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UniProtKB - Q9UGI0 (ZRAN1_HUMAN)

Entry version 183 (23 Feb 2022)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
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Protein

Ubiquitin thioesterase ZRANB1

Gene

ZRANB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577).

Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465).

Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465).

Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724).

Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987).

Required in the stress fiber dynamics and cell migration (PubMed:21834987).

7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi10Zinc 1PROSITE-ProRule annotationCombined sources1 Publication1
Metal bindingi13Zinc 1PROSITE-ProRule annotationCombined sources1 Publication1
Metal bindingi24Zinc 1PROSITE-ProRule annotationCombined sources1 Publication1
Metal bindingi27Zinc 1PROSITE-ProRule annotationCombined sources1 Publication1
Metal bindingi90Zinc 2PROSITE-ProRule annotation1
Metal bindingi93Zinc 2PROSITE-ProRule annotation1
Metal bindingi104Zinc 2PROSITE-ProRule annotation1
Metal bindingi107Zinc 2PROSITE-ProRule annotation1
Metal bindingi155Zinc 3PROSITE-ProRule annotation1
Metal bindingi158Zinc 3PROSITE-ProRule annotation1
Metal bindingi169Zinc 3PROSITE-ProRule annotation1
Metal bindingi172Zinc 3PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei443Nucleophile1 Publication1
Active sitei585Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3 – 33RanBP2-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri84 – 113RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri149 – 178RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway, Wnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UGI0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-5689896, Ovarian tumor domain proteases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UGI0

Protein family/group databases

MEROPS protease database

More...MEROPSi		C64.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin thioesterase ZRANB1Curated (EC:3.4.19.124 Publications)
Alternative name(s):
TRAF-binding domain-containing protein1 Publication
Short name:
hTrabid1 Publication
Zinc finger Ran-binding domain-containing protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZRANB11 PublicationImported
Synonyms:TRABID1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18224, ZRANB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611749, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UGI0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000019995

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi10C → A: Abolishes the binding to ubiquitin chains but not the deubiquitinating activity; when associated with 14-LV-15; A-90; 94-LV-95; A-155 and 159-LV-160. 1 Publication1
Mutagenesisi12Y → A: Does not affect binding to 'Lys-29'- and 'Lys-33'-linked ubiquitin. 1 Publication1
Mutagenesisi14 – 15TY → LV: Abolishes the binding to ubiquitin chains but not the deubiquitinating activity; when associated with A-10; A-90; 94-LV-95; A-155 and 159-LV-160. 1 Publication2
Mutagenesisi14T → A: Abolished binding to 'Lys-29'- and 'Lys-33'-linked ubiquitin. 1 Publication1
Mutagenesisi15Y → F: Strongly reduced binding to 'Lys-29'- and 'Lys-33'-linked ubiquitin. 2 Publications1
Mutagenesisi16E → A: Does not affect binding to 'Lys-29'- and 'Lys-33'-linked ubiquitin. 1 Publication1
Mutagenesisi18W → A: Abolished binding to 'Lys-33'-linked diubiquitin. 1 Publication1
Mutagenesisi20S → R: Strongly reduced binding to 'Lys-33'-linked diubiquitin. 1 Publication1
Mutagenesisi25T → A: Does not affect binding to 'Lys-29'- and 'Lys-33'-linked ubiquitin. 1 Publication1
Mutagenesisi25T → D: Abolished binding to 'Lys-33'-linked diubiquitin. 1 Publication1
Mutagenesisi26M → A: Abolished binding to 'Lys-29'- and 'Lys-33'-linked ubiquitin. 1 Publication1
Mutagenesisi90C → A: Abolishes the binding to ubiquitin chains but not the deubiquitinating activity; when associated with A-10; 14-LV-15; 94-LV-95; A-155 and 159-LV-160. 1 Publication1
Mutagenesisi94 – 95TY → LV: Abolishes the binding to ubiquitin chains but not the deubiquitinating activity; when associated with A-10; 14-LV-15; A-90; A-155 and 159-LV-160. 1 Publication2
Mutagenesisi155C → A: Abolishes the binding to ubiquitin chains but not the deubiquitinating activity; when associated with A-10; 14-LV-15; A-90; 94-LV-95 and 159-LV-160. 1 Publication1
Mutagenesisi159 – 160TY → LV: Abolishes the binding to ubiquitin chains but not the deubiquitinating activity; when associated with A-10; 14-LV-15; A-90; 94-LV-95; and A-155. 1 Publication2
Mutagenesisi443C → S: Abolishes the deubiquitinating activity but not the binding to ubiquitin chains. 3 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		54764

