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Entry version 148 (10 Apr 2019)
Sequence version 3 (13 Sep 2005)
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Protein

5'-AMP-activated protein kinase subunit gamma-3

Gene

PRKAG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei225AMP, ADP or ATP 2By similarity1
Binding sitei285AMP, ADP or ATP 1; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei306AMP 3By similarity1
Binding sitei325AMP, ADP or ATP 2By similarity1
Binding sitei355AMP 3By similarity1
Binding sitei360AMP 3; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei424AMP, ADP or ATP 2By similarity1
Binding sitei432AMP, ADP or ATP 2; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei453AMP 3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi242 – 245AMP, ADP or ATP 1By similarity4
Nucleotide bindingi306 – 307AMP, ADP or ATP 1By similarity2
Nucleotide bindingi381 – 382AMP 3By similarity2
Nucleotide bindingi397 – 400AMP, ADP or ATP 2By similarity4
Nucleotide bindingi453 – 454AMP, ADP or ATP 2By similarity2
Nucleotide bindingi469 – 472AMP 3By similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1632852 Macroautophagy
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-9619483 Activation of AMPK downstream of NMDARs

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UGI9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-AMP-activated protein kinase subunit gamma-3
Short name:
AMPK gamma3
Short name:
AMPK subunit gamma-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKAG3
Synonyms:AMPKG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115592.11

Human Gene Nomenclature Database

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HGNCi
HGNC:9387 PRKAG3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604976 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UGI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
53632
MIMi604976 gene+phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33753

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3038457

Drug and drug target database

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DrugBanki
DB00945 Acetylsalicylic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRKAG3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85681287

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002043841 – 4895'-AMP-activated protein kinase subunit gamma-3Add BLAST489

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UGI9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UGI9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UGI9

PeptideAtlas

More...
PeptideAtlasi
Q9UGI9

PRoteomics IDEntifications database

More...
PRIDEi
Q9UGI9

ProteomicsDB human proteome resource

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ProteomicsDBi
84220
84221 [Q9UGI9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UGI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skeletal muscle, with weak expression in heart and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115592 Expressed in 57 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UGI9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UGI9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119791, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UGI9

Protein interaction database and analysis system

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IntActi
Q9UGI9, 4 interactors

Molecular INTeraction database

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MINTi
Q9UGI9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000397133

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UGI9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UGI9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini197 – 258CBS 1PROSITE-ProRule annotationAdd BLAST62
Domaini280 – 340CBS 2PROSITE-ProRule annotationAdd BLAST61
Domaini355 – 415CBS 3PROSITE-ProRule annotationAdd BLAST61
Domaini427 – 486CBS 4PROSITE-ProRule annotationAdd BLAST60

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi293 – 314AMPK pseudosubstrateAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1.
The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1764 Eukaryota
COG0517 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183019

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000176880

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050431

KEGG Orthology (KO)

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KOi
K07200

Identification of Orthologs from Complete Genome Data

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OMAi
AKASRWT

Database of Orthologous Groups

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OrthoDBi
631088at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGI9

TreeFam database of animal gene trees

More...
TreeFami
TF313247

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039168 AMPKG-3
IPR000644 CBS_dom

