Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9UF02 (CCG5_HUMAN)

Entry version 152 (02 Dec 2020)
Sequence version 2 (10 May 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Voltage-dependent calcium channel gamma-5 subunit

Gene

CACNG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UF02

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-5 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-5 subunit
Transmembrane AMPAR regulatory protein gamma-5
Short name:
TARP gamma-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNG5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000075429.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:1409, CACNG5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606405, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UF02

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27091

Open Targets

More...OpenTargetsi		ENSG00000075429

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26019

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UF02, Tdark

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363032

Drug and drug target database

More...DrugBanki		DB13746, Bioallethrin
DB11148, Butamben
DB00228, Enflurane
DB00153, Ergocalciferol
DB00421, Spironolactone

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CACNG5

Domain mapping of disease mutations (DMDM)

More...DMDMi		20532390

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001646811 – 275Voltage-dependent calcium channel gamma-5 subunitAdd BLAST275

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UF02

PeptideAtlas

More...PeptideAtlasi		Q9UF02

PRoteomics IDEntifications database

More...PRIDEi		Q9UF02

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84162

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UF02

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UF02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000075429, Expressed in hypothalamus and 34 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UF02, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000075429, Group enriched (brain, lymphoid tissue, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs).

Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8.

Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117993, 41 interactors

Protein interaction database and analysis system

More...IntActi		Q9UF02, 39 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000436836

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UF02, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTQ7, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214383

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_053704_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UF02

Identification of Orthologs from Complete Genome Data

More...OMAi		EEIYRPH

Database of Orthologous Groups

More...OrthoDBi		1093662at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UF02

TreeFam database of animal gene trees

More...TreeFami		TF327980

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004031, PMP22/EMP/MP20/Claudin
IPR008369, VDCC_g5su
IPR008368, VDCC_gsu

The PANTHER Classification System

More...PANTHERi		PTHR12107:SF4, PTHR12107:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00822, PMP22_Claudin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01792, VDCCGAMMA
PR01793, VDCCGAMMA5

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UF02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI 
        60         70         80         90        100
KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA 
       110        120        130        140        150
TPFPLVSLFF MFIGFILNNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV 
       160        170        180        190        200
LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF 
       210        220        230        240        250
MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG RSPSDISSEA 
       260        270 
SLQMNSNYPA LLKCPDYDQM SSSPC
Length:275
Mass (Da):30,903
Last modified:May 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i889E04DAC036C2AE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A669KBF6A0A669KBF6_HUMAN
Voltage-dependent calcium channel g...
CACNG5
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191 – 275SAGVM…SSSPC → VKPVTLSMDRLGLGTAPLSR GEWGWGRRDIPQPFWTPDHP LYFPSSSQNVSLSYLSGSPP ARMSPGPCSCPHVHFPPHSS CVLCRPQPREMRQAPAASPS SAVFSL in AAF03089 (PubMed:10613843).CuratedAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF142621 AF142620 Genomic DNA Translation: AAF03089.1
AF148220 mRNA Translation: AAF00132.1
AF361351 mRNA Translation: AAL50046.1
AF458898 mRNA Translation: AAM00595.1
AK290171 mRNA Translation: BAF82860.1
BC101607 mRNA Translation: AAI01608.1
BC101633 mRNA Translation: AAI01634.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11665.1

NCBI Reference Sequences

More...RefSeqi		NP_665810.1, NM_145811.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000307139; ENSP00000303092; ENSG00000075429
ENST00000533854; ENSP00000436836; ENSG00000075429

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27091

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27091

UCSC genome browser

More...UCSCi		uc010wqi.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142621 AF142620 Genomic DNA Translation: AAF03089.1
AF148220 mRNA Translation: AAF00132.1
AF361351 mRNA Translation: AAL50046.1
AF458898 mRNA Translation: AAM00595.1
AK290171 mRNA Translation: BAF82860.1
BC101607 mRNA Translation: AAI01608.1
BC101633 mRNA Translation: AAI01634.1
CCDSiCCDS11665.1
RefSeqiNP_665810.1, NM_145811.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117993, 41 interactors
IntActiQ9UF02, 39 interactors
STRINGi9606.ENSP00000436836

Chemistry databases

ChEMBLiCHEMBL2363032
DrugBankiDB13746, Bioallethrin
DB11148, Butamben
DB00228, Enflurane
DB00153, Ergocalciferol
DB00421, Spironolactone

PTM databases

iPTMnetiQ9UF02
PhosphoSitePlusiQ9UF02

Polymorphism and mutation databases

BioMutaiCACNG5
DMDMi20532390

Proteomic databases

PaxDbiQ9UF02
PeptideAtlasiQ9UF02
PRIDEiQ9UF02
ProteomicsDBi84162

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31684, 90 antibodies

Genome annotation databases

EnsembliENST00000307139; ENSP00000303092; ENSG00000075429
ENST00000533854; ENSP00000436836; ENSG00000075429
GeneIDi27091
KEGGihsa:27091
UCSCiuc010wqi.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27091
DisGeNETi27091
EuPathDBiHostDB:ENSG00000075429.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		CACNG5
HGNCiHGNC:1409, CACNG5
HPAiENSG00000075429, Group enriched (brain, lymphoid tissue, retina)
MIMi606405, gene
neXtProtiNX_Q9UF02
OpenTargetsiENSG00000075429
PharmGKBiPA26019

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTQ7, Eukaryota
GeneTreeiENSGT01000000214383
HOGENOMiCLU_053704_1_1_1
InParanoidiQ9UF02
OMAiEEIYRPH
OrthoDBi1093662at2759
PhylomeDBiQ9UF02
TreeFamiTF327980

Enzyme and pathway databases

PathwayCommonsiQ9UF02

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27091, 4 hits in 836 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CACNG5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27091
PharosiQ9UF02, Tdark

Protein Ontology

More...PROi		PR:Q9UF02
RNActiQ9UF02, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000075429, Expressed in hypothalamus and 34 other tissues
GenevisibleiQ9UF02, HS

Family and domain databases

InterProiView protein in InterPro
IPR004031, PMP22/EMP/MP20/Claudin
IPR008369, VDCC_g5su
IPR008368, VDCC_gsu
PANTHERiPTHR12107:SF4, PTHR12107:SF4, 1 hit
PfamiView protein in Pfam
PF00822, PMP22_Claudin, 1 hit
PRINTSiPR01792, VDCCGAMMA
PR01793, VDCCGAMMA5

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCG5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UF02
Secondary accession number(s): A8K2A6
, Q547R3, Q8WXS7, Q9UHM3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: December 2, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again