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Entry version 143 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Peptide chain release factor 1-like, mitochondrial

Gene

MTRF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UGC7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5419276, Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptide chain release factor 1-like, mitochondrial
Alternative name(s):
Mitochondrial translational release factor 1-like
mtRF1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTRF1L
Synonyms:MTRF1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21051, MTRF1L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613542, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UGC7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000112031.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54516

Open Targets

More...
OpenTargetsi
ENSG00000112031

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134870441

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UGC7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MTRF1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753314

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 26MitochondrionAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033094427 – 380Peptide chain release factor 1-like, mitochondrialAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei252N5-methylglutamine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UGC7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UGC7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UGC7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UGC7

PeptideAtlas

More...
PeptideAtlasi
Q9UGC7

PRoteomics IDEntifications database

More...
PRIDEi
Q9UGC7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84207 [Q9UGC7-1]
84208 [Q9UGC7-2]
84209 [Q9UGC7-3]
84210 [Q9UGC7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UGC7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGC7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112031, Expressed in deltoid and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UGC7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UGC7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112031, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120010, 238 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UGC7, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356202

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UGC7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UGC7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili63 – 117Sequence analysisAdd BLAST55

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2726, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155683

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036856_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UGC7

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISDHRVG

Database of Orthologous Groups

More...
OrthoDBi
1313171at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGC7

TreeFam database of animal gene trees

More...
TreeFami
TF313720

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005139, PCRF
IPR000352, Pep_chain_release_fac_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03462, PCRF, 1 hit
PF00472, RF-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00937, PCRF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00745, RF_PROK_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSRVLWGAA RWLWPRRAVG PARRPLSSGS PPLEELFTRG GPLRTFLERQ
60 70 80 90 100
AGSEAHLKVR RPELLAVIKL LNEKERELRE TEHLLHDENE DLRKLAENEI
110 120 130 140 150
TLCQKEITQL KHQIILLLVP SEETDENDLI LEVTAGVGGQ EAMLFTSEIF
160 170 180 190 200
DMYQQYAAFK RWHFETLEYF PSELGGLRHA SASIGGSEAY RHMKFEGGVH
210 220 230 240 250
RVQRVPKTEK QGRVHTSTMT VAILPQPTEI NLVINPKDLR IDTKRASGAG
260 270 280 290 300
GQHVNTTDSA VRIVHLPTGV VSECQQERSQ LKNKELAMTK LRAKLYSMHL
310 320 330 340 350
EEEINKRQNA RKIQIGSKGR SEKIRTYNFP QNRVTDHRIN KTLHDLETFM
360 370 380
QGDYLLDELV QSLKEYADYE SLVEIISQKV
Length:380
Mass (Da):43,600
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69632427972521C3
GO
Isoform 2 (identifier: Q9UGC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-271: GVV → DWK
     272-380: Missing.

Show »
Length:271
Mass (Da):30,832
Checksum:iB39FD6515C79633A
GO
Isoform 3 (identifier: Q9UGC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:238
Mass (Da):27,392
Checksum:iB8C2ACF69435FAFB
GO
Isoform 4 (identifier: Q9UGC7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-174: Missing.
     269-271: GVV → DWK
     272-380: Missing.

Show »
Length:235
Mass (Da):26,395
Checksum:i4C89C7FD0C90C2D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TF45Q5TF45_HUMAN
Peptide chain release factor 1-like...
MTRF1L
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RKB4X6RKB4_HUMAN
Peptide chain release factor 1-like...
MTRF1L
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04272538T → A2 PublicationsCorresponds to variant dbSNP:rs3818125Ensembl.1
Natural variantiVAR_04272676R → Q2 PublicationsCorresponds to variant dbSNP:rs3818123Ensembl.1
Natural variantiVAR_042727177L → F. Corresponds to variant dbSNP:rs12660881Ensembl.1
Natural variantiVAR_042728214V → I. Corresponds to variant dbSNP:rs3192723Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0331391 – 142Missing in isoform 3. 1 PublicationAdd BLAST142
Alternative sequenceiVSP_033140139 – 174Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_033141269 – 271GVV → DWK in isoform 2 and isoform 4. 2 Publications3
Alternative sequenceiVSP_033142272 – 380Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027684 mRNA Translation: BAB55295.1
AK095240 mRNA Translation: BAG53012.1
AK290662 mRNA Translation: BAF83351.1
AL080276 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47712.1
BC011873 mRNA Translation: AAH11873.1
BC014428 mRNA Translation: AAH14428.1
BC105973 mRNA Translation: AAI05974.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47502.1 [Q9UGC7-2]
CCDS5243.1 [Q9UGC7-1]
CCDS75540.1 [Q9UGC7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001107656.1, NM_001114184.2 [Q9UGC7-2]
NP_001287976.1, NM_001301047.2 [Q9UGC7-4]
NP_001288799.1, NM_001301870.1
NP_001288800.1, NM_001301871.1 [Q9UGC7-3]
NP_061914.3, NM_019041.6 [Q9UGC7-1]
XP_016866448.1, XM_017010959.1
XP_016866449.1, XM_017010960.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367230; ENSP00000356199; ENSG00000112031 [Q9UGC7-4]
ENST00000367231; ENSP00000356200; ENSG00000112031 [Q9UGC7-2]
ENST00000367233; ENSP00000356202; ENSG00000112031 [Q9UGC7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54516

