145.1
AJ010101 mRNA Translation: CAB52291.1
AJ010102 mRNA Translation: CAB52292.1
AJ010103 mRNA Translation: CAB52293.1
AJ224864 mRNA Translation: CAB55347.1
AF020314 mRNA Translation: AAD01646.1
AF176991
, AF176985, AF176986, AF176987, AF176988, AF176989, AF176990 Genomic DNA Translation: AAF89957.1
AF161346 mRNA Translation: AAF28906.1 Sequence problems.
AC079325 Genomic DNA No translation available.
BC032352 mRNA Translation: AAH32352.1
CCDSiCCDS32720.1 [Q9UGN4-1]
CCDS58590.1 [Q9UGN4-2]
CCDS82196.1 [Q9UGN4-4]
RefSeqiNP_001243770.1, NM_001256841.1 [Q9UGN4-2]
NP_001317386.1, NM_001330457.1 [Q9UGN4-4]
NP_009192.2, NM_007261.3 [Q9UGN4-1]
UniGeneiHs.9688

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q87X-ray1.70A/B/C19-125[»]
ProteinModelPortaliQ9UGN4
SMRiQ9UGN4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116445, 2 interactors
IntActiQ9UGN4, 7 interactors
STRINGi9606.ENSP00000353259

PTM databases

iPTMnetiQ9UGN4
PhosphoSitePlusiQ9UGN4

Polymorphism and mutation databases

BioMutaiCD300A
DMDMi126302534

Proteomic databases

PaxDbiQ9UGN4
PeptideAtlasiQ9UGN4
PRIDEiQ9UGN4
ProteomicsDBi84246
84247 [Q9UGN4-2]
84248 [Q9UGN4-3]
84249 [Q9UGN4-4]
TopDownProteomicsiQ9UGN4-1 [Q9UGN4-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310828; ENSP00000308188; ENSG00000167851 [Q9UGN4-2]
ENST00000360141; ENSP00000353259; ENSG00000167851 [Q9UGN4-1]
ENST00000361933; ENSP00000354564; ENSG00000167851 [Q9UGN4-3]
ENST00000392625; ENSP00000376401; ENSG00000167851 [Q9UGN4-4]
GeneIDi11314
KEGGihsa:11314
UCSCiuc002jkv.5 human [Q9UGN4-1]

Organism-specific databases

CTDi11314
DisGeNETi11314
EuPathDBiHostDB:ENSG00000167851.13
GeneCardsiCD300A
HGNCiHGNC:19319 CD300A
HPAiHPA011645
MIMi606790 gene
neXtProtiNX_Q9UGN4
OpenTargetsiENSG00000167851
PharmGKBiPA142672149
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXT8 Eukaryota
ENOG410ZH9V LUCA
GeneTreeiENSGT00470000042273
HOVERGENiHBG100050
InParanoidiQ9UGN4
KOiK06719
OMAiLWVPGCF
OrthoDBiEOG091G0RAD
PhylomeDBiQ9UGN4
TreeFamiTF334441

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiQ9UGN4
GeneWikiiCD300A
GenomeRNAii11314
PROiPR:Q9UGN4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167851 Expressed in 167 organ(s), highest expression level in blood
CleanExiHS_CD300A
ExpressionAtlasiQ9UGN4 baseline and differential
GenevisibleiQ9UGN4 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLM8_HUMAN
AccessioniPrimary (citable) accession number: Q9UGN4
Secondary accession number(s): A8MW96
, O95100, Q9HD97, Q9P0F3, Q9UBK4, Q9UMS9, Q9UMT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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