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Entry version 169 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

Gamma-tubulin complex component 4

Gene

TUBGCP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UGJ1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-tubulin complex component 4
Short name:
GCP-4
Short name:
hGCP4
Alternative name(s):
Gamma-ring complex protein 76 kDa
Short name:
h76p
Short name:
hGrip76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUBGCP4
Synonyms:76P, GCP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137822.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16691, TUBGCP4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609610, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UGJ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly and chorioretinopathy, autosomal recessive, 3 (MCCRP3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by congenital microcephaly and chorioretinal dysplasia associated with poor vision and nystagmus. Variable ocular anomalies include microphthalmia, retinal folding, retinal detachment, optic nerve hypoplasia, absence of retinal vessels, round areas of chorioretinal atrophy, and attenuated electroretinogram. Most patients have mild developmental delay and mild learning difficulties.
Related information in OMIM

Keywords - Diseasei

Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNET

More...
DisGeNETi
27229

MalaCards human disease database

More...
MalaCardsi
TUBGCP4
MIMi616335, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137822

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2518, Autosomal recessive chorioretinopathy-microcephaly syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162407404

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UGJ1, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TUBGCP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22095730

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781241 – 667Gamma-tubulin complex component 4Add BLAST667

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UGJ1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UGJ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UGJ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UGJ1

PeptideAtlas

More...
PeptideAtlasi
Q9UGJ1

PRoteomics IDEntifications database

More...
PRIDEi
Q9UGJ1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84225 [Q9UGJ1-1]
84226 [Q9UGJ1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UGJ1

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9UGJ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGJ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137822, Expressed in frontal cortex and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UGJ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UGJ1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137822, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.

Interacts with NINL.

Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118078, 122 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UGJ1

Database of interacting proteins

More...
DIPi
DIP-50536N

Protein interaction database and analysis system

More...
IntActi
Q9UGJ1, 60 interactors

Molecular INTeraction database

More...
MINTi
Q9UGJ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260383

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UGJ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1667
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UGJ1

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UGJ1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2065, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156677

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012029_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UGJ1

KEGG Orthology (KO)

More...
KOi
K16571

Identification of Orthologs from Complete Genome Data

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OMAi
SEFFIKF

Database of Orthologous Groups

More...
OrthoDBi
1137416at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGJ1

TreeFam database of animal gene trees

More...
TreeFami
TF324188

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1900, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007259, GCP
IPR040457, GCP_C
IPR042241, GCP_C_sf
IPR041470, GCP_N

The PANTHER Classification System

More...
PANTHERi
PTHR19302, PTHR19302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04130, GCP_C_terminal, 1 hit
PF17681, GCP_N_terminal, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIHELLLALS GYPGSIFTWN KRSGLQVSQD FPFLHPSETS VLNRLCRLGT
60 70 80 90 100
DYIRFTEFIE QYTGHVQQQD HHPSQQGQGG LHGIYLRAFC TGLDSVLQPY
110 120 130 140 150
RQALLDLEQE FLGDPHLSIS HVNYFLDQFQ LLFPSVMVVV EQIKSQKIHG
160 170 180 190 200
CQILETVYKH SCGGLPPVRS ALEKILAVCH GVMYKQLSAW MLHGLLLDQH
210 220 230 240 250
EEFFIKQGPS SGNVSAQPEE DEEDLGIGGL TGKQLRELQD LRLIEEENML
260 270 280 290 300
APSLKQFSLR VEILPSYIPV RVAEKILFVG ESVQMFENQN VNLTRKGSIL
310 320 330 340 350
KNQEDTFAAE LHRLKQQPLF SLVDFEQVVD RIRSTVAEHL WKLMVEESDL
360 370 380 390 400
LGQLKIIKDF YLLGRGELFQ AFIDTAQHML KTPPTAVTEH DVNVAFQQSA
410 420 430 440 450
HKVLLDDDNL LPLLHLTIEY HGKEHKADAT QAREGPSRET SPREAPASGW
460 470 480 490 500
AALGLSYKVQ WPLHILFTPA VLEKYNVVFK YLLSVRRVQA ELQHCWALQM
510 520 530 540 550
QRKHLKSNQT DAIKWRLRNH MAFLVDNLQY YLQVDVLESQ FSQLLHQINS
560 570 580 590 600
TRDFESIRLA HDHFLSNLLA QSFILLKPVF HCLNEILDLC HSFCSLVSQN
610 620 630 640 650
LGPLDERGAA QLSILVKGFS RQSSLLFKIL SSVRNHQINS DLAQLLLRLD
660
YNKYYTQAGG TLGSFGM
Length:667
Mass (Da):76,089
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2030EEDF290F5FAC
GO
Isoform 2 (identifier: Q9UGJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-427: Missing.

Show »
Length:666
Mass (Da):76,018
Checksum:i5BF032C026829F3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPU4H3BPU4_HUMAN
Gamma-tubulin complex component
TUBGCP4
397Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQY4H3BQY4_HUMAN
Gamma-tubulin complex component
TUBGCP4
103Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNL9H3BNL9_HUMAN
Gamma-tubulin complex component
TUBGCP4
171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS59H3BS59_HUMAN
Gamma-tubulin complex component
TUBGCP4
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN56H3BN56_HUMAN
Gamma-tubulin complex component
TUBGCP4
82Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ12H3BQ12_HUMAN
Gamma-tubulin complex component 4
TUBGCP4
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91802 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040085427Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ249677 mRNA Translation: CAB62539.1
AK001639 mRNA Translation: BAA91802.1 Different initiation.
AK027703 mRNA Translation: BAG51368.1
AC018924 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92603.1
BC009870 mRNA Translation: AAH09870.1
BC012801 mRNA Translation: AAH12801.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42030.1 [Q9UGJ1-2]
CCDS66745.1 [Q9UGJ1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001273343.1, NM_001286414.2 [Q9UGJ1-1]
NP_055259.2, NM_014444.4 [Q9UGJ1-2]
XP_011519757.1, XM_011521455.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260383; ENSP00000260383; ENSG00000137822 [Q9UGJ1-1]
ENST00000564079; ENSP00000456648; ENSG00000137822 [Q9UGJ1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27229

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27229

UCSC genome browser

More...
UCSCi
uc001zrn.5, human [Q9UGJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249677 mRNA Translation: CAB62539.1
AK001639 mRNA Translation: BAA91802.1 Different initiation.
AK027703 mRNA Translation: BAG51368.1
AC018924 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92603.1
BC009870 mRNA Translation: AAH09870.1
BC012801 mRNA Translation: AAH12801.1
CCDSiCCDS42030.1 [Q9UGJ1-2]
CCDS66745.1 [Q9UGJ1-1]
RefSeqiNP_001273343.1, NM_001286414.2 [Q9UGJ1-1]
NP_055259.2, NM_014444.4 [Q9UGJ1-2]
XP_011519757.1, XM_011521455.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RIPX-ray2.30A1-667[»]
6V69electron microscopy4.20I1-667[»]
6V6Selectron microscopy4.30I/K1-667[»]
SMRiQ9UGJ1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118078, 122 interactors
CORUMiQ9UGJ1
DIPiDIP-50536N
IntActiQ9UGJ1, 60 interactors
MINTiQ9UGJ1
STRINGi9606.ENSP00000260383

PTM databases

iPTMnetiQ9UGJ1
MetOSiteiQ9UGJ1
PhosphoSitePlusiQ9UGJ1

Polymorphism and mutation databases

BioMutaiTUBGCP4
DMDMi22095730

Proteomic databases

EPDiQ9UGJ1
jPOSTiQ9UGJ1
MassIVEiQ9UGJ1
PaxDbiQ9UGJ1
PeptideAtlasiQ9UGJ1
PRIDEiQ9UGJ1
ProteomicsDBi84225 [Q9UGJ1-1]
84226 [Q9UGJ1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23879, 205 antibodies

The DNASU plasmid repository

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DNASUi
27229

Genome annotation databases

EnsembliENST00000260383; ENSP00000260383; ENSG00000137822 [Q9UGJ1-1]
ENST00000564079; ENSP00000456648; ENSG00000137822 [Q9UGJ1-2]
GeneIDi27229
KEGGihsa:27229
UCSCiuc001zrn.5, human [Q9UGJ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27229
DisGeNETi27229
EuPathDBiHostDB:ENSG00000137822.12

GeneCards: human genes, protein and diseases

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GeneCardsi
TUBGCP4
HGNCiHGNC:16691, TUBGCP4
HPAiENSG00000137822, Low tissue specificity
MalaCardsiTUBGCP4
MIMi609610, gene
616335, phenotype
neXtProtiNX_Q9UGJ1
OpenTargetsiENSG00000137822
Orphaneti2518, Autosomal recessive chorioretinopathy-microcephaly syndrome
PharmGKBiPA162407404

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2065, Eukaryota
GeneTreeiENSGT00940000156677
HOGENOMiCLU_012029_0_0_1
InParanoidiQ9UGJ1
KOiK16571
OMAiSEFFIKF
OrthoDBi1137416at2759
PhylomeDBiQ9UGJ1
TreeFamiTF324188

Enzyme and pathway databases

PathwayCommonsiQ9UGJ1
ReactomeiR-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
27229, 744 hits in 882 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TUBGCP4, human
EvolutionaryTraceiQ9UGJ1

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TUBGCP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27229
PharosiQ9UGJ1, Tbio

Protein Ontology

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PROi
PR:Q9UGJ1
RNActiQ9UGJ1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137822, Expressed in frontal cortex and 217 other tissues
ExpressionAtlasiQ9UGJ1, baseline and differential
GenevisibleiQ9UGJ1, HS

Family and domain databases

Gene3Di1.20.120.1900, 1 hit
InterProiView protein in InterPro
IPR007259, GCP
IPR040457, GCP_C
IPR042241, GCP_C_sf
IPR041470, GCP_N
PANTHERiPTHR19302, PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130, GCP_C_terminal, 1 hit
PF17681, GCP_N_terminal, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCP4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGJ1
Secondary accession number(s): B3KNK6, Q969X3, Q9NVF0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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