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Protein

Ephrin type-A receptor 6

Gene

EPHA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei663ATPPROSITE-ProRule annotation1
Active sitei798Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi637 – 645ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
SignaLinkiQ9UF33
SIGNORiQ9UF33

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 6 (EC:2.7.10.1)
Alternative name(s):
EPH homology kinase 2
Short name:
EHK-2
EPH-like kinase 12
Short name:
EK12
Gene namesi
Name:EPHA6
Synonyms:EHK2, HEK12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000080224.17
HGNCiHGNC:19296 EPHA6
MIMi600066 gene
neXtProtiNX_Q9UF33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 550ExtracellularSequence analysisAdd BLAST528
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 1036CytoplasmicSequence analysisAdd BLAST465

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi285220
OpenTargetsiENSG00000080224
PharmGKBiPA134866684

Chemistry databases

ChEMBLiCHEMBL4526

Polymorphism and mutation databases

DMDMi97048747

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000023568423 – 1036Ephrin type-A receptor 6Add BLAST1014

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei606Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei612Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei831Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei978Phosphotyrosine; by autocatalysisSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UF33
PaxDbiQ9UF33
PeptideAtlasiQ9UF33
PRIDEiQ9UF33
ProteomicsDBi84168
84169 [Q9UF33-2]

PTM databases

iPTMnetiQ9UF33
PhosphoSitePlusiQ9UF33

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

BgeeiENSG00000080224 Expressed in 78 organ(s), highest expression level in corpus callosum
CleanExiHS_EPHA6
ExpressionAtlasiQ9UF33 baseline and differential
GenevisibleiQ9UF33 HS

Organism-specific databases

HPAiHPA007397
HPA058047

Interactioni

Subunit structurei

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).By similarity

Protein-protein interaction databases

BioGridi130049, 6 interactors
STRINGi9606.ENSP00000374323

Chemistry databases

BindingDBiQ9UF33

Structurei

3D structure databases

ProteinModelPortaliQ9UF33
SMRiQ9UF33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 212Eph LBDPROSITE-ProRule annotationAdd BLAST179
Domaini331 – 441Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST111
Domaini442 – 537Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini631 – 944Protein kinasePROSITE-ProRule annotationAdd BLAST314
Domaini961 – 1025SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1034 – 1036PDZ-bindingSequence analysis3

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
HOGENOMiHOG000233858
HOVERGENiHBG062180
InParanoidiQ9UF33
KOiK05107

