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Entry version 181 (17 Jun 2020)
Sequence version 2 (10 Jan 2006)
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Protein

Deleted in malignant brain tumors 1 protein

Gene

DMBT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAntiviral defense, Differentiation, Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5683826 Surfactant metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deleted in malignant brain tumors 1 protein
Alternative name(s):
Glycoprotein 340
Short name:
Gp-340
Hensin
Salivary agglutinin
Short name:
SAG
Surfactant pulmonary-associated D-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMBT11 PublicationImported
Synonyms:GP340
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187908.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2926 DMBT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601969 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UGM3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glioma (GLM)
The gene represented in this entry is involved in disease pathogenesis. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well.
Disease descriptionGliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Related information in OMIM

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
1755
MIMi137800 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000187908

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27376

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UGM3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DMBT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85687556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004538720 – 2413Deleted in malignant brain tumors 1 proteinAdd BLAST2394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi127 ↔ 191By similarity
Disulfide bondi140 ↔ 201By similarity
Disulfide bondi171 ↔ 181By similarity
Disulfide bondi259 ↔ 323By similarity
Disulfide bondi272 ↔ 333By similarity
Disulfide bondi303 ↔ 313By similarity
Disulfide bondi388 ↔ 452By similarity
Disulfide bondi401 ↔ 462By similarity
Disulfide bondi432 ↔ 442By similarity
Disulfide bondi519 ↔ 583By similarity
Disulfide bondi532 ↔ 593By similarity
Disulfide bondi563 ↔ 573By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi627 ↔ 691By similarity
Disulfide bondi640 ↔ 701By similarity
Disulfide bondi671 ↔ 681By similarity
Glycosylationi737N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi758 ↔ 822By similarity
Disulfide bondi771 ↔ 832By similarity
Disulfide bondi802 ↔ 812By similarity
Disulfide bondi887 ↔ 951By similarity
Disulfide bondi900 ↔ 961By similarity
Disulfide bondi931 ↔ 941By similarity
Disulfide bondi1018 ↔ 1082By similarity
Disulfide bondi1031 ↔ 1092By similarity
Disulfide bondi1062 ↔ 1072By similarity
Disulfide bondi1147 ↔ 1211By similarity
Disulfide bondi1160 ↔ 1221By similarity
Disulfide bondi1191 ↔ 1201By similarity
Disulfide bondi1276 ↔ 1340By similarity
Disulfide bondi1289 ↔ 1350By similarity
Disulfide bondi1320 ↔ 1330By similarity
Disulfide bondi1405 ↔ 1469By similarity
Disulfide bondi1418 ↔ 1479By similarity
Disulfide bondi1449 ↔ 1459By similarity
Disulfide bondi1534 ↔ 1598By similarity
Disulfide bondi1547 ↔ 1608By similarity
Disulfide bondi1578 ↔ 1588By similarity
Disulfide bondi1665 ↔ 1729By similarity
Disulfide bondi1678 ↔ 1739By similarity
Disulfide bondi1709 ↔ 1719By similarity
Glycosylationi1712N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1745N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1766 ↔ 1792By similarity
Glycosylationi1818N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1819 ↔ 1841By similarity
Glycosylationi1832N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1842N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1889N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1911 ↔ 1975By similarity
Disulfide bondi1924 ↔ 1985By similarity
Disulfide bondi1955 ↔ 1965By similarity
Glycosylationi1998N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2008 ↔ 2034By similarity
Disulfide bondi2059 ↔ 2081By similarity
Glycosylationi2120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2188N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2256N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2302 ↔ 2360By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly N- and O-glycosylated. The O-glycans are heavily sulfated (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UGM3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UGM3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UGM3

PeptideAtlas

More...
PeptideAtlasi
Q9UGM3

PRoteomics IDEntifications database

More...
PRIDEi
Q9UGM3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
31825
84235 [Q9UGM3-1]
84236 [Q9UGM3-2]
84237 [Q9UGM3-3]
84238 [Q9UGM3-4]
84239 [Q9UGM3-5]
84240 [Q9UGM3-6]
84241 [Q9UGM3-7]
84242 [Q9UGM3-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UGM3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGM3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract.7 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal lung, intestine and skin. Secreted to the extracellular matrix (ECM) in certain fetal epithelia.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in intestinal epithelial cells in response to proinflammatory stimuli including TNF and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187908 Expressed in parotid gland and 128 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UGM3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187908 Group enriched (intestine, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LGALS3 (By similarity). Binds SFTPD and SPAR in a calcium-dependent manner.

