UniProtKB - Q9UGK3 (STAP2_HUMAN)
Protein
Signal-transducing adaptor protein 2
Gene
STAP2
Organism
Homo sapiens (Human)
Status
Functioni
Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.1 Publication
GO - Molecular functioni
- signaling adaptor activity Source: InterPro
GO - Biological processi
- positive regulation of tyrosine phosphorylation of STAT protein Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q9UGK3 |
Reactomei | R-HSA-8849474, PTK6 Activates STAT3 |
SignaLinki | Q9UGK3 |
SIGNORi | Q9UGK3 |
Names & Taxonomyi
Protein namesi | Recommended name: Signal-transducing adaptor protein 2Short name: STAP-2 Alternative name(s): Breast tumor kinase substrate Short name: BRK substrate |
Gene namesi | Name:STAP2 Synonyms:BKS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30430, STAP2 |
MIMi | 607881, gene |
neXtProti | NX_Q9UGK3 |
VEuPathDBi | HostDB:ENSG00000178078.11 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 22 | Y → F: Small decrease in tyrosine phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 250 | Y → F: Loss of tyrosine phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 310 | Y → F: Decrease in tyrosine phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 322 | Y → F: Decrease in tyrosine phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 55620 |
OpenTargetsi | ENSG00000178078 |
PharmGKBi | PA162404971 |
Miscellaneous databases
Pharosi | Q9UGK3, Tbio |
Genetic variation databases
BioMutai | STAP2 |
DMDMi | 229462752 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072239 | 1 – 403 | Signal-transducing adaptor protein 2Add BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 250 | Phosphotyrosine; by PTK62 Publications | 1 | |
Modified residuei | 310 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 322 | Phosphotyrosine; by SRC1 Publication | 1 |
Post-translational modificationi
Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.2 Publications
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UGK3 |
jPOSTi | Q9UGK3 |
MassIVEi | Q9UGK3 |
PeptideAtlasi | Q9UGK3 |
PRIDEi | Q9UGK3 |
ProteomicsDBi | 84227 [Q9UGK3-1] 84228 [Q9UGK3-2] |
PTM databases
iPTMneti | Q9UGK3 |
PhosphoSitePlusi | Q9UGK3 |
Expressioni
Tissue specificityi
Widely expressed.2 Publications
Gene expression databases
Bgeei | ENSG00000178078, Expressed in mucosa of transverse colon and 169 other tissues |
ExpressionAtlasi | Q9UGK3, baseline and differential |
Genevisiblei | Q9UGK3, HS |
Organism-specific databases
HPAi | ENSG00000178078, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Interacts with PTK6 and CSF1R.
2 PublicationsBinary interactionsi
Hide detailsQ9UGK3
Protein-protein interaction databases
BioGRIDi | 120759, 16 interactors |
IntActi | Q9UGK3, 97 interactors |
MINTi | Q9UGK3 |
Miscellaneous databases
RNActi | Q9UGK3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UGK3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UGK3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 130 | PHAdd BLAST | 113 | |
Domaini | 133 – 248 | SH2PROSITE-ProRule annotationAdd BLAST | 116 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 382 – 402 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 271 – 359 | Pro-richAdd BLAST | 89 |
Keywords - Domaini
Coiled coil, SH2 domainPhylogenomic databases
GeneTreei | ENSGT00530000063841 |
HOGENOMi | CLU_043957_0_0_1 |
InParanoidi | Q9UGK3 |
OMAi | SQLPPCY |
OrthoDBi | 680358at2759 |
PhylomeDBi | Q9UGK3 |
TreeFami | TF332087 |
Family and domain databases
CDDi | cd10404, SH2_STAP2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000980, SH2 IPR036860, SH2_dom_sf IPR039111, STAP1/STAP2 IPR035878, STAP2_SH2 |
PANTHERi | PTHR16186, PTHR16186, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UGK3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASALRPPRV PKPKGVLPSH YYESFLEKKG PCDRDYKKFW AGLQGLTIYF
60 70 80 90 100
YNSNRDFQHV EKLNLGAFEK LTDEIPWGSS RDPGTHFSLI LRDQEIKFKV
110 120 130 140 150
ETLECREMWK GFILTVVELR VPTDLTLLPG HLYMMSEVLA KEEARRALET
160 170 180 190 200
PSCFLKVSRL EAQLLLERYP ECGNLLLRPS GDGADGVSVT TRQMHNGTHV
210 220 230 240 250
VRHYKVKREG PKYVIDVEQP FSCTSLDAVV NYFVSHTKKA LVPFLLDEDY
260 270 280 290 300
EKVLGYVEAD KENGENVWVA PSAPGPGPAP CTGGPKPLSP ASSQDKLPPL
310 320 330 340 350
