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Entry version 168 (31 Jul 2019)
Sequence version 1 (01 May 2000)
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Protein

Solute carrier family 23 member 2

Gene

SLC23A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196836 Vitamin C (ascorbate) metabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.40.6.2 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Nucleobase transporter-like 1 protein
Sodium-dependent vitamin C transporter 2
Short name:
hSVCT2
Yolk sac permease-like molecule 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC23A2
Synonyms:KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10973 SLC23A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603791 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UGH3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini9 – 110CytoplasmicSequence analysisAdd BLAST102
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 139ExtracellularSequence analysis8
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161CytoplasmicSequence analysis1
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 218ExtracellularSequence analysisAdd BLAST36
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 266CytoplasmicSequence analysisAdd BLAST27
Transmembranei267 – 284HelicalSequence analysisAdd BLAST18
Topological domaini285 – 288ExtracellularSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei289 – 302HelicalSequence analysisAdd BLAST14
Topological domaini303 – 309ExtracellularSequence analysis7
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 371CytoplasmicSequence analysisAdd BLAST41
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 417ExtracellularSequence analysisAdd BLAST25
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 461CytoplasmicSequence analysisAdd BLAST23
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 485ExtracellularSequence analysis3
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 516CytoplasmicSequence analysis10
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 547ExtracellularSequence analysis10
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 650CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9962

Open Targets

More...
OpenTargetsi
ENSG00000089057

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35849

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3271

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC23A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24212469

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001659781 – 650Solute carrier family 23 member 2Add BLAST650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei70PhosphoserineBy similarity1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei81PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei649PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UGH3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UGH3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UGH3

PeptideAtlas

More...
PeptideAtlasi
Q9UGH3

PRoteomics IDEntifications database

More...
PRIDEi
Q9UGH3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
4421
84214 [Q9UGH3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UGH3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000089057 Expressed in 214 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UGH3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UGH3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052825
HPA059314

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115287, 4 interactors

Protein interaction database and analysis system

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IntActi
Q9UGH3, 5 interactors

Molecular INTeraction database

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MINTi
Q9UGH3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368637

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1292 Eukaryota
COG2233 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038201

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UGH3

KEGG Orthology (KO)

More...
KOi
K14611

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKCNNTD

Database of Orthologous Groups

More...
OrthoDBi
387031at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGH3

TreeFam database of animal gene trees

More...
TreeFami
TF313272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029956 SlC23A2
IPR006042 Xan_ur_permease
IPR006043 Xant/urac/vitC

The PANTHER Classification System

More...
PANTHERi
PTHR11119:SF33 PTHR11119:SF33, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00860 Xan_ur_permease, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01116 XANTH_URACIL_PERMASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD
60 70 80 90 100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY
110 120 130 140 150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GYDQWATSQL IGTIFFCVGI
160 170 180 190 200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT DVSVANGTAE
210 220 230 240 250
LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK YIGPLTITPT
260 270 280 290 300
VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK
310 320 330 340 350
KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD
360 370 380 390 400
ARQGVLLVAP WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA
410 420 430 440 450
CARLSCAPPP PIHAINRGIF VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI
460 470 480 490 500
TKVGSRRVIQ CGAALMLALG MIGKFSALFA SLPDPVLGAL FCTLFGMITA
510 520 530 540 550
VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV TGITGIDQVL
560 570 580 590 600
NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES
610 620 630 640 650
YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG
Length:650
Mass (Da):70,337
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28C9E190D9528D39
GO
Isoform 2 (identifier: Q9UGH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-275: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):58,177
Checksum:iB4CA6A0D1B57592A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y544H0Y544_HUMAN
Solute carrier family 23 member 2
SLC23A2
304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13244 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30P → R in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti141I → T in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti167A → T in AAC78806 (PubMed:9804989).Curated1
Sequence conflicti182L → S in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti215I → V in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti314F → L in CAC83100 (PubMed:11396616).Curated1
Sequence conflicti418 – 424GIFVEGL → YVPEKTS (PubMed:15489334).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056485162 – 275Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF058319 mRNA Translation: AAC78806.1
AJ269478 mRNA Translation: CAB58120.1
AF164142 mRNA Translation: AAF80493.1
AF092511 mRNA Translation: AAD11783.1
AJ292318 mRNA Translation: CAC83100.1
AY380556 mRNA Translation: AAQ79775.1
D87075 mRNA Translation: BAA13244.2 Different initiation.
AK296304 mRNA Translation: BAG59003.1
AL109841 Genomic DNA No translation available.
AL121890 Genomic DNA No translation available.
AL389886 Genomic DNA No translation available.
BC013112 mRNA Translation: AAH13112.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13085.1 [Q9UGH3-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC7095

