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Protein

Peptide chain release factor 1-like, mitochondrial

Gene

MTRF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mitochondrial translational termination Source: GO_Central
  • translational termination Source: GO_Central

Keywordsi

Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1-like, mitochondrial
Alternative name(s):
Mitochondrial translational release factor 1-like
mtRF1a
Gene namesi
Name:MTRF1L
Synonyms:MTRF1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112031.15
HGNCiHGNC:21051 MTRF1L
MIMi613542 gene
neXtProtiNX_Q9UGC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112031
PharmGKBiPA134870441

Polymorphism and mutation databases

BioMutaiMTRF1L
DMDMi74753314

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionAdd BLAST26
ChainiPRO_000033094427 – 380Peptide chain release factor 1-like, mitochondrialAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252N5-methylglutamine1 Publication1

Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9UGC7
PaxDbiQ9UGC7
PeptideAtlasiQ9UGC7
PRIDEiQ9UGC7
ProteomicsDBi84207
84208 [Q9UGC7-2]
84209 [Q9UGC7-3]
84210 [Q9UGC7-4]

PTM databases

iPTMnetiQ9UGC7
PhosphoSitePlusiQ9UGC7

Expressioni

Tissue specificityi

Expressed in skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000112031 Expressed in 211 organ(s), highest expression level in deltoid
CleanExiHS_MTRF1L
ExpressionAtlasiQ9UGC7 baseline and differential
GenevisibleiQ9UGC7 HS

Organism-specific databases

HPAiHPA036367

Interactioni

Protein-protein interaction databases

BioGridi120010, 5 interactors
IntActiQ9UGC7, 3 interactors
STRINGi9606.ENSP00000356202

Structurei

3D structure databases

ProteinModelPortaliQ9UGC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 117Sequence analysisAdd BLAST55

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00390000011879
HOVERGENiHBG017071
InParanoidiQ9UGC7
KOiK02835
OMAiWKVEIVS
OrthoDBiEOG091G0O7T
PhylomeDBiQ9UGC7
TreeFamiTF313720

Family and domain databases

InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSRVLWGAA RWLWPRRAVG PARRPLSSGS PPLEELFTRG GPLRTFLERQ
60 70 80 90 100
AGSEAHLKVR RPELLAVIKL LNEKERELRE TEHLLHDENE DLRKLAENEI
110 120 130 140 150
TLCQKEITQL KHQIILLLVP SEETDENDLI LEVTAGVGGQ EAMLFTSEIF
160 170 180 190 200
DMYQQYAAFK RWHFETLEYF PSELGGLRHA SASIGGSEAY RHMKFEGGVH
210 220 230 240 250
RVQRVPKTEK QGRVHTSTMT VAILPQPTEI NLVINPKDLR IDTKRASGAG
260 270 280 290 300
GQHVNTTDSA VRIVHLPTGV VSECQQERSQ LKNKELAMTK LRAKLYSMHL
310 320 330 340 350
EEEINKRQNA RKIQIGSKGR SEKIRTYNFP QNRVTDHRIN KTLHDLETFM
360 370 380
QGDYLLDELV QSLKEYADYE SLVEIISQKV
Length:380
Mass (Da):43,600
Last modified:May 1, 2000 - v1
Checksum:i69632427972521C3
GO
Isoform 2 (identifier: Q9UGC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-271: GVV → DWK
     272-380: Missing.

Show »
Length:271
Mass (Da):30,832
Checksum:iB39FD6515C79633A
GO
Isoform 3 (identifier: Q9UGC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:238
Mass (Da):27,392
Checksum:iB8C2ACF69435FAFB
GO
Isoform 4 (identifier: Q9UGC7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-174: Missing.
     269-271: GVV → DWK
     272-380: Missing.

Show »
Length:235
Mass (Da):26,395
Checksum:i4C89C7FD0C90C2D8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TF45Q5TF45_HUMAN
Peptide chain release factor 1-like...
MTRF1L
163Annotation score:
X6RKB4X6RKB4_HUMAN
Peptide chain release factor 1-like...
MTRF1L
231Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04272538T → A2 PublicationsCorresponds to variant dbSNP:rs3818125Ensembl.1
Natural variantiVAR_04272676R → Q2 PublicationsCorresponds to variant dbSNP:rs3818123Ensembl.1
Natural variantiVAR_042727177L → F. Corresponds to variant dbSNP:rs12660881Ensembl.1
Natural variantiVAR_042728214V → I. Corresponds to variant dbSNP:rs3192723Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0331391 – 142Missing in isoform 3. 1 PublicationAdd BLAST142
Alternative sequenceiVSP_033140139 – 174Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_033141269 – 271GVV → DWK in isoform 2 and isoform 4. 2 Publications3
Alternative sequenceiVSP_033142272 – 380Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027684 mRNA Translation: BAB55295.1
AK095240 mRNA Translation: BAG53012.1
AK290662 mRNA Translation: BAF83351.1
AL080276 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47712.1
BC011873 mRNA Translation: AAH11873.1
BC014428 mRNA Translation: AAH14428.1
BC105973 mRNA Translation: AAI05974.1
CCDSiCCDS47502.1 [Q9UGC7-2]
CCDS5243.1 [Q9UGC7-1]
CCDS75540.1 [Q9UGC7-4]
RefSeqiNP_001107656.1, NM_001114184.2 [Q9UGC7-2]
NP_001287976.1, NM_001301047.2 [Q9UGC7-4]
NP_001288799.1, NM_001301870.1
NP_001288800.1, NM_001301871.1 [Q9UGC7-3]
NP_061914.3, NM_019041.6 [Q9UGC7-1]
XP_016866448.1, XM_017010959.1
XP_016866449.1, XM_017010960.1
UniGeneiHs.225836
Hs.304818
Hs.732132

