UniProtKB - Q9UER7 (DAXX_HUMAN)
Death domain-associated protein 6
DAXX
Functioni
GO - Molecular functioni
- androgen receptor binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- heat shock protein binding Source: UniProtKB
- histone binding Source: UniProtKB
- p53 binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase activator activity Source: ParkinsonsUK-UCL
- protein kinase binding Source: ParkinsonsUK-UCL
- protein N-terminus binding Source: UniProtKB
- sumo-dependent protein binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
- transcription factor binding Source: UniProtKB
- transcription regulator inhibitor activity Source: GO_Central
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- activation of JUN kinase activity Source: ProtInc
- androgen receptor signaling pathway Source: UniProtKB
- cellular response to cadmium ion Source: UniProtKB
- cellular response to copper ion Source: UniProtKB
- cellular response to diamide Source: UniProtKB
- cellular response to heat Source: UniProtKB
- cellular response to sodium arsenite Source: UniProtKB
- cellular response to unfolded protein Source: UniProtKB
- chromatin remodeling Source: UniProtKB
- extrinsic apoptotic signaling pathway via death domain receptors Source: ProtInc
- negative regulation of DNA recombination at telomere Source: Reactome
- negative regulation of transcription, DNA-templated Source: UniProtKB
- nucleosome assembly Source: UniProtKB
- positive regulation of histone exchange Source: Reactome
- positive regulation of neuron death Source: ParkinsonsUK-UCL
- positive regulation of protein kinase activity Source: ParkinsonsUK-UCL
- positive regulation of protein phosphorylation Source: ParkinsonsUK-UCL
- regulation of apoptotic process Source: GO_Central
- regulation of protein ubiquitination Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: Reactome
- regulation of transcription, DNA-templated Source: MGI
- viral life cycle Source: Reactome
Keywordsi
Molecular function | Chaperone, Chromatin regulator, Repressor |
Biological process | Apoptosis, Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
BRENDAi | 2.7.7.19, 2681 |
PathwayCommonsi | Q9UER7 |
Reactomei | R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-6804757, Regulation of TP53 Degradation R-HSA-9609690, HCMV Early Events R-HSA-9670095, Inhibition of DNA recombination at telomere R-HSA-9670613, Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670615, Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations |
SignaLinki | Q9UER7 |
SIGNORi | Q9UER7 |
Names & Taxonomyi
Protein namesi | Recommended name: Death domain-associated protein 6Alternative name(s): Daxx Short name: hDaxx ETS1-associated protein 1 Short name: EAP1 Fas death domain-associated protein |
Gene namesi | Name:DAXX Synonyms:BING2, DAP6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2681, DAXX |
MIMi | 603186, gene |
neXtProti | NX_Q9UER7 |
VEuPathDBi | HostDB:ENSG00000204209.10 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 4 Publications
Nucleus
- nucleoplasm 5 Publications
- PML body 8 Publications
- nucleolus 1 Publication
Other locations
- centromere 2 Publications
Note: Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli (Probable). Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies (PubMed:12953102, PubMed:14990586, PubMed:23222847, PubMed:24200965). Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres (PubMed:9645950). Detected in cytoplasmic punctate structures (PubMed:11842083). Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress (PubMed:12968034). Colocalizes with RASSF1 in the nucleus (PubMed:18566590). Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures (PubMed:16845383).1 Publication9 Publications
Nucleus
- Nucleus 1 Publication
Note: Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1.1 Publication
Nucleus
- Nucleus 1 Publication
Note: Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1.1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nuclear body Source: HPA
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
- PML body Source: UniProtKB
Other locations