Open Targets

More...OpenTargetsi		ENSG00000019995

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134933584

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UGI0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZRANB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276487

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000655951 – 708Ubiquitin thioesterase ZRANB1Add BLAST708

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UGI0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UGI0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UGI0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UGI0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UGI0

PeptideAtlas

More...PeptideAtlasi		Q9UGI0

PRoteomics IDEntifications database

More...PRIDEi		Q9UGI0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84215

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UGI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UGI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000019995, Expressed in gastrocnemius and 218 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UGI0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000019995, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF6 (PubMed:11463333).

Interacts with APC (PubMed:18281465).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9UGI0
With#Exp.IntAct
ANKRD11 [X5D778]3EBI-527853,EBI-17183751
AP1M1 [Q9BXS5]3EBI-527853,EBI-541426
ARHGEF5 [Q12774]3EBI-527853,EBI-602199
ARRDC2 [Q8TBH0]3EBI-527853,EBI-12191751
ARRDC3 [Q96B67]3EBI-527853,EBI-2875665
BAHD1 [Q8TBE0]3EBI-527853,EBI-742750
BRD1 [O95696]3EBI-527853,EBI-714754
BYSL [Q13895]3EBI-527853,EBI-358049
CARD9 - isoform 2 [Q9H257-2]3EBI-527853,EBI-11530605
CBX7 [O95931]3EBI-527853,EBI-3923843
CBX8 [Q9HC52]3EBI-527853,EBI-712912
CCDC120 [Q96HB5]3EBI-527853,EBI-744556
CCDC13 [Q8IYE1]3EBI-527853,EBI-10961312
CCDC185 [Q8N715]3EBI-527853,EBI-740814
CCNL1 [Q9UK58]3EBI-527853,EBI-2836773
CDC45 [O75419]3EBI-527853,EBI-374969
CDC5L [Q99459]3EBI-527853,EBI-374880
CDK18 [Q07002]3EBI-527853,EBI-746238
CDKL3 [Q8IVW4]3EBI-527853,EBI-3919850
CNNM3 [Q8NE01]3EBI-527853,EBI-741032
CPNE7 - isoform 2 [Q9UBL6-2]3EBI-527853,EBI-12012272
CWF19L2 [Q2TBE0]3EBI-527853,EBI-5453285
DCX - isoform 2 [O43602-2]3EBI-527853,EBI-14148644
DDX6 [P26196]3EBI-527853,EBI-351257
DNAJB13 [P59910]3EBI-527853,EBI-11514233
DTNB - isoform 5 [O60941-5]3EBI-527853,EBI-11984733
DUSP13 [Q9UII6]3EBI-527853,EBI-749800