The PANTHER Classification System

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PANTHERi
PTHR13780:SF31 PTHR13780:SF31, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00571 CBS, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00116 CBS, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51371 CBS, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPGLEHALR RTPSWSSLGG SEHQEMSFLE QENSSSWPSP AVTSSSERIR
60 70 80 90 100
GKRRAKALRW TRQKSVEEGE PPGQGEGPRS RPAAESTGLE ATFPKTTPLA
110 120 130 140 150
QADPAGVGTP PTGWDCLPSD CTASAAGSST DDVELATEFP ATEAWECELE
160 170 180 190 200
GLLEERPALC LSPQAPFPKL GWDDELRKPG AQIYMRFMQE HTCYDAMATS
210 220 230 240 250
SKLVIFDTML EIKKAFFALV ANGVRAAPLW DSKKQSFVGM LTITDFILVL
260 270 280 290 300
HRYYRSPLVQ IYEIEQHKIE TWREIYLQGC FKPLVSISPN DSLFEAVYTL
310 320 330 340 350
IKNRIHRLPV LDPVSGNVLH ILTHKRLLKF LHIFGSLLPR PSFLYRTIQD
360 370 380 390 400
LGIGTFRDLA VVLETAPILT ALDIFVDRRV SALPVVNECG QVVGLYSRFD
410 420 430 440 450
VIHLAAQQTY NHLDMSVGEA LRQRTLCLEG VLSCQPHESL GEVIDRIARE
460 470 480
QVHRLVLVDE TQHLLGVVSL SDILQALVLS PAGIDALGA
Length:489
Mass (Da):54,258
Last modified:September 13, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E93E2B5117B328D
GO
Isoform 2 (identifier: Q9UGI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:464
Mass (Da):51,484
Checksum:i6404770D3EA7E2E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DUK8B4DUK8_HUMAN
cDNA FLJ60036, highly similar to 5'...
PRKAG3
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIC7C9JIC7_HUMAN
5'-AMP-activated protein kinase sub...
PRKAG3
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83A → T in AAF73987 (PubMed:10818001).Curated1
Sequence conflicti188 – 189MQ → IE in CAB65117 (PubMed:10698692).Curated2
Sequence conflicti423Q → K in CAB65117 (PubMed:10698692).Curated1
Sequence conflicti486 – 489ALGA → PSGPEKI in CAB65117 (PubMed:10698692).Curated4

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

PRKAG3 genetic variants can be associated with increased glycogen content in skeletal muscle [MIMi:604976]. Muscle fibers from carriers of variant Trp-225 have approximately 90% more muscle glycogen content than controls and decreased levels of intramuscular triglyceride.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02348471P → A2 PublicationsCorresponds to variant dbSNP:rs692243Ensembl.1
Natural variantiVAR_06947076E → Q1 PublicationCorresponds to variant dbSNP:rs864622003EnsemblClinVar.1
Natural variantiVAR_069471103D → G1 PublicationCorresponds to variant dbSNP:rs371222838EnsemblClinVar.1
Natural variantiVAR_069472113G → V1 PublicationCorresponds to variant dbSNP:rs864622004EnsemblClinVar.1
Natural variantiVAR_048251153L → V1 PublicationCorresponds to variant dbSNP:rs35050588Ensembl.1
Natural variantiVAR_069473161L → P1 PublicationCorresponds to variant dbSNP:rs962993719Ensembl.1
Natural variantiVAR_069474171G → S1 PublicationCorresponds to variant dbSNP:rs200004875Ensembl.1
Natural variantiVAR_069475180G → S1 PublicationCorresponds to variant dbSNP:rs372752820EnsemblClinVar.1
Natural variantiVAR_069476197M → T1 PublicationCorresponds to variant dbSNP:rs776255177EnsemblClinVar.1
Natural variantiVAR_069477211E → Q1 PublicationCorresponds to variant dbSNP:rs776263291EnsemblClinVar.1
Natural variantiVAR_069478225R → Q1 PublicationCorresponds to variant dbSNP:rs370008874EnsemblClinVar.1
Natural variantiVAR_069479225R → W1 PublicationCorresponds to variant dbSNP:rs138130157EnsemblClinVar.1
Natural variantiVAR_069480260Q → R1 PublicationCorresponds to variant dbSNP:rs41272689Ensembl.1
Natural variantiVAR_069481269I → T1 PublicationCorresponds to variant dbSNP:rs367916025EnsemblClinVar.1
Natural variantiVAR_069482307R → C1 PublicationCorresponds to variant dbSNP:rs864622005EnsemblClinVar.1
Natural variantiVAR_069483340R → Q1 PublicationCorresponds to variant dbSNP:rs551272603EnsemblClinVar.1
Natural variantiVAR_048252340R → W1 PublicationCorresponds to variant dbSNP:rs33985460Ensembl.1
Natural variantiVAR_069484446R → M1 PublicationCorresponds to variant dbSNP:rs200750014Ensembl.1
Natural variantiVAR_069485482A → V1 PublicationCorresponds to variant dbSNP:rs34720726Ensembl.1
Natural variantiVAR_069486485D → N1 PublicationCorresponds to variant dbSNP:rs149508864Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0155871 – 25Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ249977 mRNA Translation: CAB65117.1
AF214519 mRNA Translation: AAF73987.1
BC098102 mRNA Translation: AAH98102.1
BC098255 mRNA Translation: AAH98255.1
BC098277 mRNA Translation: AAH98277.1
BC098306 mRNA Translation: AAH98306.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2424.1 [Q9UGI9-1]