- chromosome, centromeric region Source: CACAO
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 206 | Q → L: Impairs interaction with histones H3 and H4. 1 Publication | 1 | |
Mutagenesisi | 220 | S → A: Abolishes interaction with histones H3 and H4. 1 Publication | 1 | |
Mutagenesisi | 222 | Y → A or S: Abolishes interaction with histones H3 and H4. 2 Publications | 1 | |
Mutagenesisi | 222 | Y → E: Abolishes interaction with histone H3.3. 2 Publications | 1 | |
Mutagenesisi | 225 | E → L: Impairs interaction with histones H3 and H4. 1 Publication | 1 | |
Mutagenesisi | 229 | K → A or L: Impairs interaction with histones H3 and H4. 1 Publication | 1 | |
Mutagenesisi | 251 | R → A: Abolishes interaction with histones H3 and H4. 1 Publication | 1 | |
Mutagenesisi | 317 | F → A: Abolishes interaction with histones H3 and H4. 1 Publication | 1 | |
Mutagenesisi | 328 | R → A: Abolishes interaction with histones H3 and H4. 1 Publication | 1 | |
Mutagenesisi | 331 | D → A: Abolishes interaction with histones H3 and H4. 1 Publication | 1 | |
Mutagenesisi | 630 | K → A: Abolishes sumoylation; when associated with A-631. 1 Publication | 1 | |
Mutagenesisi | 631 | K → A: Abolishes sumoylation; when associated with A-630. 1 Publication | 1 | |
Mutagenesisi | 668 | S → A: No translocation to the cytosol upon glucose deprivation. 1 Publication | 1 | |
Mutagenesisi | 671 | S → A: No effect on cytosol translocation. upon glucose deprivation. 1 Publication | 1 | |
Mutagenesisi | 733 – 740 | Missing : Abolishes sumoylation. 1 Publication | 8 |
Organism-specific databases
DisGeNETi | 1616 |
MalaCardsi | DAXX |
OpenTargetsi | ENSG00000204209 |
Orphaneti | 100075, Neuroendocrine tumor of stomach |
PharmGKBi | PA27148 |
Miscellaneous databases
Pharosi | Q9UER7, Tbio |
Genetic variation databases
BioMutai | DAXX |
DMDMi | 24636785 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000151258 | 1 – 740 | Death domain-associated protein 6Add BLAST | 740 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Cross-linki | 142 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 178 | PhosphoserineCombined sources | 1 | |
Modified residuei | 213 | PhosphoserineCombined sources | 1 | |
Modified residuei | 412 | PhosphoserineCombined sources | 1 | |
Modified residuei | 424 | PhosphoserineCombined sources | 1 | |
Modified residuei | 459 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 495 | PhosphoserineCombined sources | 1 | |
Modified residuei | 498 | PhosphoserineBy similarity | 1 | |
Modified residuei | 512 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 561 | PhosphoserineBy similarity | 1 | |
Modified residuei | 580 | PhosphoserineBy similarity | 1 | |
Cross-linki | 630 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication | ||
Cross-linki | 631 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication | ||
Modified residuei | 668 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 671 | PhosphoserineCombined sources | 1 | |
Modified residuei | 688 | PhosphoserineCombined sources | 1 | |
Modified residuei | 702 | PhosphoserineCombined sources | 1 | |
Modified residuei | 737 | PhosphoserineCombined sources | 1 | |
Modified residuei | 739 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UER7 |
jPOSTi | Q9UER7 |
MassIVEi | Q9UER7 |
PaxDbi | Q9UER7 |
PeptideAtlasi | Q9UER7 |
PRIDEi | Q9UER7 |
ProteomicsDBi | 25260 84150 [Q9UER7-1] 84151 [Q9UER7-2] |
PTM databases
iPTMneti | Q9UER7 |
PhosphoSitePlusi | Q9UER7 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000204209, Expressed in granulocyte and 234 other tissues |
ExpressionAtlasi | Q9UER7, baseline and differential |
Genevisiblei | Q9UER7, HS |
Organism-specific databases
HPAi | ENSG00000204209, Low tissue specificity |
Interactioni
Subunit structurei
Homomultimer.
Interacts (via C-terminus) with TNFRSF6 (via death domain).
Interacts with PAX5, SLC2A4/GLUT4, MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC, ETS1, sumoylated PML, UBE2I, MCRS1 and TP53.
Interacts (via N-terminus) with HIPK2 and HIPK3.
Interacts with HIPK1, which induces translocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1.
