UniProtKB - Q9UGI8 (TES_HUMAN)

BLAST

>sp|Q9UGI8|TES_HUMAN Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1
MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEED
RKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQ
ALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVK
KYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCK
LSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPR
CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVV
CQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM
S

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History
Entry version 163 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

Testin

Gene

TES

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.3 Publications

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21278383

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11420696

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Testin Alternative name(s): TESS
Gene namesⁱ	Name:TES
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135269.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14620 TES
MIMⁱ	606085 gene
neXtProtⁱ	NX_Q9UGI8

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	328	C → A: Abolishes interaction with ACTL7A. 1 Publication		1
Mutagenesisⁱ	391	C → A: Abolishes localization at focal adhesions. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26136
Open Targets More...OpenTargetsⁱ	ENSG00000135269
PharmGKBⁱ	PA37906

Polymorphism and mutation databases

BioMutaⁱ	TES
DMDMⁱ	17380320

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000075906	1 – 421	TestinAdd BLAST		421

Proteomic databases

PaxDbⁱ	Q9UGI8
PeptideAtlas More...PeptideAtlasⁱ	Q9UGI8
PRIDEⁱ	Q9UGI8
ProteomicsDBⁱ	84218 84219 [Q9UGI8-2]

PTM databases

iPTMnetⁱ	Q9UGI8
PhosphoSitePlusⁱ	Q9UGI8

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000135269 Expressed in 217 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_TES
ExpressionAtlasⁱ	Q9UGI8 baseline and differential
Genevisibleⁱ	Q9UGI8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015269 HPA018123

HPAⁱ

HPA015269
HPA018123

Interactionⁱ

Subunit structureⁱ

Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ACTL7A	Q9Y615	9	EBI-2561654,EBI-10825302
ENAH	Q8N8S7	2	EBI-2561654,EBI-2834410

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117572, 288 interactors
IntActⁱ	Q9UGI8, 37 interactors
Molecular INTeraction database More...MINTⁱ	Q9UGI8
STRINGⁱ	9606.ENSP00000350937

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	302 – 304	Combined sources	3
Beta strandⁱ	305 – 307	Combined sources	3
Beta strandⁱ	313 – 316	Combined sources	4
Beta strandⁱ	319 – 321	Combined sources	3
Helixⁱ	323 – 325	Combined sources	3
Turnⁱ	329 – 331	Combined sources	3
Beta strandⁱ	338 – 343	Combined sources	6
Beta strandⁱ	346 – 349	Combined sources	4
Helixⁱ	350 – 356	Combined sources	7
Turnⁱ	362 – 364	Combined sources	3
Beta strandⁱ	365 – 368	Combined sources	4
Beta strandⁱ	374 – 377	Combined sources	4
Beta strandⁱ	380 – 383	Combined sources	4
Turnⁱ	384 – 387	Combined sources	4
Turnⁱ	392 – 394	Combined sources	3
Beta strandⁱ	404 – 406	Combined sources	3
Beta strandⁱ	409 – 413	Combined sources	5
Helixⁱ	414 – 418	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UGI8
SMRⁱ	Q9UGI8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UGI8

EvolutionaryTraceⁱ

Q9UGI8

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	92 – 199	PETPROSITE-ProRule annotationAdd BLAST	108
Domainⁱ	234 – 297	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	64
Domainⁱ	299 – 359	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	61
Domainⁱ	362 – 421	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	60

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	22 – 46	Cys-richAdd BLAST		25

Domainⁱ

The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.1 Publication

Sequence similaritiesⁱ

Belongs to the prickle / espinas / testin family.Curated

Keywords - Domainⁱ

LIM domain, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410INGJ Eukaryota ENOG410XQU0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074438
HOGENOMⁱ	HOG000231628
HOVERGENⁱ	HBG001038
InParanoidⁱ	Q9UGI8
OMAⁱ	NNFNWHA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07C5
PhylomeDBⁱ	Q9UGI8
TreeFamⁱ	TF313265

