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Protein

DnaJ homolog subfamily C member 5B

Gene

DNAJC5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 5B
Alternative name(s):
Cysteine string protein beta
Short name:
CSP-beta
Gene namesi
Name:DNAJC5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147570.9
HGNCiHGNC:24138 DNAJC5B
MIMi613945 gene
neXtProtiNX_Q9UF47

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147570
PharmGKBiPA134962894

Polymorphism and mutation databases

BioMutaiDNAJC5B
DMDMi20141445

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710551 – 199DnaJ homolog subfamily C member 5BAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated. Palmitoylation is not required for membrane association.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9UF47
PeptideAtlasiQ9UF47
PRIDEiQ9UF47
ProteomicsDBi84170

PTM databases

iPTMnetiQ9UF47
PhosphoSitePlusiQ9UF47
SwissPalmiQ9UF47

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000147570
CleanExiHS_DNAJC5B
ExpressionAtlasiQ9UF47 baseline and differential
GenevisibleiQ9UF47 HS

Organism-specific databases

HPAiHPA077389

Interactioni

Subunit structurei

Interacts with the chaperone complex consisting of HSC70 and SGTA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TFCP2Q128003EBI-10320535,EBI-717422

Protein-protein interaction databases

BioGridi124554, 1 interactor
IntActiQ9UF47, 1 interactor
STRINGi9606.ENSP00000276570

Structurei

3D structure databases

ProteinModelPortaliQ9UF47
SMRiQ9UF47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 84JPROSITE-ProRule annotationAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi123 – 140Cys-richAdd BLAST18
Compositional biasi126 – 137Poly-CysAdd BLAST12

Phylogenomic databases

eggNOGiKOG0716 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00920000148989
HOGENOMiHOG000231969
HOVERGENiHBG005414
InParanoidiQ9UF47
KOiK09525
OMAiSWWAKTL
OrthoDBiEOG091G0QJP
PhylomeDBiQ9UF47
TreeFamiTF105164

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UF47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK
60 70 80 90 100
NPDDPAATEK FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN
110 120 130 140 150
TYFMLSSWWA KALFVIVGLL TGCYFCCCLC CCCNCCCGHC RPESSVPEED
160 170 180 190
FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN ANEKTQLIKE GSRSYCTDS
Length:199
Mass (Da):22,496
Last modified:April 3, 2002 - v2
Checksum:i4FDBF489D16B6EC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41 – 44KLAL → LENP in CAB63773 (PubMed:17974005).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368276 mRNA Translation: AAK60571.1
BC016742 mRNA Translation: AAH16742.1
AL133660 mRNA Translation: CAB63773.2
CCDSiCCDS6183.1
PIRiT43470
RefSeqiNP_149096.2, NM_033105.4
XP_011515920.1, XM_011517618.2
UniGeneiHs.491885

Genome annotation databases

EnsembliENST00000276570; ENSP00000276570; ENSG00000147570
GeneIDi85479
KEGGihsa:85479
UCSCiuc003xvs.2 human

Similar proteinsi

Entry informationi

Entry nameiDNJ5B_HUMAN
AccessioniPrimary (citable) accession number: Q9UF47
Secondary accession number(s): Q969Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 3, 2002
Last modified: June 20, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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