Interacts (non-phosphorylated) with PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and histones H2A, H2B, H3, H3.3 and H4.
Interacts with SPOP; mediating CUL3-dependent proteosomal degradation.
Interacts with CBP; the interaction is dependent the sumoylation of CBP and suppresses CBP transcriptional activity via recruitment of HDAC2 directly in the complex with TP53 and HIPK2.
Interacts with AXIN1; the interaction stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 on and induces cell death on UV irradiation.
Interacts with MDM2; the interaction is direct.
Interacts with USP7; the interaction is direct and independent of MDM2 and TP53.
Part of a complex with DAXX, MDM2 and USP7 under non-stress conditions.
Interacts (via N-terminus) with RASSF1 (via C-terminus); the interaction is independent of MDM2 and TP53; RASSF1 isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Interacts with ATRX to form the chromatin remodeling complex ATRX:DAXX.
Interacts with HSF1 (via homotrimeric form preferentially); this interaction relieves homotrimeric HSF1 from repression of its transcriptional activity by HSP90-dependent multichaperone complex upon heat shock (PubMed:15016915).
Interacts with SUMO1P1/SUMO5 (PubMed:27211601).
29 Publications(Microbial infection) Interacts with human cytomegalovirus/HHV-5 tegument phosphoprotein pp71 and protein UL123.
1 Publication(Microbial infection) Interacts with Epstein-Barr virus protein BNRF1.
1 Publication(Microbial infection) Interacts with human adenovirus 5 E1B-55K protein; this interaction might alterate the normal interactions of DAXX, PML, and TP53, which may contribute to cell transformation.
1 PublicationBinary interactionsi
Q9UER7
Isoform 1 [Q9UER7-1]
GO - Molecular functioni
- androgen receptor binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- heat shock protein binding Source: UniProtKB
- histone binding Source: UniProtKB
- p53 binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: ParkinsonsUK-UCL
- protein N-terminus binding Source: UniProtKB
- sumo-dependent protein binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107985, 276 interactors |
CORUMi | Q9UER7 |
DIPi | DIP-27628N |
IntActi | Q9UER7, 162 interactors |
MINTi | Q9UER7 |
STRINGi | 9606.ENSP00000363668 |
Miscellaneous databases
RNActi | Q9UER7, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9UER7 |
SMRi | Q9UER7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UER7 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 160 | Necessary for interaction with USP7 and ATRXAdd BLAST | 160 | |
Regioni | 183 – 417 | Interaction with histone H3.3Add BLAST | 235 | |
Regioni | 347 – 570 | Necessary for interaction with USP7Add BLAST | 224 | |
Regioni | 501 – 625 | Interaction with MAP3K5Add BLAST | 125 | |
Regioni | 626 – 740 | Interaction with SPOP1 PublicationAdd BLAST | 115 | |
Regioni | 733 – 740 | Sumo interaction motif (SIM) | 8 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 180 – 217 | Sequence analysisAdd BLAST | 38 | |
Coiled coili | 358 – 399 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 430 – 489 | Sequence analysisAdd BLAST | 60 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 391 – 395 | Nuclear localization signalSequence analysis | 5 | |
Motifi | 628 – 634 | Nuclear localization signalSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 16 | Poly-Asp | 6 | |
