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Entry version 159 (31 Jul 2019)
Sequence version 3 (18 May 2010)
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Protein

Lysine-specific demethylase 5B

Gene

KDM5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).By similarity9 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Several specific inhibitors are being developed and tested (PubMed:27214403, PubMed:26741168). The inhibitor KDOAM-25 inhibits its demethylase activity, resulting to cell cycle arrest in myeloma cells (PubMed:28262558).3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kcat are 1.9 min(-1) and 2.0 min(-1) for 2-oxoglutarate and histone H3K4me3, respectively.1 Publication
  1. KM=9 µM for 2-oxoglutarate1 Publication
  2. KM=4 µM for histone H3K4me31 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei4252-oxoglutarateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi499Iron; catalytic3 Publications1
    Metal bindingi501Iron; catalytic3 Publications1
    Binding sitei5072-oxoglutarateBy similarity1
    Binding sitei5092-oxoglutarateBy similarity1
    Binding sitei5172-oxoglutarateBy similarity1
    Metal bindingi587Iron; catalytic3 Publications1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri309 – 359PHD-type 1Combined sources1 PublicationAdd BLAST51
    Zinc fingeri692 – 744C5HC23 PublicationsAdd BLAST53
    Zinc fingeri1176 – 1224PHD-type 2PROSITE-ProRule annotationAdd BLAST49
    Zinc fingeri1484 – 1538PHD-type 3Combined sourcesAdd BLAST55

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase, Repressor
    Biological processBiological rhythms, Transcription, Transcription regulation
    LigandIron, Metal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-3214842 HDMs demethylate histones
    R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q9UGL1

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Lysine-specific demethylase 5B (EC:1.14.11.-)
    Alternative name(s):
    Cancer/testis antigen 31
    Short name:
    CT31
    Histone demethylase JARID1B
    Jumonji/ARID domain-containing protein 1B
    PLU-1
    Retinoblastoma-binding protein 2 homolog 1
    Short name:
    RBP2-H1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:KDM5B
    Synonyms:JARID1B, PLU1, RBBP2H1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:18039 KDM5B

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605393 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9UGL1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Mental retardation, autosomal recessive 65 (MRT65)2 Publications
    The disease may be caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT65 patients have moderate to severe intellectual disability, developmental delay, and facial dysmorphism. Camptodactyly is present in some patients.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081276299 – 1544Missing in MRT65. 1 PublicationAdd BLAST1246
    Natural variantiVAR_0812771370 – 1544Missing in MRT65. 1 PublicationAdd BLAST175

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi308D → A: Slightly decreases interaction with histone H3. Decreases by 21% demethylase activity and repression of tumor suppressor genes expression. 1 Publication1
    Mutagenesisi309L → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi310Y → A: Slightly decreases interaction with histone H3. 1 Publication1
    Mutagenesisi310Y → F: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi311V → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi321E → A: Decreases interaction with histone H3. 1 Publication1
    Mutagenesisi322D → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi324L → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi325L → A: Abolishes interaction with histone H3. Decreases by 44% demethylase activity and repression of tumor suppressor genes expression; when associated with A-328. 1 Publication1
    Mutagenesisi326L → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi328D → A: Almost abolishes interaction with histone H3. Decreases by 44% demethylase activity and repression of tumor suppressor genes expression; when associated with A-325. 1 Publication1
    Mutagenesisi332D → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi333S → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi334Y → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi335H → A: Slightly impairs transcription repression ability. 1 Publication1
    Mutagenesisi345D → A: No effect on interaction with histone H3. 1 Publication1
    Mutagenesisi351W → A: Abolishes interaction with histone H3. Decreases by 28% demethylase activity and repression of tumor suppressor genes expression. 1 Publication1
    Mutagenesisi499 – 501HIE → AIA: Abolishes lysine-specific histone demethylase activity. 1 Publication3
    Mutagenesisi499H → Y: Abolishes lysine-specific histone demethylase activity. 1 Publication1
    Mutagenesisi1200H → A: Impairs transcription repression ability and interaction with HDAC4. 1 Publication1

