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Entry version 131 (31 Jul 2019)
Sequence version 1 (01 May 2000)
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Protein

Peptide chain release factor 1-like, mitochondrial

Gene

MTRF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5419276 Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptide chain release factor 1-like, mitochondrial
Alternative name(s):
Mitochondrial translational release factor 1-like
mtRF1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTRF1L
Synonyms:MTRF1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21051 MTRF1L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613542 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UGC7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000112031

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134870441

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MTRF1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753314

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 26MitochondrionAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033094427 – 380Peptide chain release factor 1-like, mitochondrialAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei252N5-methylglutamine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UGC7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UGC7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UGC7

PeptideAtlas

More...
PeptideAtlasi
Q9UGC7

PRoteomics IDEntifications database

More...
PRIDEi
Q9UGC7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84207 [Q9UGC7-1]
84208 [Q9UGC7-2]
84209 [Q9UGC7-3]
84210 [Q9UGC7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UGC7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGC7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112031 Expressed in 211 organ(s), highest expression level in deltoid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UGC7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UGC7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036367

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120010, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UGC7, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356202

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UGC7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili63 – 117Sequence analysisAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2726 Eukaryota
COG0216 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155683

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UGC7

KEGG Orthology (KO)

More...
KOi
K02835

Identification of Orthologs from Complete Genome Data

More...
OMAi
DLFRMYQ

Database of Orthologous Groups

More...
OrthoDBi
1313171at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGC7

TreeFam database of animal gene trees

More...
TreeFami
TF313720

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00937 PCRF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00745 RF_PROK_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSRVLWGAA RWLWPRRAVG PARRPLSSGS PPLEELFTRG GPLRTFLERQ
60 70 80 90 100
AGSEAHLKVR RPELLAVIKL LNEKERELRE TEHLLHDENE DLRKLAENEI
110 120 130 140 150
TLCQKEITQL KHQIILLLVP SEETDENDLI LEVTAGVGGQ EAMLFTSEIF
160 170 180 190 200
DMYQQYAAFK RWHFETLEYF PSELGGLRHA SASIGGSEAY RHMKFEGGVH
210 220 230 240 250
RVQRVPKTEK QGRVHTSTMT VAILPQPTEI NLVINPKDLR IDTKRASGAG
260 270 280 290 300
GQHVNTTDSA VRIVHLPTGV VSECQQERSQ LKNKELAMTK LRAKLYSMHL
310 320 330 340 350
EEEINKRQNA RKIQIGSKGR SEKIRTYNFP QNRVTDHRIN KTLHDLETFM
360 370 380
QGDYLLDELV QSLKEYADYE SLVEIISQKV
Length:380
Mass (Da):43,600
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69632427972521C3
GO
Isoform 2 (identifier: Q9UGC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-271: GVV → DWK
     272-380: Missing.

Show »
Length:271
Mass (Da):30,832
Checksum:iB39FD6515C79633A
GO
Isoform 3 (identifier: Q9UGC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:238
Mass (Da):27,392
Checksum:iB8C2ACF69435FAFB
GO
Isoform 4 (identifier: Q9UGC7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-174: Missing.
     269-271: GVV → DWK
     272-380: Missing.

