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Protein

Regulator of G-protein signaling 17

Gene

RGS17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418597 G alpha (z) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 17
Short name:
RGS17
Gene namesi
Name:RGS17
Synonyms:RGSZ21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000091844.7
HGNCiHGNC:14088 RGS17
MIMi607191 gene
neXtProtiNX_Q9UGC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi26575
OpenTargetsiENSG00000091844
PharmGKBiPA34368

Polymorphism and mutation databases

BioMutaiRGS17
DMDMi15214238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042241 – 210Regulator of G-protein signaling 17Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137PhosphotyrosineBy similarity1

Post-translational modificationi

N- and O-glycosylated in synapsomal membranes.By similarity
Serine phosphorylated in synapsomal membranes.By similarity
Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UGC6
PaxDbiQ9UGC6
PeptideAtlasiQ9UGC6
PRIDEiQ9UGC6
ProteomicsDBi84206

PTM databases

iPTMnetiQ9UGC6
PhosphoSitePlusiQ9UGC6

Expressioni

Tissue specificityi

Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000091844 Expressed in 193 organ(s), highest expression level in neocortex
CleanExiHS_RGS17
GenevisibleiQ9UGC6 HS

Organism-specific databases

HPAiHPA022276
HPA056493

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAQ (PubMed:18434541). Interacts with GNAZ and GNAI2. Interacts with OPRM1. Forms a complex with mu-opioid receptors and G(alpha)z/i2 subunits, including GNAZ and GNAI2; the formation of this complex results in mu-opioid receptor desensitization (By similarity).By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi117744, 19 interactors
DIPiDIP-59095N
IntActiQ9UGC6, 41 interactors
STRINGi9606.ENSP00000206262

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UGC6
SMRiQ9UGC6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UGC6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 200RGSPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 40Poly-CysAdd BLAST13

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ9UGC6
KOiK16449
OMAiCQNPTSD
OrthoDBiEOG091G0BDG
PhylomeDBiQ9UGC6
TreeFamiTF315837

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UGC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE
60 70 80 90 100
NAGRPTHTTK MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE
110 120 130 140 150
FLRTEYSEEN LLFWLACEDL KKEQNKKVIE EKARMIYEDY ISILSPKEVS
160 170 180 190 200
LDSRVREVIN RNLLDPNPHM YEDAQLQIYT LMHRDSFPRF LNSQIYKSFV
210
ESTAGSSSES
Length:210
Mass (Da):24,359
Last modified:August 14, 2001 - v2
Checksum:i0AFA22A43BF5E481
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202257 mRNA Translation: AAF08978.3
BT006997 mRNA Translation: AAP35643.1
AL080276 Genomic DNA No translation available.
BC013117 mRNA Translation: AAH13117.1
AF493938 mRNA Translation: AAM12652.1
CCDSiCCDS5244.1
RefSeqiNP_036551.3, NM_012419.4
UniGeneiHs.166313

Genome annotation databases

EnsembliENST00000206262; ENSP00000206262; ENSG00000091844
ENST00000367225; ENSP00000356194; ENSG00000091844
GeneIDi26575
KEGGihsa:26575
UCSCiuc003qpm.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202257 mRNA Translation: AAF08978.3
BT006997 mRNA Translation: AAP35643.1
AL080276 Genomic DNA No translation available.
BC013117 mRNA Translation: AAH13117.1
AF493938 mRNA Translation: AAM12652.1
CCDSiCCDS5244.1
RefSeqiNP_036551.3, NM_012419.4
UniGeneiHs.166313

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZV4X-ray2.40X72-206[»]
ProteinModelPortaliQ9UGC6
SMRiQ9UGC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117744, 19 interactors
DIPiDIP-59095N
IntActiQ9UGC6, 41 interactors
STRINGi9606.ENSP00000206262

PTM databases

iPTMnetiQ9UGC6
PhosphoSitePlusiQ9UGC6

Polymorphism and mutation databases

BioMutaiRGS17
DMDMi15214238

Proteomic databases

EPDiQ9UGC6
PaxDbiQ9UGC6
PeptideAtlasiQ9UGC6
PRIDEiQ9UGC6
ProteomicsDBi84206

Protocols and materials databases

DNASUi26575
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206262; ENSP00000206262; ENSG00000091844
ENST00000367225; ENSP00000356194; ENSG00000091844
GeneIDi26575
KEGGihsa:26575
UCSCiuc003qpm.4 human

Organism-specific databases

CTDi26575
DisGeNETi26575
EuPathDBiHostDB:ENSG00000091844.7
GeneCardsiRGS17
HGNCiHGNC:14088 RGS17
HPAiHPA022276
HPA056493
MIMi607191 gene
neXtProtiNX_Q9UGC6
OpenTargetsiENSG00000091844
PharmGKBiPA34368
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ9UGC6
KOiK16449
OMAiCQNPTSD
OrthoDBiEOG091G0BDG
PhylomeDBiQ9UGC6
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418597 G alpha (z) signalling events

Miscellaneous databases

ChiTaRSiRGS17 human
EvolutionaryTraceiQ9UGC6
GeneWikiiRGS17
GenomeRNAii26575
PROiPR:Q9UGC6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091844 Expressed in 193 organ(s), highest expression level in neocortex
CleanExiHS_RGS17
GenevisibleiQ9UGC6 HS

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS17_HUMAN
AccessioniPrimary (citable) accession number: Q9UGC6
Secondary accession number(s): Q5TF49, Q8TD61, Q9UJS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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