Compositional biasi | 434 – 572 | Asp/Glu-rich (acidic)Add BLAST | 139 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QRS6, Eukaryota |
GeneTreei | ENSGT00390000009448 |
HOGENOMi | CLU_022811_1_0_1 |
InParanoidi | Q9UER7 |
OMAi | AMMQDKS |
PhylomeDBi | Q9UER7 |
TreeFami | TF325803 |
Family and domain databases
CDDi | cd13151, DAXX_helical_bundle, 1 hit |
DisProti | DP00707 |
Gene3Di | 1.10.8.810, 1 hit |
IDEALi | IID00398 |
InterProi | View protein in InterPro IPR005012, Daxx IPR031333, Daxx_N IPR038298, Daxx_N_sf |
PANTHERi | PTHR12766:SF7, PTHR12766:SF7, 1 hit |
Pfami | View protein in Pfam PF03344, Daxx, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS SSEPHGARGS
60 70 80 90 100
SSSGGKKCYK LENEKLFEEF LELCKMQTAD HPEVVPFLYN RQQRAHSLFL
110 120 130 140 150
ASAEFCNILS RVLSRARSRP AKLYVYINEL CTVLKAHSAK KKLNLAPAAT
160 170 180 190 200
TSNEPSGNNP PTHLSLDPTN AENTASQSPR TRGSRRQIQR LEQLLALYVA
210 220 230 240 250
EIRRLQEKEL DLSELDDPDS AYLQEARLKR KLIRLFGRLC ELKDCSSLTG
260 270 280 290 300
RVIEQRIPYR GTRYPEVNRR IERLINKPGP DTFPDYGDVL RAVEKAAARH
310 320 330 340 350
SLGLPRQQLQ LMAQDAFRDV GIRLQERRHL DLIYNFGCHL TDDYRPGVDP
360 370 380 390 400
ALSDPVLARR LRENRSLAMS RLDEVISKYA MLQDKSEEGE RKKRRARLQG
410 420 430 440 450
TSSHSADTPE ASLDSGEGPS GMASQGCPSA SRAETDDEDD EESDEEEEEE
460 470 480 490 500
EEEEEEEATD SEEEEDLEQM QEGQEDDEEE DEEEEAAAGK DGDKSPMSSL
510 520 530 540 550
QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP SSIDAESNGE
560 570 580 590 600
QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV
610 620 630 640 650
LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE
660 670 680 690 700
RQRSVHEKNG KKICTLPSPP SPLASLAPVA DSSTRVDSPS HGLVTSSLCI
710 720 730 740
PSPARLSQTP HSQPPRPGTC KTSVATQCDP EEIIVLSDSD
The sequence of this isoform differs from the canonical sequence as follows:
653-688: RSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDS → SPAVPNPPFTASSAWYLQDKCGHTMRSRRDHRALRL
689-740: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
648-682: YVERQRSVHEKNGKKICTLPSPPSPLASLAPVADS → PAVPNPPFTASSAWYLQDKCGHTMRSRRDHRALRL
683-740: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ4VX54 | Q4VX54_HUMAN | Death domain-associated protein 6 | DAXX | 178 | Annotation score: | ||
A2AB94 | A2AB94_HUMAN | Death domain-associated protein 6 | DAXX | 48 | Annotation score: | ||
A0A0G2JJZ4 | A0A0G2JJZ4_HUMAN | Death domain-associated protein 6 | DAXX | 129 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 177 | Q → R in AAB66585 (PubMed:9407001).Curated | 1 | |
Sequence conflicti | 263 | R → H in AAC72843 (PubMed:10698492).Curated | 1 | |
Sequence conflicti | 323 | R → W in AAB66585 (PubMed:9407001).Curated | 1 | |
Sequence conflicti | 365 | R → Q in AAB66585 (PubMed:9407001).Curated | 1 | |
Sequence conflicti | 382 | L → S in AAB66585 (PubMed:9407001).Curated | 1 | |
Sequence conflicti | 505 | E → G in BAG64795 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 647 | S → R in CAB09986 (PubMed:14574404).Curated | 1 | |
Sequence conflicti | 647 | S → R in CAB09989 (PubMed:14574404).Curated | 1 | |
Sequence conflicti | 722 | T → A in CAB09986 (PubMed:14574404).Curated | 1 | |
Sequence conflicti | 722 | T → A in CAB09989 (PubMed:14574404).Curated | 1 | |