NCBI Reference Sequences

More...
RefSeqi
NP_005107.4, NM_005116.5 [Q9UGH3-1]
NP_976072.1, NM_203327.1 [Q9UGH3-1]
XP_011527716.1, XM_011529414.2
XP_011527717.1, XM_011529415.2
XP_011527718.1, XM_011529416.2
XP_011527719.1, XM_011529417.2
XP_016883660.1, XM_017028171.1
XP_016883661.1, XM_017028172.1
XP_016883662.1, XM_017028173.1
XP_016883663.1, XM_017028174.1
XP_016883665.1, XM_017028176.1
XP_016883666.1, XM_017028177.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338244; ENSP00000344322; ENSG00000089057 [Q9UGH3-1]
ENST00000379333; ENSP00000368637; ENSG00000089057 [Q9UGH3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9962

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9962

UCSC genome browser

More...
UCSCi
uc002wlg.1 human [Q9UGH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058319 mRNA Translation: AAC78806.1
AJ269478 mRNA Translation: CAB58120.1
AF164142 mRNA Translation: AAF80493.1
AF092511 mRNA Translation: AAD11783.1
AJ292318 mRNA Translation: CAC83100.1
AY380556 mRNA Translation: AAQ79775.1
D87075 mRNA Translation: BAA13244.2 Different initiation.
AK296304 mRNA Translation: BAG59003.1
AL109841 Genomic DNA No translation available.
AL121890 Genomic DNA No translation available.
AL389886 Genomic DNA No translation available.
BC013112 mRNA Translation: AAH13112.1
CCDSiCCDS13085.1 [Q9UGH3-1]
PIRiJC7095
RefSeqiNP_005107.4, NM_005116.5 [Q9UGH3-1]
NP_976072.1, NM_203327.1 [Q9UGH3-1]
XP_011527716.1, XM_011529414.2
XP_011527717.1, XM_011529415.2
XP_011527718.1, XM_011529416.2
XP_011527719.1, XM_011529417.2
XP_016883660.1, XM_017028171.1
XP_016883661.1, XM_017028172.1
XP_016883662.1, XM_017028173.1
XP_016883663.1, XM_017028174.1
XP_016883665.1, XM_017028176.1
XP_016883666.1, XM_017028177.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115287, 4 interactors
IntActiQ9UGH3, 5 interactors
MINTiQ9UGH3
STRINGi9606.ENSP00000368637

Chemistry databases

ChEMBLiCHEMBL3271

Protein family/group databases

TCDBi2.A.40.6.2 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

PTM databases

iPTMnetiQ9UGH3
PhosphoSitePlusiQ9UGH3

Polymorphism and mutation databases

BioMutaiSLC23A2
DMDMi24212469

Proteomic databases

EPDiQ9UGH3
jPOSTiQ9UGH3
PaxDbiQ9UGH3
PeptideAtlasiQ9UGH3
PRIDEiQ9UGH3
ProteomicsDBi4421
84214 [Q9UGH3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338244; ENSP00000344322; ENSG00000089057 [Q9UGH3-1]
ENST00000379333; ENSP00000368637; ENSG00000089057 [Q9UGH3-1]
GeneIDi9962
KEGGihsa:9962
UCSCiuc002wlg.1 human [Q9UGH3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9962
DisGeNETi9962

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC23A2
HGNCiHGNC:10973 SLC23A2
HPAiHPA052825
HPA059314
MIMi603791 gene
neXtProtiNX_Q9UGH3
OpenTargetsiENSG00000089057
PharmGKBiPA35849

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1292 Eukaryota
COG2233 LUCA
GeneTreeiENSGT00950000182953
HOGENOMiHOG000038201
InParanoidiQ9UGH3
KOiK14611
OMAiWKCNNTD
OrthoDBi387031at2759
PhylomeDBiQ9UGH3
TreeFamiTF313272

Enzyme and pathway databases

ReactomeiR-HSA-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC23A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC23A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9962

Protein Ontology

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PROi
PR:Q9UGH3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000089057 Expressed in 214 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiQ9UGH3 baseline and differential
GenevisibleiQ9UGH3 HS

Family and domain databases

InterProiView protein in InterPro
IPR029956 SlC23A2
IPR006042 Xan_ur_permease
IPR006043 Xant/urac/vitC
PANTHERiPTHR11119:SF33 PTHR11119:SF33, 1 hit
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit
PROSITEiView protein in PROSITE
PS01116 XANTH_URACIL_PERMASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS23A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGH3
Secondary accession number(s): B4DJZ1
, Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: July 31, 2019
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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