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Protein

Mitochondrial fission process protein 1

Gene

MTFP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.2 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mitochondrial fission Source: UniProtKB
  • response to muscle activity Source: Ensembl

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission process protein 1
Alternative name(s):
Mitochondrial 18 kDa protein
Short name:
MTP18
Gene namesi
Name:MTFP1
Synonyms:MTP18
ORF Names:HSPC242, My022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000242114.5
HGNCiHGNC:26945 MTFP1
MIMi610235 gene
neXtProtiNX_Q9UDX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51537
OpenTargetsiENSG00000242114

Polymorphism and mutation databases

BioMutaiMTFP1
DMDMi52783151

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124111 – 166Mitochondrial fission process protein 1Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123N6-succinyllysineBy similarity1

Proteomic databases

EPDiQ9UDX5
PaxDbiQ9UDX5
PeptideAtlasiQ9UDX5
PRIDEiQ9UDX5
ProteomicsDBi84125
84126 [Q9UDX5-2]
TopDownProteomicsiQ9UDX5-1 [Q9UDX5-1]

PTM databases

iPTMnetiQ9UDX5
PhosphoSitePlusiQ9UDX5

Expressioni

Inductioni

Expression is regulated by the phosphatidylinositol (PI) 3-kinase pathway.1 Publication

Gene expression databases

BgeeiENSG00000242114 Expressed in 91 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ9UDX5 baseline and differential
GenevisibleiQ9UDX5 HS

Organism-specific databases

HPAiHPA077396

Interactioni

Protein-protein interaction databases

BioGridi119597, 13 interactors
IntActiQ9UDX5, 1 interactor
STRINGi9606.ENSP00000266263

Structurei

3D structure databases

ProteinModelPortaliQ9UDX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MTFP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3945 Eukaryota
ENOG4111JTM LUCA
GeneTreeiENSGT00390000004019
HOGENOMiHOG000293217
HOVERGENiHBG052517
InParanoidiQ9UDX5
KOiK17981
OMAiTINRICA
OrthoDBiEOG091G0PGM
PhylomeDBiQ9UDX5
TreeFamiTF324605

Family and domain databases

InterProiView protein in InterPro
IPR019560 Mitochondrial_18_kDa_protein_
PANTHERiPTHR11001 PTHR11001, 1 hit
PfamiView protein in Pfam
PF10558 MTP18, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UDX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEPQPRGAE RDLYRDTWVR YLGYANEVGE AFRSLVPAAV VWLSYGVASS
60 70 80 90 100
YVLADAIDKG KKAGEVPSPE AGRSARVTVA VVDTFVWQAL ASVAIPGFTI
110 120 130 140 150
NRVCAASLYV LGTATRWPLA VRKWTTTALG LLTIPIIIHP IDRSVDFLLD
160
SSLRKLYPTV GKPSSS
Length:166
Mass (Da):18,010
Last modified:May 1, 2000 - v1
Checksum:i447D3BA5CC1ACA2D
GO
Isoform 2 (identifier: Q9UDX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-166: PSPEAGRSAR...YPTVGKPSSS → GGFPPGLQPA...TWVGLSWTEA

Show »
Length:135
Mass (Da):14,513
Checksum:iBEE06B767A4D8585
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEN7F8WEN7_HUMAN
Mitochondrial fission process prote...
MTFP1
74Annotation score:
B5MC22B5MC22_HUMAN
Mitochondrial fission process prote...
MTFP1
143Annotation score:

Sequence cautioni

The sequence AAF36162 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAG43136 differs from that shown. Reason: Frameshift at positions 66 and 84.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92S → A in AAG43136 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04142567 – 166PSPEA…KPSSS → GGFPPGLQPAQALPNSGEAQ LLLIILWYLACASASCFMST SYSCQGMWTPGSLVSKDPGT WVGLSWTEA in isoform 2. CuratedAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151076 mRNA Translation: AAF36162.1 Sequence problems.
AF060924 mRNA Translation: AAG43136.1 Frameshift.
CR456345 mRNA Translation: CAG30231.1
AC004832 Genomic DNA Translation: AAF19257.1
BC001608 mRNA Translation: AAH01608.1
BC009300 mRNA Translation: AAH09300.1
BC014446 mRNA Translation: AAH14446.1
BC030989 mRNA Translation: AAH30989.1
BC038831 mRNA Translation: AAH38831.1
BC046132 mRNA Translation: AAH46132.1
CCDSiCCDS33634.1 [Q9UDX5-2]
CCDS33635.1 [Q9UDX5-1]
RefSeqiNP_001003704.1, NM_001003704.2 [Q9UDX5-2]
NP_057582.2, NM_016498.4 [Q9UDX5-1]
UniGeneiHs.713636

