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Protein

Solute carrier family 23 member 2

Gene

SLC23A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

  • L-ascorbic acid transmembrane transporter activity Source: UniProtKB
  • nucleobase transmembrane transporter activity Source: ProtInc
  • sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • L-ascorbic acid metabolic process Source: Reactome
  • L-ascorbic acid transmembrane transport Source: UniProtKB
  • nucleobase-containing compound metabolic process Source: ProtInc
  • nucleobase transport Source: ProtInc
  • response to oxidative stress Source: Ensembl
  • transepithelial L-ascorbic acid transport Source: UniProtKB

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-196836 Vitamin C (ascorbate) metabolism

Protein family/group databases

TCDBi2.A.40.6.2 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Nucleobase transporter-like 1 protein
Sodium-dependent vitamin C transporter 2
Short name:
hSVCT2
Yolk sac permease-like molecule 2
Gene namesi
Name:SLC23A2
Synonyms:KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000089057.14
HGNCiHGNC:10973 SLC23A2
MIMi603791 gene
neXtProtiNX_Q9UGH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini9 – 110CytoplasmicSequence analysisAdd BLAST102
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 139ExtracellularSequence analysis8
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161CytoplasmicSequence analysis1
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 218ExtracellularSequence analysisAdd BLAST36
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 266CytoplasmicSequence analysisAdd BLAST27
Transmembranei267 – 284HelicalSequence analysisAdd BLAST18
Topological domaini285 – 288ExtracellularSequence analysis4
Intramembranei289 – 302HelicalSequence analysisAdd BLAST14
Topological domaini303 – 309ExtracellularSequence analysis7
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 371CytoplasmicSequence analysisAdd BLAST41
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 417ExtracellularSequence analysisAdd BLAST25
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 461CytoplasmicSequence analysisAdd BLAST23
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 485ExtracellularSequence analysis3
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 516CytoplasmicSequence analysis10
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 547ExtracellularSequence analysis10
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 650CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9962
OpenTargetsiENSG00000089057
PharmGKBiPA35849

Chemistry databases

ChEMBLiCHEMBL3271

Polymorphism and mutation databases

BioMutaiSLC23A2
DMDMi24212469

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659781 – 650Solute carrier family 23 member 2Add BLAST650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineBy similarity1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei81PhosphoserineCombined sources1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei649PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UGH3
PaxDbiQ9UGH3
PeptideAtlasiQ9UGH3
PRIDEiQ9UGH3
ProteomicsDBi84214

PTM databases

iPTMnetiQ9UGH3
PhosphoSitePlusiQ9UGH3

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000089057
CleanExiHS_SLC23A1
HS_SLC23A2
ExpressionAtlasiQ9UGH3 baseline and differential
GenevisibleiQ9UGH3 HS

Organism-specific databases

HPAiHPA052825
HPA059314

Interactioni

Protein-protein interaction databases

BioGridi115287, 4 interactors
IntActiQ9UGH3, 1 interactor
STRINGi9606.ENSP00000344322

Structurei

3D structure databases

ProteinModelPortaliQ9UGH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292 Eukaryota
COG2233 LUCA
GeneTreeiENSGT00390000015686
HOGENOMiHOG000038201
HOVERGENiHBG056256
InParanoidiQ9UGH3
KOiK14611
OMAiMGVGKNT
OrthoDBiEOG091G063Y
PhylomeDBiQ9UGH3
TreeFamiTF313272

Family and domain databases

InterProiView protein in InterPro
IPR029956 SlC23A2
IPR006042 Xan_ur_permease
IPR006043 Xant/urac/vitC
PANTHERiPTHR11119:SF33 PTHR11119:SF33, 1 hit
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit
PROSITEiView protein in PROSITE
PS01116 XANTH_URACIL_PERMASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UGH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD
60 70 80 90 100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY
110 120 130 140 150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GYDQWATSQL IGTIFFCVGI
160 170 180 190 200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT DVSVANGTAE
210 220 230 240 250
LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK YIGPLTITPT
260 270 280 290 300
VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK
310 320 330 340 350
KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD
360 370 380 390 400
ARQGVLLVAP WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA
410 420 430 440 450
CARLSCAPPP PIHAINRGIF VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI
460 470 480 490 500
TKVGSRRVIQ CGAALMLALG MIGKFSALFA SLPDPVLGAL FCTLFGMITA
510 520 530 540 550
VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV TGITGIDQVL
560 570 580 590 600
NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES
610 620 630 640 650
YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG
Length:650
Mass (Da):70,337
Last modified:May 1, 2000 - v1
Checksum:i28C9E190D9528D39
GO
Isoform 2 (identifier: Q9UGH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-275: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):58,177
Checksum:iB4CA6A0D1B57592A
GO

Sequence cautioni

The sequence BAA13244 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30P → R in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti141I → T in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti167A → T in AAC78806 (PubMed:9804989).Curated1
Sequence conflicti182L → S in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti215I → V in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti314F → L in CAC83100 (PubMed:11396616).Curated1
Sequence conflicti418 – 424GIFVEGL → YVPEKTS (PubMed:15489334).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056485162 – 275Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058319 mRNA Translation: AAC78806.1
AJ269478 mRNA Translation: CAB58120.1
AF164142 mRNA Translation: AAF80493.1
AF092511 mRNA Translation: AAD11783.1
AJ292318 mRNA Translation: CAC83100.1
AY380556 mRNA Translation: AAQ79775.1
D87075 mRNA Translation: BAA13244.2 Different initiation.
AK296304 mRNA Translation: BAG59003.1
AL109841 Genomic DNA No translation available.
AL121890 Genomic DNA No translation available.
AL389886 Genomic DNA No translation available.
BC013112 mRNA Translation: AAH13112.1
CCDSiCCDS13085.1 [Q9UGH3-1]
PIRiJC7095
RefSeqiNP_005107.4, NM_005116.5 [Q9UGH3-1]
NP_976072.1, NM_203327.1 [Q9UGH3-1]
XP_011527716.1, XM_011529414.2 [Q9UGH3-1]
XP_011527717.1, XM_011529415.2 [Q9UGH3-1]
XP_011527718.1, XM_011529416.2 [Q9UGH3-1]
XP_011527719.1, XM_011529417.2 [Q9UGH3-1]
XP_016883660.1, XM_017028171.1 [Q9UGH3-1]
XP_016883661.1, XM_017028172.1 [Q9UGH3-1]
XP_016883662.1, XM_017028173.1 [Q9UGH3-1]
XP_016883663.1, XM_017028174.1 [Q9UGH3-1]
XP_016883665.1, XM_017028176.1 [Q9UGH3-2]
XP_016883666.1, XM_017028177.1 [Q9UGH3-2]
UniGeneiHs.516866

Genome annotation databases

EnsembliENST00000338244; ENSP00000344322; ENSG00000089057 [Q9UGH3-1]
ENST00000379333; ENSP00000368637; ENSG00000089057 [Q9UGH3-1]
GeneIDi9962
KEGGihsa:9962
UCSCiuc002wlg.1 human [Q9UGH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS23A2_HUMAN
AccessioniPrimary (citable) accession number: Q9UGH3
Secondary accession number(s): B4DJZ1
, Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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