NCBI Reference Sequences

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RefSeqi
NP_059127.2, NM_017431.2 [Q9UGI9-1]
XP_016859832.1, XM_017004343.1 [Q9UGI9-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591634

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000233944; ENSP00000233944; ENSG00000115592 [Q9UGI9-1]
ENST00000439262; ENSP00000397133; ENSG00000115592 [Q9UGI9-1]
ENST00000529249; ENSP00000436068; ENSG00000115592 [Q9UGI9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53632

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:53632

UCSC genome browser

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UCSCi
uc002vjb.2 human [Q9UGI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249977 mRNA Translation: CAB65117.1
AF214519 mRNA Translation: AAF73987.1
BC098102 mRNA Translation: AAH98102.1
BC098255 mRNA Translation: AAH98255.1
BC098277 mRNA Translation: AAH98277.1
BC098306 mRNA Translation: AAH98306.1
CCDSiCCDS2424.1 [Q9UGI9-1]
RefSeqiNP_059127.2, NM_017431.2 [Q9UGI9-1]
XP_016859832.1, XM_017004343.1 [Q9UGI9-1]
UniGeneiHs.591634

3D structure databases

ProteinModelPortaliQ9UGI9
SMRiQ9UGI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119791, 12 interactors
CORUMiQ9UGI9
IntActiQ9UGI9, 4 interactors
MINTiQ9UGI9
STRINGi9606.ENSP00000397133

Chemistry databases

ChEMBLiCHEMBL3038457
DrugBankiDB00945 Acetylsalicylic acid

PTM databases

iPTMnetiQ9UGI9
PhosphoSitePlusiQ9UGI9

Polymorphism and mutation databases

BioMutaiPRKAG3
DMDMi85681287

Proteomic databases

EPDiQ9UGI9
jPOSTiQ9UGI9
PaxDbiQ9UGI9
PeptideAtlasiQ9UGI9
PRIDEiQ9UGI9
ProteomicsDBi84220
84221 [Q9UGI9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233944; ENSP00000233944; ENSG00000115592 [Q9UGI9-1]
ENST00000439262; ENSP00000397133; ENSG00000115592 [Q9UGI9-1]
ENST00000529249; ENSP00000436068; ENSG00000115592 [Q9UGI9-1]
GeneIDi53632
KEGGihsa:53632
UCSCiuc002vjb.2 human [Q9UGI9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53632
DisGeNETi53632
EuPathDBiHostDB:ENSG00000115592.11

GeneCards: human genes, protein and diseases

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GeneCardsi
PRKAG3
HGNCiHGNC:9387 PRKAG3
MIMi604976 gene+phenotype
neXtProtiNX_Q9UGI9
OpenTargetsiENSG00000115592
PharmGKBiPA33753

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1764 Eukaryota
COG0517 LUCA
GeneTreeiENSGT00950000183019
HOGENOMiHOG000176880
HOVERGENiHBG050431
KOiK07200
OMAiAKASRWT
OrthoDBi631088at2759
PhylomeDBiQ9UGI9
TreeFamiTF313247

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1632852 Macroautophagy
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-9619483 Activation of AMPK downstream of NMDARs
SIGNORiQ9UGI9

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PRKAG3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
53632

Protein Ontology

More...
PROi
PR:Q9UGI9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115592 Expressed in 57 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ9UGI9 baseline and differential
GenevisibleiQ9UGI9 HS

Family and domain databases

InterProiView protein in InterPro
IPR039168 AMPKG-3
IPR000644 CBS_dom
PANTHERiPTHR13780:SF31 PTHR13780:SF31, 1 hit
PfamiView protein in Pfam
PF00571 CBS, 3 hits
SMARTiView protein in SMART
SM00116 CBS, 4 hits
PROSITEiView protein in PROSITE
PS51371 CBS, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAKG3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGI9
Secondary accession number(s): Q4QQG8, Q4V779, Q9NRL1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: September 13, 2005
Last modified: April 10, 2019
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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