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Protein

Serine/threonine-protein kinase 17A

Gene

STK17A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Inhibited by thiazolidinedione-type compounds: inhibited by furan- and pyridone- thiazolidinediones.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90ATP1
Active sitei186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 75ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9UEE5
SIGNORiQ9UEE5

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 17A (EC:2.7.11.1)
Alternative name(s):
DAP kinase-related apoptosis-inducing protein kinase 1
Gene namesi
Name:STK17A
Synonyms:DRAK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164543.5
HGNCiHGNC:11395 STK17A
MIMi604726 gene
neXtProtiNX_Q9UEE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi90K → A: Loss of activity and of apoptotic function. 1 Publication1

Organism-specific databases

DisGeNETi9263
OpenTargetsiENSG00000164543
PharmGKBiPA36203

Chemistry databases

ChEMBLiCHEMBL4525
GuidetoPHARMACOLOGYi2214

Polymorphism and mutation databases

BioMutaiSTK17A
DMDMi317373279

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867041 – 414Serine/threonine-protein kinase 17AAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UEE5
MaxQBiQ9UEE5
PaxDbiQ9UEE5
PeptideAtlasiQ9UEE5
PRIDEiQ9UEE5
ProteomicsDBi84141

PTM databases

iPTMnetiQ9UEE5
PhosphoSitePlusiQ9UEE5

Expressioni

Tissue specificityi

Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas.1 Publication

Inductioni

Directly regulated by p53/TP53: induced following cisplatin treatment in a p53/TP53-dependent manner. p53/TP53 activates expression by directly binding to its regulatory regions.2 Publications

Gene expression databases

BgeeiENSG00000164543 Expressed in 222 organ(s), highest expression level in tonsil
CleanExiHS_STK17A
GenevisibleiQ9UEE5 HS

Organism-specific databases

HPAiHPA018138
HPA037979

Interactioni

Protein-protein interaction databases

BioGridi114685, 2 interactors
IntActiQ9UEE5, 4 interactors
STRINGi9606.ENSP00000319192

Chemistry databases

BindingDBiQ9UEE5

Structurei

3D structure databases

ProteinModelPortaliQ9UEE5
SMRiQ9UEE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 321Protein kinasePROSITE-ProRule annotationAdd BLAST261

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 37Poly-Pro5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118877
HOGENOMiHOG000233016
HOVERGENiHBG106718
InParanoidiQ9UEE5
KOiK08804
OMAiWVINLHE
OrthoDBiEOG091G0J2O
PhylomeDBiQ9UEE5
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UEE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPLEKPGSG GSSPGATSGS GRAGRGLSGP CRPPPPPQAR GLLTEIRAVV
60 70 80 90 100
RTEPFQDGYS LCPGRELGRG KFAVVRKCIK KDSGKEFAAK FMRKRRKGQD
110 120 130 140 150
CRMEIIHEIA VLELAQDNPW VINLHEVYET ASEMILVLEY AAGGEIFDQC
160 170 180 190 200
VADREEAFKE KDVQRLMRQI LEGVHFLHTR DVVHLDLKPQ NILLTSESPL
210 220 230 240 250
GDIKIVDFGL SRILKNSEEL REIMGTPEYV APEILSYDPI SMATDMWSIG
260 270 280 290 300
VLTYVMLTGI SPFLGNDKQE TFLNISQMNL SYSEEEFDVL SESAVDFIRT
310 320 330 340 350
LLVKKPEDRA TAEECLKHPW LTQSSIQEPS FRMEKALEEA NALQEGHSVP
360 370 380 390 400
EINSDTDKSE TKESIVTEEL IVVTSYTLGQ CRQSEKEKME QKAISKRFKF
410
EEPLLQEIPG EFIY
Length:414
Mass (Da):46,558
Last modified:January 11, 2011 - v2
Checksum:iE2140290492C2A10
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041145126E → D1 PublicationCorresponds to variant dbSNP:rs56286238Ensembl.1
Natural variantiVAR_041146167M → T1 PublicationCorresponds to variant dbSNP:rs35940029Ensembl.1
Natural variantiVAR_032823286E → Q1 PublicationCorresponds to variant dbSNP:rs3779062Ensembl.1
Natural variantiVAR_019991362K → E5 PublicationsCorresponds to variant dbSNP:rs1044141Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011420 mRNA Translation: BAA34126.1
CH236951 Genomic DNA Translation: EAL24008.1
AC005189 Genomic DNA No translation available.
AC011738 Genomic DNA No translation available.
AC093645 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW94162.1
BC023508 mRNA Translation: AAH23508.2
BC047696 mRNA Translation: AAH47696.1
CCDSiCCDS5470.1
RefSeqiNP_004751.2, NM_004760.2
UniGeneiHs.709489

Genome annotation databases

EnsembliENST00000319357; ENSP00000319192; ENSG00000164543
GeneIDi9263
KEGGihsa:9263
UCSCiuc003tih.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011420 mRNA Translation: BAA34126.1
CH236951 Genomic DNA Translation: EAL24008.1
AC005189 Genomic DNA No translation available.
AC011738 Genomic DNA No translation available.
AC093645 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW94162.1
BC023508 mRNA Translation: AAH23508.2
BC047696 mRNA Translation: AAH47696.1
CCDSiCCDS5470.1
RefSeqiNP_004751.2, NM_004760.2
UniGeneiHs.709489

3D structure databases

ProteinModelPortaliQ9UEE5
SMRiQ9UEE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114685, 2 interactors
IntActiQ9UEE5, 4 interactors
STRINGi9606.ENSP00000319192

Chemistry databases

BindingDBiQ9UEE5
ChEMBLiCHEMBL4525
GuidetoPHARMACOLOGYi2214

PTM databases

iPTMnetiQ9UEE5
PhosphoSitePlusiQ9UEE5

Polymorphism and mutation databases

BioMutaiSTK17A
DMDMi317373279

Proteomic databases

EPDiQ9UEE5
MaxQBiQ9UEE5
PaxDbiQ9UEE5
PeptideAtlasiQ9UEE5
PRIDEiQ9UEE5
ProteomicsDBi84141

Protocols and materials databases

DNASUi9263
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319357; ENSP00000319192; ENSG00000164543
GeneIDi9263
KEGGihsa:9263
UCSCiuc003tih.4 human

Organism-specific databases

CTDi9263
DisGeNETi9263
EuPathDBiHostDB:ENSG00000164543.5
GeneCardsiSTK17A
H-InvDBiHIX0019195
HIX0025491
HGNCiHGNC:11395 STK17A
HPAiHPA018138
HPA037979
MIMi604726 gene
neXtProtiNX_Q9UEE5
OpenTargetsiENSG00000164543
PharmGKBiPA36203
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118877
HOGENOMiHOG000233016
HOVERGENiHBG106718
InParanoidiQ9UEE5
KOiK08804
OMAiWVINLHE
OrthoDBiEOG091G0J2O
PhylomeDBiQ9UEE5
TreeFamiTF314166

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9UEE5
SIGNORiQ9UEE5

Miscellaneous databases

ChiTaRSiSTK17A human
GenomeRNAii9263
PROiPR:Q9UEE5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164543 Expressed in 222 organ(s), highest expression level in tonsil
CleanExiHS_STK17A
GenevisibleiQ9UEE5 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiST17A_HUMAN
AccessioniPrimary (citable) accession number: Q9UEE5
Secondary accession number(s): A4D1V6, Q8IVC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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