By similarity2 Publications

(Microbial infection) Interacts with HIV-1 glycoprotein 120.

1 Publication

(Microbial infection) Interacts with S.aureus SraP; the interaction is inhibited by N-acetylneuraminic acid (PubMed:23439307).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108095, 24 interactors

Database of interacting proteins

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DIPi
DIP-50763N

Protein interaction database and analysis system

More...
IntActi
Q9UGM3, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357905

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UGM3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UGM3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 202SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini234 – 334SRCR 2PROSITE-ProRule annotationAdd BLAST101
Domaini363 – 463SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini494 – 594SRCR 4PROSITE-ProRule annotationAdd BLAST101
Domaini602 – 702SRCR 5PROSITE-ProRule annotationAdd BLAST101
Domaini733 – 833SRCR 6PROSITE-ProRule annotationAdd BLAST101
Domaini862 – 962SRCR 7PROSITE-ProRule annotationAdd BLAST101
Domaini993 – 1093SRCR 8PROSITE-ProRule annotationAdd BLAST101
Domaini1122 – 1222SRCR 9PROSITE-ProRule annotationAdd BLAST101
Domaini1251 – 1351SRCR 10PROSITE-ProRule annotationAdd BLAST101
Domaini1380 – 1480SRCR 11PROSITE-ProRule annotationAdd BLAST101
Domaini1509 – 1609SRCR 12PROSITE-ProRule annotationAdd BLAST101
Domaini1640 – 1740SRCR 13PROSITE-ProRule annotationAdd BLAST101
Domaini1766 – 1877CUB 1PROSITE-ProRule annotationAdd BLAST112
Domaini1883 – 1986SRCR 14PROSITE-ProRule annotationAdd BLAST104
Domaini2008 – 2117CUB 2PROSITE-ProRule annotationAdd BLAST110
Domaini2126 – 2381ZPPROSITE-ProRule annotationAdd BLAST256

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1755 – 1759Poly-Thr5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SRCR domains mediate binding to bacteria. The minimal bacterial-binding site is an 11-residue repeat of GRVEVLYRGSW where VEVL and W are critical residues.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DMBT1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHBC Eukaryota
ENOG410XQVR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183145

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_230903_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UGM3

KEGG Orthology (KO)

More...
KOi
K13912

Identification of Orthologs from Complete Genome Data

More...
OMAi
DNWDTND

Database of Orthologous Groups

More...
OrthoDBi
1095487at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGM3

TreeFam database of animal gene trees

More...
TreeFami
TF329295

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 2 hits
3.10.250.10, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001507 ZP_dom
IPR017977 ZP_dom_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 2 hits
PF00530 SRCR, 14 hits
PF00100 Zona_pellucida, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00258 SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042 CUB, 2 hits
SM00202 SR, 14 hits
SM00241 ZP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 2 hits
SSF56487 SSF56487, 14 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 2 hits
PS00420 SRCR_1, 13 hits
PS50287 SRCR_2, 14 hits
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: More isoforms may exist.

