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Protein

Gamma-tubulin complex component 4

Gene

TUBGCP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

GO - Molecular functioni

  • gamma-tubulin binding Source: GO_Central
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 4
Short name:
GCP-4
Short name:
hGCP4
Alternative name(s):
Gamma-ring complex protein 76 kDa
Short name:
h76p
Short name:
hGrip76
Gene namesi
Name:TUBGCP4
Synonyms:76P, GCP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137822.12
HGNCiHGNC:16691 TUBGCP4
MIMi609610 gene
neXtProtiNX_Q9UGJ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Microcephaly and chorioretinopathy, autosomal recessive, 3 (MCCRP3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by congenital microcephaly and chorioretinal dysplasia associated with poor vision and nystagmus. Variable ocular anomalies include microphthalmia, retinal folding, retinal detachment, optic nerve hypoplasia, absence of retinal vessels, round areas of chorioretinal atrophy, and attenuated electroretinogram. Most patients have mild developmental delay and mild learning difficulties.
See also OMIM:616335

Keywords - Diseasei

Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNETi27229
MalaCardsiTUBGCP4
MIMi616335 phenotype
OpenTargetsiENSG00000137822
Orphaneti2518 Autosomal recessive chorioretinopathy-microcephaly syndrome
PharmGKBiPA162407404

Polymorphism and mutation databases

BioMutaiTUBGCP4
DMDMi22095730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781241 – 667Gamma-tubulin complex component 4Add BLAST667

Proteomic databases

EPDiQ9UGJ1
PaxDbiQ9UGJ1
PeptideAtlasiQ9UGJ1
PRIDEiQ9UGJ1
ProteomicsDBi84225
84226 [Q9UGJ1-2]

PTM databases

iPTMnetiQ9UGJ1
PhosphoSitePlusiQ9UGJ1

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000137822 Expressed in 205 organ(s), highest expression level in frontal cortex
CleanExiHS_TUBGCP4
ExpressionAtlasiQ9UGJ1 baseline and differential
GenevisibleiQ9UGJ1 HS

Organism-specific databases

HPAiHPA043212

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with NINL. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385).2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118078, 119 interactors
DIPiDIP-50536N
IntActiQ9UGJ1, 42 interactors
MINTiQ9UGJ1
STRINGi9606.ENSP00000456648

Structurei

Secondary structure

1667
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UGJ1
SMRiQ9UGJ1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UGJ1

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2065 Eukaryota
ENOG410XPES LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000234444
HOVERGENiHBG023386
InParanoidiQ9UGJ1
KOiK16571
OMAiIDNLQYY
OrthoDBiEOG091G01V2
PhylomeDBiQ9UGJ1
TreeFamiTF324188

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIHELLLALS GYPGSIFTWN KRSGLQVSQD FPFLHPSETS VLNRLCRLGT
60 70 80 90 100
DYIRFTEFIE QYTGHVQQQD HHPSQQGQGG LHGIYLRAFC TGLDSVLQPY
110 120 130 140 150
RQALLDLEQE FLGDPHLSIS HVNYFLDQFQ LLFPSVMVVV EQIKSQKIHG
160 170 180 190 200
CQILETVYKH SCGGLPPVRS ALEKILAVCH GVMYKQLSAW MLHGLLLDQH
210 220 230 240 250
EEFFIKQGPS SGNVSAQPEE DEEDLGIGGL TGKQLRELQD LRLIEEENML
260 270 280 290 300
APSLKQFSLR VEILPSYIPV RVAEKILFVG ESVQMFENQN VNLTRKGSIL
310 320 330 340 350
KNQEDTFAAE LHRLKQQPLF SLVDFEQVVD RIRSTVAEHL WKLMVEESDL
360 370 380 390 400
LGQLKIIKDF YLLGRGELFQ AFIDTAQHML KTPPTAVTEH DVNVAFQQSA
410 420 430 440 450
HKVLLDDDNL LPLLHLTIEY HGKEHKADAT QAREGPSRET SPREAPASGW
460 470 480 490 500
AALGLSYKVQ WPLHILFTPA VLEKYNVVFK YLLSVRRVQA ELQHCWALQM
510 520 530 540 550
QRKHLKSNQT DAIKWRLRNH MAFLVDNLQY YLQVDVLESQ FSQLLHQINS
560 570 580 590 600
TRDFESIRLA HDHFLSNLLA QSFILLKPVF HCLNEILDLC HSFCSLVSQN
610 620 630 640 650
LGPLDERGAA QLSILVKGFS RQSSLLFKIL SSVRNHQINS DLAQLLLRLD
660
YNKYYTQAGG TLGSFGM
Length:667
Mass (Da):76,089
Last modified:May 1, 2000 - v1
Checksum:i2030EEDF290F5FAC
GO
Isoform 2 (identifier: Q9UGJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-427: Missing.

