UniProtKB - Q9UF02 (CCG5_HUMAN)
Protein
Voltage-dependent calcium channel gamma-5 subunit
Gene
CACNG5
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity
GO - Molecular functioni
- channel regulator activity Source: GO_Central
- ion transmembrane transporter activity Source: ProtInc
- voltage-gated calcium channel activity Source: GO_Central
GO - Biological processi
- cardiac conduction Source: Reactome
- neurotransmitter receptor internalization Source: GO_Central
- neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: GO_Central
- positive regulation of synaptic transmission, glutamatergic Source: GO_Central
- postsynaptic neurotransmitter receptor diffusion trapping Source: GO_Central
- regulation of AMPA receptor activity Source: UniProtKB
- regulation of postsynaptic neurotransmitter receptor activity Source: SynGO
- transmission of nerve impulse Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9UF02 |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent calcium channel gamma-5 subunitAlternative name(s): Neuronal voltage-gated calcium channel gamma-5 subunit Transmembrane AMPAR regulatory protein gamma-5 Short name: TARP gamma-5 |
Gene namesi | Name:CACNG5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000075429.8 |
HGNCi | HGNC:1409, CACNG5 |
MIMi | 606405, gene |
neXtProti | NX_Q9UF02 |
Subcellular locationi
Plasma membrane
- postsynaptic density membrane By similarity
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- AMPA glutamate receptor complex Source: UniProtKB
- plasma membrane Source: Reactome
- postsynaptic density membrane Source: GO_Central
Other locations
- glutamatergic synapse Source: SynGO
- postsynaptic density Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 27091 |
OpenTargetsi | ENSG00000075429 |
PharmGKBi | PA26019 |
Miscellaneous databases
Pharosi | Q9UF02, Tdark |
Chemistry databases
ChEMBLi | CHEMBL2363032 |
DrugBanki | DB13746, Bioallethrin DB11148, Butamben DB00228, Enflurane DB00153, Ergocalciferol DB00421, Spironolactone |
Polymorphism and mutation databases
BioMutai | CACNG5 |
DMDMi | 20532390 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164681 | 1 – 275 | Voltage-dependent calcium channel gamma-5 subunitAdd BLAST | 275 |
Proteomic databases
PaxDbi | Q9UF02 |
PeptideAtlasi | Q9UF02 |
PRIDEi | Q9UF02 |
ProteomicsDBi | 84162 |
PTM databases
iPTMneti | Q9UF02 |
PhosphoSitePlusi | Q9UF02 |
Expressioni
Gene expression databases
Bgeei | ENSG00000075429, Expressed in hypothalamus and 34 other tissues |
Genevisiblei | Q9UF02, HS |
Organism-specific databases
HPAi | ENSG00000075429, Group enriched (brain, lymphoid tissue, retina) |
Interactioni
Subunit structurei
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs).
Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8.
Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 117993, 41 interactors |
IntActi | Q9UF02, 39 interactors |
STRINGi | 9606.ENSP00000436836 |
Miscellaneous databases
RNActi | Q9UF02, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTQ7, Eukaryota |
GeneTreei | ENSGT01000000214383 |
HOGENOMi | CLU_053704_1_1_1 |
InParanoidi | Q9UF02 |
OMAi | EEIYRPH |
OrthoDBi | 1093662at2759 |
PhylomeDBi | Q9UF02 |
TreeFami | TF327980 |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR008369, VDCC_g5su IPR008368, VDCC_gsu |
PANTHERi | PTHR12107:SF4, PTHR12107:SF4, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01792, VDCCGAMMA PR01793, VDCCGAMMA5 |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9UF02-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI
60 70 80 90 100
KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA
110 120 130 140 150
TPFPLVSLFF MFIGFILNNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF
210 220 230 240 250
MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG RSPSDISSEA
260 270
SLQMNSNYPA LLKCPDYDQM SSSPC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A669KBF6 | A0A669KBF6_HUMAN | Voltage-dependent calcium channel g... | CACNG5 | 165 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 – 275 | SAGVM…SSSPC → VKPVTLSMDRLGLGTAPLSR GEWGWGRRDIPQPFWTPDHP LYFPSSSQNVSLSYLSGSPP ARMSPGPCSCPHVHFPPHSS CVLCRPQPREMRQAPAASPS SAVFSL in AAF03089 (PubMed:10613843).CuratedAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF142621 , AF142618, AF142619, AF142620 Genomic DNA Translation: AAF03089.1 AF148220 mRNA Translation: AAF00132.1 AF361351 mRNA Translation: AAL50046.1 AF458898 mRNA Translation: AAM00595.1 AK290171 mRNA Translation: BAF82860.1 BC101607 mRNA Translation: AAI01608.1 BC101633 mRNA Translation: AAI01634.1 |
CCDSi | CCDS11665.1 |
RefSeqi | NP_665810.1, NM_145811.2 |
Genome annotation databases
Ensembli | ENST00000307139; ENSP00000303092; ENSG00000075429 ENST00000533854; ENSP00000436836; ENSG00000075429 |
GeneIDi | 27091 |
KEGGi | hsa:27091 |
UCSCi | uc010wqi.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF142621 , AF142618, AF142619, AF142620 Genomic DNA Translation: AAF03089.1 AF148220 mRNA Translation: AAF00132.1 AF361351 mRNA Translation: AAL50046.1 AF458898 mRNA Translation: AAM00595.1 AK290171 mRNA Translation: BAF82860.1 BC101607 mRNA Translation: AAI01608.1 BC101633 mRNA Translation: AAI01634.1 |
CCDSi | CCDS11665.1 |
RefSeqi | NP_665810.1, NM_145811.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117993, 41 interactors |
IntActi | Q9UF02, 39 interactors |
STRINGi | 9606.ENSP00000436836 |
Chemistry databases
ChEMBLi | CHEMBL2363032 |
DrugBanki | DB13746, Bioallethrin DB11148, Butamben DB00228, Enflurane DB00153, Ergocalciferol DB00421, Spironolactone |
PTM databases
iPTMneti | Q9UF02 |
PhosphoSitePlusi | Q9UF02 |
Polymorphism and mutation databases
BioMutai | CACNG5 |
DMDMi | 20532390 |
Proteomic databases
PaxDbi | Q9UF02 |
PeptideAtlasi | Q9UF02 |
PRIDEi | Q9UF02 |
ProteomicsDBi | 84162 |
Protocols and materials databases
Antibodypediai | 31684, 90 antibodies |
Genome annotation databases
Ensembli | ENST00000307139; ENSP00000303092; ENSG00000075429 ENST00000533854; ENSP00000436836; ENSG00000075429 |
GeneIDi | 27091 |
KEGGi | hsa:27091 |
UCSCi | uc010wqi.3, human |
Organism-specific databases
CTDi | 27091 |
DisGeNETi | 27091 |
EuPathDBi | HostDB:ENSG00000075429.8 |
GeneCardsi | CACNG5 |
HGNCi | HGNC:1409, CACNG5 |
HPAi | ENSG00000075429, Group enriched (brain, lymphoid tissue, retina) |
MIMi | 606405, gene |
neXtProti | NX_Q9UF02 |
OpenTargetsi | ENSG00000075429 |
PharmGKBi | PA26019 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTQ7, Eukaryota |
GeneTreei | ENSGT01000000214383 |
HOGENOMi | CLU_053704_1_1_1 |
InParanoidi | Q9UF02 |
OMAi | EEIYRPH |
OrthoDBi | 1093662at2759 |
PhylomeDBi | Q9UF02 |
TreeFami | TF327980 |
Enzyme and pathway databases
PathwayCommonsi | Q9UF02 |
Miscellaneous databases
BioGRID-ORCSi | 27091, 4 hits in 836 CRISPR screens |
ChiTaRSi | CACNG5, human |
GenomeRNAii | 27091 |
Pharosi | Q9UF02, Tdark |
PROi | PR:Q9UF02 |
RNActi | Q9UF02, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075429, Expressed in hypothalamus and 34 other tissues |
Genevisiblei | Q9UF02, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR008369, VDCC_g5su IPR008368, VDCC_gsu |
PANTHERi | PTHR12107:SF4, PTHR12107:SF4, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01792, VDCCGAMMA PR01793, VDCCGAMMA5 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCG5_HUMAN | |
Accessioni | Q9UF02Primary (citable) accession number: Q9UF02 Secondary accession number(s): A8K2A6 Q9UHM3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 10, 2002 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM