UniProtKB - Q9UGK3 (STAP2_HUMAN)

BLAST

>sp|Q9UGK3|STAP2_HUMAN Signal-transducing adaptor protein 2 OS=Homo sapiens OX=9606 GN=STAP2 PE=1 SV=2
MASALRPPRVPKPKGVLPSHYYESFLEKKGPCDRDYKKFWAGLQGLTIYFYNSNRDFQHV
EKLNLGAFEKLTDEIPWGSSRDPGTHFSLILRDQEIKFKVETLECREMWKGFILTVVELR
VPTDLTLLPGHLYMMSEVLAKEEARRALETPSCFLKVSRLEAQLLLERYPECGNLLLRPS
GDGADGVSVTTRQMHNGTHVVRHYKVKREGPKYVIDVEQPFSCTSLDAVVNYFVSHTKKA
LVPFLLDEDYEKVLGYVEADKENGENVWVAPSAPGPGPAPCTGGPKPLSPASSQDKLPPL
PPLPNQEENYVTPIGDGPAVDYENQDVASSSWPVILKPKKLPKPPAKLPKPPVGPKPEPK
VFNGGLGRKLPVSSAQPLFPTAGLADMTAELQKKLEKRRALEH

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History
Entry version 141 (12 Sep 2018)
Sequence version 2 (05 May 2009)
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Protein

Signal-transducing adaptor protein 2

Gene

STAP2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.1 Publication

GO - Molecular functionⁱ

signaling adaptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of tyrosine phosphorylation of STAT protein Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8849474 PTK6 Activates STAT3
SignaLinkⁱ	Q9UGK3
SIGNORⁱ	Q9UGK3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Signal-transducing adaptor protein 2 Short name: STAP-2 Alternative name(s): Breast tumor kinase substrate Short name: BRK substrate
Gene namesⁱ	Name:STAP2 Synonyms:BKS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000178078.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30430 STAP2
MIMⁱ	607881 gene
neXtProtⁱ	NX_Q9UGK3

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	22	Y → F: Small decrease in tyrosine phosphorylation. 1 Publication	1
Mutagenesisⁱ	250	Y → F: Loss of tyrosine phosphorylation. 1 Publication	1
Mutagenesisⁱ	310	Y → F: Decrease in tyrosine phosphorylation. 1 Publication	1
Mutagenesisⁱ	322	Y → F: Decrease in tyrosine phosphorylation. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55620
Open Targets More...OpenTargetsⁱ	ENSG00000178078
PharmGKBⁱ	PA162404971

Polymorphism and mutation databases

BioMutaⁱ	STAP2
DMDMⁱ	229462752

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072239	1 – 403	Signal-transducing adaptor protein 2Add BLAST		403

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	22	Phosphotyrosine; by SRC1 Publication	1
Modified residueⁱ	250	Phosphotyrosine; by PTK62 Publications	1
Modified residueⁱ	310	Phosphotyrosine1 Publication	1
Modified residueⁱ	322	Phosphotyrosine; by SRC1 Publication	1

Post-translational modificationⁱ

Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.2 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UGK3
PeptideAtlas More...PeptideAtlasⁱ	Q9UGK3
PRIDEⁱ	Q9UGK3
ProteomicsDBⁱ	84227 84228 [Q9UGK3-2]

PTM databases

iPTMnetⁱ	Q9UGK3
PhosphoSitePlusⁱ	Q9UGK3

Expressionⁱ

Tissue specificityⁱ

Widely expressed.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000178078 Expressed in 150 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_STAP2
ExpressionAtlasⁱ	Q9UGK3 baseline and differential
Genevisibleⁱ	Q9UGK3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002375 HPA027761

HPAⁱ

HPA002375
HPA027761

Interactionⁱ

Subunit structureⁱ

Interacts with PTK6 and CSF1R.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IKBKB	O14920	7	EBI-1553984,EBI-81266
MYD88	Q99836	3	EBI-1553984,EBI-447677

Protein-protein interaction databases

BioGridⁱ	120759, 11 interactors
IntActⁱ	Q9UGK3, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q9UGK3

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	148 – 150	Combined sources	3
Helixⁱ	159 – 168	Combined sources	10
Beta strandⁱ	174 – 179	Combined sources	6
Beta strandⁱ	182 – 191	Combined sources	10
Beta strandⁱ	202 – 204	Combined sources	3
Beta strandⁱ	215 – 219	Combined sources	5
Helixⁱ	226 – 236	Combined sources	11
Beta strandⁱ	237 – 239	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UGK3
SMRⁱ	Q9UGK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UGK3

EvolutionaryTraceⁱ

Q9UGK3

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 130	PHAdd BLAST		113
Domainⁱ	133 – 248	SH2PROSITE-ProRule annotationAdd BLAST		116

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	382 – 402	Sequence analysisAdd BLAST		21

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	271 – 359	Pro-richAdd BLAST		89

Keywords - Domainⁱ

Coiled coil, SH2 domain

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063841
HOGENOMⁱ	HOG000063725
HOVERGENⁱ	HBG108516
InParanoidⁱ	Q9UGK3
OMAⁱ	PDCGNML
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0929
PhylomeDBⁱ	Q9UGK3
TreeFamⁱ	TF332087