This entry has 9 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGM3-1) [UniParc]FASTAAdd to basket
Also known as: DMBT1/8kb.2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGISTVILEM CLLWGQVLST GGWIPRTTDY ASLIPSEVPL DPTVAEGSPF
60 70 80 90 100
PSESTLESTV AEGSPISLES TLESTVAEGS LIPSESTLES TVAEGSDSGL
110 120 130 140 150
ALRLVNGDGR CQGRVEILYR GSWGTVCDDS WDTNDANVVC RQLGCGWAMS
160 170 180 190 200
APGNAWFGQG SGPIALDDVR CSGHESYLWS CPHNGWLSHN CGHGEDAGVI
210 220 230 240 250
CSAAQPQSTL RPESWPVRIS PPVPTEGSES SLALRLVNGG DRCRGRVEVL
260 270 280 290 300
YRGSWGTVCD DYWDTNDANV VCRQLGCGWA MSAPGNAQFG QGSGPIVLDD
310 320 330 340 350
VRCSGHESYL WSCPHNGWLT HNCGHSEDAG VICSAPQSRP TPSPDTWPTS
360 370 380 390 400
HASTAGPESS LALRLVNGGD RCQGRVEVLY RGSWGTVCDD SWDTSDANVV
410 420 430 440 450
CRQLGCGWAT SAPGNARFGQ GSGPIVLDDV RCSGYESYLW SCPHNGWLSH
460 470 480 490 500
NCQHSEDAGV ICSAAHSWST PSPDTLPTIT LPASTVGSES SLALRLVNGG
510 520 530 540 550
DRCQGRVEVL YRGSWGTVCD DSWDTNDANV VCRQLGCGWA MLAPGNARFG
560 570 580 590 600
QGSGPIVLDD VRCSGNESYL WSCPHNGWLS HNCGHSEDAG VICSGPESSL
610 620 630 640 650
ALRLVNGGDR CQGRVEVLYR GSWGTVCDDS WDTNDANVVC RQLGCGWATS
660 670 680 690 700
APGNARFGQG SGPIVLDDVR CSGHESYLWS CPNNGWLSHN CGHHEDAGVI
710 720 730 740 750
CSAAQSRSTP RPDTLSTITL PPSTVGSESS LTLRLVNGSD RCQGRVEVLY
760 770 780 790 800
RGSWGTVCDD SWDTNDANVV CRQLGCGWAT SAPGNARFGQ GSGPIVLDDV
810 820 830 840 850
RCSGHESYLW SCPHNGWLSH NCGHHEDAGV ICSVSQSRPT PSPDTWPTSH
860 870 880 890 900
ASTAGPESSL ALRLVNGGDR CQGRVEVLYR GSWGTVCDDS WDTSDANVVC
910 920 930 940 950
RQLGCGWATS APGNARFGQG SGPIVLDDVR CSGYESYLWS CPHNGWLSHN
960 970 980 990 1000
CQHSEDAGVI CSAAHSWSTP SPDTLPTITL PASTVGSESS LALRLVNGGD
1010 1020 1030 1040 1050
RCQGRVEVLY QGSWGTVCDD SWDTNDANVV CRQLGCGWAM SAPGNARFGQ
1060 1070 1080 1090 1100
GSGPIVLDDV RCSGHESYLW SCPHNGWLSH NCGHSEDAGV ICSASQSRPT
1110 1120 1130 1140 1150
PSPDTWPTSH ASTAGSESSL ALRLVNGGDR CQGRVEVLYR GSWGTVCDDY
1160 1170 1180 1190 1200
WDTNDANVVC RQLGCGWAMS APGNARFGQG SGPIVLDDVR CSGHESYLWS
1210 1220 1230 1240 1250
CPHNGWLSHN CGHHEDAGVI CSASQSQPTP SPDTWPTSHA STAGSESSLA
1260 1270 1280 1290 1300
LRLVNGGDRC QGRVEVLYRG SWGTVCDDYW DTNDANVVCR QLGCGWATSA
1310 1320 1330 1340 1350
PGNARFGQGS GPIVLDDVRC SGHESYLWSC PHNGWLSHNC GHHEDAGVIC
1360 1370 1380 1390 1400
SASQSQPTPS PDTWPTSHAS TAGSESSLAL RLVNGGDRCQ GRVEVLYRGS
1410 1420 1430 1440 1450
WGTVCDDYWD TNDANVVCRQ LGCGWATSAP GNARFGQGSG PIVLDDVRCS
1460 1470 1480 1490 1500
GHESYLWSCP HNGWLSHNCG HHEDAGVICS ASQSQPTPSP DTWPTSRAST
1510 1520 1530 1540 1550
AGSESTLALR LVNGGDRCRG RVEVLYQGSW GTVCDDYWDT NDANVVCRQL
1560 1570 1580 1590 1600
GCGWAMSAPG NAQFGQGSGP IVLDDVRCSG HESYLWSCPH NGWLSHNCGH
1610 1620 1630 1640 1650
HEDAGVICSA AQSQSTPRPD TWLTTNLPAL TVGSESSLAL RLVNGGDRCR
1660 1670 1680 1690 1700
GRVEVLYRGS WGTVCDDSWD TNDANVVCRQ LGCGWAMSAP GNARFGQGSG
1710 1720 1730 1740 1750
PIVLDDVRCS GNESYLWSCP HKGWLTHNCG HHEDAGVICS ATQINSTTTD
1760 1770 1780 1790 1800
WWHPTTTTTA RPSSNCGGFL FYASGTFSSP SYPAYYPNNA KCVWEIEVNS
1810 1820 1830 1840 1850
GYRINLGFSN LKLEAHHNCS FDYVEIFDGS LNSSLLLGKI CNDTRQIFTS
1860 1870 1880 1890 1900
SYNRMTIHFR SDISFQNTGF LAWYNSFPSD ATLRLVNLNS SYGLCAGRVE
1910 1920 1930 1940 1950
IYHGGTWGTV CDDSWTIQEA EVVCRQLGCG RAVSALGNAY FGSGSGPITL
1960 1970 1980 1990 2000
DDVECSGTES TLWQCRNRGW FSHNCNHRED AGVICSGNHL STPAPFLNIT
2010 2020 2030 2040 2050
RPNTDYSCGG FLSQPSGDFS SPFYPGNYPN NAKCVWDIEV QNNYRVTVIF
2060 2070 2080 2090 2100
RDVQLEGGCN YDYIEVFDGP YRSSPLIARV CDGARGSFTS SSNFMSIRFI
2110 2120 2130 2140 2150
SDHSITRRGF RAEYYSSPSN DSTNLLCLPN HMQASVSRSY LQSLGFSASD
2160 2170 2180 2190 2200
LVISTWNGYY ECRPQITPNL VIFTIPYSGC GTFKQADNDT IDYSNFLTAA
2210 2220 2230 2240 2250
VSGGIIKRRT DLRIHVSCRM LQNTWVDTMY IANDTIHVAN NTIQVEEVQY
2260 2270 2280 2290 2300
GNFDVNISFY TSSSFLYPVT SRPYYVDLNQ DLYVQAEILH SDAVLTLFVD
2310 2320 2330 2340 2350
TCVASPYSND FTSLTYDLIR SGCVRDDTYG PYSSPSLRIA RFRFRAFHFL
2360 2370 2380 2390 2400
NRFPSVYLRC KMVVCRAYDP SSRCYRGCVL RSKRDVGSYQ EKVDVVLGPI
2410
QLQTPPRREE EPR
Length:2,413
Mass (Da):260,735
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25363E6263234F15
GO
Isoform 2 (identifier: Q9UGM3-2) [UniParc]FASTAAdd to basket
Also known as: DMBT1/6kb.1