EHHADH [Q08426]3EBI-527853,EBI-2339219
EIF3D [O15371]3EBI-527853,EBI-353818
ENKD1 [Q9H0I2]3EBI-527853,EBI-744099
ERF [P50548]3EBI-527853,EBI-8465203
FAIM - isoform 2 [Q9NVQ4-2]3EBI-527853,EBI-12039347
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-527853,EBI-11986315
FAM161A [Q3B820]3EBI-527853,EBI-719941
FAM161B [Q96MY7]3EBI-527853,EBI-7225287
FAM214B [Q7L5A3]3EBI-527853,EBI-745689
FAM50B [Q9Y247]3EBI-527853,EBI-742802
FARS2 [O95363]3EBI-527853,EBI-2513774
FNDC11 [Q9BVV2]3EBI-527853,EBI-744935
GADD45GIP1 [Q8TAE8]3EBI-527853,EBI-372506
GAS2L2 [Q8NHY3]3EBI-527853,EBI-7960826
GEM [P55040]3EBI-527853,EBI-744104
GLIS2 [Q9BZE0]3EBI-527853,EBI-7251368
GPANK1 [O95872]3EBI-527853,EBI-751540
GPKOW [Q92917]3EBI-527853,EBI-746309
HOXB5 [P09067]3EBI-527853,EBI-3893317
HOXC8 [P31273]3EBI-527853,EBI-1752118
IL16 - isoform 2 [Q14005-2]3EBI-527853,EBI-17178971
INO80B [Q9C086]3EBI-527853,EBI-715611
IP6K3 [Q96PC2]3EBI-527853,EBI-10990676
IQUB [Q8NA54]3EBI-527853,EBI-10220600
JRK - isoform 2 [O75564-2]3EBI-527853,EBI-17181882
KANK2 [Q63ZY3]3EBI-527853,EBI-2556193
KIF9 [Q9HAQ2]3EBI-527853,EBI-8472129
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-527853,EBI-14069005
LENG1 [Q96BZ8]3EBI-527853,EBI-726510
LMO3 - isoform 4 [Q8TAP4-4]3EBI-527853,EBI-11742507
LNX1 [Q8TBB1]3EBI-527853,EBI-739832
MAGEB4 [O15481]3EBI-527853,EBI-751857
MAGOH [P61326]3EBI-527853,EBI-299134
MCRS1 [Q96EZ8]3EBI-527853,EBI-348259
METAP1 [P53582]4EBI-527853,EBI-1051435
METTL21A [Q8WXB1]3EBI-527853,EBI-8652459
MFAP1 [P55081]3EBI-527853,EBI-1048159
MGC50722 [Q8IVT4]3EBI-527853,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]3EBI-527853,EBI-10172526
MMTAG2 [Q9BU76]3EBI-527853,EBI-742459
MPPED1 - isoform 2 [O15442-2]3EBI-527853,EBI-12183511
MYEF2 - isoform 2 [Q9P2K5-2]3EBI-527853,EBI-10318831
NEK6 - isoform 4 [Q9HC98-4]3EBI-527853,EBI-11750983
NUDT16L1 [Q9BRJ7]3EBI-527853,EBI-2949792
NUDT21 [O43809]3EBI-527853,EBI-355720
PBLD [P30039]4EBI-527853,EBI-750589
PHF1 [O43189]3EBI-527853,EBI-530034
PHF19 [Q5T6S3]3EBI-527853,EBI-2339674
PKN1 [Q16512]3EBI-527853,EBI-602382
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-527853,EBI-12014286
PNMA5 [Q96PV4]3EBI-527853,EBI-10171633
POLDIP3 [Q8WUT1]3EBI-527853,EBI-10276663
POLL - isoform 2 [Q9UGP5-2]3EBI-527853,EBI-10320765
POLR1C [O15160]3EBI-527853,EBI-1055079
PPP1R18 [Q6NYC8]3EBI-527853,EBI-2557469
PRPF18 [Q99633]3EBI-527853,EBI-2798416
PRPF3 [O43395]3EBI-527853,EBI-744322