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54516

UCSC genome browser

More...
UCSCi
uc003qpi.5, human [Q9UGC7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027684 mRNA Translation: BAB55295.1
AK095240 mRNA Translation: BAG53012.1
AK290662 mRNA Translation: BAF83351.1
AL080276 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47712.1
BC011873 mRNA Translation: AAH11873.1
BC014428 mRNA Translation: AAH14428.1
BC105973 mRNA Translation: AAI05974.1
CCDSiCCDS47502.1 [Q9UGC7-2]
CCDS5243.1 [Q9UGC7-1]
CCDS75540.1 [Q9UGC7-4]
RefSeqiNP_001107656.1, NM_001114184.2 [Q9UGC7-2]
NP_001287976.1, NM_001301047.2 [Q9UGC7-4]
NP_001288799.1, NM_001301870.1
NP_001288800.1, NM_001301871.1 [Q9UGC7-3]
NP_061914.3, NM_019041.6 [Q9UGC7-1]
XP_016866448.1, XM_017010959.1
XP_016866449.1, XM_017010960.1

3D structure databases

SMRiQ9UGC7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120010, 238 interactors
IntActiQ9UGC7, 8 interactors
STRINGi9606.ENSP00000356202

PTM databases

iPTMnetiQ9UGC7
PhosphoSitePlusiQ9UGC7

Genetic variation databases

BioMutaiMTRF1L
DMDMi74753314

Proteomic databases

EPDiQ9UGC7
jPOSTiQ9UGC7
MassIVEiQ9UGC7
PaxDbiQ9UGC7
PeptideAtlasiQ9UGC7
PRIDEiQ9UGC7
ProteomicsDBi84207 [Q9UGC7-1]
84208 [Q9UGC7-2]
84209 [Q9UGC7-3]
84210 [Q9UGC7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33386, 212 antibodies

The DNASU plasmid repository

More...
DNASUi
54516

Genome annotation databases

EnsembliENST00000367230; ENSP00000356199; ENSG00000112031 [Q9UGC7-4]
ENST00000367231; ENSP00000356200; ENSG00000112031 [Q9UGC7-2]
ENST00000367233; ENSP00000356202; ENSG00000112031 [Q9UGC7-1]
GeneIDi54516
KEGGihsa:54516
UCSCiuc003qpi.5, human [Q9UGC7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54516
DisGeNETi54516

GeneCards: human genes, protein and diseases

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GeneCardsi
MTRF1L
HGNCiHGNC:21051, MTRF1L
HPAiENSG00000112031, Low tissue specificity
MIMi613542, gene
neXtProtiNX_Q9UGC7
OpenTargetsiENSG00000112031
PharmGKBiPA134870441
VEuPathDBiHostDB:ENSG00000112031.15

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2726, Eukaryota
GeneTreeiENSGT00940000155683
HOGENOMiCLU_036856_0_3_1
InParanoidiQ9UGC7
OMAiISDHRVG
OrthoDBi1313171at2759
PhylomeDBiQ9UGC7
TreeFamiTF313720

Enzyme and pathway databases

PathwayCommonsiQ9UGC7
ReactomeiR-HSA-5419276, Mitochondrial translation termination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54516, 174 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MTRF1L, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MTRF1L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54516
PharosiQ9UGC7, Tbio

Protein Ontology

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PROi
PR:Q9UGC7
RNActiQ9UGC7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000112031, Expressed in deltoid and 227 other tissues
ExpressionAtlasiQ9UGC7, baseline and differential
GenevisibleiQ9UGC7, HS

Family and domain databases

InterProiView protein in InterPro
IPR005139, PCRF
IPR000352, Pep_chain_release_fac_I
PfamiView protein in Pfam
PF03462, PCRF, 1 hit
PF00472, RF-1, 1 hit
SMARTiView protein in SMART
SM00937, PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745, RF_PROK_I, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRF1ML_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGC7
Secondary accession number(s): B3KTA0
, Q3KR06, Q5TF44, Q5TF50, Q96CC5, Q96EX4, Q96K40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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