Family and domain databases

CDDicd10484 EphR_LBD_A6, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034280 EphA6_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 2 hits
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UF33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGCEVREFL LQFGFFLPLL TAWPGDCSHV SNNQVVLLDT TTVLGELGWK
60 70 80 90 100
TYPLNGWDAI TEMDEHNRPI HTYQVCNVME PNQNNWLRTN WISRDAAQKI
110 120 130 140 150
YVEMKFTLRD CNSIPWVLGT CKETFNLFYM ESDESHGIKF KPNQYTKIDT
160 170 180 190 200
IAADESFTQM DLGDRILKLN TEIREVGPIE RKGFYLAFQD IGACIALVSV
210 220 230 240 250
RVFYKKCPFT VRNLAMFPDT IPRVDSSSLV EVRGSCVKSA EERDTPKLYC
260 270 280 290 300
GADGDWLVPL GRCICSTGYE EIEGSCHACR PGFYKAFAGN TKCSKCPPHS
310 320 330 340 350
LTYMEATSVC QCEKGYFRAE KDPPSMACTR PPSAPRNVVF NINETALILE
360 370 380 390 400
WSPPSDTGGR KDLTYSVICK KCGLDTSQCE DCGGGLRFIP RHTGLINNSV
410 420 430 440 450
IVLDFVSHVN YTFEIEAMNG VSELSFSPKP FTAITVTTDQ DAPSLIGVVR
460 470 480 490 500
KDWASQNSIA LSWQAPAFSN GAILDYEIKY YEKEHEQLTY SSTRSKAPSV
510 520 530 540 550
IITGLKPATK YVFHIRVRTA TGYSGYSQKF EFETGDETSD MAAEQGQILV
560 570 580 590 600
IATAAVGGFT LLVILTLFFL ITGRCQWYIK AKMKSEEKRR NHLQNGHLRF
610 620 630 640 650
PGIKTYIDPD TYEDPSLAVH EFAKEIDPSR IRIERVIGAG EFGEVCSGRL
660 670 680 690 700
KTPGKREIPV AIKTLKGGHM DRQRRDFLRE ASIMGQFDHP NIIRLEGVVT
710 720 730 740 750
KRSFPAIGVE AFCPSFLRAG FLNSIQAPHP VPGGGSLPPR IPAGRPVMIV
760 770 780 790 800
VEYMENGSLD SFLRKHDGHF TVIQLVGMLR GIASGMKYLS DMGYVHRDLA
810 820 830 840 850
ARNILVNSNL VCKVSDFGLS RVLEDDPEAA YTTTGGKIPI RWTAPEAIAY
860 870 880 890 900
RKFSSASDAW SYGIVMWEVM SYGERPYWEM SNQDVILSIE EGYRLPAPMG
910 920 930 940 950
CPASLHQLML HCWQKERNHR PKFTDIVSFL DKLIRNPSAL HTLVEDILVM
960 970 980 990 1000
PESPGEVPEY PLFVTVGDWL DSIKMGQYKN NFVAAGFTTF DLISRMSIDD
1010 1020 1030
IRRIGVILIG HQRRIVSSIQ TLRLHMMHIQ EKGFHV
Length:1,036
Mass (Da):116,379
Last modified:May 14, 2014 - v3
Checksum:i53402C6DCD7CD32C
GO
Isoform 2 (identifier: Q9UF33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-514: Missing.
     515-538: IRVRTATGYSGYSQKFEFETGDET → MKDSPFQVTKLYWLNEKWDFIASA
     835-848: GGKIPIRWTAPEAI → DLFQTLTLNLCYSA
     849-1036: Missing.

Show »
Length:334
Mass (Da):37,274
Checksum:iDF89BC8423AC1A60
GO
Isoform 3 (identifier: Q9UF33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-514: Missing.
     515-538: IRVRTATGYSGYSQKFEFETGDET → MKDSPFQVTKLYWLNEKWDFIASA
     835-912: GGKIPIRWTA...ASLHQLMLHC → RPTNHNKEQS...TLTLNLCYSA
     913-1036: Missing.

Show »
Length:398
Mass (Da):44,466
Checksum:i6A414ED81CCC5C47
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1T8A0A0B4J1T8_HUMAN
Ephrin type-A receptor 6
EPHA6
1,130Annotation score:
J3KR66J3KR66_HUMAN
Ephrin type-A receptor 6
EPHA6
373Annotation score:
H0Y9V0H0Y9V0_HUMAN
Ephrin type-A receptor 6
EPHA6
324Annotation score:
E7EU71E7EU71_HUMAN
Ephrin type-A receptor 6
EPHA6
547Annotation score:
B4DXQ6B4DXQ6_HUMAN
Ephrin type-A receptor 6
EPHA6
241Annotation score:
B4DXM2B4DXM2_HUMAN
cDNA FLJ60941, highly similar to Ep...
EPHA6
208Annotation score:
H0Y8K5H0Y8K5_HUMAN
Ephrin type-A receptor 6
EPHA6
55Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042149704F → S1 Publication1
Natural variantiVAR_055991711A → V. Corresponds to variant dbSNP:rs4857276Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0184731 – 514Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST514
Alternative sequenceiVSP_018474515 – 538IRVRT…TGDET → MKDSPFQVTKLYWLNEKWDF IASA in isoform 2 and isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_054716835 – 912GGKIP…LMLHC → RPTNHNKEQSELVKEDGLES LCEQCESSSGYGTGLVLMWK RNRRAMGASGQTRKQCDKRD NPPTDLFQTLTLNLCYSA in isoform 3. CuratedAdd BLAST78
Alternative sequenceiVSP_018475835 – 848GGKIP…APEAI → DLFQTLTLNLCYSA in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_018476849 – 1036Missing in isoform 2. 1 PublicationAdd BLAST188
Alternative sequenceiVSP_054717913 – 1036Missing in isoform 3. CuratedAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133666 mRNA Translation: CAB63775.1
AC109782 Genomic DNA No translation available.
AC108714 Genomic DNA No translation available.
AC110717 Genomic DNA No translation available.
AC134730 Genomic DNA No translation available.
AC135369 Genomic DNA No translation available.
AC119745 Genomic DNA No translation available.
AC107482 Genomic DNA No translation available.
AC117470 Genomic DNA No translation available.
AC130510 Genomic DNA No translation available.
AC117439 Genomic DNA No translation available.
CCDSiCCDS54616.1 [Q9UF33-2]
CCDS63697.1 [Q9UF33-3]
PIRiT43450
RefSeqiNP_001265229.1, NM_001278300.1 [Q9UF33-3]
NP_775926.1, NM_173655.3 [Q9UF33-2]
UniGeneiHs.272208
Hs.653244

