Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tripartite motif-containing protein 10

Gene

TRIM10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to play an important role in erythropoiesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 10
Alternative name(s):
B30-RING finger protein
RING finger protein 9
Gene namesi
Name:TRIM10
Synonyms:RFB30, RNF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204613.10
HGNCiHGNC:10072 TRIM10
MIMi605701 gene
neXtProtiNX_Q9UDY6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10107
OpenTargetsiENSG00000204613
PharmGKBiPA35536

Polymorphism and mutation databases

BioMutaiTRIM10
DMDMi50403805

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562111 – 481Tripartite motif-containing protein 10Add BLAST481

Proteomic databases

EPDiQ9UDY6
PaxDbiQ9UDY6
PeptideAtlasiQ9UDY6
PRIDEiQ9UDY6
ProteomicsDBi84134
84135 [Q9UDY6-2]

PTM databases

PhosphoSitePlusiQ9UDY6

Expressioni

Gene expression databases

BgeeiENSG00000204613 Expressed in 54 organ(s), highest expression level in liver
CleanExiHS_TRIM10
ExpressionAtlasiQ9UDY6 baseline and differential
GenevisibleiQ9UDY6 HS

Organism-specific databases

HPAiHPA043325

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115413, 26 interactors
IntActiQ9UDY6, 12 interactors
STRINGi9606.ENSP00000397073

Structurei

3D structure databases

ProteinModelPortaliQ9UDY6
SMRiQ9UDY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 481B30.2/SPRYPROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili150 – 177Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ9UDY6
KOiK12002
OMAiDEMQLCV
OrthoDBiEOG093708UY
PhylomeDBiQ9UDY6
TreeFamiTF342569

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Alpha (identifier: Q9UDY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD
60 70 80 90 100
LEESPTCPLC KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ
110 120 130 140 150
EHGEKIYFFC EDDEMQLCVV CREAGEHATH TMRFLEDAAA PYREQIHKCL
160 170 180 190 200
KCLRKEREEI QEIQSRENKR MQVLLTQVST KRQQVISEFA HLRKFLEEQQ
210 220 230 240 250
SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE EKNERPAREL
260 270 280 290 300
LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK
310 320 330 340 350
LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR
360 370 380 390 400
ATCVLAHTGI TGGRHTWVVS IDLAHGGSCT VGVVSEDVQR KGELRLRPEE
410 420 430 440 450
GVWAVRLAWG FVSALGSFPT RLTLKEQPRQ VRVSLDYEVG WVTFTNAVTR
460 470 480
EPIYTFTASF TRKVIPFFGL WGRGSSFSLS S
Length:481
Mass (Da):55,037
Last modified:July 19, 2004 - v3
Checksum:i49A1A11F391F5F98
GO
Isoform Beta (identifier: Q9UDY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-481: VSIDLAHGGS...GRGSSFSLSS → WMARVPGDSGCCQFCSPPSVLGTEVAA

Show »
Length:395
Mass (Da):45,252
Checksum:iEDEFCB7027B6C15D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104E → G in CAB52384 (PubMed:9271628).Curated1
Sequence conflicti104E → SR in AAG53495 (PubMed:11331580).Curated1
Sequence conflicti104E → SR in AAG53496 (PubMed:11331580).Curated1
Sequence conflicti167E → K in AAG53495 (PubMed:11331580).Curated1
Sequence conflicti167E → K in AAG53496 (PubMed:11331580).Curated1
Sequence conflicti336Y → S in CAB52384 (PubMed:9271628).Curated1
Sequence conflicti336Y → S in AAG53495 (PubMed:11331580).Curated1
Sequence conflicti377G → A in CAB52384 (PubMed:9271628).Curated1
Sequence conflicti377G → A in AAG53495 (PubMed:11331580).Curated1
Isoform Beta (identifier: Q9UDY6-2)
Sequence conflicti379C → G in AAG53496 (PubMed:11331580).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05212765R → H. Corresponds to variant dbSNP:rs12212092Ensembl.1
Natural variantiVAR_052128119V → M. Corresponds to variant dbSNP:rs17194446Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005748369 – 481VSIDL…FSLSS → WMARVPGDSGCCQFCSPPSV LGTEVAA in isoform Beta. 2 PublicationsAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07829 Genomic DNA Translation: CAB52384.1
AF220122 mRNA Translation: AAG53495.1
AF220123 mRNA Translation: AAG53496.1
AB202085 Genomic DNA Translation: BAE78605.1
AB103595 Genomic DNA Translation: BAF31256.1
BA000025 Genomic DNA Translation: BAB63332.1
AB088089 Genomic DNA Translation: BAC54921.1
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
AL844220 Genomic DNA No translation available.
BX005441 Genomic DNA No translation available.
BX927221 Genomic DNA No translation available.
CR753815 Genomic DNA No translation available.
CR759838 Genomic DNA No translation available.
CR788282 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03268.1
CH471081 Genomic DNA Translation: EAX03269.1
BC093926 mRNA Translation: AAH93926.1
BC113419 mRNA Translation: AAI13420.1
CCDSiCCDS34375.1 [Q9UDY6-1]
CCDS4676.1 [Q9UDY6-2]
RefSeqiNP_006769.2, NM_006778.3 [Q9UDY6-1]
NP_439893.2, NM_052828.2 [Q9UDY6-2]
UniGeneiHs.709483

