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Entry version 159 (10 Apr 2019)
Sequence version 2 (05 Dec 2018)
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Protein

Small conductance calcium-activated potassium channel protein 3

Gene

KCNN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296052 Ca2+ activated K+ channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.16.7 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 3
Short name:
SK3
Short name:
SKCa 3
Short name:
SKCa3
Alternative name(s):
KCa2.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNN3
Synonyms:K3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143603.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6292 KCNN3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602983 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9UGI6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei288 – 308Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei315 – 335Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei366 – 386Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei405 – 425Helical; Name=Segment S4Sequence analysisAdd BLAST21
Transmembranei454 – 474Helical; Name=Segment S5Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei494 – 514Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei523 – 543Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3782

Open Targets

More...
OpenTargetsi
ENSG00000143603

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30072

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3381

Drug and drug target database

More...
DrugBanki
DB01110 Miconazole
DB00721 Procaine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
383

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17367120

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550131 – 731Small conductance calcium-activated potassium channel protein 3Add BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei167PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UGI6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UGI6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UGI6

PeptideAtlas

More...
PeptideAtlasi
Q9UGI6

PRoteomics IDEntifications database

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PRIDEi
Q9UGI6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84216
84217 [Q9UGI6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UGI6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGI6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143603 Expressed in 188 organ(s), highest expression level in hypothalamus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UGI6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UGI6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017990
HPA057127

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109983, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UGI6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000481848

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UGI6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UGI6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni561 – 637Calmodulin-bindingBy similarityAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 94Gln-richAdd BLAST65
Compositional biasi42 – 64Pro-richAdd BLAST23
Compositional biasi683 – 687Poly-Gln5
Compositional biasi727 – 730Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3684 Eukaryota
ENOG410XT9D LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276908

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052241

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UGI6

KEGG Orthology (KO)

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KOi
K04944

Database of Orthologous Groups

More...
OrthoDBi
907751at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGI6

TreeFam database of animal gene trees

More...
TreeFami
TF315015

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004178 CaM-bd_dom
IPR036122 CaM-bd_dom_sf
IPR015449 K_chnl_Ca-activ_SK
IPR013099 K_chnl_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10153 PTHR10153, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02888 CaMBD, 1 hit
PF07885 Ion_trans_2, 1 hit
PF03530 SK_channel, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01451 SKCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01053 CaMBD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81327 SSF81327, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQQQQQQ QPPPPAPPAA
60 70 80 90 100
PQQPLGPSLQ PQPPQLQQQQ QQQQQQQQQQ PPHPLSQLAQ LQSQPVHPGL
110 120 130 140 150
LHSSPTAFRA PPSSNSTAIL HPSSRQGSQL NLNDHLLGHS PSSTATSGPG
160 170 180 190 200
GGSRHRQASP LVHRRDSNPF TEIAMSSCKY SGGVMKPLSR LSASRRNLIE
210 220 230 240 250
AETEGQPLQL FSPSNPPEIV ISSREDNHAH QTLLHHPNAT HNHQHAGTTA
260 270 280 290 300
SSTTFPKANK RKNQNIGYKL GHRRALFEKR KRLSDYALIF GMFGIVVMVI
310 320 330 340 350
ETELSWGLYS KDSMFSLALK CLISLSTIIL LGLIIAYHTR EVQLFVIDNG
360 370 380 390 400
ADDWRIAMTY ERILYISLEM LVCAIHPIPG EYKFFWTARL AFSYTPSRAE
410 420 430 440 450
ADVDIILSIP MFLRLYLIAR VMLLHSKLFT DASSRSIGAL NKINFNTRFV
460 470 480 490 500
MKTLMTICPG TVLLVFSISL WIIAAWTVRV CERYHDQQDV TSNFLGAMWL
510 520 530 540 550
ISITFLSIGY GDMVPHTYCG KGVCLLTGIM GAGCTALVVA VVARKLELTK
560 570 580 590 600
AEKHVHNFMM DTQLTKRIKN AAANVLRETW LIYKHTKLLK KIDHAKVRKH
610 620 630 640 650
QRKFLQAIHQ LRSVKMEQRK LSDQANTLVD LSKMQNVMYD LITELNDRSE
660 670 680 690 700
DLEKQIGSLE SKLEHLTASF NSLPLLIADT LRQQQQQLLS AIIEARGVSV
710 720 730
AVGTTHTPIS DSPIGVSSTS FPTPYTSSSS C
Length:731
Mass (Da):81,385
Last modified:December 5, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02E5E79D7EAAAC29
GO
Isoform 2 (identifier: Q9UGI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-305: Missing.
     306-310: WGLYS → MERPI

Show »
Length:426
Mass (Da):48,050
Checksum:i1EBE12900FA7719D
GO
Isoform 3 (identifier: Q9UGI6-3) [UniParc]FASTAAdd to basket
Also known as: SK3-1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-313: Missing.