Genome annotation databases

EnsembliENST00000502694; ENSP00000423950; ENSG00000080224 [Q9UF33-2]
ENST00000514100; ENSP00000421711; ENSG00000080224 [Q9UF33-3]
GeneIDi285220
KEGGihsa:285220
UCSCiuc003drr.6 human [Q9UF33-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133666 mRNA Translation: CAB63775.1
AC109782 Genomic DNA No translation available.
AC108714 Genomic DNA No translation available.
AC110717 Genomic DNA No translation available.
AC134730 Genomic DNA No translation available.
AC135369 Genomic DNA No translation available.
AC119745 Genomic DNA No translation available.
AC107482 Genomic DNA No translation available.
AC117470 Genomic DNA No translation available.
AC130510 Genomic DNA No translation available.
AC117439 Genomic DNA No translation available.
CCDSiCCDS54616.1 [Q9UF33-2]
CCDS63697.1 [Q9UF33-3]
PIRiT43450
RefSeqiNP_001265229.1, NM_001278300.1 [Q9UF33-3]
NP_775926.1, NM_173655.3 [Q9UF33-2]
UniGeneiHs.272208
Hs.653244

3D structure databases

ProteinModelPortaliQ9UF33
SMRiQ9UF33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130049, 6 interactors
STRINGi9606.ENSP00000374323

Chemistry databases

BindingDBiQ9UF33
ChEMBLiCHEMBL4526

PTM databases

iPTMnetiQ9UF33
PhosphoSitePlusiQ9UF33

Polymorphism and mutation databases

DMDMi97048747

Proteomic databases

EPDiQ9UF33
PaxDbiQ9UF33
PeptideAtlasiQ9UF33
PRIDEiQ9UF33
ProteomicsDBi84168
84169 [Q9UF33-2]

Protocols and materials databases

DNASUi285220
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502694; ENSP00000423950; ENSG00000080224 [Q9UF33-2]
ENST00000514100; ENSP00000421711; ENSG00000080224 [Q9UF33-3]
GeneIDi285220
KEGGihsa:285220
UCSCiuc003drr.6 human [Q9UF33-1]

Organism-specific databases

CTDi285220
DisGeNETi285220
EuPathDBiHostDB:ENSG00000080224.17
GeneCardsiEPHA6
HGNCiHGNC:19296 EPHA6
HPAiHPA007397
HPA058047
MIMi600066 gene
neXtProtiNX_Q9UF33
OpenTargetsiENSG00000080224
PharmGKBiPA134866684
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
HOGENOMiHOG000233858
HOVERGENiHBG062180
InParanoidiQ9UF33
KOiK05107

Enzyme and pathway databases

ReactomeiR-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
SignaLinkiQ9UF33
SIGNORiQ9UF33

Miscellaneous databases

ChiTaRSiEPHA6 human
GeneWikiiEPHA6
GenomeRNAii285220
PROiPR:Q9UF33
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080224 Expressed in 78 organ(s), highest expression level in corpus callosum
CleanExiHS_EPHA6
ExpressionAtlasiQ9UF33 baseline and differential
GenevisibleiQ9UF33 HS

Family and domain databases

CDDicd10484 EphR_LBD_A6, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034280 EphA6_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 2 hits
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEPHA6_HUMAN
AccessioniPrimary (citable) accession number: Q9UF33
Secondary accession number(s): D6RAL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 14, 2014
Last modified: November 7, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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