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    10765

    MalaCards human disease database

    More...
    MalaCardsi
    KDM5B
    MIMi618109 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000117139

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    178469 Autosomal dominant non-syndromic intellectual disability
    88616 Autosomal recessive non-syndromic intellectual disability

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA164721626

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3774295

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2681

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    KDM5B

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296439317

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002924121 – 1544Lysine-specific demethylase 5BAdd BLAST1544

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki769Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei832N6-acetyllysineBy similarity1
    Modified residuei986PhosphoserineCombined sources1
    Modified residuei1328PhosphoserineCombined sources1
    Cross-linki1450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Modified residuei1456PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9UGL1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9UGL1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9UGL1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9UGL1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9UGL1

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    84231 [Q9UGL1-1]
    84232 [Q9UGL1-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9UGL1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9UGL1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).5 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000117139 Expressed in 213 organ(s), highest expression level in sperm

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9UGL1 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9UGL1 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB068193
    HPA027179
    HPA053723

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with FOXG1B, PAX9, MYC, MYCN and RB1.

    Interacts with HDAC1, HDAC4, HDAC5 and HDAC7.

    Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4'; the interaction is inhibited when histone H3 is methylated at 'Arg-2' or 'Lys-4' (PubMed:24952722).

    6 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTCFP497118EBI-2514978,EBI-932887

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    115984, 67 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q9UGL1

    Database of interacting proteins

    More...
    DIPi
    DIP-53652N

    Protein interaction database and analysis system

    More...
    IntActi
    Q9UGL1, 5 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000356234

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9UGL1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    11544
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9UGL1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 73JmjNPROSITE-ProRule annotationAdd BLAST42
    Domaini97 – 187ARIDPROSITE-ProRule annotationAdd BLAST91
    Domaini453 – 619JmjCPROSITE-ProRule annotationAdd BLAST167

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1434 – 1439Poly-Lys6

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Both the JmjC domain and the JmjN domain are required for enzymatic activity. However ARID and PHD-type 1 domain are not required for activity per se but contributed to recognition of the H3(1-21)K4me2 substrate peptide.1 Publication
    The 2 first PHD-type zinc finger domains are required for transcription repression activity.

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the JARID1 histone demethylase family.Curated

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri309 – 359PHD-type 1Combined sources1 PublicationAdd BLAST51
    Zinc fingeri692 – 744C5HC23 PublicationsAdd BLAST53
    Zinc fingeri1176 – 1224PHD-type 2PROSITE-ProRule annotationAdd BLAST49
    Zinc fingeri1484 – 1538PHD-type 3Combined sourcesAdd BLAST55

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1246 Eukaryota
    ENOG410XR9J LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157076

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000290719

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9UGL1

    KEGG Orthology (KO)

    More...
    KOi
    K11446

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VEMKVCL

    Database of Orthologous Groups

    More...
    OrthoDBi
    664180at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9UGL1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106476

    Family and domain databases

    Database of protein disorder

    More...
    DisProti
    DP00712

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.150.60, 1 hit
    3.30.40.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001606 ARID_dom
    IPR036431 ARID_dom_sf
    IPR003347 JmjC_dom
    IPR003349 JmjN
    IPR013637 Lys_sp_deMease-like_dom
    IPR019786 Zinc_finger_PHD-type_CS
    IPR004198 Znf_C5HC2
    IPR011011 Znf_FYVE_PHD
    IPR001965 Znf_PHD
    IPR019787 Znf_PHD-finger
    IPR013083 Znf_RING/FYVE/PHD