The sequence of this isoform differs from the canonical sequence as follows:
     337-835: Missing.
     1170-1298: Missing.

Show »
Length:1,785
Mass (Da):193,971
Checksum:iA01C68AF13C478BB
GO
Isoform 3 (identifier: Q9UGM3-3) [UniParc]FASTAAdd to basket
Also known as: DMBT1/8kb.1

The sequence of this isoform differs from the canonical sequence as follows:
     464-473: Missing.

Show »
Length:2,403
Mass (Da):259,713
Checksum:iC46A2BD09B2C874D
GO
Isoform 4 (identifier: Q9UGM3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     523-1408: Missing.

Show »
Length:1,527
Mass (Da):166,501
Checksum:iED984E0EF2736C69
GO
Isoform 6 (identifier: Q9UGM3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1169-1169: M → MSAPGNARFG...CRQLGCGWAT

Show »
Length:2,542
Mass (Da):274,465
Checksum:iA6390E0D194E6A22
GO
Isoform 7 (identifier: Q9UGM3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     464-473: Missing.
     1169-1169: M → MSAPGNARFG...CRQLGCGWAT

Show »
Length:2,532
Mass (Da):273,443
Checksum:i3E96E2D1F87EA45A
GO
Isoform 8 (identifier: Q9UGM3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-478: SPDTLPT → RPGERPR
     479-971: Missing.
     1099-1356: Missing.