Show »
Length:235
Mass (Da):26,395
Checksum:i4C89C7FD0C90C2D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TF45Q5TF45_HUMAN
Peptide chain release factor 1-like...
MTRF1L
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RKB4X6RKB4_HUMAN
Peptide chain release factor 1-like...
MTRF1L
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04272538T → A2 PublicationsCorresponds to variant dbSNP:rs3818125Ensembl.1
Natural variantiVAR_04272676R → Q2 PublicationsCorresponds to variant dbSNP:rs3818123Ensembl.1
Natural variantiVAR_042727177L → F. Corresponds to variant dbSNP:rs12660881Ensembl.1
Natural variantiVAR_042728214V → I. Corresponds to variant dbSNP:rs3192723Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0331391 – 142Missing in isoform 3. 1 PublicationAdd BLAST142
Alternative sequenceiVSP_033140139 – 174Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_033141269 – 271GVV → DWK in isoform 2 and isoform 4. 2 Publications3
Alternative sequenceiVSP_033142272 – 380Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027684 mRNA Translation: BAB55295.1
AK095240 mRNA Translation: BAG53012.1
AK290662 mRNA Translation: BAF83351.1
AL080276 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47712.1
BC011873 mRNA Translation: AAH11873.1
BC014428 mRNA Translation: AAH14428.1
BC105973 mRNA Translation: AAI05974.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47502.1 [Q9UGC7-2]
CCDS5243.1 [Q9UGC7-1]
CCDS75540.1 [Q9UGC7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001107656.1, NM_001114184.2 [Q9UGC7-2]
NP_001287976.1, NM_001301047.2 [Q9UGC7-4]
NP_001288799.1, NM_001301870.1
NP_001288800.1, NM_001301871.1 [Q9UGC7-3]
NP_061914.3, NM_019041.6 [Q9UGC7-1]
XP_016866448.1, XM_017010959.1
XP_016866449.1, XM_017010960.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367230; ENSP00000356199; ENSG00000112031 [Q9UGC7-4]
ENST00000367231; ENSP00000356200; ENSG00000112031 [Q9UGC7-2]
ENST00000367233; ENSP00000356202; ENSG00000112031 [Q9UGC7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54516

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54516

UCSC genome browser

More...
UCSCi
uc003qpi.5 human [Q9UGC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027684 mRNA Translation: BAB55295.1
AK095240 mRNA Translation: BAG53012.1
AK290662 mRNA Translation: BAF83351.1
AL080276 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47712.1
BC011873 mRNA Translation: AAH11873.1
BC014428 mRNA Translation: AAH14428.1
BC105973 mRNA Translation: AAI05974.1
CCDSiCCDS47502.1 [Q9UGC7-2]
CCDS5243.1 [Q9UGC7-1]
CCDS75540.1 [Q9UGC7-4]
RefSeqiNP_001107656.1, NM_001114184.2 [Q9UGC7-2]
NP_001287976.1, NM_001301047.2 [Q9UGC7-4]
NP_001288799.1, NM_001301870.1
NP_001288800.1, NM_001301871.1 [Q9UGC7-3]
NP_061914.3, NM_019041.6 [Q9UGC7-1]
XP_016866448.1, XM_017010959.1
XP_016866449.1, XM_017010960.1

3D structure databases

SMRiQ9UGC7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120010, 5 interactors
IntActiQ9UGC7, 5 interactors
STRINGi9606.ENSP00000356202

PTM databases

iPTMnetiQ9UGC7
PhosphoSitePlusiQ9UGC7

Polymorphism and mutation databases

BioMutaiMTRF1L
DMDMi74753314

Proteomic databases

EPDiQ9UGC7
jPOSTiQ9UGC7
PaxDbiQ9UGC7
PeptideAtlasiQ9UGC7
PRIDEiQ9UGC7
ProteomicsDBi84207 [Q9UGC7-1]
84208 [Q9UGC7-2]
84209 [Q9UGC7-3]
84210 [Q9UGC7-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54516
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367230; ENSP00000356199; ENSG00000112031 [Q9UGC7-4]
ENST00000367231; ENSP00000356200; ENSG00000112031 [Q9UGC7-2]
ENST00000367233; ENSP00000356202; ENSG00000112031 [Q9UGC7-1]
GeneIDi54516
KEGGihsa:54516
UCSCiuc003qpi.5 human [Q9UGC7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54516

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MTRF1L
HGNCiHGNC:21051 MTRF1L
HPAiHPA036367
MIMi613542 gene
neXtProtiNX_Q9UGC7
OpenTargetsiENSG00000112031
PharmGKBiPA134870441

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00940000155683
InParanoidiQ9UGC7
KOiK02835
OMAiDLFRMYQ
OrthoDBi1313171at2759
PhylomeDBiQ9UGC7
TreeFamiTF313720

Enzyme and pathway databases

ReactomeiR-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MTRF1L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54516

Protein Ontology

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PROi
PR:Q9UGC7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000112031 Expressed in 211 organ(s), highest expression level in deltoid
ExpressionAtlasiQ9UGC7 baseline and differential
GenevisibleiQ9UGC7 HS

Family and domain databases

InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRF1ML_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGC7
Secondary accession number(s): B3KTA0
, Q3KR06, Q5TF44, Q5TF50, Q96CC5, Q96EX4, Q96K40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 2000
Last modified: July 31, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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