Genome annotation databases

EnsembliENST00000367230; ENSP00000356199; ENSG00000112031 [Q9UGC7-4]
ENST00000367231; ENSP00000356200; ENSG00000112031 [Q9UGC7-2]
ENST00000367233; ENSP00000356202; ENSG00000112031 [Q9UGC7-1]
GeneIDi54516
KEGGihsa:54516
UCSCiuc003qpi.5 human [Q9UGC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027684 mRNA Translation: BAB55295.1
AK095240 mRNA Translation: BAG53012.1
AK290662 mRNA Translation: BAF83351.1
AL080276 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47712.1
BC011873 mRNA Translation: AAH11873.1
BC014428 mRNA Translation: AAH14428.1
BC105973 mRNA Translation: AAI05974.1
CCDSiCCDS47502.1 [Q9UGC7-2]
CCDS5243.1 [Q9UGC7-1]
CCDS75540.1 [Q9UGC7-4]
RefSeqiNP_001107656.1, NM_001114184.2 [Q9UGC7-2]
NP_001287976.1, NM_001301047.2 [Q9UGC7-4]
NP_001288799.1, NM_001301870.1
NP_001288800.1, NM_001301871.1 [Q9UGC7-3]
NP_061914.3, NM_019041.6 [Q9UGC7-1]
XP_016866448.1, XM_017010959.1
XP_016866449.1, XM_017010960.1
UniGeneiHs.225836
Hs.304818
Hs.732132

3D structure databases

ProteinModelPortaliQ9UGC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120010, 5 interactors
IntActiQ9UGC7, 3 interactors
STRINGi9606.ENSP00000356202

PTM databases

iPTMnetiQ9UGC7
PhosphoSitePlusiQ9UGC7

Polymorphism and mutation databases

BioMutaiMTRF1L
DMDMi74753314

Proteomic databases

EPDiQ9UGC7
PaxDbiQ9UGC7
PeptideAtlasiQ9UGC7
PRIDEiQ9UGC7
ProteomicsDBi84207
84208 [Q9UGC7-2]
84209 [Q9UGC7-3]
84210 [Q9UGC7-4]

Protocols and materials databases

DNASUi54516
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367230; ENSP00000356199; ENSG00000112031 [Q9UGC7-4]
ENST00000367231; ENSP00000356200; ENSG00000112031 [Q9UGC7-2]
ENST00000367233; ENSP00000356202; ENSG00000112031 [Q9UGC7-1]
GeneIDi54516
KEGGihsa:54516
UCSCiuc003qpi.5 human [Q9UGC7-1]

Organism-specific databases

CTDi54516
EuPathDBiHostDB:ENSG00000112031.15
GeneCardsiMTRF1L
H-InvDBiHIX0006308
HGNCiHGNC:21051 MTRF1L
HPAiHPA036367
MIMi613542 gene
neXtProtiNX_Q9UGC7
OpenTargetsiENSG00000112031
PharmGKBiPA134870441
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00390000011879
HOVERGENiHBG017071
InParanoidiQ9UGC7
KOiK02835
OMAiWKVEIVS
OrthoDBiEOG091G0O7T
PhylomeDBiQ9UGC7
TreeFamiTF313720

Enzyme and pathway databases

ReactomeiR-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GeneWikiiMTRF1L
GenomeRNAii54516
PROiPR:Q9UGC7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112031 Expressed in 211 organ(s), highest expression level in deltoid
CleanExiHS_MTRF1L
ExpressionAtlasiQ9UGC7 baseline and differential
GenevisibleiQ9UGC7 HS

Family and domain databases

InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRF1ML_HUMAN
AccessioniPrimary (citable) accession number: Q9UGC7
Secondary accession number(s): B3KTA0
, Q3KR06, Q5TF44, Q5TF50, Q96CC5, Q96EX4, Q96K40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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