Genome annotation databases

EnsembliENST00000259941; ENSP00000259941; ENSG00000137394 [Q9UDY6-2]
ENST00000354038; ENSP00000343695; ENSG00000137394 [Q9UDY6-1]
ENST00000376704; ENSP00000365894; ENSG00000204613 [Q9UDY6-2]
ENST00000413055; ENSP00000393787; ENSG00000227472 [Q9UDY6-2]
ENST00000416714; ENSP00000405578; ENSG00000229381 [Q9UDY6-2]
ENST00000417411; ENSP00000393576; ENSG00000237192 [Q9UDY6-2]
ENST00000426996; ENSP00000397440; ENSG00000227472 [Q9UDY6-1]
ENST00000428611; ENSP00000412370; ENSG00000229346 [Q9UDY6-2]
ENST00000431258; ENSP00000395598; ENSG00000235025 [Q9UDY6-1]
ENST00000446013; ENSP00000398404; ENSG00000237703 [Q9UDY6-2]
ENST00000447465; ENSP00000393976; ENSG00000235025 [Q9UDY6-2]
ENST00000448645; ENSP00000399446; ENSG00000229346 [Q9UDY6-1]
ENST00000449208; ENSP00000390497; ENSG00000237703 [Q9UDY6-1]
ENST00000449742; ENSP00000397073; ENSG00000204613 [Q9UDY6-1]
ENST00000451727; ENSP00000391445; ENSG00000237192 [Q9UDY6-1]
ENST00000456988; ENSP00000410849; ENSG00000229381 [Q9UDY6-1]
GeneIDi10107
KEGGihsa:10107
UCSCiuc003npn.3 human [Q9UDY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07829 Genomic DNA Translation: CAB52384.1
AF220122 mRNA Translation: AAG53495.1
AF220123 mRNA Translation: AAG53496.1
AB202085 Genomic DNA Translation: BAE78605.1
AB103595 Genomic DNA Translation: BAF31256.1
BA000025 Genomic DNA Translation: BAB63332.1
AB088089 Genomic DNA Translation: BAC54921.1
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
AL844220 Genomic DNA No translation available.
BX005441 Genomic DNA No translation available.
BX927221 Genomic DNA No translation available.
CR753815 Genomic DNA No translation available.
CR759838 Genomic DNA No translation available.
CR788282 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03268.1
CH471081 Genomic DNA Translation: EAX03269.1
BC093926 mRNA Translation: AAH93926.1
BC113419 mRNA Translation: AAI13420.1
CCDSiCCDS34375.1 [Q9UDY6-1]
CCDS4676.1 [Q9UDY6-2]
RefSeqiNP_006769.2, NM_006778.3 [Q9UDY6-1]
NP_439893.2, NM_052828.2 [Q9UDY6-2]
UniGeneiHs.709483

3D structure databases

ProteinModelPortaliQ9UDY6
SMRiQ9UDY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115413, 26 interactors
IntActiQ9UDY6, 12 interactors
STRINGi9606.ENSP00000397073

PTM databases

PhosphoSitePlusiQ9UDY6

Polymorphism and mutation databases

BioMutaiTRIM10
DMDMi50403805

Proteomic databases

EPDiQ9UDY6
PaxDbiQ9UDY6
PeptideAtlasiQ9UDY6
PRIDEiQ9UDY6
ProteomicsDBi84134
84135 [Q9UDY6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259941; ENSP00000259941; ENSG00000137394 [Q9UDY6-2]
ENST00000354038; ENSP00000343695; ENSG00000137394 [Q9UDY6-1]
ENST00000376704; ENSP00000365894; ENSG00000204613 [Q9UDY6-2]
ENST00000413055; ENSP00000393787; ENSG00000227472 [Q9UDY6-2]
ENST00000416714; ENSP00000405578; ENSG00000229381 [Q9UDY6-2]
ENST00000417411; ENSP00000393576; ENSG00000237192 [Q9UDY6-2]
ENST00000426996; ENSP00000397440; ENSG00000227472 [Q9UDY6-1]
ENST00000428611; ENSP00000412370; ENSG00000229346 [Q9UDY6-2]
ENST00000431258; ENSP00000395598; ENSG00000235025 [Q9UDY6-1]
ENST00000446013; ENSP00000398404; ENSG00000237703 [Q9UDY6-2]
ENST00000447465; ENSP00000393976; ENSG00000235025 [Q9UDY6-2]
ENST00000448645; ENSP00000399446; ENSG00000229346 [Q9UDY6-1]
ENST00000449208; ENSP00000390497; ENSG00000237703 [Q9UDY6-1]
ENST00000449742; ENSP00000397073; ENSG00000204613 [Q9UDY6-1]
ENST00000451727; ENSP00000391445; ENSG00000237192 [Q9UDY6-1]
ENST00000456988; ENSP00000410849; ENSG00000229381 [Q9UDY6-1]
GeneIDi10107
KEGGihsa:10107
UCSCiuc003npn.3 human [Q9UDY6-1]

Organism-specific databases

CTDi10107
DisGeNETi10107
EuPathDBiHostDB:ENSG00000204613.10
GeneCardsiTRIM10
H-InvDBiHIX0032788
HGNCiHGNC:10072 TRIM10
HPAiHPA043325
MIMi605701 gene
neXtProtiNX_Q9UDY6
OpenTargetsiENSG00000204613
PharmGKBiPA35536
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ9UDY6
KOiK12002
OMAiDEMQLCV
OrthoDBiEOG093708UY
PhylomeDBiQ9UDY6
TreeFamiTF342569

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRSiTRIM10 human
GenomeRNAii10107
PROiPR:Q9UDY6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204613 Expressed in 54 organ(s), highest expression level in liver
CleanExiHS_TRIM10
ExpressionAtlasiQ9UDY6 baseline and differential
GenevisibleiQ9UDY6 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI10_HUMAN
AccessioniPrimary (citable) accession number: Q9UDY6
Secondary accession number(s): A6NF84
, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again