We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q9UEE9 (CFDP1_HUMAN)
Protein
Craniofacial development protein 1
Gene
CFDP1
Organism
Homo sapiens (Human)
Status
Functioni
May play a role during embryogenesis.
By similarityGO - Biological processi
- cell adhesion Source: Ensembl
- chromatin remodeling Source: GO_Central
- negative regulation of fibroblast apoptotic process Source: Ensembl
- regulation of cell population proliferation Source: Ensembl
- regulation of cell shape Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | Q9UEE9 |
SignaLinki | Q9UEE9 |
Names & Taxonomyi
Protein namesi | Recommended name: Craniofacial development protein 1Alternative name(s): Bucentaur |
Gene namesi | Name:CFDP1 Synonyms:BCNT, CENP-29 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1873, CFDP1 |
MIMi | 608108, gene |
neXtProti | NX_Q9UEE9 |
VEuPathDBi | HostDB:ENSG00000153774 |
Subcellular locationi
Other locations
- kinetochore 1 Publication
Nucleus
- nucleus Source: GO_Central
- Swr1 complex Source: GO_Central
Other locations
- kinetochore Source: UniProtKB-KW
Keywords - Cellular componenti
Centromere, Chromosome, KinetochorePathology & Biotechi
Organism-specific databases
DisGeNETi | 10428 |
OpenTargetsi | ENSG00000153774 |
PharmGKBi | PA26422 |
Miscellaneous databases
Pharosi | Q9UEE9, Tbio |
Genetic variation databases
BioMutai | CFDP1 |
DMDMi | 74734998 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212494 | 1 – 299 | Craniofacial development protein 1Add BLAST | 299 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 82 | PhosphoserineBy similarity | 1 | |
Modified residuei | 85 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | PhosphoserineBy similarity | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Cross-linki | 150 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 216 | PhosphoserineCombined sources | 1 | |
Modified residuei | 219 | N6-methyllysineCombined sources | 1 | |
Modified residuei | 250 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by CK2 (casein kinase II) in vitro.1 Publication
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UEE9 |
jPOSTi | Q9UEE9 |
MassIVEi | Q9UEE9 |
MaxQBi | Q9UEE9 |
PaxDbi | Q9UEE9 |
PeptideAtlasi | Q9UEE9 |
PRIDEi | Q9UEE9 |
ProteomicsDBi | 84142 [Q9UEE9-1] 84143 [Q9UEE9-2] |
PTM databases
iPTMneti | Q9UEE9 |
MetOSitei | Q9UEE9 |
PhosphoSitePlusi | Q9UEE9 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000153774, Expressed in testis and 246 other tissues |
ExpressionAtlasi | Q9UEE9, baseline and differential |
Genevisiblei | Q9UEE9, HS |
Organism-specific databases
HPAi | ENSG00000153774, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115697, 58 interactors |
IntActi | Q9UEE9, 21 interactors |
MINTi | Q9UEE9 |
STRINGi | 9606.ENSP00000283882 |
Miscellaneous databases
RNActi | Q9UEE9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 218 – 299 | BCNT-CPROSITE-ProRule annotationAdd BLAST | 82 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 156 | DisorderedSequence analysisAdd BLAST | 156 | |
Regioni | 178 – 217 | HydrophilicAdd BLAST | 40 | |
Regioni | 192 – 224 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 23 | Acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 71 – 97 | Acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 98 – 115 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 131 – 156 | Basic and acidic residuesSequence analysisAdd BLAST | 26 |
Phylogenomic databases
eggNOGi | KOG4776, Eukaryota |
GeneTreei | ENSGT00390000018141 |
HOGENOMi | CLU_080190_0_0_1 |
InParanoidi | Q9UEE9 |
OMAi | LDWAAYV |
OrthoDBi | 1372508at2759 |
PhylomeDBi | Q9UEE9 |
TreeFami | TF313182 |
Family and domain databases
InterProi | View protein in InterPro IPR011421, BCNT-C IPR027124, Swc5/CFDP1/2 |
PANTHERi | PTHR23227, PTHR23227, 1 hit |
Pfami | View protein in Pfam PF07572, BCNT, 1 hit |
PROSITEi | View protein in PROSITE PS51279, BCNT_C, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UEE9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEFDSEDFS TSEEDEDYVP SGGEYSEDDV NELVKEDEVD GEEQTQKTQG
60 70 80 90 100
KKRKAQSIPA RKRRQGGLSL EEEEEEDANS ESEGSSSEEE DDAAEQEKGI
110 120 130 140 150
GSEDARKKKE DELWASFLND VGPKSKVPPS TQVKKGEETE ETSSSKLLVK
160 170 180 190 200
AEELEKPKET EKVKITKVFD FAGEEVRVTK EVDATSKEAK SFFKQNEKEK
210 220 230 240 250
PQANVPSALP SLPAGSGLKR SSGMSSLLGK IGAKKQKMST LEKSKLDWES
260 270 280 290