Show »
Length:666
Mass (Da):76,018
Checksum:i5BF032C026829F3A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPU4H3BPU4_HUMAN
Gamma-tubulin complex component
TUBGCP4
397Annotation score:
H3BQY4H3BQY4_HUMAN
Gamma-tubulin complex component
TUBGCP4
103Annotation score:
H3BN56H3BN56_HUMAN
Gamma-tubulin complex component
TUBGCP4
82Annotation score:
H3BS59H3BS59_HUMAN
Gamma-tubulin complex component
TUBGCP4
105Annotation score:
H3BNL9H3BNL9_HUMAN
Gamma-tubulin complex component
TUBGCP4
171Annotation score:
H3BQ12H3BQ12_HUMAN
Gamma-tubulin complex component 4
TUBGCP4
66Annotation score:

Sequence cautioni

The sequence BAA91802 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040085427Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249677 mRNA Translation: CAB62539.1
AK001639 mRNA Translation: BAA91802.1 Different initiation.
AK027703 mRNA Translation: BAG51368.1
AC018924 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92603.1
BC009870 mRNA Translation: AAH09870.1
BC012801 mRNA Translation: AAH12801.1
CCDSiCCDS42030.1 [Q9UGJ1-2]
CCDS66745.1 [Q9UGJ1-1]
RefSeqiNP_001273343.1, NM_001286414.2 [Q9UGJ1-1]
NP_055259.2, NM_014444.4 [Q9UGJ1-2]
XP_011519757.1, XM_011521455.2
UniGeneiHs.584887
Hs.598799

Genome annotation databases

EnsembliENST00000260383; ENSP00000260383; ENSG00000137822 [Q9UGJ1-1]
ENST00000564079; ENSP00000456648; ENSG00000137822 [Q9UGJ1-2]
GeneIDi27229
KEGGihsa:27229
UCSCiuc001zrn.5 human [Q9UGJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249677 mRNA Translation: CAB62539.1
AK001639 mRNA Translation: BAA91802.1 Different initiation.
AK027703 mRNA Translation: BAG51368.1
AC018924 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92603.1
BC009870 mRNA Translation: AAH09870.1
BC012801 mRNA Translation: AAH12801.1
CCDSiCCDS42030.1 [Q9UGJ1-2]
CCDS66745.1 [Q9UGJ1-1]
RefSeqiNP_001273343.1, NM_001286414.2 [Q9UGJ1-1]
NP_055259.2, NM_014444.4 [Q9UGJ1-2]
XP_011519757.1, XM_011521455.2
UniGeneiHs.584887
Hs.598799

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RIPX-ray2.30A1-667[»]
ProteinModelPortaliQ9UGJ1
SMRiQ9UGJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118078, 119 interactors
DIPiDIP-50536N
IntActiQ9UGJ1, 42 interactors
MINTiQ9UGJ1
STRINGi9606.ENSP00000456648

PTM databases

iPTMnetiQ9UGJ1
PhosphoSitePlusiQ9UGJ1

Polymorphism and mutation databases

BioMutaiTUBGCP4
DMDMi22095730

Proteomic databases

EPDiQ9UGJ1
PaxDbiQ9UGJ1
PeptideAtlasiQ9UGJ1
PRIDEiQ9UGJ1
ProteomicsDBi84225
84226 [Q9UGJ1-2]

Protocols and materials databases

DNASUi27229
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260383; ENSP00000260383; ENSG00000137822 [Q9UGJ1-1]
ENST00000564079; ENSP00000456648; ENSG00000137822 [Q9UGJ1-2]
GeneIDi27229
KEGGihsa:27229
UCSCiuc001zrn.5 human [Q9UGJ1-1]

Organism-specific databases

CTDi27229
DisGeNETi27229
EuPathDBiHostDB:ENSG00000137822.12
GeneCardsiTUBGCP4
H-InvDBiHIX0012185
HIX0172821
HGNCiHGNC:16691 TUBGCP4
HPAiHPA043212
MalaCardsiTUBGCP4
MIMi609610 gene
616335 phenotype
neXtProtiNX_Q9UGJ1
OpenTargetsiENSG00000137822
Orphaneti2518 Autosomal recessive chorioretinopathy-microcephaly syndrome
PharmGKBiPA162407404
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2065 Eukaryota
ENOG410XPES LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000234444
HOVERGENiHBG023386
InParanoidiQ9UGJ1
KOiK16571
OMAiIDNLQYY
OrthoDBiEOG091G01V2
PhylomeDBiQ9UGJ1
TreeFamiTF324188

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

ChiTaRSiTUBGCP4 human
EvolutionaryTraceiQ9UGJ1
GeneWikiiTUBGCP4
GenomeRNAii27229
PROiPR:Q9UGJ1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137822 Expressed in 205 organ(s), highest expression level in frontal cortex
CleanExiHS_TUBGCP4
ExpressionAtlasiQ9UGJ1 baseline and differential
GenevisibleiQ9UGJ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCP4_HUMAN
AccessioniPrimary (citable) accession number: Q9UGJ1
Secondary accession number(s): B3KNK6, Q969X3, Q9NVF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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