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Protein

Testin

Gene

TES

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.3 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • RNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • negative regulation of cell proliferation Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Testin
Alternative name(s):
TESS
Gene namesi
Name:TES
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000135269.17
HGNCiHGNC:14620 TES
MIMi606085 gene
neXtProtiNX_Q9UGI8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi328C → A: Abolishes interaction with ACTL7A. 1 Publication1
Mutagenesisi391C → A: Abolishes localization at focal adhesions. 1 Publication1

Organism-specific databases

DisGeNETi26136
OpenTargetsiENSG00000135269
PharmGKBiPA37906

Polymorphism and mutation databases

BioMutaiTES
DMDMi17380320

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759061 – 421TestinAdd BLAST421

Proteomic databases

PaxDbiQ9UGI8
PeptideAtlasiQ9UGI8
PRIDEiQ9UGI8
ProteomicsDBi84218
84219 [Q9UGI8-2]

PTM databases

iPTMnetiQ9UGI8
PhosphoSitePlusiQ9UGI8

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000135269 Expressed in 217 organ(s), highest expression level in amniotic fluid
CleanExiHS_TES
ExpressionAtlasiQ9UGI8 baseline and differential
GenevisibleiQ9UGI8 HS

Organism-specific databases

HPAiHPA015269
HPA018123

Interactioni

Subunit structurei

Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117572, 288 interactors
IntActiQ9UGI8, 37 interactors
MINTiQ9UGI8
STRINGi9606.ENSP00000350937

Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UGI8
SMRiQ9UGI8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UGI8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 199PETPROSITE-ProRule annotationAdd BLAST108
Domaini234 – 297LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST64
Domaini299 – 359LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini362 – 421LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 46Cys-richAdd BLAST25

Domaini

The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.1 Publication

Sequence similaritiesi

Belongs to the prickle / espinas / testin family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410INGJ Eukaryota
ENOG410XQU0 LUCA
GeneTreeiENSGT00550000074438
HOGENOMiHOG000231628
HOVERGENiHBG001038
InParanoidiQ9UGI8
OMAiNNFNWHA
OrthoDBiEOG091G07C5
PhylomeDBiQ9UGI8
TreeFamiTF313265

Family and domain databases

CDDicd09413 LIM1_Testin, 1 hit
cd09416 LIM2_Testin, 1 hit
cd09419 LIM3_Testin, 1 hit
cd09829 PET_testin, 1 hit
InterProiView protein in InterPro
IPR034958 LIM1_Testin
IPR034959 LIM2_Testin
IPR034960 LIM3_Testin
IPR010442 PET_domain
IPR033724 PET_testin
IPR027683 Testin
IPR001781 Znf_LIM
PANTHERiPTHR24211:SF1 PTHR24211:SF1, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 2 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits
PS51303 PET, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLENKVKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE
60 70 80 90 100
HDVLLSNEED RKVGKLFEDT KYTTLIAKLK SDGIPMYKRN VMILTNPVAA
110 120 130 140 150
KKNVSINTVT YEWAPPVQNQ ALARQYMQML PKEKQPVAGS EGAQYRKKQL
160 170 180 190 200
AKQLPAHDQD PSKCHELSPR EVKEMEQFVK KYKSEALGVG DVKLPCEMDA
210 220 230 240 250
QGPKQMNIPG GDRSTPAAVG AMEDKSAEHK RTQYSCYCCK LSMKEGDPAI
260 270 280 290 300
YAERAGYDKL WHPACFVCST CHELLVDMIY FWKNEKLYCG RHYCDSEKPR
310 320 330 340 350
CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDSILAGEIY VMVNDKPVCK
360 370 380 390 400
PCYVKNHAVV CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG
410 420
QKFMPVEGMV FCSVECKKRM S
Length:421
Mass (Da):47,996
Last modified:May 1, 2000 - v1
Checksum:iAB9FF6669C50D492
GO
Isoform 2 (identifier: Q9UGI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:412
Mass (Da):46,910
Checksum:iC97A6D97364B3569
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYK1H7BYK1_HUMAN
Testin
TES
192Annotation score:
F8W7T0F8W7T0_HUMAN
Testin
TES
79Annotation score:
F8WDI4F8WDI4_HUMAN
Testin
TES
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132K → E in BAB13846 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050170221A → V. Corresponds to variant dbSNP:rs2272193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0031221 – 9Missing in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260225 Genomic DNA Translation: AAG17635.1
AF260225 Genomic DNA Translation: AAG17636.1
AF245356 mRNA Translation: AAG17612.1
AF245357 mRNA Translation: AAG17613.1
AJ250865 mRNA Translation: CAB65119.1
AK021575 mRNA Translation: BAB13846.1
AK291802 mRNA Translation: BAF84491.1
AC073130 Genomic DNA Translation: AAQ93367.1
CH236947 Genomic DNA Translation: EAL24365.1
BC001451 mRNA Translation: AAH01451.1
CCDSiCCDS5763.1 [Q9UGI8-1]
CCDS5764.1 [Q9UGI8-2]
RefSeqiNP_056456.1, NM_015641.3 [Q9UGI8-1]
NP_690042.1, NM_152829.2 [Q9UGI8-2]
UniGeneiHs.592286
Hs.664957