Sequence conflicti | 731 – 732 | EE → KK in AAC72843 (PubMed:10698492).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045588 | 1 – 75 | Missing in isoform 3. 1 PublicationAdd BLAST | 75 | |
Alternative sequenceiVSP_057437 | 648 – 682 | YVERQ…PVADS → PAVPNPPFTASSAWYLQDKC GHTMRSRRDHRALRL in isoform gamma. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_057438 | 653 – 688 | RSVHE…TRVDS → SPAVPNPPFTASSAWYLQDK CGHTMRSRRDHRALRL in isoform beta. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_057439 | 683 – 740 | Missing in isoform gamma. 1 PublicationAdd BLAST | 58 | |
Alternative sequenceiVSP_057440 | 689 – 740 | Missing in isoform beta. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_001270 | 696 – 740 | SSLCI…LSDSD → PAKNLGRRRSKQDQG in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF039136 mRNA Translation: AAB92671.1 AF006041 mRNA Translation: AAB63043.1 AF015956 mRNA Translation: AAB66585.2 AF050179 mRNA Translation: AAC39853.1 AF097742 mRNA Translation: AAC72843.1 HQ436528 mRNA Translation: AEC33235.1 HQ436529 mRNA Translation: AEC33236.1 AB015051 mRNA Translation: BAA34295.1 AK303854 mRNA Translation: BAG64795.1 CR457085 mRNA Translation: CAG33366.1 AL662820 Genomic DNA No translation available. AL662827 Genomic DNA No translation available. BX248088 Genomic DNA No translation available. CR759793 Genomic DNA No translation available. CR759786 Genomic DNA No translation available. CR759817 Genomic DNA No translation available. Z97183, Z97184 Genomic DNA Translation: CAB09986.2 Z97184, Z97183 Genomic DNA Translation: CAB09989.2 CH471081 Genomic DNA Translation: EAX03722.1 BC000220 mRNA Translation: AAH00220.1 BC109073 mRNA Translation: AAI09074.1 BC109074 mRNA Translation: AAI09075.1 |
CCDSi | CCDS4776.1 [Q9UER7-1] CCDS59008.1 [Q9UER7-3] |
PIRi | T03847 |
RefSeqi | NP_001135441.1, NM_001141969.1 [Q9UER7-1] NP_001241646.1, NM_001254717.1 [Q9UER7-3] NP_001341.1, NM_001350.4 [Q9UER7-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF039136 mRNA Translation: AAB92671.1 AF006041 mRNA Translation: AAB63043.1 AF015956 mRNA Translation: AAB66585.2 AF050179 mRNA Translation: AAC39853.1 AF097742 mRNA Translation: AAC72843.1 HQ436528 mRNA Translation: AEC33235.1 HQ436529 mRNA Translation: AEC33236.1 AB015051 mRNA Translation: BAA34295.1 AK303854 mRNA Translation: BAG64795.1 CR457085 mRNA Translation: CAG33366.1 AL662820 Genomic DNA No translation available. AL662827 Genomic DNA No translation available. BX248088 Genomic DNA No translation available. CR759793 Genomic DNA No translation available. CR759786 Genomic DNA No translation available. CR759817 Genomic DNA No translation available. Z97183, Z97184 Genomic DNA Translation: CAB09986.2 Z97184, Z97183 Genomic DNA Translation: CAB09989.2 CH471081 Genomic DNA Translation: EAX03722.1 BC000220 mRNA Translation: AAH00220.1 BC109073 mRNA Translation: AAI09074.1 BC109074 mRNA Translation: AAI09075.1 |
CCDSi | CCDS4776.1 [Q9UER7-1] CCDS59008.1 [Q9UER7-3] |
PIRi | T03847 |
RefSeqi | NP_001135441.1, NM_001141969.1 [Q9UER7-1] NP_001241646.1, NM_001254717.1 [Q9UER7-3] NP_001341.1, NM_001350.4 [Q9UER7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KQS | NMR | - | B | 721-740 | [»] | |
2KZS | NMR | - | A | 55-144 | [»] | |
2KZU | NMR | - | A | 55-144 | [»] | |
4H9N | X-ray | 1.95 | C | 178-389 | [»] | |
4H9O | X-ray | 2.05 | C | 178-389 | [»] | |