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01388 ARID, 1 hit
    PF02373 JmjC, 1 hit
    PF02375 JmjN, 1 hit
    PF00628 PHD, 3 hits
    PF08429 PLU-1, 1 hit
    PF02928 zf-C5HC2, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00501 BRIGHT, 1 hit
    SM00558 JmjC, 1 hit
    SM00545 JmjN, 1 hit
    SM00249 PHD, 3 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF46774 SSF46774, 1 hit
    SSF57903 SSF57903, 3 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51011 ARID, 1 hit
    PS51184 JMJC, 1 hit
    PS51183 JMJN, 1 hit
    PS01359 ZF_PHD_1, 2 hits
    PS50016 ZF_PHD_2, 3 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9UGL1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEAATTLHPG PRPALPLGGP GPLGEFLPPP ECPVFEPSWE EFADPFAFIH
    60 70 80 90 100
    KIRPIAEQTG ICKVRPPPDW QPPFACDVDK LHFTPRIQRL NELEAQTRVK
    110 120 130 140 150
    LNFLDQIAKY WELQGSTLKI PHVERKILDL FQLNKLVAEE GGFAVVCKDR
    160 170 180 190 200
    KWTKIATKMG FAPGKAVGSH IRGHYERILN PYNLFLSGDS LRCLQKPNLT
    210 220 230 240 250
    TDTKDKEYKP HDIPQRQSVQ PSETCPPARR AKRMRAEAMN IKIEPEETTE
    260 270 280 290 300
    ARTHNLRRRM GCPTPKCENE KEMKSSIKQE PIERKDYIVE NEKEKPKSRS
    310 320 330 340 350
    KKATNAVDLY VCLLCGSGND EDRLLLCDGC DDSYHTFCLI PPLHDVPKGD
    360 370 380 390 400
    WRCPKCLAQE CSKPQEAFGF EQAARDYTLR TFGEMADAFK SDYFNMPVHM
    410 420 430 440 450
    VPTELVEKEF WRLVSTIEED VTVEYGADIA SKEFGSGFPV RDGKIKLSPE
    460 470 480 490 500
    EEEYLDSGWN LNNMPVMEQS VLAHITADIC GMKLPWLYVG MCFSSFCWHI
    510 520 530 540 550
    EDHWSYSINY LHWGEPKTWY GVPGYAAEQL ENVMKKLAPE LFVSQPDLLH
    560 570 580 590 600
    QLVTIMNPNT LMTHEVPVYR TNQCAGEFVI TFPRAYHSGF NQGFNFAEAV
    610 620 630 640 650
    NFCTVDWLPL GRQCVEHYRL LHRYCVFSHD EMICKMASKA DVLDVVVAST
    660 670 680 690 700
    VQKDMAIMIE DEKALRETVR KLGVIDSERM DFELLPDDER QCVKCKTTCF
    710 720 730 740 750
    MSAISCSCKP GLLVCLHHVK ELCSCPPYKY KLRYRYTLDD LYPMMNALKL
    760 770 780 790 800
    RAESYNEWAL NVNEALEAKI NKKKSLVSFK ALIEESEMKK FPDNDLLRHL
    810 820 830 840 850
    RLVTQDAEKC ASVAQQLLNG KRQTRYRSGG GKSQNQLTVN ELRQFVTQLY
    860 870 880 890 900
    ALPCVLSQTP LLKDLLNRVE DFQQHSQKLL SEETPSAAEL QDLLDVSFEF
    910 920 930 940 950
    DVELPQLAEM RIRLEQARWL EEVQQACLDP SSLTLDDMRR LIDLGVGLAP
    960 970 980 990 1000
    YSAVEKAMAR LQELLTVSEH WDDKAKSLLK ARPRHSLNSL ATAVKEIEEI
    1010 1020 1030 1040 1050
    PAYLPNGAAL KDSVQRARDW LQDVEGLQAG GRVPVLDTLI ELVTRGRSIP
    1060 1070 1080 1090 1100
    VHLNSLPRLE TLVAEVQAWK ECAVNTFLTE NSPYSLLEVL CPRCDIGLLG
    1110 1120 1130 1140 1150
    LKRKQRKLKE PLPNGKKKST KLESLSDLER ALTESKETAS AMATLGEARL
    1160 1170 1180 1190 1200
    REMEALQSLR LANEGKLLSP LQDVDIKICL CQKAPAAPMI QCELCRDAFH
    1210 1220 1230 1240 1250
    TSCVAVPSIS QGLRIWLCPH CRRSEKPPLE KILPLLASLQ RIRVRLPEGD
    1260 1270 1280 1290 1300
    ALRYMIERTV NWQHRAQQLL SSGNLKFVQD RVGSGLLYSR WQASAGQVSD
    1310 1320 1330 1340 1350
    TNKVSQPPGT TSFSLPDDWD NRTSYLHSPF STGRSCIPLH GVSPEVNELL
    1360 1370 1380 1390 1400
    MEAQLLQVSL PEIQELYQTL LAKPSPAQQT DRSSPVRPSS EKNDCCRGKR
    1410 1420 1430 1440 1450
    DGINSLERKL KRRLEREGLS SERWERVKKM RTPKKKKIKL SHPKDMNNFK
    1460 1470 1480 1490 1500
    LERERSYELV RSAETHSLPS DTSYSEQEDS EDEDAICPAV SCLQPEGDEV
    1510 1520 1530 1540
    DWVQCDGSCN QWFHQVCVGV SPEMAEKEDY ICVRCTVKDA PSRK
    Length:1,544
    Mass (Da):175,658
    Last modified:May 18, 2010 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70A0738D9A709F61
    GO
    Isoform 2 (identifier: Q9UGL1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         237-237: E → ERQSLAVLPRLECSGAILAHCNLRLLDSSNSSASASQ