PPLPNQEENY VTPIGDGPAV DYENQDVASS SWPVILKPKK LPKPPAKLPK
360 370 380 390 400
PPVGPKPEPK VFNGGLGRKL PVSSAQPLFP TAGLADMTAE LQKKLEKRRA
LEH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QY82 | M0QY82_HUMAN | Signal-transducing adaptor protein ... | STAP2 | 106 | Annotation score: | ||
M0R2W4 | M0R2W4_HUMAN | Signal-transducing adaptor protein ... | STAP2 | 260 | Annotation score: | ||
M0R0J5 | M0R0J5_HUMAN | Signal-transducing adaptor protein ... | STAP2 | 159 | Annotation score: | ||
M0QZ60 | M0QZ60_HUMAN | Signal-transducing adaptor protein ... | STAP2 | 105 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055239 | 93 | D → N3 PublicationsCorresponds to variant dbSNP:rs7247504Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041403 | 356 | K → KPVEKGFHHVAQAGLELLTS SDPPTSASQSAGITGVSHHT WPHLSSL in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ245719 mRNA Translation: CAB65105.1 AK000241 mRNA Translation: BAA91028.1 AC008616 Genomic DNA No translation available. BC000795 mRNA Translation: AAH00795.1 |
CCDSi | CCDS12128.1 [Q9UGK3-2] CCDS45926.1 [Q9UGK3-1] |
RefSeqi | NP_001013863.1, NM_001013841.1 [Q9UGK3-1] NP_060190.2, NM_017720.2 [Q9UGK3-2] |
Genome annotation databases
Ensembli | ENST00000594605; ENSP00000471052; ENSG00000178078 [Q9UGK3-1] ENST00000600324; ENSP00000468927; ENSG00000178078 [Q9UGK3-2] |
GeneIDi | 55620 |
KEGGi | hsa:55620 |
UCSCi | uc060rvu.1, human [Q9UGK3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ245719 mRNA Translation: CAB65105.1 AK000241 mRNA Translation: BAA91028.1 AC008616 Genomic DNA No translation available. BC000795 mRNA Translation: AAH00795.1 |
CCDSi | CCDS12128.1 [Q9UGK3-2] CCDS45926.1 [Q9UGK3-1] |
RefSeqi | NP_001013863.1, NM_001013841.1 [Q9UGK3-1] NP_060190.2, NM_017720.2 [Q9UGK3-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EL8 | NMR | - | A | 137-247 | [»] | |
SMRi | Q9UGK3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120759, 16 interactors |
IntActi | Q9UGK3, 97 interactors |
MINTi | Q9UGK3 |
PTM databases
iPTMneti | Q9UGK3 |
PhosphoSitePlusi | Q9UGK3 |
Genetic variation databases
BioMutai | STAP2 |
DMDMi | 229462752 |
Proteomic databases
EPDi | Q9UGK3 |
jPOSTi | Q9UGK3 |
MassIVEi | Q9UGK3 |
PeptideAtlasi | Q9UGK3 |
PRIDEi | Q9UGK3 |
ProteomicsDBi | 84227 [Q9UGK3-1] 84228 [Q9UGK3-2] |
Protocols and materials databases
Antibodypediai | 1197, 310 antibodies |
DNASUi | 55620 |
Genome annotation databases
Ensembli | ENST00000594605; ENSP00000471052; ENSG00000178078 [Q9UGK3-1] ENST00000600324; ENSP00000468927; ENSG00000178078 [Q9UGK3-2] |
GeneIDi | 55620 |
KEGGi | hsa:55620 |
UCSCi | uc060rvu.1, human [Q9UGK3-1] |
Organism-specific databases
CTDi | 55620 |
DisGeNETi | 55620 |
GeneCardsi | STAP2 |
HGNCi | HGNC:30430, STAP2 |
HPAi | ENSG00000178078, Tissue enhanced (intestine) |
MIMi | 607881, gene |
neXtProti | NX_Q9UGK3 |
OpenTargetsi | ENSG00000178078 |
PharmGKBi | PA162404971 |
VEuPathDBi | HostDB:ENSG00000178078.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000063841 |
HOGENOMi | CLU_043957_0_0_1 |
InParanoidi | Q9UGK3 |
OMAi | SQLPPCY |
OrthoDBi | 680358at2759 |
PhylomeDBi | Q9UGK3 |
TreeFami | TF332087 |
Enzyme and pathway databases
PathwayCommonsi | Q9UGK3 |
Reactomei | R-HSA-8849474, PTK6 Activates STAT3 |
SignaLinki | Q9UGK3 |
SIGNORi | Q9UGK3 |
Miscellaneous databases
BioGRID-ORCSi | 55620, 1 hit in 994 CRISPR screens |
ChiTaRSi | STAP2, human |
EvolutionaryTracei | Q9UGK3 |
GeneWikii | STAP2 |
GenomeRNAii | 55620 |
Pharosi | Q9UGK3, Tbio |
PROi | PR:Q9UGK3 |
RNActi | Q9UGK3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178078, Expressed in mucosa of transverse colon and 169 other tissues |
ExpressionAtlasi | Q9UGK3, baseline and differential |
Genevisiblei | Q9UGK3, HS |
Family and domain databases
CDDi | cd10404, SH2_STAP2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000980, SH2 IPR036860, SH2_dom_sf IPR039111, STAP1/STAP2 IPR035878, STAP2_SH2 |
PANTHERi | PTHR16186, PTHR16186, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAP2_HUMAN | |
Accessioni | Q9UGK3Primary (citable) accession number: Q9UGK3 Secondary accession number(s): A6NKK3, Q9NXI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | May 5, 2009 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references