4H9P | X-ray | 2.20 | C | 178-389 | [»] | |
4H9Q | X-ray | 1.95 | C | 178-389 | [»] | |
4H9R | X-ray | 2.20 | C | 178-389 | [»] | |
4H9S | X-ray | 2.60 | E/F | 183-398 | [»] | |
4HGA | X-ray | 2.80 | A | 184-390 | [»] | |
5GRQ | X-ray | 1.58 | A | 55-144 | [»] | |
B | 55-143 | [»] | ||||
5KDM | X-ray | 3.50 | C | 178-389 | [»] | |
5Y18 | X-ray | 2.20 | A | 55-144 | [»] | |
5Y6O | X-ray | 3.10 | A/B/C/D/E/F/G/H/I | 50-144 | [»] | |
BMRBi | Q9UER7 | |||||
SMRi | Q9UER7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107985, 276 interactors |
CORUMi | Q9UER7 |
DIPi | DIP-27628N |
IntActi | Q9UER7, 162 interactors |
MINTi | Q9UER7 |
STRINGi | 9606.ENSP00000363668 |
PTM databases
iPTMneti | Q9UER7 |
PhosphoSitePlusi | Q9UER7 |
Genetic variation databases
BioMutai | DAXX |
DMDMi | 24636785 |
Proteomic databases
EPDi | Q9UER7 |
jPOSTi | Q9UER7 |
MassIVEi | Q9UER7 |
PaxDbi | Q9UER7 |
PeptideAtlasi | Q9UER7 |
PRIDEi | Q9UER7 |
ProteomicsDBi | 25260 84150 [Q9UER7-1] 84151 [Q9UER7-2] |
Protocols and materials databases
Antibodypediai | 1411, 993 antibodies |
DNASUi | 1616 |
Genome annotation databases
Organism-specific databases
CTDi | 1616 |
DisGeNETi | 1616 |
GeneCardsi | DAXX |
HGNCi | HGNC:2681, DAXX |
HPAi | ENSG00000204209, Low tissue specificity |
MalaCardsi | DAXX |
MIMi | 603186, gene |
neXtProti | NX_Q9UER7 |
OpenTargetsi | ENSG00000204209 |
Orphaneti | 100075, Neuroendocrine tumor of stomach |
PharmGKBi | PA27148 |
VEuPathDBi | HostDB:ENSG00000204209.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRS6, Eukaryota |
GeneTreei | ENSGT00390000009448 |
HOGENOMi | CLU_022811_1_0_1 |
InParanoidi | Q9UER7 |
OMAi | AMMQDKS |
PhylomeDBi | Q9UER7 |
TreeFami | TF325803 |
Enzyme and pathway databases
BRENDAi | 2.7.7.19, 2681 |
PathwayCommonsi | Q9UER7 |
Reactomei | R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-6804757, Regulation of TP53 Degradation R-HSA-9609690, HCMV Early Events R-HSA-9670095, Inhibition of DNA recombination at telomere R-HSA-9670613, Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670615, Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations |
SignaLinki | Q9UER7 |
SIGNORi | Q9UER7 |
Miscellaneous databases
BioGRID-ORCSi | 1616, 110 hits in 995 CRISPR screens |
ChiTaRSi | DAXX, human |
EvolutionaryTracei | Q9UER7 |
GeneWikii | Death-associated_protein_6 |
GenomeRNAii | 1616 |
Pharosi | Q9UER7, Tbio |
PROi | PR:Q9UER7 |
RNActi | Q9UER7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204209, Expressed in granulocyte and 234 other tissues |
ExpressionAtlasi | Q9UER7, baseline and differential |
Genevisiblei | Q9UER7, HS |
Family and domain databases
CDDi | cd13151, DAXX_helical_bundle, 1 hit |
DisProti | DP00707 |
Gene3Di | 1.10.8.810, 1 hit |
IDEALi | IID00398 |
InterProi | View protein in InterPro IPR005012, Daxx IPR031333, Daxx_N IPR038298, Daxx_N_sf |
PANTHERi | PTHR12766:SF7, PTHR12766:SF7, 1 hit |
Pfami | View protein in Pfam PF03344, Daxx, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DAXX_HUMAN | |
Accessioni | Q9UER7Primary (citable) accession number: Q9UER7 Secondary accession number(s): B4E1I3 Q9BWI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 2002 |
Last sequence update: | November 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 207 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families