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Protein

DnaJ homolog subfamily B member 4

Gene

DNAJB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).1 Publication

GO - Molecular functioni

  • ATPase activator activity Source: UniProtKB
  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 4
Alternative name(s):
Heat shock 40 kDa protein 1 homolog
Short name:
HSP40 homolog
Short name:
Heat shock protein 40 homolog
Human liver DnaJ-like protein
Gene namesi
Name:DNAJB4
Synonyms:DNAJW, HLJ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162616.8
HGNCiHGNC:14886 DNAJB4
MIMi611327 gene
neXtProtiNX_Q9UDY4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11080
OpenTargetsiENSG00000162616
PharmGKBiPA27416

Polymorphism and mutation databases

BioMutaiDNAJB4
DMDMi8928155

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000710212 – 337DnaJ homolog subfamily B member 4Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UDY4
MaxQBiQ9UDY4
PaxDbiQ9UDY4
PeptideAtlasiQ9UDY4
PRIDEiQ9UDY4
ProteomicsDBi84132

PTM databases

iPTMnetiQ9UDY4
PhosphoSitePlusiQ9UDY4

Expressioni

Tissue specificityi

Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.1 Publication

Inductioni

By heat shock.1 Publication

Gene expression databases

BgeeiENSG00000162616 Expressed in 231 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_DNAJB4
ExpressionAtlasiQ9UDY4 baseline and differential
GenevisibleiQ9UDY4 HS

Organism-specific databases

HPAiCAB004995
HPA028383
HPA028385

Interactioni

Subunit structurei

Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116263, 67 interactors
IntActiQ9UDY4, 31 interactors
MINTiQ9UDY4
STRINGi9606.ENSP00000359799

Structurei

3D structure databases

ProteinModelPortaliQ9UDY4
SMRiQ9UDY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 70JPROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00760000118947
HOVERGENiHBG066727
InParanoidiQ9UDY4
KOiK09510
OMAiMDGRTIP
OrthoDBiEOG091G0DLS
PhylomeDBiQ9UDY4
TreeFamiTF105141

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UDY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKDYYCILG IEKGASDEDI KKAYRKQALK FHPDKNKSPQ AEEKFKEVAE
60 70 80 90 100
AYEVLSDPKK REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA
110 120 130 140 150
FFGGSNPFEI FFGRRMGGGR DSEEMEIDGD PFSAFGFSMN GYPRDRNSVG
160 170 180 190 200
PSRLKQDPPV IHELRVSLEE IYSGCTKRMK ISRKRLNADG RSYRSEDKIL
210 220 230 240 250
TIEIKKGWKE GTKITFPREG DETPNSIPAD IVFIIKDKDH PKFKRDGSNI
260 270 280 290 300
IYTAKISLRE ALCGCSINVP TLDGRNIPMS VNDIVKPGMR RRIIGYGLPF
310 320 330
PKNPDQRGDL LIEFEVSFPD TISSSSKEVL RKHLPAS
Length:337
Mass (Da):37,807
Last modified:May 1, 2000 - v1
Checksum:iC7A9C613F73BCDAC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUL4C9JUL4_HUMAN
DnaJ homolog subfamily B member 4
DNAJB4
172Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40992 mRNA Translation: AAC14483.2
AK313205 mRNA Translation: BAG36021.1
CH471059 Genomic DNA Translation: EAX06354.1
BC034721 mRNA Translation: AAH34721.1
U41290 Genomic DNA Translation: AAB07346.1 Frameshift.
CCDSiCCDS684.1
PIRiG02272
RefSeqiNP_001304028.1, NM_001317099.1
NP_001304029.1, NM_001317100.1
NP_001304030.1, NM_001317101.1
NP_001304031.1, NM_001317102.1
NP_001304032.1, NM_001317103.1
NP_008965.2, NM_007034.4
UniGeneiHs.13852
Hs.690049

Genome annotation databases

EnsembliENST00000370763; ENSP00000359799; ENSG00000162616
GeneIDi11080
KEGGihsa:11080
UCSCiuc001dij.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40992 mRNA Translation: AAC14483.2
AK313205 mRNA Translation: BAG36021.1
CH471059 Genomic DNA Translation: EAX06354.1
BC034721 mRNA Translation: AAH34721.1
U41290 Genomic DNA Translation: AAB07346.1 Frameshift.
CCDSiCCDS684.1
PIRiG02272
RefSeqiNP_001304028.1, NM_001317099.1
NP_001304029.1, NM_001317100.1
NP_001304030.1, NM_001317101.1
NP_001304031.1, NM_001317102.1
NP_001304032.1, NM_001317103.1
NP_008965.2, NM_007034.4
UniGeneiHs.13852
Hs.690049

3D structure databases

ProteinModelPortaliQ9UDY4
SMRiQ9UDY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116263, 67 interactors
IntActiQ9UDY4, 31 interactors
MINTiQ9UDY4
STRINGi9606.ENSP00000359799

PTM databases

iPTMnetiQ9UDY4
PhosphoSitePlusiQ9UDY4

Polymorphism and mutation databases

BioMutaiDNAJB4
DMDMi8928155

Proteomic databases

EPDiQ9UDY4
MaxQBiQ9UDY4
PaxDbiQ9UDY4
PeptideAtlasiQ9UDY4
PRIDEiQ9UDY4
ProteomicsDBi84132

Protocols and materials databases

DNASUi11080
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370763; ENSP00000359799; ENSG00000162616
GeneIDi11080
KEGGihsa:11080
UCSCiuc001dij.4 human

Organism-specific databases

CTDi11080
DisGeNETi11080
EuPathDBiHostDB:ENSG00000162616.8
GeneCardsiDNAJB4
HGNCiHGNC:14886 DNAJB4
HPAiCAB004995
HPA028383
HPA028385
MIMi611327 gene
neXtProtiNX_Q9UDY4
OpenTargetsiENSG00000162616
PharmGKBiPA27416
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00760000118947
HOVERGENiHBG066727
InParanoidiQ9UDY4
KOiK09510
OMAiMDGRTIP
OrthoDBiEOG091G0DLS
PhylomeDBiQ9UDY4
TreeFamiTF105141

Miscellaneous databases

ChiTaRSiDNAJB4 human
GeneWikiiDNAJB4
GenomeRNAii11080
PROiPR:Q9UDY4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162616 Expressed in 231 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_DNAJB4
ExpressionAtlasiQ9UDY4 baseline and differential
GenevisibleiQ9UDY4 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNJB4_HUMAN
AccessioniPrimary (citable) accession number: Q9UDY4
Secondary accession number(s): B2R824, Q13431
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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