    Show »
    Length:1,580
    Mass (Da):179,409
    Checksum:i61B03B8A7EE16B3C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B3KV94B3KV94_HUMAN
    Jumonji, AT rich interactive domain...
    KDM5B JARID1B, hCG_2027322
    1,275Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ITA8A0A3B3ITA8_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    1,499Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3IS40A0A3B3IS40_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    1,539Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ITE7A0A3B3ITE7_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    1,505Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ITJ7A0A3B3ITJ7_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    1,503Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3IT25A0A3B3IT25_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    1,517Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ISE6A0A3B3ISE6_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    1,472Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3IT85A0A3B3IT85_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    316Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ITR3A0A3B3ITR3_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    142Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3IS31A0A3B3IS31_HUMAN
    Lysine-specific demethylase 5B
    KDM5B
    215Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAB63108 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78V → G in CAB63108 (PubMed:10878660).Curated1
    Sequence conflicti585 – 589AYHSG → VPQW in AAD16061 (PubMed:10616211).Curated5
    Sequence conflicti708C → W in AAD16061 (PubMed:10616211).Curated1
    Sequence conflicti759A → P in AAD16061 (PubMed:10616211).Curated1
    Sequence conflicti771N → T in AAD16061 (PubMed:10616211).Curated1
    Sequence conflicti771N → T in CAB63108 (PubMed:10878660).Curated1
    Sequence conflicti1182Q → R in AAD16061 (PubMed:10616211).Curated1
    Sequence conflicti1293A → P in AAD16061 (PubMed:10616211).Curated1
    Sequence conflicti1307P → L in AAD16061 (PubMed:10616211).Curated1
    Sequence conflicti1331S → ST in AAD16061 (PubMed:10616211).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_081276299 – 1544Missing in MRT65. 1 PublicationAdd BLAST1246
    Natural variantiVAR_0812771370 – 1544Missing in MRT65. 1 PublicationAdd BLAST175

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026408237E → ERQSLAVLPRLECSGAILAH CNLRLLDSSNSSASASQ in isoform 2. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ132440 mRNA Translation: CAB43532.1
    AF087481 mRNA Translation: AAD16061.1
    AJ243706 mRNA Translation: CAB63108.1 Different initiation.
    AC098934 Genomic DNA No translation available.
    AC104463 Genomic DNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS30974.1 [Q9UGL1-1]
    CCDS81417.1 [Q9UGL1-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001300971.1, NM_001314042.1 [Q9UGL1-2]
    NP_006609.3, NM_006618.4 [Q9UGL1-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000367264; ENSP00000356233; ENSG00000117139 [Q9UGL1-2]
    ENST00000367265; ENSP00000356234; ENSG00000117139 [Q9UGL1-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    10765

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:10765

    UCSC genome browser

    More...
    UCSCi
    uc001gyf.4 human [Q9UGL1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ132440 mRNA Translation: CAB43532.1
    AF087481 mRNA Translation: AAD16061.1
    AJ243706 mRNA Translation: CAB63108.1 Different initiation.
    AC098934 Genomic DNA No translation available.
    AC104463 Genomic DNA No translation available.
    CCDSiCCDS30974.1 [Q9UGL1-1]
    CCDS81417.1 [Q9UGL1-2]
    RefSeqiNP_001300971.1, NM_001314042.1 [Q9UGL1-2]
    NP_006609.3, NM_006618.4 [Q9UGL1-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2MA5NMR-A1487-1544[»]
    2MNYNMR-A306-360[»]
    2MNZNMR-A306-360[»]
    5A1FX-ray2.10A26-770[»]
    5A3NX-ray2.00A26-101[»]
    A374-772[»]
    5A3PX-ray2.01A26-101[»]
    A374-770[»]
    5A3TX-ray1.90A26-101[»]
    A374-772[»]
    5A3WX-ray2.00A26-101[»]
    A374-772[»]
    5FPLX-ray2.35A26-101[»]
    A374-772[»]
    5FPUX-ray2.24A26-101[»]
    A374-772[»]
    5FUNX-ray2.30A26-101[»]
    A374-772[»]
    5FUPX-ray2.15A26-101[»]
    A374-770[»]
    5FV3X-ray2.37A26-101[»]
    A374-770[»]
    5FY4X-ray2.10A26-101[»]
    A374-770[»]
    5FY5X-ray2.47A26-101[»]
    A374-770[»]
    5FY9X-ray2.03A26-101[»]
    A374-770[»]
    5FYBX-ray1.87A26-101[»]
    A374-770[»]
    5FYSX-ray1.89A26-101[»]
    A374-770[»]
    5FYTX-ray1.87A26-101[»]
    A374-770[»]
    5FYUX-ray2.06A26-101[»]
    A374-770[»]
    5FYVX-ray1.87A26-101[»]
    A374-770[»]
    5FYYX-ray2.18A26-101[»]
    A374-770[»]
    5FYZX-ray1.75A26-101[»]
    A374-770[»]
    5FZ0X-ray2.42A26-101[»]
    A374-770[»]
    5FZ1X-ray2.39A26-101[»]
    A374-770[»]
    5FZ3X-ray2.50A26-101[»]
    A374-770[»]
    5FZ4X-ray2.07A26-101[»]
    A374-770[»]
    5FZ6X-ray2.33A26-101[»]
    A374-770[»]
    5FZ7X-ray2.30A26-101[»]
    A374-770[»]
    5FZ8X-ray1.86A26-101[»]
    A374-770[»]
    5FZ9X-ray2.06A26-101[»]
    A374-770[»]
    5FZAX-ray2.10A26-101[»]
    A374-770[»]
    5FZBX-ray2.18A26-101[»]
    A374-770[»]
    5FZCX-ray2.05A26-101[»]
    A374-770[»]
    5FZDX-ray2.05A26-101[»]
    A374-770[»]
    5FZEX-ray2.02A26-101[»]
    A374-770[»]
    5FZFX-ray1.97A26-101[»]
    A374-770[»]
    5FZGX-ray1.96A26-101[»]
    A374-770[»]
    5FZHX-ray2.09A26-101[»]
    A374-442[»]
    A444-770[»]
    5FZIX-ray1.95A26-101[»]
    A374-770[»]
    5FZKX-ray2.05A26-101[»]
    A374-770[»]
    5FZLX-ray2.55A26-101[»]
    A374-770[»]
    5FZMX-ray2.49A26-101[»]
    A376-770[»]
    5LW9X-ray2.30A26-99[»]
    A374-772[»]
    5LWBX-ray2.39A26-101[»]
    A374-772[»]
    6EINX-ray2.11A26-101[»]
    A374-772[»]
    6EIUX-ray1.88A26-100[»]
    A374-754[»]
    6EIYX-ray2.15A26-100[»]
    A374-754[»]
    6EJ0X-ray2.06A26-98[»]
    A375-754[»]
    6EJ1X-ray2.07A26-98[»]
    A375-754[»]
    6EK6X-ray2.05A347-754[»]
    SMRiQ9UGL1
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi115984, 67 interactors
    CORUMiQ9UGL1
    DIPiDIP-53652N
    IntActiQ9UGL1, 5 interactors
    STRINGi9606.ENSP00000356234