Show »
Length:1,662
Mass (Da):180,973
Checksum:iB9655F67233F6AE3
GO
Isoform 5 (identifier: Q9UGM3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1741-1761: ATQINSTTTDWWHPTTTTTAR → G

Show »
Length:2,393
Mass (Da):258,420
Checksum:iD2AA22898581A701
GO
Isoform 9 (identifier: Q9UGM3-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-332: Missing.
     344-1360: Missing.
     1608-1738: Missing.

Show »
Length:1,133
Mass (Da):124,452
Checksum:i59ED2884BD6C86A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A590UJ76A0A590UJ76_HUMAN
Deleted in malignant brain tumors 1...
DMBT1
2,412Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJZ9A0A590UJZ9_HUMAN
Deleted in malignant brain tumors 1...
DMBT1
1,527Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UIX5A0A590UIX5_HUMAN
Deleted in malignant brain tumors 1...
DMBT1
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK99A0A590UK99_HUMAN
Deleted in malignant brain tumors 1...
DMBT1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJF8A0A590UJF8_HUMAN
Deleted in malignant brain tumors 1...
DMBT1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10M → V in CAC44122 (PubMed:11751412).Curated1
Sequence conflicti13L → S in BAH14118 (PubMed:14702039).Curated1
Sequence conflicti31A → T in AAI53300 (PubMed:15489334).Curated1
Sequence conflicti42P → Q in AAD49696 (PubMed:10485905).Curated1
Sequence conflicti42P → Q in AAI53300 (PubMed:15489334).Curated1
Sequence conflicti74S → T in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti125T → A in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti188S → T in BAH14118 (PubMed:14702039).Curated1
Sequence conflicti194G → S in BAH14118 (PubMed:14702039).Curated1
Sequence conflicti468W → R in CAC44122 (PubMed:11751412).Curated1
Sequence conflicti594S → SDTLPTTTLPASTV in CAB63941 (PubMed:10597221).Curated1
Sequence conflicti603R → G in CAB63942 (PubMed:10597221).Curated1
Sequence conflicti711R → G in CAC44122 (PubMed:11751412).Curated1
Sequence conflicti902Q → R in CAB63942 (PubMed:10597221).Curated1
Sequence conflicti1034L → P in CAA04019 (PubMed:9288095).Curated1
Sequence conflicti1034L → P in AAD49696 (PubMed:10485905).Curated1
Sequence conflicti1060V → A in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti1069L → P in CAA04019 (PubMed:9288095).Curated1
Sequence conflicti1069L → P in AAD49696 (PubMed:10485905).Curated1
Sequence conflicti1159V → A in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti1204N → D in CAB63942 (PubMed:10597221).Curated1
Sequence conflicti1271S → P in CAB63942 (PubMed:10597221).Curated1
Sequence conflicti1295G → S in CAC44122 (PubMed:11751412).Curated1
Sequence conflicti1336L → F in CAC44122 (PubMed:11751412).Curated1
Sequence conflicti1411T → I in AAI53300 (PubMed:15489334).Curated1
Sequence conflicti1432N → S in CAB63942 (PubMed:10597221).Curated1
Sequence conflicti1443V → A in CAB63942 (PubMed:10597221).Curated1
Sequence conflicti1448R → H in AAI53300 (PubMed:15489334).Curated1
Sequence conflicti1482S → F in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti1583S → P in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti1591N → K in BAH14118 (PubMed:14702039).Curated1
Sequence conflicti1595S → T in BAH14118 (PubMed:14702039).Curated1
Sequence conflicti1705D → G in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti1845R → G (PubMed:17974005).Curated1
Sequence conflicti1909T → A in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti2004 – 2005TD → N in CAB56155 (PubMed:10485905).Curated2
Sequence conflicti2196F → L in CAB56155 (PubMed:10485905).Curated1
Sequence conflicti2380L → S in AAI53300 (PubMed:15489334).Curated1
Sequence conflicti2405P → A in CAC44122 (PubMed:11751412).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The number of SRCR and SRCR-interspersed domains is polymorphic in a variety of tumors and may represent the major site of alterations in cancer.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02478842P → T6 PublicationsCorresponds to variant dbSNP:rs11523871Ensembl.1
Natural variantiVAR_02478952S → W2 PublicationsCorresponds to variant dbSNP:rs75209396Ensembl.1
Natural variantiVAR_02479054S → L6 PublicationsCorresponds to variant dbSNP:rs3013236Ensembl.1
Natural variantiVAR_02479160V → A4 Publications1
Natural variantiVAR_02479265P → L1 PublicationCorresponds to variant dbSNP:rs185045706Ensembl.1
Natural variantiVAR_057981162G → E in a glioma cell line. 1 PublicationCorresponds to variant dbSNP:rs200664624Ensembl.1
Natural variantiVAR_044417322N → D1 PublicationCorresponds to variant dbSNP:rs1969620Ensembl.1
Natural variantiVAR_024793337Q → L2 Publications1
Natural variantiVAR_024794357P → S2 PublicationsCorresponds to variant dbSNP:rs141757453Ensembl.1
Natural variantiVAR_024795364R → G1 Publication1
Natural variantiVAR_024796420Q → H in a glioma sample; glioblastoma multiforme; somatic mutation. Corresponds to variant dbSNP:rs104894156Ensembl.1
Natural variantiVAR_057982546N → S in a glioma cell line. 1 PublicationCorresponds to variant dbSNP:rs200713568Ensembl.1
Natural variantiVAR_024797607G → V in a glioma sample; pilocytic astrocytoma. 1
Natural variantiVAR_024798649T → M2 PublicationsCorresponds to variant dbSNP:rs189478437Ensembl.1
Natural variantiVAR_024799656R → W. Corresponds to variant dbSNP:rs989419742Ensembl.1
Natural variantiVAR_052994670R → C. Corresponds to variant dbSNP:rs2277237Ensembl.1
Natural variantiVAR_052995719T → M. Corresponds to variant dbSNP:rs2277238Ensembl.1
Natural variantiVAR_024800780T → M2 PublicationsCorresponds to variant dbSNP:rs199704744Ensembl.1
Natural variantiVAR_024801856P → S4 PublicationsCorresponds to variant dbSNP:rs144450471Ensembl.1
Natural variantiVAR_080764969T → R Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1195952221Ensembl.1
Natural variantiVAR_0248021084H → Y1 PublicationCorresponds to variant dbSNP:rs2277244Ensembl.1
Natural variantiVAR_0579831095S → P1 PublicationCorresponds to variant dbSNP:rs200551848Ensembl.1
Natural variantiVAR_0579841102S → T1 PublicationCorresponds to variant dbSNP:rs566926424Ensembl.1
Natural variantiVAR_0248031169M → T1 PublicationCorresponds to variant dbSNP:rs149099696Ensembl.1
Natural variantiVAR_0248041176R → W1 PublicationCorresponds to variant dbSNP:rs761527369Ensembl.1
Natural variantiVAR_0579851434R → W1 Publication1
Natural variantiVAR_0248051545V → M1 PublicationCorresponds to variant dbSNP:rs189221852Ensembl.1
Natural variantiVAR_0248061732H → S Requires 2 nucleotide substitutions. 2 Publications1
Natural variantiVAR_0444181860R → L. Corresponds to variant dbSNP:rs7099177Ensembl.1
Natural variantiVAR_0248071961T → P1 Publication1
Natural variantiVAR_0579862255V → M1 PublicationCorresponds to variant dbSNP:rs183135544Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053979201 – 332Missing in isoform 9. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_016846337 – 835Missing in isoform 2. 1 PublicationAdd BLAST499
Alternative sequenceiVSP_053980344 – 1360Missing in isoform 9. 1 PublicationAdd BLAST1017
Alternative sequenceiVSP_016847464 – 473Missing in isoform 3 and isoform 7. 1 Publication10
Alternative sequenceiVSP_034653472 – 478SPDTLPT → RPGERPR in isoform 8. 1 Publication7
Alternative sequenceiVSP_034654479 – 971Missing in isoform 8. 1 PublicationAdd BLAST493
Alternative sequenceiVSP_016848523 – 1408Missing in isoform 4. 1 PublicationAdd BLAST886
Alternative sequenceiVSP_0346551099 – 1356Missing in isoform 8. 1 PublicationAdd BLAST258
Alternative sequenceiVSP_0346561169M → MSAPGNARFGQGSGPIVLDD VRCSGHESYLWSCPHNGWLS HNCGHHEDAGVICSASQSQP TPSPDTWPTSHASTAGSESS LALRLVNGGDRCQGRVEVLY RGSWGTVCDDYWDTNDANVV CRQLGCGWAT in isoform 6 and isoform 7. Curated1
Alternative sequenceiVSP_0168491170 – 1298Missing in isoform 2. 1 PublicationAdd BLAST129
Alternative sequenceiVSP_0539811608 – 1738Missing in isoform 9. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_0168501741 – 1761ATQIN…TTTAR → G in isoform 5. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ000342 mRNA Translation: CAA04019.1
AF159456 mRNA Translation: AAD49696.1
AJ243212 mRNA Translation: CAB56155.1
AJ243211 Genomic DNA Translation: CAB63941.1
AJ243224 mRNA Translation: CAB63942.1
AB020851 Genomic DNA Translation: BAA78577.1
AJ297935 mRNA Translation: CAC44122.1
AK304149 mRNA Translation: BAH14118.1
AL603764 Genomic DNA No translation available.
BC153299 mRNA Translation: AAI53300.1
AB209691 mRNA Translation: BAD92928.1
BX640988 mRNA Translation: CAE45995.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44490.1 [Q9UGM3-1]
CCDS44491.1 [Q9UGM3-2]
CCDS44492.1 [Q9UGM3-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A59386