FKEEEGIGEE LAIHNRGKEG YIERKAFLDR VDHRQFEIER DLRLSKMKP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BQ17 | H3BQ17_HUMAN | Craniofacial development protein 1 | CFDP1 | 50 | Annotation score: | ||
A0A087WXQ2 | A0A087WXQ2_HUMAN | Craniofacial development protein 1 | CFDP1 | 17 | Annotation score: | ||
J3KT89 | J3KT89_HUMAN | Craniofacial development protein 1 | CFDP1 | 19 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 – 24 | GE → IP in BAA20070 (PubMed:9006920).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048408 | 60 | A → T. Corresponds to variant dbSNP:rs16963331Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016242 | 218 – 299 | Missing in isoform 2. 1 PublicationAdd BLAST | 82 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D85939 mRNA Translation: BAA20069.1 D86549 mRNA Translation: BAA20070.1 AB004907 Genomic DNA Translation: BAA31860.1 AB009269 Genomic DNA Translation: BAA31864.1 AB009270 Genomic DNA Translation: BAA31865.1 AB009285 mRNA Translation: BAA31867.1 BT009819 mRNA Translation: AAP88821.1 CR542111 mRNA Translation: CAG46908.1 BC000991 mRNA Translation: AAH00991.1 |
CCDSi | CCDS10916.1 [Q9UEE9-1] |
RefSeqi | NP_006315.1, NM_006324.2 [Q9UEE9-1] |
Genome annotation databases
Ensembli | ENST00000283882.4; ENSP00000283882.3; ENSG00000153774.9 |
GeneIDi | 10428 |
KEGGi | hsa:10428 |
MANE-Selecti | ENST00000283882.4; ENSP00000283882.3; NM_006324.3; NP_006315.1 |
UCSCi | uc002fdy.4, human [Q9UEE9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D85939 mRNA Translation: BAA20069.1 D86549 mRNA Translation: BAA20070.1 AB004907 Genomic DNA Translation: BAA31860.1 AB009269 Genomic DNA Translation: BAA31864.1 AB009270 Genomic DNA Translation: BAA31865.1 AB009285 mRNA Translation: BAA31867.1 BT009819 mRNA Translation: AAP88821.1 CR542111 mRNA Translation: CAG46908.1 BC000991 mRNA Translation: AAH00991.1 |
CCDSi | CCDS10916.1 [Q9UEE9-1] |
RefSeqi | NP_006315.1, NM_006324.2 [Q9UEE9-1] |
3D structure databases
AlphaFoldDBi | Q9UEE9 |
SMRi | Q9UEE9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115697, 58 interactors |
IntActi | Q9UEE9, 21 interactors |
MINTi | Q9UEE9 |
STRINGi | 9606.ENSP00000283882 |
PTM databases
iPTMneti | Q9UEE9 |
MetOSitei | Q9UEE9 |
PhosphoSitePlusi | Q9UEE9 |
Genetic variation databases
BioMutai | CFDP1 |
DMDMi | 74734998 |
Proteomic databases
EPDi | Q9UEE9 |
jPOSTi | Q9UEE9 |
MassIVEi | Q9UEE9 |
MaxQBi | Q9UEE9 |
PaxDbi | Q9UEE9 |
PeptideAtlasi | Q9UEE9 |
PRIDEi | Q9UEE9 |
ProteomicsDBi | 84142 [Q9UEE9-1] 84143 [Q9UEE9-2] |
Protocols and materials databases
Antibodypediai | 30309, 265 antibodies from 26 providers |
DNASUi | 10428 |
Genome annotation databases
Ensembli | ENST00000283882.4; ENSP00000283882.3; ENSG00000153774.9 |
GeneIDi | 10428 |
KEGGi | hsa:10428 |
MANE-Selecti | ENST00000283882.4; ENSP00000283882.3; NM_006324.3; NP_006315.1 |
UCSCi | uc002fdy.4, human [Q9UEE9-1] |
Organism-specific databases
CTDi | 10428 |
DisGeNETi | 10428 |
GeneCardsi | CFDP1 |
HGNCi | HGNC:1873, CFDP1 |
HPAi | ENSG00000153774, Low tissue specificity |
MIMi | 608108, gene |
neXtProti | NX_Q9UEE9 |
OpenTargetsi | ENSG00000153774 |
PharmGKBi | PA26422 |
VEuPathDBi | HostDB:ENSG00000153774 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4776, Eukaryota |
GeneTreei | ENSGT00390000018141 |
HOGENOMi | CLU_080190_0_0_1 |
InParanoidi | Q9UEE9 |
OMAi | LDWAAYV |
OrthoDBi | 1372508at2759 |
PhylomeDBi | Q9UEE9 |
TreeFami | TF313182 |
Enzyme and pathway databases
PathwayCommonsi | Q9UEE9 |
SignaLinki | Q9UEE9 |
Miscellaneous databases
BioGRID-ORCSi | 10428, 334 hits in 1087 CRISPR screens |
ChiTaRSi | CFDP1, human |
GeneWikii | CFDP1 |
GenomeRNAii | 10428 |
Pharosi | Q9UEE9, Tbio |
PROi | PR:Q9UEE9 |
RNActi | Q9UEE9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153774, Expressed in testis and 246 other tissues |
ExpressionAtlasi | Q9UEE9, baseline and differential |
Genevisiblei | Q9UEE9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011421, BCNT-C IPR027124, Swc5/CFDP1/2 |
PANTHERi | PTHR23227, PTHR23227, 1 hit |
Pfami | View protein in Pfam PF07572, BCNT, 1 hit |
PROSITEi | View protein in PROSITE PS51279, BCNT_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CFDP1_HUMAN | |
Accessioni | Q9UEE9Primary (citable) accession number: Q9UEE9 Secondary accession number(s): O00393 Q9UEF8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot