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Entry version 169 (13 Nov 2019)
Sequence version 1 (01 May 2000)
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Protein

CCR4-NOT transcription complex subunit 8

Gene

CNOT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi40Divalent metal cation 1; catalyticBy similarity1
Metal bindingi40Divalent metal cation 2; catalyticBy similarity1
Metal bindingi42Divalent metal cation 2; catalyticBy similarity1
Metal bindingi161Divalent metal cation 1; catalyticBy similarity1
Metal bindingi230Divalent metal cation 2; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, Repressor, RNA-binding
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation
LigandMetal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 8 (EC:3.1.13.4)
Alternative name(s):
CAF1-like protein
Short name:
CALIFp
CAF2
CCR4-associated factor 8
Caf1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNOT8
Synonyms:CALIF, POP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9207 CNOT8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603731 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UFF9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40D → A: Impairs deadenylation and decay of mRNAi-targeted mRNA; when associated with A-42. 1 Publication1
Mutagenesisi42E → A: Impairs deadenylation and decay of mRNAi-targeted mRNA; when associated with A-40. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9337

Open Targets

More...
OpenTargetsi
ENSG00000155508

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26679

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UFF9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNOT8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
15213949

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002128461 – 292CCR4-NOT transcription complex subunit 8Add BLAST292

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UFF9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UFF9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UFF9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UFF9

PeptideAtlas

More...
PeptideAtlasi
Q9UFF9

PRoteomics IDEntifications database

More...
PRIDEi
Q9UFF9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2533
6971
84181 [Q9UFF9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UFF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UFF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000155508 Expressed in 233 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UFF9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UFF9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051398

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. In the complex interacts directly with CNOT1.

Interacts with BTG1, BTG2 and TOB1.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114744, 42 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UFF9

Database of interacting proteins

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DIPi
DIP-29084N

Protein interaction database and analysis system

More...
IntActi
Q9UFF9, 35 interactors

Molecular INTeraction database

More...
MINTi
Q9UFF9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000430493

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UFF9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0304 Eukaryota
COG5228 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000080

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000173077

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UFF9

KEGG Orthology (KO)

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KOi
K12581

Identification of Orthologs from Complete Genome Data

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OMAi
TSQIICE

Database of Orthologous Groups

More...
OrthoDBi
931256at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UFF9

TreeFam database of animal gene trees

More...
TreeFami
TF314185

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039637 CNOT7/CNOT8/Pop2
IPR027212 Cnot8
IPR006941 RNase_CAF1
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10797 PTHR10797, 1 hit
PTHR10797:SF1 PTHR10797:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04857 CAF1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UFF9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAALVENSQ VICEVWASNL EEEMRKIREI VLSYSYIAMD TEFPGVVVRP
60 70 80 90 100
IGEFRSSIDY QYQLLRCNVD LLKIIQLGLT FTNEKGEYPS GINTWQFNFK
110 120 130 140 150
FNLTEDMYSQ DSIDLLANSG LQFQKHEEEG IDTLHFAELL MTSGVVLCDN
160 170 180 190 200
VKWLSFHSGY DFGYMVKLLT DSRLPEEEHE FFHILNLFFP SIYDVKYLMK
210 220 230 240 250
SCKNLKGGLQ EVADQLDLQR IGRQHQAGSD SLLTGMAFFR MKELFFEDSI
260 270 280 290
DDAKYCGRLY GLGTGVAQKQ NEDVDSAQEK MSILAIINNM QQ
Length:292
Mass (Da):33,540
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81027A966E51AFDB
GO
Isoform 2 (identifier: Q9UFF9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Note: No experimental confirmation available.
Show »
Length:186
Mass (Da):21,239
Checksum:i7704142451AE8485
GO
Isoform 3 (identifier: Q9UFF9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-158: Missing.

Note: No experimental confirmation available.
Show »
Length:238
Mass (Da):27,415
Checksum:i0EC415BBE87D19BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z9U0B7Z9U0_HUMAN
cDNA, FLJ78954, highly similar to C...
CNOT8
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIL2E5RIL2_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFJ4E5RFJ4_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHL9E5RHL9_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHP3E5RHP3_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGE4E5RGE4_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJC5E5RJC5_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHD6E5RHD6_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHG0E5RHG0_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIU0E5RIU0_HUMAN
CCR4-NOT transcription complex subu...
CNOT8
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99 – 105FKFNLTE → CKLYLTV in AAP97157 (Ref. 3) Curated7
Sequence conflicti152K → R in BAB15119 (Ref. 5) Curated1
Sequence conflicti182F → L in AAD02685 (PubMed:10036195).Curated1
Sequence conflicti189F → S in AAD02685 (PubMed:10036195).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04875132L → P1 PublicationCorresponds to variant dbSNP:rs1139980Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0555271 – 106Missing in isoform 2. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_055528105 – 158Missing in isoform 3. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF053318 mRNA Translation: AAD02685.1
AF180476 mRNA Translation: AAF29830.1
AF087844 mRNA Translation: AAP97157.1
AL122045 mRNA Translation: CAB59181.1
BT006857 mRNA Translation: AAP35503.1
AK025358 mRNA Translation: BAB15119.1
AK315864 mRNA Translation: BAF98755.1
AK297381 mRNA Translation: BAH12567.1
AK303775 mRNA Translation: BAH14047.1
AK314317 mRNA Translation: BAG36965.1
AK316221 mRNA Translation: BAH14592.1
AK316269 mRNA Translation: BAH14640.1
AC112169 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61625.1
CH471062 Genomic DNA Translation: EAW61626.1
CH471062 Genomic DNA Translation: EAW61627.1
CH471062 Genomic DNA Translation: EAW61628.1
BC017366 mRNA Translation: AAH17366.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4329.1 [Q9UFF9-1]
CCDS75361.1 [Q9UFF9-3]
CCDS78074.1 [Q9UFF9-2]

Protein sequence database of the Protein Information Resource

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PIRi
T34529
T52257

NCBI Reference Sequences

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RefSeqi
NP_001288002.1, NM_001301073.1 [Q9UFF9-1]
NP_001288003.1, NM_001301074.1 [Q9UFF9-3]
NP_001288004.1, NM_001301075.1 [Q9UFF9-2]
NP_001288006.1, NM_001301077.1 [Q9UFF9-2]
NP_001288009.1, NM_001301080.1 [Q9UFF9-2]
NP_001288011.1, NM_001301082.1 [Q9UFF9-2]
NP_001288012.1, NM_001301083.1 [Q9UFF9-2]
NP_001288015.1, NM_001301086.1
NP_004770.4, NM_004779.5 [Q9UFF9-1]
XP_005268584.1, XM_005268527.2 [Q9UFF9-3]
XP_011536008.1, XM_011537706.1 [Q9UFF9-2]
XP_011536010.1, XM_011537708.2 [Q9UFF9-2]
XP_016865537.1, XM_017010048.1 [Q9UFF9-1]
XP_016865538.1, XM_017010049.1 [Q9UFF9-1]
XP_016865539.1, XM_017010050.1 [Q9UFF9-1]
XP_016865540.1, XM_017010051.1 [Q9UFF9-1]
XP_016865541.1, XM_017010052.1 [Q9UFF9-3]
XP_016865542.1, XM_017010053.1 [Q9UFF9-3]
XP_016865543.1, XM_017010054.1 [Q9UFF9-3]
XP_016865544.1, XM_017010055.1 [Q9UFF9-3]
XP_016865545.1, XM_017010056.1 [Q9UFF9-3]
XP_016865546.1, XM_017010057.1 [Q9UFF9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000285896; ENSP00000285896; ENSG00000155508 [Q9UFF9-1]
ENST00000403027; ENSP00000384747; ENSG00000155508 [Q9UFF9-1]
ENST00000517876; ENSP00000430493; ENSG00000155508 [Q9UFF9-1]
ENST00000519404; ENSP00000430833; ENSG00000155508 [Q9UFF9-3]
ENST00000520671; ENSP00000428305; ENSG00000155508 [Q9UFF9-2]
ENST00000521450; ENSP00000431034; ENSG00000155508 [Q9UFF9-2]
ENST00000521583; ENSP00000429882; ENSG00000155508 [Q9UFF9-2]
ENST00000523698; ENSP00000428565; ENSG00000155508 [Q9UFF9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9337

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9337

UCSC genome browser

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UCSCi
uc003lvu.4 human [Q9UFF9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053318 mRNA Translation: AAD02685.1
AF180476 mRNA Translation: AAF29830.1
AF087844 mRNA Translation: AAP97157.1
AL122045 mRNA Translation: CAB59181.1
BT006857 mRNA Translation: AAP35503.1
AK025358 mRNA Translation: BAB15119.1
AK315864 mRNA Translation: BAF98755.1
AK297381 mRNA Translation: BAH12567.1
AK303775 mRNA Translation: BAH14047.1
AK314317 mRNA Translation: BAG36965.1
AK316221 mRNA Translation: BAH14592.1
AK316269 mRNA Translation: BAH14640.1
AC112169 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61625.1
CH471062 Genomic DNA Translation: EAW61626.1
CH471062 Genomic DNA Translation: EAW61627.1
CH471062 Genomic DNA Translation: EAW61628.1
BC017366 mRNA Translation: AAH17366.1
CCDSiCCDS4329.1 [Q9UFF9-1]
CCDS75361.1 [Q9UFF9-3]
CCDS78074.1 [Q9UFF9-2]
PIRiT34529
T52257
RefSeqiNP_001288002.1, NM_001301073.1 [Q9UFF9-1]
NP_001288003.1, NM_001301074.1 [Q9UFF9-3]
NP_001288004.1, NM_001301075.1 [Q9UFF9-2]
NP_001288006.1, NM_001301077.1 [Q9UFF9-2]
NP_001288009.1, NM_001301080.1 [Q9UFF9-2]
NP_001288011.1, NM_001301082.1 [Q9UFF9-2]
NP_001288012.1, NM_001301083.1 [Q9UFF9-2]
NP_001288015.1, NM_001301086.1
NP_004770.4, NM_004779.5 [Q9UFF9-1]
XP_005268584.1, XM_005268527.2 [Q9UFF9-3]
XP_011536008.1, XM_011537706.1 [Q9UFF9-2]
XP_011536010.1, XM_011537708.2 [Q9UFF9-2]
XP_016865537.1, XM_017010048.1 [Q9UFF9-1]
XP_016865538.1, XM_017010049.1 [Q9UFF9-1]
XP_016865539.1, XM_017010050.1 [Q9UFF9-1]
XP_016865540.1, XM_017010051.1 [Q9UFF9-1]
XP_016865541.1, XM_017010052.1 [Q9UFF9-3]
XP_016865542.1, XM_017010053.1 [Q9UFF9-3]
XP_016865543.1, XM_017010054.1 [Q9UFF9-3]
XP_016865544.1, XM_017010055.1 [Q9UFF9-3]
XP_016865545.1, XM_017010056.1 [Q9UFF9-3]
XP_016865546.1, XM_017010057.1 [Q9UFF9-2]

3D structure databases

SMRiQ9UFF9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114744, 42 interactors
CORUMiQ9UFF9
DIPiDIP-29084N
IntActiQ9UFF9, 35 interactors
MINTiQ9UFF9
STRINGi9606.ENSP00000430493

PTM databases

iPTMnetiQ9UFF9
PhosphoSitePlusiQ9UFF9

Polymorphism and mutation databases

BioMutaiCNOT8
DMDMi15213949

Proteomic databases

EPDiQ9UFF9
jPOSTiQ9UFF9
MassIVEiQ9UFF9
PaxDbiQ9UFF9
PeptideAtlasiQ9UFF9
PRIDEiQ9UFF9
ProteomicsDBi2533
6971
84181 [Q9UFF9-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9337

Genome annotation databases

EnsembliENST00000285896; ENSP00000285896; ENSG00000155508 [Q9UFF9-1]
ENST00000403027; ENSP00000384747; ENSG00000155508 [Q9UFF9-1]
ENST00000517876; ENSP00000430493; ENSG00000155508 [Q9UFF9-1]
ENST00000519404; ENSP00000430833; ENSG00000155508 [Q9UFF9-3]
ENST00000520671; ENSP00000428305; ENSG00000155508 [Q9UFF9-2]
ENST00000521450; ENSP00000431034; ENSG00000155508 [Q9UFF9-2]
ENST00000521583; ENSP00000429882; ENSG00000155508 [Q9UFF9-2]
ENST00000523698; ENSP00000428565; ENSG00000155508 [Q9UFF9-2]
GeneIDi9337
KEGGihsa:9337
UCSCiuc003lvu.4 human [Q9UFF9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9337
DisGeNETi9337

GeneCards: human genes, protein and diseases

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GeneCardsi
CNOT8
HGNCiHGNC:9207 CNOT8
HPAiHPA051398
MIMi603731 gene
neXtProtiNX_Q9UFF9
OpenTargetsiENSG00000155508
PharmGKBiPA26679

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0304 Eukaryota
COG5228 LUCA
GeneTreeiENSGT00390000000080
HOGENOMiHOG000173077
InParanoidiQ9UFF9
KOiK12581
OMAiTSQIICE
OrthoDBi931256at2759
PhylomeDBiQ9UFF9
TreeFamiTF314185

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CNOT8 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CNOT8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9337
PharosiQ9UFF9

Protein Ontology

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PROi
PR:Q9UFF9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155508 Expressed in 233 organ(s), highest expression level in right lung
ExpressionAtlasiQ9UFF9 baseline and differential
GenevisibleiQ9UFF9 HS

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR039637 CNOT7/CNOT8/Pop2
IPR027212 Cnot8
IPR006941 RNase_CAF1
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10797 PTHR10797, 1 hit
PTHR10797:SF1 PTHR10797:SF1, 1 hit
PfamiView protein in Pfam
PF04857 CAF1, 2 hits
SUPFAMiSSF53098 SSF53098, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNOT8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UFF9
Secondary accession number(s): B0AZS3
, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: November 13, 2019
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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