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Protein

Olfactory receptor 12D3

Gene

OR12D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 12D3
Alternative name(s):
Hs6M1-27
Olfactory receptor OR6-27
Gene namesi
Name:OR12D3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112462.8
HGNCiHGNC:13963 OR12D3
neXtProtiNX_Q9UGF7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 215Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 316CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81797
OpenTargetsiENSG00000112462
PharmGKBiPA32029

Polymorphism and mutation databases

BioMutaiOR12D3
DMDMi14423826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507291 – 316Olfactory receptor 12D3Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UGF7
PaxDbiQ9UGF7
PeptideAtlasiQ9UGF7
PRIDEiQ9UGF7
ProteomicsDBi84213

Expressioni

Gene expression databases

BgeeiENSG00000112462 Expressed in 1 organ(s), highest expression level in vagina
CleanExiHS_OR12D3
ExpressionAtlasiQ9UGF7 baseline and differential
GenevisibleiQ9UGF7 HS

Interactioni

Protein-protein interaction databases

BioGridi123588, 3 interactors
STRINGi9606.ENSP00000366348

Structurei

3D structure databases

ProteinModelPortaliQ9UGF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH3D Eukaryota
ENOG410YBP5 LUCA
GeneTreeiENSGT00390000018942
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ9UGF7
KOiK04257
OMAiQDRMVAI
OrthoDBiEOG091G0CKO
PhylomeDBiQ9UGF7
TreeFamiTF338273

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UGF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE
60 70 80 90 100
PQLHSPMYFF LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH
110 120 130 140 150
FFHFLGSTEA ILLAIMAFDR FVAICNPLRY TVIMNPQVCI LLAAAAWLIS
160 170 180 190 200
FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK PLLELACSDT LLNQWLLSIV
210 220 230 240 250
TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC ASHFMVVCLF
260 270 280 290 300
YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL
310
KKIFGRKLFK DWQQHH
Length:316
Mass (Da):35,791
Last modified:May 1, 2000 - v1
Checksum:i07FDCF869D8989B2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JL33A0A0G2JL33_HUMAN
Olfactory receptor
OR12D3
316Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02038397T → I1 PublicationCorresponds to variant dbSNP:rs3749971Ensembl.1
Natural variantiVAR_036209250F → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs545611345Ensembl.1
Natural variantiVAR_053298277Y → H. Corresponds to variant dbSNP:rs9380122Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459858 mRNA Translation: CAD31041.1
AL096770 Genomic DNA Translation: CAB65796.1
AL662781 Genomic DNA No translation available.
BC069082 mRNA Translation: AAH69082.1
BC069154 mRNA Translation: AAH69154.1
BC103892 mRNA Translation: AAI03893.1
BC106898 mRNA No translation available.
BK004439 Genomic DNA Translation: DAA04837.1
CCDSiCCDS4658.1
RefSeqiNP_112221.1, NM_030959.2
UniGeneiHs.272280

Genome annotation databases

EnsembliENST00000383556; ENSP00000373048; ENSG00000204692
ENST00000396806; ENSP00000380023; ENSG00000112462
ENST00000430148; ENSP00000393734; ENSG00000224487
ENST00000505384; ENSP00000421215; ENSG00000242022
ENST00000550681; ENSP00000449350; ENSG00000204692
ENST00000550913; ENSP00000447580; ENSG00000224487
ENST00000552446; ENSP00000447204; ENSG00000242022
GeneIDi81797
KEGGihsa:81797
UCSCiuc003nme.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459858 mRNA Translation: CAD31041.1
AL096770 Genomic DNA Translation: CAB65796.1
AL662781 Genomic DNA No translation available.
BC069082 mRNA Translation: AAH69082.1
BC069154 mRNA Translation: AAH69154.1
BC103892 mRNA Translation: AAI03893.1
BC106898 mRNA No translation available.
BK004439 Genomic DNA Translation: DAA04837.1
CCDSiCCDS4658.1
RefSeqiNP_112221.1, NM_030959.2
UniGeneiHs.272280

3D structure databases

ProteinModelPortaliQ9UGF7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123588, 3 interactors
STRINGi9606.ENSP00000366348

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR12D3
DMDMi14423826

Proteomic databases

EPDiQ9UGF7
PaxDbiQ9UGF7
PeptideAtlasiQ9UGF7
PRIDEiQ9UGF7
ProteomicsDBi84213

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383556; ENSP00000373048; ENSG00000204692
ENST00000396806; ENSP00000380023; ENSG00000112462
ENST00000430148; ENSP00000393734; ENSG00000224487
ENST00000505384; ENSP00000421215; ENSG00000242022
ENST00000550681; ENSP00000449350; ENSG00000204692
ENST00000550913; ENSP00000447580; ENSG00000224487
ENST00000552446; ENSP00000447204; ENSG00000242022
GeneIDi81797
KEGGihsa:81797
UCSCiuc003nme.3 human

Organism-specific databases

CTDi81797
DisGeNETi81797
EuPathDBiHostDB:ENSG00000112462.8
GeneCardsiOR12D3
H-InvDBiHIX0166575
HIX0166829
HGNCiHGNC:13963 OR12D3
neXtProtiNX_Q9UGF7
OpenTargetsiENSG00000112462
PharmGKBiPA32029
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3D Eukaryota
ENOG410YBP5 LUCA
GeneTreeiENSGT00390000018942
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ9UGF7
KOiK04257
OMAiQDRMVAI
OrthoDBiEOG091G0CKO
PhylomeDBiQ9UGF7
TreeFamiTF338273

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR12D3
GenomeRNAii81797
PROiPR:Q9UGF7

Gene expression databases

BgeeiENSG00000112462 Expressed in 1 organ(s), highest expression level in vagina
CleanExiHS_OR12D3
ExpressionAtlasiQ9UGF7 baseline and differential
GenevisibleiQ9UGF7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO12D3_HUMAN
AccessioniPrimary (citable) accession number: Q9UGF7
Secondary accession number(s): A2BDZ1, Q5SQI8, Q6IF23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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