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Entry version 140 (26 Feb 2020)
Sequence version 1 (01 May 2000)
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Protein

Pleckstrin homology domain-containing family B member 1

Gene

PLEKHB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family B member 1
Short name:
PH domain-containing family B member 1
Alternative name(s):
Evectin-1
PH domain-containing protein in retina 1
Short name:
PHRET1
Pleckstrin homology domain retinal protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHB1
Synonyms:EVT1, KPL1, PHR11 Publication, PHRET1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19079 PLEKHB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607651 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UF11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
58473

Open Targets

More...
OpenTargetsi
ENSG00000021300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38787

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UF11 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLEKHB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48474683

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538861 – 243Pleckstrin homology domain-containing family B member 1Add BLAST243

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UF11

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UF11

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UF11

PeptideAtlas

More...
PeptideAtlasi
Q9UF11

PRoteomics IDEntifications database

More...
PRIDEi
Q9UF11

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84163 [Q9UF11-1]
84164 [Q9UF11-2]
84165 [Q9UF11-3]
84166 [Q9UF11-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UF11

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UF11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in retina and brain. Levels are very low or not detectable in all other tissues tested.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000021300 Expressed in C1 segment of cervical spinal cord and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UF11 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UF11 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts (via PH domain) with MYO1C.

Interacts (via PH domain) with MYO7A (By similarity). Binds transducins (PubMed:10585447).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121807, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UF11, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9UF11

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346127

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UF11 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UF11

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 128PHPROSITE-ProRule annotationAdd BLAST108

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXBE Eukaryota
ENOG410Y287 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013989

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_102020_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UF11

KEGG Orthology (KO)

More...
KOi
K23857

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLWRQTA

Database of Orthologous Groups

More...
OrthoDBi
1558185at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UF11

TreeFam database of animal gene trees

More...
TreeFami
TF331787

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039816 PLEKHB1
IPR039680 PLEKHB1/2

The PANTHER Classification System

More...
PANTHERi
PTHR14309 PTHR14309, 1 hit
PTHR14309:SF7 PTHR14309:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UF11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPAAPVPPD SALESPFEEM ALVRGGWLWR QSSILRRWKR NWFALWLDGT
60 70 80 90 100
LGYYHDETAQ DEEDRVLIHF NVRDIKIGPE CHDVQPPEGR SRDGLLTVNL
110 120 130 140 150
REGGRLHLCA ETKDDALAWK TALLEANSTP APAGATVPPR SRRVCSKVRC
160 170 180 190 200
VTRSWSPCKV ERRIWVRVYS PYQDYYEVVP PNAHEATYVR SYYGPPYAGP
210 220 230 240
GVTHVIVRED PCYSAGAPLA MGMLAGAATG AALGSLMWSP CWF
Length:243
Mass (Da):27,186
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F60531721CF76CA
GO
Isoform 2 (identifier: Q9UF11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-165: Missing.

Show »
Length:208
Mass (Da):23,207
Checksum:iC11C12BF6E6FE4F0
GO
Isoform 3 (identifier: Q9UF11-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:224
Mass (Da):25,233
Checksum:iCE38AF6D0DE093D1
GO
Isoform 4 (identifier: Q9UF11-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.
     131-165: Missing.

Show »
Length:189
Mass (Da):21,254
Checksum:i6A25AE30F80F7E07
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GY87F5GY87_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3M1F5H3M1_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GY96F5GY96_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0R6F5H0R6_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H114F5H114_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1B8F5H1B8_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ38F5GZ38_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZH3F5GZH3_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H190F5H190_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H866F5H866_HUMAN
Pleckstrin homology domain-containi...
PLEKHB1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0097791 – 19Missing in isoform 3 and isoform 4. 4 PublicationsAdd BLAST19
Alternative sequenceiVSP_009780131 – 165Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U89715 mRNA Translation: AAF16675.1
AF093249 mRNA Translation: AAF16684.1
AF101054 mRNA Translation: AAF18572.1
AF100612 mRNA Translation: AAF18932.1
AF081583 mRNA Translation: AAF21786.1
AK289620 mRNA Translation: BAF82309.1
AK289909 mRNA Translation: BAF82598.1
AK290109 mRNA Translation: BAF82798.1
AK301299 mRNA Translation: BAH13452.1
AK314748 mRNA Translation: BAG37288.1
CH471076 Genomic DNA Translation: EAW74900.1
CH471076 Genomic DNA Translation: EAW74903.1
CH471076 Genomic DNA Translation: EAW74904.1
BC008075 mRNA Translation: AAH08075.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44672.1 [Q9UF11-1]
CCDS44673.1 [Q9UF11-2]
CCDS44674.1 [Q9UF11-3]
CCDS44675.1 [Q9UF11-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001123505.1, NM_001130033.1 [Q9UF11-2]
NP_001123506.1, NM_001130034.1 [Q9UF11-3]
NP_001123507.1, NM_001130035.1 [Q9UF11-4]
NP_001123508.1, NM_001130036.1 [Q9UF11-4]
NP_067023.1, NM_021200.2 [Q9UF11-1]
XP_011543494.1, XM_011545192.2 [Q9UF11-3]
XP_011543495.1, XM_011545193.2 [Q9UF11-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000227214; ENSP00000227214; ENSG00000021300 [Q9UF11-4]
ENST00000354190; ENSP00000346127; ENSG00000021300 [Q9UF11-1]
ENST00000398494; ENSP00000381507; ENSG00000021300 [Q9UF11-3]
ENST00000398492; ENSP00000381505; ENSG00000021300 [Q9UF11-2]
ENST00000535129; ENSP00000442616; ENSG00000021300 [Q9UF11-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:58473