PRPF31 [Q8WWY3]3EBI-527853,EBI-1567797
PSPC1 - isoform 2 [Q8WXF1-2]3EBI-527853,EBI-12135327
QARS1 [P47897]3EBI-527853,EBI-347462
RASAL3 [Q86YV0]3EBI-527853,EBI-3437896
RHOBTB3 [O94955]3EBI-527853,EBI-2367123
RNPS1 [Q15287]3EBI-527853,EBI-395959
SDCBP [O00560]3EBI-527853,EBI-727004
STAMBPL1 [Q96FJ0]3EBI-527853,EBI-745021
STK19 [B7ZLI8]3EBI-527853,EBI-10176124
SUV39H1 [O43463]3EBI-527853,EBI-349968
SYT17 [Q9BSW7]3EBI-527853,EBI-745392
SYTL4 [Q96C24]3EBI-527853,EBI-747142
TBC1D30 - isoform 2 [Q9Y2I9-2]3EBI-527853,EBI-17455779
TBC1D3F [A6NER0]3EBI-527853,EBI-18393978
TBC1D3G [Q6DHY5]6EBI-527853,EBI-13092532
TCEA2 [Q15560]3EBI-527853,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-527853,EBI-11955057
THAP7 [Q9BT49]3EBI-527853,EBI-741350
TIE1 [P35590]3EBI-527853,EBI-2256865
TLE5 - isoform 2 [Q08117-2]3EBI-527853,EBI-11741437
TNS4 [Q8IZW8]3EBI-527853,EBI-7543499
TOLLIP [Q9H0E2]3EBI-527853,EBI-74615
TRAF3IP3 [Q9Y228]3EBI-527853,EBI-765817
TRAF4 [Q9BUZ4]3EBI-527853,EBI-3650647
TRAF6 [Q9Y4K3]4EBI-527853,EBI-359276
TRAPPC2 - isoform 3 [P0DI81-3]3EBI-527853,EBI-11961968
TSGA10IP [Q3SY00]3EBI-527853,EBI-10241197
TSPYL4 [Q9UJ04]3EBI-527853,EBI-308511
TSTD2 [Q5T7W7]3EBI-527853,EBI-8994397
UBASH3A - isoform 2 [P57075-2]3EBI-527853,EBI-7353612
UBC [P0CG48]2EBI-527853,EBI-3390054
USP2 [O75604]3EBI-527853,EBI-743272
VAV3 [Q9UKW4]3EBI-527853,EBI-297568
VEZF1 [Q14119]3EBI-527853,EBI-11980193
WT1 - isoform 6 [P19544-6]3EBI-527853,EBI-11745701
XRCC5 [P13010]3EBI-527853,EBI-357997
ZBTB24 [O43167]3EBI-527853,EBI-744471
ZBTB47 [Q9UFB7]3EBI-527853,EBI-7781767
ZNF124 [Q15973]3EBI-527853,EBI-2555767
ZNF17 [P17021]3EBI-527853,EBI-1105334
ZNF250 - isoform 3 [P15622-3]3EBI-527853,EBI-10177272
ZNF408 [Q9H9D4]3EBI-527853,EBI-347633
ZNF417 [Q8TAU3]3EBI-527853,EBI-740727
ZNF438 [Q7Z4V0]3EBI-527853,EBI-11962468
ZNF490 [Q9ULM2]3EBI-527853,EBI-1105370
ZNF497 [Q6ZNH5]3EBI-527853,EBI-10486136
ZNF552 [Q9H707]3EBI-527853,EBI-2555731
ZNF575 [Q86XF7]3EBI-527853,EBI-14069183
ZNF581 [Q9P0T4]3EBI-527853,EBI-745520
ZNF587 [Q96SQ5]3EBI-527853,EBI-6427977
ZNF599 [Q96NL3]3EBI-527853,EBI-8653994
ZNF629 [Q9UEG4]3EBI-527853,EBI-9977294
ZNF648 [Q5T619]3EBI-527853,EBI-11985915
ZNF764 [Q96H86]3EBI-527853,EBI-745775
ZNF775 [Q96BV0]3EBI-527853,EBI-7149881
ZNF792 [Q3KQV3]3EBI-527853,EBI-10240849
ZNF837 [Q96EG3]3EBI-527853,EBI-11962574
2'-O-methyltransferase nsp16 (PRO_0000449633) from Severe acute respiratory syndrome coronavirus 2.3EBI-527853,EBI-25492395

