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Entry version 121 (08 May 2019)
Sequence version 1 (01 May 2000)
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Protein

Hydroxyproline dehydrogenase

Gene

PRODH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Hydroproxyproline dehydrogenase activity is inhibited by THFA,(1R,3R)3-OH-cyclopentane-COOH and 5-OH-1H-pyrazole-3-COOH.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat with trans-4-L-hydroxyproline (Hyp) and ubiquinone-1 is 0.19 sec(-1). Proline is unable to saturate PRODH2 at least up to 750mM. kcat/KM with proline and ubiquinone-10: 0.075 M(-1)/sec. kcat with oxygen, duroquinone, menadione and CoQ1 and with trans-4-L-hydroxyproline are 0.002 sec(-1), 0.27 sec(-1), 0.28 sec(-1) and 0.19 sec(-1), respectively.1 Publication
  1. KM=200 mM for trans-4-L-hydroxyproline1 Publication
  2. KM=28 mM for oxygen1 Publication
  3. KM=143 µM for duroquinone1 Publication
  4. KM=25 µM for menadione1 Publication
  5. KM=124 µM for ubiquinone-11 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processProline metabolism
    LigandFAD, Flavoprotein

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER66-34410

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-389661 Glyoxylate metabolism and glycine degradation
    R-HSA-70688 Proline catabolism

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Hydroxyproline dehydrogenase1 Publication (EC:1.5.5.31 Publication)
    Short name:
    HYPDH1 Publication
    Alternative name(s):
    Kidney and liver proline oxidase 1
    Short name:
    HsPOX1
    Probable proline dehydrogenase 2Imported (EC:1.5.5.21 Publication)
    Probable proline oxidase 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PRODH2Imported
    Synonyms:HSPOX1Imported, HYPDH1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:17325 PRODH2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    616377 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9UF12

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    58510

    Open Targets

    More...
    OpenTargetsi
    ENSG00000250799

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA33802

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PRODH2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74720632

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003086231 – 536Hydroxyproline dehydrogenaseAdd BLAST536

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei386N6-acetyllysineBy similarity1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9UF12

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9UF12

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9UF12

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9UF12

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    84167

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9UF12

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000250799 Expressed in 136 organ(s), highest expression level in right lobe of liver

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9UF12 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9UF12 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA051287

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000301175

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the proline oxidase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0186 Eukaryota
    COG0506 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000006265

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000233406

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9UF12

    KEGG Orthology (KO)

    More...
    KOi
    K11394

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    IDAEESW

    Database of Orthologous Groups

    More...
    OrthoDBi
    948528at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9UF12

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313544

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029041 FAD-linked_oxidoreductase-like
    IPR002872 Proline_DH_dom
    IPR015659 Proline_oxidase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR13914 PTHR13914, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01619 Pro_dh, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51730 SSF51730, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q9UF12-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSPRVVSNSS VLASQSVGIT NVRTVFSNVF NNTTAFPILR GSNCHKITAP
    60 70 80 90 100
    GLGKGQLVNL LPPENLPWCG GSQGPRMLRT CYVLCSQAGP PSRGWQSLSF
    110 120 130 140 150
    DGGAFHLKGT GELTRALLVL RLCAWPPLVT HGLLLQAWSR RLLGSRLSGA
    160 170 180 190 200
    FLRASVYGQF VAGETAEEVK GCVQQLRTLS LRPLLAVPTE EEPDSAAKSG
    210 220 230 240 250
    EAWYEGNLGA MLRCVDLSRG LLEPPSLAEA SLMQLKVTAL TSTRLCKELA
    260 270 280 290 300
    SWVRRPGASL ELSPERLAEA MDSGQNLQVS CLNAEQNQHL RASLSRLHRV
    310 320 330 340 350
    AQYARAQHVR LLVDAEYTSL NPALSLLVAA LAVRWNSPGE GGPWVWNTYQ
    360 370 380 390 400
    ACLKDTFERL GRDAEAAHRA GLAFGVKLVR GAYLDKERAV AQLHGMEDPT
    410 420 430 440 450
    QPDYEATSQS YSRCLELMLT HVARHGPMCH LMVASHNEES VRQATKRMWE
    460 470 480 490 500
    LGIPLDGTVC FGQLLGMCDH VSLALGQAGY VVYKSIPYGS LEEVIPYLIR
    510 520 530
    RAQENRSVLQ GARREQELLS QELWRRLLPG CRRIPH
    Length:536
    Mass (Da):58,871
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81EB2F4B21E39E09
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7EJK5K7EJK5_HUMAN
    Proline dehydrogenase
    PRODH2
    119Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    S4R3D8S4R3D8_HUMAN
    Proline dehydrogenase
    PRODH2
    73Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03685291P → R. Corresponds to variant dbSNP:rs3848666Ensembl.1
    Natural variantiVAR_036853525R → Q. Corresponds to variant dbSNP:rs3761097Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U80018 mRNA Translation: AAF21465.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12478.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_067055.1, NM_021232.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000301175; ENSP00000301175; ENSG00000250799

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    58510

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:58510

    UCSC genome browser

    More...
    UCSCi
    uc002obx.1 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U80018 mRNA Translation: AAF21465.1
    CCDSiCCDS12478.1
    RefSeqiNP_067055.1, NM_021232.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000301175

    PTM databases

    iPTMnetiQ9UF12

    Polymorphism and mutation databases

    BioMutaiPRODH2
    DMDMi74720632

    Proteomic databases

    MaxQBiQ9UF12
    PaxDbiQ9UF12
    PeptideAtlasiQ9UF12
    PRIDEiQ9UF12
    ProteomicsDBi84167

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    58510
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000301175; ENSP00000301175; ENSG00000250799
    GeneIDi58510
    KEGGihsa:58510
    UCSCiuc002obx.1 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    58510
    DisGeNETi58510

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PRODH2
    HGNCiHGNC:17325 PRODH2
    HPAiHPA051287
    MIMi616377 gene
    neXtProtiNX_Q9UF12
    OpenTargetsiENSG00000250799
    PharmGKBiPA33802

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0186 Eukaryota
    COG0506 LUCA
    GeneTreeiENSGT00390000006265
    HOGENOMiHOG000233406
    InParanoidiQ9UF12
    KOiK11394
    OMAiIDAEESW
    OrthoDBi948528at2759
    PhylomeDBiQ9UF12
    TreeFamiTF313544

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER66-34410
    ReactomeiR-HSA-389661 Glyoxylate metabolism and glycine degradation
    R-HSA-70688 Proline catabolism

    Miscellaneous databases

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    58510

    Protein Ontology

    More...
    PROi
    PR:Q9UF12

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000250799 Expressed in 136 organ(s), highest expression level in right lobe of liver
    ExpressionAtlasiQ9UF12 baseline and differential
    GenevisibleiQ9UF12 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR029041 FAD-linked_oxidoreductase-like
    IPR002872 Proline_DH_dom
    IPR015659 Proline_oxidase
    PANTHERiPTHR13914 PTHR13914, 1 hit
    PfamiView protein in Pfam
    PF01619 Pro_dh, 1 hit
    SUPFAMiSSF51730 SSF51730, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYPDH_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UF12
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: May 1, 2000
    Last modified: May 8, 2019
    This is version 121 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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