UCSC genome browser

More...
UCSCi
uc001oua.3 human [Q9UF11-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89715 mRNA Translation: AAF16675.1
AF093249 mRNA Translation: AAF16684.1
AF101054 mRNA Translation: AAF18572.1
AF100612 mRNA Translation: AAF18932.1
AF081583 mRNA Translation: AAF21786.1
AK289620 mRNA Translation: BAF82309.1
AK289909 mRNA Translation: BAF82598.1
AK290109 mRNA Translation: BAF82798.1
AK301299 mRNA Translation: BAH13452.1
AK314748 mRNA Translation: BAG37288.1
CH471076 Genomic DNA Translation: EAW74900.1
CH471076 Genomic DNA Translation: EAW74903.1
CH471076 Genomic DNA Translation: EAW74904.1
BC008075 mRNA Translation: AAH08075.1
CCDSiCCDS44672.1 [Q9UF11-1]
CCDS44673.1 [Q9UF11-2]
CCDS44674.1 [Q9UF11-3]
CCDS44675.1 [Q9UF11-4]
RefSeqiNP_001123505.1, NM_001130033.1 [Q9UF11-2]
NP_001123506.1, NM_001130034.1 [Q9UF11-3]
NP_001123507.1, NM_001130035.1 [Q9UF11-4]
NP_001123508.1, NM_001130036.1 [Q9UF11-4]
NP_067023.1, NM_021200.2 [Q9UF11-1]
XP_011543494.1, XM_011545192.2 [Q9UF11-3]
XP_011543495.1, XM_011545193.2 [Q9UF11-4]

3D structure databases

SMRiQ9UF11
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121807, 7 interactors
IntActiQ9UF11, 11 interactors
MINTiQ9UF11
STRINGi9606.ENSP00000346127

PTM databases

iPTMnetiQ9UF11
PhosphoSitePlusiQ9UF11

Polymorphism and mutation databases

BioMutaiPLEKHB1
DMDMi48474683

Proteomic databases

jPOSTiQ9UF11
MassIVEiQ9UF11
PaxDbiQ9UF11
PeptideAtlasiQ9UF11
PRIDEiQ9UF11
ProteomicsDBi84163 [Q9UF11-1]
84164 [Q9UF11-2]
84165 [Q9UF11-3]
84166 [Q9UF11-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
58473

Genome annotation databases

EnsembliENST00000227214; ENSP00000227214; ENSG00000021300 [Q9UF11-4]
ENST00000354190; ENSP00000346127; ENSG00000021300 [Q9UF11-1]
ENST00000398494; ENSP00000381507; ENSG00000021300 [Q9UF11-3]
ENST00000398492; ENSP00000381505; ENSG00000021300 [Q9UF11-2]
ENST00000535129; ENSP00000442616; ENSG00000021300 [Q9UF11-4]
GeneIDi58473
KEGGihsa:58473
UCSCiuc001oua.3 human [Q9UF11-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58473
DisGeNETi58473

GeneCards: human genes, protein and diseases

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GeneCardsi
PLEKHB1
HGNCiHGNC:19079 PLEKHB1
MIMi607651 gene
neXtProtiNX_Q9UF11
OpenTargetsiENSG00000021300
PharmGKBiPA38787

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXBE Eukaryota
ENOG410Y287 LUCA
GeneTreeiENSGT00390000013989
HOGENOMiCLU_102020_0_0_1
InParanoidiQ9UF11
KOiK23857
OMAiWLWRQTA
OrthoDBi1558185at2759
PhylomeDBiQ9UF11
TreeFamiTF331787

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLEKHB1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
58473
PharosiQ9UF11 Tbio

Protein Ontology

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PROi
PR:Q9UF11
RNActiQ9UF11 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000021300 Expressed in C1 segment of cervical spinal cord and 207 other tissues
ExpressionAtlasiQ9UF11 baseline and differential
GenevisibleiQ9UF11 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039816 PLEKHB1
IPR039680 PLEKHB1/2
PANTHERiPTHR14309 PTHR14309, 1 hit
PTHR14309:SF7 PTHR14309:SF7, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UF11
Secondary accession number(s): A8K0Q5
, B2RBP1, B7Z716, Q9UBF5, Q9UI37, Q9UI44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 1, 2000
Last modified: February 26, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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