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120139, 189 interactors

Database of interacting proteins

More...DIPi		DIP-33806N

Protein interaction database and analysis system

More...IntActi		Q9UGI0, 168 interactors

Molecular INTeraction database

More...MINTi		Q9UGI0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352676

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UGI0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1708
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UGI0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati260 – 290ANK 1Add BLAST31
Repeati313 – 340ANK 2Add BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini432 – 592OTUPROSITE-ProRule annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 73DisorderedSequence analysisAdd BLAST36
Regioni200 – 225DisorderedSequence analysisAdd BLAST26
Regioni392 – 641TRAF-binding1 PublicationAdd BLAST250

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 65Polar residuesSequence analysisAdd BLAST16
Compositional biasi202 – 217Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RanBP2-type zinc fingers, also called NZFs, mediate the interaction with ubiquitin and determine linkage specificity (PubMed:25752577). RanBP2-type zinc fingers 1 and 2 (also named NZF1 and NZF2) specifically recognize and bind 'Lys-29'- and 'Lys-33'-linked ubiquitin (PubMed:25752573, PubMed:25752577). RanBP2-type zinc finger 3 (also named NZF3) binds 'Lys-33'-linked ubiquitin and shows weak binding to 'Lys-6'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin chains but it does not interact with 'Lys-29'-linked chains (PubMed:25752573).2 Publications
The OTU domain mediates the deubiquitinating activity.2 Publications
The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C64 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 33RanBP2-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri84 – 113RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri149 – 178RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4345, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158045

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013907_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UGI0

Identification of Orthologs from Complete Genome Data

More...OMAi		YPRWKEY

Database of Orthologous Groups

More...OrthoDBi		728724at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UGI0

TreeFam database of animal gene trees

More...TreeFami		TF323312

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041294, AnkUBD
IPR003323, OTU_dom
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18418, AnkUBD, 1 hit
PF02338, OTU, 1 hit
PF00641, zf-RanBP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00547, ZnF_RBZ, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF90209, SSF90209, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50802, OTU, 1 hit
PS01358, ZF_RANBP2_1, 3 hits
PS50199, ZF_RANBP2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UGI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSERGIKWAC EYCTYENWPS AIKCTMCRAQ RPSGTIITED PFKSGSSDVG 
        60         70         80         90        100
RDWDPSSTEG GSSPLICPDS SARPRVKSSY SMENANKWSC HMCTYLNWPR 
       110        120        130        140        150
AIRCTQCLSQ RRTRSPTESP QSSGSGSRPV AFSVDPCEEY NDRNKLNTRT 
       160        170        180        190        200
QHWTCSVCTY ENWAKAKRCV VCDHPRPNNI EAIELAETEE ASSIINEQDR 
       210        220        230        240        250
ARWRGSCSSG NSQRRSPPAT KRDSEVKMDF QRIELAGAVG SKEELEVDFK 
       260        270        280        290        300
KLKQIKNRMK KTDWLFLNAC VGVVEGDLAA IEAYKSSGGD IARQLTADEV 
       310        320        330        340        350
RLLNRPSAFD VGYTLVHLAI RFQRQDMLAI LLTEVSQQAA KCIPAMVCPE 
       360        370        380        390        400
LTEQIRREIA ASLHQRKGDF ACYFLTDLVT FTLPADIEDL PPTVQEKLFD 
       410        420        430        440        450
EVLDRDVQKE LEEESPIINW SLELATRLDS RLYALWNRTA GDCLLDSVLQ 
       460        470        480        490        500
ATWGIYDKDS VLRKALHDSL HDCSHWFYTR WKDWESWYSQ SFGLHFSLRE 
       510        520        530        540        550
EQWQEDWAFI LSLASQPGAS LEQTHIFVLA HILRRPIIVY GVKYYKSFRG 
       560        570        580        590        600
ETLGYTRFQG VYLPLLWEQS FCWKSPIALG YTRGHFSALV AMENDGYGNR 
       610        620        630        640        650
GAGANLNTDD DVTITFLPLV DSERKLLHVH FLSAQELGNE EQQEKLLREW 
       660        670        680        690        700
LDCCVTEGGV LVAMQKSSRR RNHPLVTQMV EKWLDRYRQI RPCTSLSDGE 

EDEDDEDE
Length:708
Mass (Da):80,967
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBB831697F450248
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG64010 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti374F → I in CAB64449 (PubMed:11463333).Curated1
Sequence conflicti384P → A in CAB64449 (PubMed:11463333).Curated1
Sequence conflicti602A → P in BAG64010 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ252060 mRNA Translation: CAB64449.1
AK302810 mRNA Translation: BAG64010.1 Different initiation.
AL731577 Genomic DNA No translation available.
AL731571 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49252.1
CH471066 Genomic DNA Translation: EAW49253.1
AL832925 mRNA Translation: CAH10620.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7642.1