Note: Do not produce functional channels, but selectively suppresses endogenous SK3 currents, in a dominant-negative fashion. This dominant inhibitory effect extends to other members of the SK subfamily. Widely distributed in human tissues and is present at 20-60% of SK3 in the brain.
Show »
Length:418
Mass (Da):47,093
Checksum:iB4CD0E43E758BDC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYJ0A0A087WYJ0_HUMAN
Small conductance calcium-activated...
KCNN3
746Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQW9A0A0A0MQW9_HUMAN
Small conductance calcium-activated...
KCNN3
731Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti249T → A in AAC26099 (PubMed:9491810).Curated1
Sequence conflicti276L → P in AAC26099 (PubMed:9491810).Curated1
Sequence conflicti342V → A in AAC26099 (PubMed:9491810).Curated1
Sequence conflicti480V → A in AAC26099 (PubMed:9491810).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28 in the population.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08108880Q → QQQQQQ. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0476411 – 313Missing in isoform 3. 1 PublicationAdd BLAST313
Alternative sequenceiVSP_0394611 – 305Missing in isoform 2. 2 PublicationsAdd BLAST305
Alternative sequenceiVSP_039462306 – 310WGLYS → MERPI in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF031815 mRNA Translation: AAC26099.1
AJ251016 mRNA Translation: CAB61331.1
AF438203 mRNA Translation: AAL40801.1
AF336797 Genomic DNA Translation: AAK15345.1
AY138900 mRNA Translation: AAN46636.1
AL390204 Genomic DNA No translation available.
AL606500 Genomic DNA No translation available.
AL954342 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53180.1
CH471121 Genomic DNA Translation: EAW53182.1
BC042147 mRNA Translation: AAH42147.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1072.1 [Q9UGI6-2]
CCDS30880.1 [Q9UGI6-1]

NCBI Reference Sequences

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RefSeqi
NP_001191016.1, NM_001204087.1
NP_002240.3, NM_002249.5 [Q9UGI6-1]
NP_740752.1, NM_170782.2 [Q9UGI6-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.490765

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271915; ENSP00000271915; ENSG00000143603 [Q9UGI6-1]
ENST00000358505; ENSP00000351295; ENSG00000143603 [Q9UGI6-3]
ENST00000361147; ENSP00000354764; ENSG00000143603 [Q9UGI6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3782

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3782

UCSC genome browser

More...
UCSCi
uc001ffo.4 human [Q9UGI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031815 mRNA Translation: AAC26099.1
AJ251016 mRNA Translation: CAB61331.1
AF438203 mRNA Translation: AAL40801.1
AF336797 Genomic DNA Translation: AAK15345.1
AY138900 mRNA Translation: AAN46636.1
AL390204 Genomic DNA No translation available.
AL606500 Genomic DNA No translation available.
AL954342 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53180.1
CH471121 Genomic DNA Translation: EAW53182.1
BC042147 mRNA Translation: AAH42147.1
CCDSiCCDS1072.1 [Q9UGI6-2]
CCDS30880.1 [Q9UGI6-1]
RefSeqiNP_001191016.1, NM_001204087.1
NP_002240.3, NM_002249.5 [Q9UGI6-1]
NP_740752.1, NM_170782.2 [Q9UGI6-2]
UniGeneiHs.490765

3D structure databases

ProteinModelPortaliQ9UGI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109983, 5 interactors
IntActiQ9UGI6, 4 interactors
STRINGi9606.ENSP00000481848

Chemistry databases

BindingDBiQ9UGI6
ChEMBLiCHEMBL3381
DrugBankiDB01110 Miconazole
DB00721 Procaine
GuidetoPHARMACOLOGYi383

Protein family/group databases

TCDBi1.A.1.16.7 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ9UGI6
PhosphoSitePlusiQ9UGI6

Polymorphism and mutation databases

BioMutaiKCNN3
DMDMi17367120

Proteomic databases

EPDiQ9UGI6
jPOSTiQ9UGI6
PaxDbiQ9UGI6
PeptideAtlasiQ9UGI6
PRIDEiQ9UGI6
ProteomicsDBi84216
84217 [Q9UGI6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3782
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271915; ENSP00000271915; ENSG00000143603 [Q9UGI6-1]
ENST00000358505; ENSP00000351295; ENSG00000143603 [Q9UGI6-3]
ENST00000361147; ENSP00000354764; ENSG00000143603 [Q9UGI6-2]
GeneIDi3782
KEGGihsa:3782
UCSCiuc001ffo.4 human [Q9UGI6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3782
DisGeNETi3782
EuPathDBiHostDB:ENSG00000143603.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNN3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0023527
HGNCiHGNC:6292 KCNN3
HPAiHPA017990
HPA057127
MIMi602983 gene
neXtProtiNX_Q9UGI6
OpenTargetsiENSG00000143603
PharmGKBiPA30072

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3684 Eukaryota
ENOG410XT9D LUCA
GeneTreeiENSGT00950000182904
HOGENOMiHOG000276908
HOVERGENiHBG052241
InParanoidiQ9UGI6
KOiK04944
OrthoDBi907751at2759
PhylomeDBiQ9UGI6
TreeFamiTF315015

Enzyme and pathway databases

ReactomeiR-HSA-1296052 Ca2+ activated K+ channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KCNN3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SK3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3782

Protein Ontology

More...
PROi
PR:Q9UGI6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143603 Expressed in 188 organ(s), highest expression level in hypothalamus
ExpressionAtlasiQ9UGI6 baseline and differential
GenevisibleiQ9UGI6 HS

Family and domain databases

InterProiView protein in InterPro
IPR004178 CaM-bd_dom
IPR036122 CaM-bd_dom_sf
IPR015449 K_chnl_Ca-activ_SK
IPR013099 K_chnl_dom
PANTHERiPTHR10153 PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888 CaMBD, 1 hit
PF07885 Ion_trans_2, 1 hit
PF03530 SK_channel, 1 hit
PRINTSiPR01451 SKCHANNEL
SMARTiView protein in SMART
SM01053 CaMBD, 1 hit
SUPFAMiSSF81327 SSF81327, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGI6
Secondary accession number(s): B1ANX0
, O43517, Q86VF9, Q8WXG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: December 5, 2018
Last modified: April 10, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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