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09413 LIM1_Testin, 1 hit cd09416 LIM2_Testin, 1 hit cd09419 LIM3_Testin, 1 hit cd09829 PET_testin, 1 hit
InterProⁱ	View protein in InterPro IPR034958 LIM1_Testin IPR034959 LIM2_Testin IPR034960 LIM3_Testin IPR010442 PET_domain IPR033724 PET_testin IPR027683 Testin IPR001781 Znf_LIM
PANTHERⁱ	PTHR24211:SF1 PTHR24211:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412 LIM, 2 hits PF06297 PET, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 3 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 2 hits PS50023 LIM_DOMAIN_2, 3 hits PS51303 PET, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UGI8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLENKVKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE 
        60         70         80         90        100
HDVLLSNEED RKVGKLFEDT KYTTLIAKLK SDGIPMYKRN VMILTNPVAA 
       110        120        130        140        150
KKNVSINTVT YEWAPPVQNQ ALARQYMQML PKEKQPVAGS EGAQYRKKQL 
       160        170        180        190        200
AKQLPAHDQD PSKCHELSPR EVKEMEQFVK KYKSEALGVG DVKLPCEMDA 
       210        220        230        240        250
QGPKQMNIPG GDRSTPAAVG AMEDKSAEHK RTQYSCYCCK LSMKEGDPAI 
       260        270        280        290        300
YAERAGYDKL WHPACFVCST CHELLVDMIY FWKNEKLYCG RHYCDSEKPR 
       310        320        330        340        350
CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDSILAGEIY VMVNDKPVCK 
       360        370        380        390        400
PCYVKNHAVV CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG 
       410        420 
QKFMPVEGMV FCSVECKKRM S

Length:421

Mass (Da):47,996

Last modified:May 1, 2000 - v1

Checksum:ⁱAB9FF6669C50D492

Isoform 2 (identifier: Q9UGI8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-9: Missing.

« Hide

        10         20         30         40         50
MGLGHEQGFG APCLKCKEKC EGFELHFWRK ICRNCKCGQE EHDVLLSNEE 
        60         70         80         90        100
DRKVGKLFED TKYTTLIAKL KSDGIPMYKR NVMILTNPVA AKKNVSINTV 
       110        120        130        140        150
TYEWAPPVQN QALARQYMQM LPKEKQPVAG SEGAQYRKKQ LAKQLPAHDQ 
       160        170        180        190        200
DPSKCHELSP REVKEMEQFV KKYKSEALGV GDVKLPCEMD AQGPKQMNIP 
       210        220        230        240        250
GGDRSTPAAV GAMEDKSAEH KRTQYSCYCC KLSMKEGDPA IYAERAGYDK 
       260        270        280        290        300
LWHPACFVCS TCHELLVDMI YFWKNEKLYC GRHYCDSEKP RCAGCDELIF 
       310        320        330        340        350
SNEYTQAENQ NWHLKHFCCF DCDSILAGEI YVMVNDKPVC KPCYVKNHAV 
       360        370        380        390        400
VCQGCHNAID PEVQRVTYNN FSWHASTECF LCSCCSKCLI GQKFMPVEGM 
       410 
VFCSVECKKR MS

Show »

Length:412

Mass (Da):46,910

Checksum:ⁱC97A6D97364B3569

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7BYK1	H7BYK1_HUMAN	Testin Testin	TES	192	Annotation score:
F8W7T0	F8W7T0_HUMAN	Testin Testin	TES	79	Annotation score:
F8WDI4	F8WDI4_HUMAN	Testin Testin	TES	44	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	132	K → E in BAB13846 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050170	221	A → V. Corresponds to variant dbSNP:rs2272193Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003122	1 – 9	Missing in isoform 2. 2 Publications		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF260225 Genomic DNA Translation: AAG17635.1 AF260225 Genomic DNA Translation: AAG17636.1 AF245356 mRNA Translation: AAG17612.1 AF245357 mRNA Translation: AAG17613.1 AJ250865 mRNA Translation: CAB65119.1 AK021575 mRNA Translation: BAB13846.1 AK291802 mRNA Translation: BAF84491.1 AC073130 Genomic DNA Translation: AAQ93367.1 CH236947 Genomic DNA Translation: EAL24365.1 BC001451 mRNA Translation: AAH01451.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5763.1 [Q9UGI8-1] CCDS5764.1 [Q9UGI8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_056456.1, NM_015641.3 [Q9UGI8-1] NP_690042.1, NM_152829.2 [Q9UGI8-2]
UniGeneⁱ	Hs.592286 Hs.664957

Genome annotation databases

Ensemblⁱ	ENST00000358204; ENSP00000350937; ENSG00000135269 [Q9UGI8-1] ENST00000393481; ENSP00000377121; ENSG00000135269 [Q9UGI8-2]
GeneIDⁱ	26136
KEGGⁱ	hsa:26136
UCSC genome browser More...UCSCⁱ	uc003vho.3 human [Q9UGI8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UGI8	Testin		PANTR		421	UniRef100_Q9UGI8
Testin		PONAB		421
Testis derived transcript (3 LIM domains)		HUMAN		421
TES isoform 2		PANTR		421
TES isoform 2		PONAB		421
Q9UGI8-2	Testin		PANTR		422	UniRef100_A0A2I3RWE8
Uncharacterized protein		PANPA		422
TES isoform 1		PONAB		412
Uncharacterized protein DKFZp586B2022 (Fragment)		HUMAN		136
TES isoform 1		PANTR		412
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9UGI8	Testin		PANTR		421	UniRef90_Q9UGI8
Testin		PONAB		421
Testin		HORSE		421
Testin		FELCA		421
Testin		LOXAF		421
+190