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10404 SH2_STAP2, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR000980 SH2 IPR036860 SH2_dom_sf IPR039111 STAP1/STAP2 IPR035878 STAP2_SH2
PANTHERⁱ	PTHR16186 PTHR16186, 1 hit
SUPFAMⁱ	SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UGK3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASALRPPRV PKPKGVLPSH YYESFLEKKG PCDRDYKKFW AGLQGLTIYF 
        60         70         80         90        100
YNSNRDFQHV EKLNLGAFEK LTDEIPWGSS RDPGTHFSLI LRDQEIKFKV 
       110        120        130        140        150
ETLECREMWK GFILTVVELR VPTDLTLLPG HLYMMSEVLA KEEARRALET 
       160        170        180        190        200
PSCFLKVSRL EAQLLLERYP ECGNLLLRPS GDGADGVSVT TRQMHNGTHV 
       210        220        230        240        250
VRHYKVKREG PKYVIDVEQP FSCTSLDAVV NYFVSHTKKA LVPFLLDEDY 
       260        270        280        290        300
EKVLGYVEAD KENGENVWVA PSAPGPGPAP CTGGPKPLSP ASSQDKLPPL 
       310        320        330        340        350
PPLPNQEENY VTPIGDGPAV DYENQDVASS SWPVILKPKK LPKPPAKLPK 
       360        370        380        390        400
PPVGPKPEPK VFNGGLGRKL PVSSAQPLFP TAGLADMTAE LQKKLEKRRA 

LEH

Length:403

Mass (Da):44,894

Last modified:May 5, 2009 - v2

Checksum:ⁱA5E809B3F233EFD0

Isoform 2 (identifier: Q9UGK3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
356-356: K → KPVEKGFHHVAQAGLELLTSSDPPTSASQSAGITGVSHHTWPHLSSL

« Hide

        10         20         30         40         50
MASALRPPRV PKPKGVLPSH YYESFLEKKG PCDRDYKKFW AGLQGLTIYF 
        60         70         80         90        100
YNSNRDFQHV EKLNLGAFEK LTDEIPWGSS RDPGTHFSLI LRDQEIKFKV 
       110        120        130        140        150
ETLECREMWK GFILTVVELR VPTDLTLLPG HLYMMSEVLA KEEARRALET 
       160        170        180        190        200
PSCFLKVSRL EAQLLLERYP ECGNLLLRPS GDGADGVSVT TRQMHNGTHV 
       210        220        230        240        250
VRHYKVKREG PKYVIDVEQP FSCTSLDAVV NYFVSHTKKA LVPFLLDEDY 
       260        270        280        290        300
EKVLGYVEAD KENGENVWVA PSAPGPGPAP CTGGPKPLSP ASSQDKLPPL 
       310        320        330        340        350
PPLPNQEENY VTPIGDGPAV DYENQDVASS SWPVILKPKK LPKPPAKLPK 
       360        370        380        390        400
PPVGPKPVEK GFHHVAQAGL ELLTSSDPPT SASQSAGITG VSHHTWPHLS 
       410        420        430        440 
SLPEPKVFNG GLGRKLPVSS AQPLFPTAGL ADMTAELQKK LEKRRALEH

Note: Alu insert from position 358 to 403.

Show »

Length:449

Mass (Da):49,649

Checksum:ⁱ31A9048F7B0E750F

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0R0J5	M0R0J5_HUMAN	Signal-transducing adaptor protein ... Signal-transducing adaptor protein 2	STAP2	159	Annotation score:
M0R2W4	M0R2W4_HUMAN	Signal-transducing adaptor protein ... Signal-transducing adaptor protein 2	STAP2	260	Annotation score:
M0QY82	M0QY82_HUMAN	Signal-transducing adaptor protein ... Signal-transducing adaptor protein 2	STAP2	106	Annotation score:
M0QZ60	M0QZ60_HUMAN	Signal-transducing adaptor protein ... Signal-transducing adaptor protein 2	STAP2	105	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055239	93	D → N3 PublicationsCorresponds to variant dbSNP:rs7247504Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041403	356	K → KPVEKGFHHVAQAGLELLTS SDPPTSASQSAGITGVSHHT WPHLSSL in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ245719 mRNA Translation: CAB65105.1 AK000241 mRNA Translation: BAA91028.1 AC008616 Genomic DNA No translation available. BC000795 mRNA Translation: AAH00795.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12128.1 [Q9UGK3-2] CCDS45926.1 [Q9UGK3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001013863.1, NM_001013841.1 [Q9UGK3-1] NP_060190.2, NM_017720.2 [Q9UGK3-2]
UniGeneⁱ	Hs.194385