NCBI Reference Sequences

More...RefSeqi		NP_060050.2, NM_017580.2
XP_005269983.1, XM_005269926.4
XP_016871846.1, XM_017016357.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359653; ENSP00000352676; ENSG00000019995

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54764

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54764

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000359653.4; ENSP00000352676.4; NM_017580.3; NP_060050.2

UCSC genome browser

More...UCSCi		uc001lic.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ252060 mRNA Translation: CAB64449.1
AK302810 mRNA Translation: BAG64010.1 Different initiation.
AL731577 Genomic DNA No translation available.
AL731571 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49252.1
CH471066 Genomic DNA Translation: EAW49253.1
AL832925 mRNA Translation: CAH10620.1
CCDSiCCDS7642.1
RefSeqiNP_060050.2, NM_017580.2
XP_005269983.1, XM_005269926.4
XP_016871846.1, XM_017016357.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZRHX-ray2.23A245-697[»]
5AF6X-ray3.40F/G/H/I/J1-33[»]
SMRiQ9UGI0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120139, 189 interactors
DIPiDIP-33806N
IntActiQ9UGI0, 168 interactors
MINTiQ9UGI0
STRINGi9606.ENSP00000352676

Protein family/group databases

MEROPSiC64.004

PTM databases

iPTMnetiQ9UGI0
PhosphoSitePlusiQ9UGI0

Genetic variation databases

BioMutaiZRANB1
DMDMi212276487

Proteomic databases

EPDiQ9UGI0
jPOSTiQ9UGI0
MassIVEiQ9UGI0
MaxQBiQ9UGI0
PaxDbiQ9UGI0
PeptideAtlasiQ9UGI0
PRIDEiQ9UGI0
ProteomicsDBi84215

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		35158, 164 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		54764

Genome annotation databases

EnsembliENST00000359653; ENSP00000352676; ENSG00000019995
GeneIDi54764
KEGGihsa:54764
MANE-SelectiENST00000359653.4; ENSP00000352676.4; NM_017580.3; NP_060050.2
UCSCiuc001lic.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54764
DisGeNETi54764

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZRANB1
HGNCiHGNC:18224, ZRANB1
HPAiENSG00000019995, Low tissue specificity
MIMi611749, gene
neXtProtiNX_Q9UGI0
OpenTargetsiENSG00000019995
PharmGKBiPA134933584
VEuPathDBiHostDB:ENSG00000019995

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4345, Eukaryota
GeneTreeiENSGT00940000158045
HOGENOMiCLU_013907_0_0_1
InParanoidiQ9UGI0
OMAiYPRWKEY
OrthoDBi728724at2759
PhylomeDBiQ9UGI0
TreeFamiTF323312

Enzyme and pathway databases

PathwayCommonsiQ9UGI0
ReactomeiR-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-5689896, Ovarian tumor domain proteases
SignaLinkiQ9UGI0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54764, 33 hits in 1093 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZRANB1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54764
PharosiQ9UGI0, Tbio

Protein Ontology

More...PROi		PR:Q9UGI0
RNActiQ9UGI0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000019995, Expressed in gastrocnemius and 218 other tissues
GenevisibleiQ9UGI0, HS

Family and domain databases

InterProiView protein in InterPro
IPR041294, AnkUBD
IPR003323, OTU_dom
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PfamiView protein in Pfam
PF18418, AnkUBD, 1 hit
PF02338, OTU, 1 hit
PF00641, zf-RanBP, 2 hits
SMARTiView protein in SMART
SM00547, ZnF_RBZ, 3 hits
SUPFAMiSSF90209, SSF90209, 2 hits
PROSITEiView protein in PROSITE
PS50802, OTU, 1 hit
PS01358, ZF_RANBP2_1, 3 hits
PS50199, ZF_RANBP2_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZRAN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGI0
Secondary accession number(s): B4DZ98
, D3DRF4, Q5SQP6, Q69YK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 4, 2008
Last modified: February 23, 2022
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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