Genome annotation databases

EnsembliENST00000266263; ENSP00000266263; ENSG00000242114 [Q9UDX5-1]
ENST00000355143; ENSP00000347267; ENSG00000242114 [Q9UDX5-2]
GeneIDi51537
KEGGihsa:51537
UCSCiuc003ahw.3 human [Q9UDX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151076 mRNA Translation: AAF36162.1 Sequence problems.
AF060924 mRNA Translation: AAG43136.1 Frameshift.
CR456345 mRNA Translation: CAG30231.1
AC004832 Genomic DNA Translation: AAF19257.1
BC001608 mRNA Translation: AAH01608.1
BC009300 mRNA Translation: AAH09300.1
BC014446 mRNA Translation: AAH14446.1
BC030989 mRNA Translation: AAH30989.1
BC038831 mRNA Translation: AAH38831.1
BC046132 mRNA Translation: AAH46132.1
CCDSiCCDS33634.1 [Q9UDX5-2]
CCDS33635.1 [Q9UDX5-1]
RefSeqiNP_001003704.1, NM_001003704.2 [Q9UDX5-2]
NP_057582.2, NM_016498.4 [Q9UDX5-1]
UniGeneiHs.713636

3D structure databases

ProteinModelPortaliQ9UDX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119597, 13 interactors
IntActiQ9UDX5, 1 interactor
STRINGi9606.ENSP00000266263

PTM databases

iPTMnetiQ9UDX5
PhosphoSitePlusiQ9UDX5

Polymorphism and mutation databases

BioMutaiMTFP1
DMDMi52783151

Proteomic databases

EPDiQ9UDX5
PaxDbiQ9UDX5
PeptideAtlasiQ9UDX5
PRIDEiQ9UDX5
ProteomicsDBi84125
84126 [Q9UDX5-2]
TopDownProteomicsiQ9UDX5-1 [Q9UDX5-1]

Protocols and materials databases

DNASUi51537
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266263; ENSP00000266263; ENSG00000242114 [Q9UDX5-1]
ENST00000355143; ENSP00000347267; ENSG00000242114 [Q9UDX5-2]
GeneIDi51537
KEGGihsa:51537
UCSCiuc003ahw.3 human [Q9UDX5-1]

Organism-specific databases

CTDi51537
DisGeNETi51537
EuPathDBiHostDB:ENSG00000242114.5
GeneCardsiMTFP1
H-InvDBiHIX0213393
HGNCiHGNC:26945 MTFP1
HPAiHPA077396
MIMi610235 gene
neXtProtiNX_Q9UDX5
OpenTargetsiENSG00000242114
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3945 Eukaryota
ENOG4111JTM LUCA
GeneTreeiENSGT00390000004019
HOGENOMiHOG000293217
HOVERGENiHBG052517
InParanoidiQ9UDX5
KOiK17981
OMAiTINRICA
OrthoDBiEOG091G0PGM
PhylomeDBiQ9UDX5
TreeFamiTF324605

Miscellaneous databases

GeneWikiiMTP18
GenomeRNAii51537
PROiPR:Q9UDX5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242114 Expressed in 91 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ9UDX5 baseline and differential
GenevisibleiQ9UDX5 HS

Family and domain databases

InterProiView protein in InterPro
IPR019560 Mitochondrial_18_kDa_protein_
PANTHERiPTHR11001 PTHR11001, 1 hit
PfamiView protein in Pfam
PF10558 MTP18, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTFP1_HUMAN
AccessioniPrimary (citable) accession number: Q9UDX5
Secondary accession number(s): A6NFQ5, Q9H3K1, Q9P0N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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