Genome annotation databases

Ensemblⁱ	ENST00000594605; ENSP00000471052; ENSG00000178078 [Q9UGK3-1] ENST00000600324; ENSP00000468927; ENSG00000178078 [Q9UGK3-2]
GeneIDⁱ	55620
KEGGⁱ	hsa:55620
UCSC genome browser More...UCSCⁱ	uc060rvu.1 human [Q9UGK3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UGK3	Signal-transducing adaptor protein 2 isoform 2		CALJA		410	UniRef90_Q9UGK3
Uncharacterized protein		Cebus capucinus imitator		410
STAP2 isoform 2		PONAB		410
STAP2 isoform 2		PANTR		407
Uncharacterized protein		PANPA		407
+2
Q9UGK3-2	STAP2 isoform 4		PONAB		456	UniRef90_Q9UGK3-2
Signal transducing adaptor family member 2		CALJA		456
STAP2 isoform 4		PANTR		453
UPI0005334B2C		RHIRO		456
UPI0005F50F13		MANLE		456
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9UGK3	Signal-transducing adaptor protein 2		MOUSE		411	UniRef50_Q9UGK3
Uncharacterized protein		Cebus capucinus imitator		410
STAP2 isoform 2		PONAB		410
Signal-transducing adaptor protein 2 isoform 2		CALJA		410
STAP2 isoform 2		PANTR		407
+162
Q9UGK3-2	STAP2 isoform 4		PONAB		456	UniRef50_Q9UGK3-2
Signal transducing adaptor family member 2		CALJA		456
STAP2 isoform 4		PANTR		453
Uncharacterized protein		PIG		436
Uncharacterized protein		COLAP		433
+48

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ245719 mRNA Translation: CAB65105.1 AK000241 mRNA Translation: BAA91028.1 AC008616 Genomic DNA No translation available. BC000795 mRNA Translation: AAH00795.1
CCDSⁱ	CCDS12128.1 [Q9UGK3-2] CCDS45926.1 [Q9UGK3-1]
RefSeqⁱ	NP_001013863.1, NM_001013841.1 [Q9UGK3-1] NP_060190.2, NM_017720.2 [Q9UGK3-2]
UniGeneⁱ	Hs.194385

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EL8	NMR	-	A	137-247	[»]
ProteinModelPortalⁱ	Q9UGK3
SMRⁱ	Q9UGK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120759, 11 interactors
IntActⁱ	Q9UGK3, 7 interactors
MINTⁱ	Q9UGK3

PTM databases

iPTMnetⁱ	Q9UGK3
PhosphoSitePlusⁱ	Q9UGK3

Polymorphism and mutation databases

BioMutaⁱ	STAP2
DMDMⁱ	229462752

Proteomic databases

EPDⁱ	Q9UGK3
PeptideAtlasⁱ	Q9UGK3
PRIDEⁱ	Q9UGK3
ProteomicsDBⁱ	84227 84228 [Q9UGK3-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55620
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000594605; ENSP00000471052; ENSG00000178078 [Q9UGK3-1] ENST00000600324; ENSP00000468927; ENSG00000178078 [Q9UGK3-2]
GeneIDⁱ	55620
KEGGⁱ	hsa:55620
UCSCⁱ	uc060rvu.1 human [Q9UGK3-1]

Organism-specific databases

CTDⁱ	55620
DisGeNETⁱ	55620
EuPathDBⁱ	HostDB:ENSG00000178078.11
GeneCardsⁱ	STAP2
H-InvDBⁱ	HIX0018702
HGNCⁱ	HGNC:30430 STAP2
HPAⁱ	HPA002375 HPA027761
MIMⁱ	607881 gene
neXtProtⁱ	NX_Q9UGK3
OpenTargetsⁱ	ENSG00000178078
PharmGKBⁱ	PA162404971
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00530000063841
HOGENOMⁱ	HOG000063725
HOVERGENⁱ	HBG108516
InParanoidⁱ	Q9UGK3
OMAⁱ	PDCGNML
OrthoDBⁱ	EOG091G0929
PhylomeDBⁱ	Q9UGK3
TreeFamⁱ	TF332087

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8849474 PTK6 Activates STAT3
SignaLinkⁱ	Q9UGK3
SIGNORⁱ	Q9UGK3

Miscellaneous databases

ChiTaRSⁱ	STAP2 human
EvolutionaryTraceⁱ	Q9UGK3
GeneWikiⁱ	STAP2
GenomeRNAiⁱ	55620
Protein Ontology More...PROⁱ	PR:Q9UGK3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000178078 Expressed in 150 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_STAP2
ExpressionAtlasⁱ	Q9UGK3 baseline and differential
Genevisibleⁱ	Q9UGK3 HS

Family and domain databases

CDDⁱ	cd10404 SH2_STAP2, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR000980 SH2 IPR036860 SH2_dom_sf IPR039111 STAP1/STAP2 IPR035878 STAP2_SH2
PANTHERⁱ	PTHR16186 PTHR16186, 1 hit
SUPFAMⁱ	SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STAP2_HUMAN
Accessionⁱ	Q9UGK3Primary (citable) accession number: Q9UGK3 Secondary accession number(s): A6NKK3, Q9NXI2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
	Last sequence update:	May 5, 2009
	Last modified:	September 12, 2018
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9UGK3 (STAP2_HUMAN)

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Signal-transducing adaptor protein 2

STAP2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