NCBI Reference Sequences

More...
RefSeqi
NP_001307573.1, NM_001320644.1
NP_004397.2, NM_004406.2 [Q9UGM3-2]
NP_015568.2, NM_007329.2 [Q9UGM3-1]
NP_060049.2, NM_017579.2 [Q9UGM3-3]
XP_011537690.1, XM_011539388.2 [Q9UGM3-6]
XP_011537693.1, XM_011539391.2 [Q9UGM3-7]
XP_011537707.1, XM_011539405.2 [Q9UGM3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330163; ENSP00000327747; ENSG00000187908 [Q9UGM3-2]
ENST00000338354; ENSP00000342210; ENSG00000187908 [Q9UGM3-6]
ENST00000344338; ENSP00000343175; ENSG00000187908 [Q9UGM3-3]
ENST00000368909; ENSP00000357905; ENSG00000187908 [Q9UGM3-1]
ENST00000368955; ENSP00000357951; ENSG00000187908 [Q9UGM3-3]
ENST00000368956; ENSP00000357952; ENSG00000187908 [Q9UGM3-2]
ENST00000619379; ENSP00000484603; ENSG00000187908 [Q9UGM3-1]
ENST00000652446; ENSP00000498825; ENSG00000187908 [Q9UGM3-1]
ENST00000653442; ENSP00000499436; ENSG00000187908 [Q9UGM3-5]
ENST00000657942; ENSP00000499391; ENSG00000187908 [Q9UGM3-9]
ENST00000664692; ENSP00000499397; ENSG00000187908 [Q9UGM3-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1755

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1755

UCSC genome browser

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UCSCi
uc001lgk.1 human [Q9UGM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000342 mRNA Translation: CAA04019.1
AF159456 mRNA Translation: AAD49696.1
AJ243212 mRNA Translation: CAB56155.1
AJ243211 Genomic DNA Translation: CAB63941.1
AJ243224 mRNA Translation: CAB63942.1
AB020851 Genomic DNA Translation: BAA78577.1
AJ297935 mRNA Translation: CAC44122.1
AK304149 mRNA Translation: BAH14118.1
AL603764 Genomic DNA No translation available.
BC153299 mRNA Translation: AAI53300.1
AB209691 mRNA Translation: BAD92928.1
BX640988 mRNA Translation: CAE45995.1
CCDSiCCDS44490.1 [Q9UGM3-1]
CCDS44491.1 [Q9UGM3-2]
CCDS44492.1 [Q9UGM3-3]
PIRiA59386
RefSeqiNP_001307573.1, NM_001320644.1
NP_004397.2, NM_004406.2 [Q9UGM3-2]
NP_015568.2, NM_007329.2 [Q9UGM3-1]
NP_060049.2, NM_017579.2 [Q9UGM3-3]
XP_011537690.1, XM_011539388.2 [Q9UGM3-6]
XP_011537693.1, XM_011539391.2 [Q9UGM3-7]
XP_011537707.1, XM_011539405.2 [Q9UGM3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6SA4X-ray1.77A95-203[»]
6SA5X-ray1.29A986-1094[»]
6SANX-ray1.36A/B986-1094[»]
SMRiQ9UGM3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108095, 24 interactors
DIPiDIP-50763N
IntActiQ9UGM3, 16 interactors
STRINGi9606.ENSP00000357905