    Chemistry databases

    BindingDBiQ9UGL1
    ChEMBLiCHEMBL3774295
    GuidetoPHARMACOLOGYi2681

    PTM databases

    iPTMnetiQ9UGL1
    PhosphoSitePlusiQ9UGL1

    Polymorphism and mutation databases

    BioMutaiKDM5B
    DMDMi296439317

    Proteomic databases

    EPDiQ9UGL1
    jPOSTiQ9UGL1
    PaxDbiQ9UGL1
    PeptideAtlasiQ9UGL1
    PRIDEiQ9UGL1
    ProteomicsDBi84231 [Q9UGL1-1]
    84232 [Q9UGL1-2]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000367264; ENSP00000356233; ENSG00000117139 [Q9UGL1-2]
    ENST00000367265; ENSP00000356234; ENSG00000117139 [Q9UGL1-1]
    GeneIDi10765
    KEGGihsa:10765
    UCSCiuc001gyf.4 human [Q9UGL1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10765
    DisGeNETi10765

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    KDM5B
    HGNCiHGNC:18039 KDM5B
    HPAiCAB068193
    HPA027179
    HPA053723
    MalaCardsiKDM5B
    MIMi605393 gene
    618109 phenotype
    neXtProtiNX_Q9UGL1
    OpenTargetsiENSG00000117139
    Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
    88616 Autosomal recessive non-syndromic intellectual disability
    PharmGKBiPA164721626

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1246 Eukaryota
    ENOG410XR9J LUCA
    GeneTreeiENSGT00940000157076
    HOGENOMiHOG000290719
    InParanoidiQ9UGL1
    KOiK11446
    OMAiVEMKVCL
    OrthoDBi664180at2759
    PhylomeDBiQ9UGL1
    TreeFamiTF106476

    Enzyme and pathway databases

    ReactomeiR-HSA-3214842 HDMs demethylate histones
    R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
    SIGNORiQ9UGL1

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    KDM5B human

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    JARID1B

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    10765

    Protein Ontology

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    PROi
    PR:Q9UGL1

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000117139 Expressed in 213 organ(s), highest expression level in sperm
    ExpressionAtlasiQ9UGL1 baseline and differential
    GenevisibleiQ9UGL1 HS

    Family and domain databases

    DisProtiDP00712
    Gene3Di1.10.150.60, 1 hit
    3.30.40.10, 2 hits
    InterProiView protein in InterPro
    IPR001606 ARID_dom
    IPR036431 ARID_dom_sf
    IPR003347 JmjC_dom
    IPR003349 JmjN
    IPR013637 Lys_sp_deMease-like_dom
    IPR019786 Zinc_finger_PHD-type_CS
    IPR004198 Znf_C5HC2
    IPR011011 Znf_FYVE_PHD
    IPR001965 Znf_PHD
    IPR019787 Znf_PHD-finger
    IPR013083 Znf_RING/FYVE/PHD
    PfamiView protein in Pfam
    PF01388 ARID, 1 hit
    PF02373 JmjC, 1 hit
    PF02375 JmjN, 1 hit
    PF00628 PHD, 3 hits
    PF08429 PLU-1, 1 hit
    PF02928 zf-C5HC2, 1 hit
    SMARTiView protein in SMART
    SM00501 BRIGHT, 1 hit
    SM00558 JmjC, 1 hit
    SM00545 JmjN, 1 hit
    SM00249 PHD, 3 hits
    SUPFAMiSSF46774 SSF46774, 1 hit
    SSF57903 SSF57903, 3 hits
    PROSITEiView protein in PROSITE
    PS51011 ARID, 1 hit
    PS51184 JMJC, 1 hit
    PS51183 JMJN, 1 hit
    PS01359 ZF_PHD_1, 2 hits
    PS50016 ZF_PHD_2, 3 hits

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDM5B_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGL1
    Secondary accession number(s): O95811, Q15752, Q9Y3Q5
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: May 18, 2010
    Last modified: July 31, 2019
    This is version 159 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
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