Genome annotation databases

EnsembliENST00000358204; ENSP00000350937; ENSG00000135269 [Q9UGI8-1]
ENST00000393481; ENSP00000377121; ENSG00000135269 [Q9UGI8-2]
GeneIDi26136
KEGGihsa:26136
UCSCiuc003vho.3 human [Q9UGI8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260225 Genomic DNA Translation: AAG17635.1
AF260225 Genomic DNA Translation: AAG17636.1
AF245356 mRNA Translation: AAG17612.1
AF245357 mRNA Translation: AAG17613.1
AJ250865 mRNA Translation: CAB65119.1
AK021575 mRNA Translation: BAB13846.1
AK291802 mRNA Translation: BAF84491.1
AC073130 Genomic DNA Translation: AAQ93367.1
CH236947 Genomic DNA Translation: EAL24365.1
BC001451 mRNA Translation: AAH01451.1
CCDSiCCDS5763.1 [Q9UGI8-1]
CCDS5764.1 [Q9UGI8-2]
RefSeqiNP_056456.1, NM_015641.3 [Q9UGI8-1]
NP_690042.1, NM_152829.2 [Q9UGI8-2]
UniGeneiHs.592286
Hs.664957

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IYBX-ray2.35E/F/G/H357-421[»]
2XQNX-ray2.62T296-421[»]
ProteinModelPortaliQ9UGI8
SMRiQ9UGI8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117572, 288 interactors
IntActiQ9UGI8, 37 interactors
MINTiQ9UGI8
STRINGi9606.ENSP00000350937

PTM databases

iPTMnetiQ9UGI8
PhosphoSitePlusiQ9UGI8

Polymorphism and mutation databases

BioMutaiTES
DMDMi17380320

Proteomic databases

PaxDbiQ9UGI8
PeptideAtlasiQ9UGI8
PRIDEiQ9UGI8
ProteomicsDBi84218
84219 [Q9UGI8-2]

Protocols and materials databases

DNASUi26136
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358204; ENSP00000350937; ENSG00000135269 [Q9UGI8-1]
ENST00000393481; ENSP00000377121; ENSG00000135269 [Q9UGI8-2]
GeneIDi26136
KEGGihsa:26136
UCSCiuc003vho.3 human [Q9UGI8-1]

Organism-specific databases

CTDi26136
DisGeNETi26136
EuPathDBiHostDB:ENSG00000135269.17
GeneCardsiTES
HGNCiHGNC:14620 TES
HPAiHPA015269
HPA018123
MIMi606085 gene
neXtProtiNX_Q9UGI8
OpenTargetsiENSG00000135269
PharmGKBiPA37906
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INGJ Eukaryota
ENOG410XQU0 LUCA
GeneTreeiENSGT00550000074438
HOGENOMiHOG000231628
HOVERGENiHBG001038
InParanoidiQ9UGI8
OMAiNNFNWHA
OrthoDBiEOG091G07C5
PhylomeDBiQ9UGI8
TreeFamiTF313265

Miscellaneous databases

ChiTaRSiTES human
EvolutionaryTraceiQ9UGI8
GeneWikiiTestin
GenomeRNAii26136
PROiPR:Q9UGI8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135269 Expressed in 217 organ(s), highest expression level in amniotic fluid
CleanExiHS_TES
ExpressionAtlasiQ9UGI8 baseline and differential
GenevisibleiQ9UGI8 HS

Family and domain databases

CDDicd09413 LIM1_Testin, 1 hit
cd09416 LIM2_Testin, 1 hit
cd09419 LIM3_Testin, 1 hit
cd09829 PET_testin, 1 hit
InterProiView protein in InterPro
IPR034958 LIM1_Testin
IPR034959 LIM2_Testin
IPR034960 LIM3_Testin
IPR010442 PET_domain
IPR033724 PET_testin
IPR027683 Testin
IPR001781 Znf_LIM
PANTHERiPTHR24211:SF1 PTHR24211:SF1, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 2 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits
PS51303 PET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTES_HUMAN
AccessioniPrimary (citable) accession number: Q9UGI8
Secondary accession number(s): A4D0U6, Q9GZQ1, Q9HAJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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