PTM databases

iPTMnetiQ9UGM3
PhosphoSitePlusiQ9UGM3

Polymorphism and mutation databases

BioMutaiDMBT1
DMDMi85687556

Proteomic databases

jPOSTiQ9UGM3
MassIVEiQ9UGM3
PaxDbiQ9UGM3
PeptideAtlasiQ9UGM3
PRIDEiQ9UGM3
ProteomicsDBi31825
84235 [Q9UGM3-1]
84236 [Q9UGM3-2]
84237 [Q9UGM3-3]
84238 [Q9UGM3-4]
84239 [Q9UGM3-5]
84240 [Q9UGM3-6]
84241 [Q9UGM3-7]
84242 [Q9UGM3-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32275 188 antibodies

The DNASU plasmid repository

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DNASUi
1755

Genome annotation databases

EnsembliENST00000330163; ENSP00000327747; ENSG00000187908 [Q9UGM3-2]
ENST00000338354; ENSP00000342210; ENSG00000187908 [Q9UGM3-6]
ENST00000344338; ENSP00000343175; ENSG00000187908 [Q9UGM3-3]
ENST00000368909; ENSP00000357905; ENSG00000187908 [Q9UGM3-1]
ENST00000368955; ENSP00000357951; ENSG00000187908 [Q9UGM3-3]
ENST00000368956; ENSP00000357952; ENSG00000187908 [Q9UGM3-2]
ENST00000619379; ENSP00000484603; ENSG00000187908 [Q9UGM3-1]
ENST00000652446; ENSP00000498825; ENSG00000187908 [Q9UGM3-1]
ENST00000653442; ENSP00000499436; ENSG00000187908 [Q9UGM3-5]
ENST00000657942; ENSP00000499391; ENSG00000187908 [Q9UGM3-9]
ENST00000664692; ENSP00000499397; ENSG00000187908 [Q9UGM3-7]
GeneIDi1755
KEGGihsa:1755
UCSCiuc001lgk.1 human [Q9UGM3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1755
DisGeNETi1755
EuPathDBiHostDB:ENSG00000187908.15

GeneCards: human genes, protein and diseases

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GeneCardsi
DMBT1
HGNCiHGNC:2926 DMBT1
HPAiENSG00000187908 Group enriched (intestine, salivary gland)
MIMi137800 phenotype
601969 gene
neXtProtiNX_Q9UGM3
OpenTargetsiENSG00000187908
PharmGKBiPA27376

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHBC Eukaryota
ENOG410XQVR LUCA
GeneTreeiENSGT00950000183145
HOGENOMiCLU_230903_0_0_1
InParanoidiQ9UGM3
KOiK13912
OMAiDNWDTND
OrthoDBi1095487at2759
PhylomeDBiQ9UGM3
TreeFamiTF329295

Enzyme and pathway databases

ReactomeiR-HSA-5683826 Surfactant metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
1755 2 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DMBT1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DMBT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1755
PharosiQ9UGM3 Tbio

Protein Ontology

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PROi
PR:Q9UGM3
RNActiQ9UGM3 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187908 Expressed in parotid gland and 128 other tissues
GenevisibleiQ9UGM3 HS

Family and domain databases

CDDicd00041 CUB, 2 hits
Gene3Di2.60.120.290, 2 hits
3.10.250.10, 14 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00530 SRCR, 14 hits
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00202 SR, 14 hits
SM00241 ZP, 1 hit
SUPFAMiSSF49854 SSF49854, 2 hits
SSF56487 SSF56487, 14 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS00420 SRCR_1, 13 hits
PS50287 SRCR_2, 14 hits
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMBT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGM3
Secondary accession number(s): A6NDG4
, A6NDJ5, A8E4R5, B1ARE7, B1ARE8, B1ARE9, B1ARF0, B7Z8Y2, F8WEF7, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: June 17, 2020
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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