Protein	Similar proteins		Species	Score	Length	Source
Q9UGI8	Testin		PANTR		421	UniRef50_Q9UGI8
Testin		PONAB		421
Testin		OTOGA		421
Testin		ATEAB		421
Testin		RABIT		421
+401

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF260225 Genomic DNA Translation: AAG17635.1 AF260225 Genomic DNA Translation: AAG17636.1 AF245356 mRNA Translation: AAG17612.1 AF245357 mRNA Translation: AAG17613.1 AJ250865 mRNA Translation: CAB65119.1 AK021575 mRNA Translation: BAB13846.1 AK291802 mRNA Translation: BAF84491.1 AC073130 Genomic DNA Translation: AAQ93367.1 CH236947 Genomic DNA Translation: EAL24365.1 BC001451 mRNA Translation: AAH01451.1
CCDSⁱ	CCDS5763.1 [Q9UGI8-1] CCDS5764.1 [Q9UGI8-2]
RefSeqⁱ	NP_056456.1, NM_015641.3 [Q9UGI8-1] NP_690042.1, NM_152829.2 [Q9UGI8-2]
UniGeneⁱ	Hs.592286 Hs.664957

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2IYB	X-ray	2.35	E/F/G/H	357-421	[»]
	2XQN	X-ray	2.62	T	296-421	[»]
ProteinModelPortalⁱ	Q9UGI8
SMRⁱ	Q9UGI8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117572, 288 interactors
IntActⁱ	Q9UGI8, 37 interactors
MINTⁱ	Q9UGI8
STRINGⁱ	9606.ENSP00000350937

PTM databases

iPTMnetⁱ	Q9UGI8
PhosphoSitePlusⁱ	Q9UGI8

Polymorphism and mutation databases

BioMutaⁱ	TES
DMDMⁱ	17380320

Proteomic databases

PaxDbⁱ	Q9UGI8
PeptideAtlasⁱ	Q9UGI8
PRIDEⁱ	Q9UGI8
ProteomicsDBⁱ	84218 84219 [Q9UGI8-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26136
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000358204; ENSP00000350937; ENSG00000135269 [Q9UGI8-1] ENST00000393481; ENSP00000377121; ENSG00000135269 [Q9UGI8-2]
GeneIDⁱ	26136
KEGGⁱ	hsa:26136
UCSCⁱ	uc003vho.3 human [Q9UGI8-1]

Organism-specific databases

CTDⁱ	26136
DisGeNETⁱ	26136
EuPathDBⁱ	HostDB:ENSG00000135269.17
GeneCardsⁱ	TES
HGNCⁱ	HGNC:14620 TES
HPAⁱ	HPA015269 HPA018123
MIMⁱ	606085 gene
neXtProtⁱ	NX_Q9UGI8
OpenTargetsⁱ	ENSG00000135269
PharmGKBⁱ	PA37906
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410INGJ Eukaryota ENOG410XQU0 LUCA
GeneTreeⁱ	ENSGT00550000074438
HOGENOMⁱ	HOG000231628
HOVERGENⁱ	HBG001038
InParanoidⁱ	Q9UGI8
OMAⁱ	NNFNWHA
OrthoDBⁱ	EOG091G07C5
PhylomeDBⁱ	Q9UGI8
TreeFamⁱ	TF313265

Miscellaneous databases

ChiTaRSⁱ	TES human
EvolutionaryTraceⁱ	Q9UGI8
GeneWikiⁱ	Testin
GenomeRNAiⁱ	26136
Protein Ontology More...PROⁱ	PR:Q9UGI8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135269 Expressed in 217 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_TES
ExpressionAtlasⁱ	Q9UGI8 baseline and differential
Genevisibleⁱ	Q9UGI8 HS

Family and domain databases

CDDⁱ	cd09413 LIM1_Testin, 1 hit cd09416 LIM2_Testin, 1 hit cd09419 LIM3_Testin, 1 hit cd09829 PET_testin, 1 hit
InterProⁱ	View protein in InterPro IPR034958 LIM1_Testin IPR034959 LIM2_Testin IPR034960 LIM3_Testin IPR010442 PET_domain IPR033724 PET_testin IPR027683 Testin IPR001781 Znf_LIM
PANTHERⁱ	PTHR24211:SF1 PTHR24211:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF00412 LIM, 2 hits PF06297 PET, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 3 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 2 hits PS50023 LIM_DOMAIN_2, 3 hits PS51303 PET, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TES_HUMAN
Accessionⁱ	Q9UGI8Primary (citable) accession number: Q9UGI8 Secondary accession number(s): A4D0U6, Q9GZQ1, Q9HAJ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q9UGI8 (TES_HUMAN)

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Testin

TES

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