UniProtKB - Q9UDX4 (S14L3_HUMAN)
Protein
SEC14-like protein 3
Gene
SEC14L3
Organism
Homo sapiens (Human)
Status
Functioni
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
GO - Molecular functioni
- lipid binding Source: UniProtKB-KW
Keywordsi
Biological process | Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UDX4 |
Names & Taxonomyi
Protein namesi | Recommended name: SEC14-like protein 3Alternative name(s): Tocopherol-associated protein 2 |
Gene namesi | Name:SEC14L3 Synonyms:TAP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18655, SEC14L3 |
MIMi | 612824, gene |
neXtProti | NX_Q9UDX4 |
VEuPathDBi | HostDB:ENSG00000100012.11 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 266629 |
OpenTargetsi | ENSG00000100012 |
PharmGKBi | PA134960743 |
Miscellaneous databases
Pharosi | Q9UDX4, Tbio |
Chemistry databases
DrugBanki | DB14003, alpha-Tocopherol acetate DB14001, alpha-Tocopherol succinate DB14002, D-alpha-Tocopherol acetate DB11635, Tocofersolan DB11251, Tocopherol DB00163, Vitamin E |
Genetic variation databases
BioMutai | SEC14L3 |
DMDMi | 29428056 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210758 | 1 – 400 | SEC14-like protein 3Add BLAST | 400 |
Proteomic databases
EPDi | Q9UDX4 |
jPOSTi | Q9UDX4 |
MassIVEi | Q9UDX4 |
PaxDbi | Q9UDX4 |
PeptideAtlasi | Q9UDX4 |
PRIDEi | Q9UDX4 |
ProteomicsDBi | 17097 19815 84124 [Q9UDX4-1] |
PTM databases
iPTMneti | Q9UDX4 |
PhosphoSitePlusi | Q9UDX4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100012, Expressed in bronchial epithelial cell and 45 other tissues |
ExpressionAtlasi | Q9UDX4, baseline and differential |
Genevisiblei | Q9UDX4, HS |
Organism-specific databases
HPAi | ENSG00000100012, Tissue enhanced (bone marrow, liver, thyroid gland) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129297, 5 interactors |
IntActi | Q9UDX4, 3 interactors |
STRINGi | 9606.ENSP00000215812 |
Miscellaneous databases
RNActi | Q9UDX4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UDX4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 249 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 174 | |
Domaini | 275 – 383 | GOLDPROSITE-ProRule annotationAdd BLAST | 109 |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000162077 |
HOGENOMi | CLU_014001_2_1_1 |
InParanoidi | Q9UDX4 |
OMAi | EMARVAF |
PhylomeDBi | Q9UDX4 |
TreeFami | TF313988 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf IPR009038, GOLD_dom IPR036598, GOLD_dom_sf |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF101576, SSF101576, 1 hit SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit PS50866, GOLD, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UDX4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ
60 70 80 90 100
KSEALLRKYM EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY
110 120 130 140 150
DIIGPLDPKG LLFSVTKQDL LKTKMRDCER ILHECDLQTE RLGKKIETIV
160 170 180 190 200
MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE NYPETLKFML IVKATKLFPV
210 220 230 240 250
GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ FGGTLTDPDG
260 270 280 290 300
NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG
310 320 330 340 350
CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED
360 370 380 390 400
GNLTCSEAGV YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C1Y0 | H7C1Y0_HUMAN | SEC14-like protein 3 | SEC14L3 | 231 | Annotation score: | ||
B5MC44 | B5MC44_HUMAN | SEC14-like protein 3 | SEC14L3 | 353 | Annotation score: | ||
F8WB08 | F8WB08_HUMAN | SEC14-like protein 3 | SEC14L3 | 51 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024627 | 103 | I → T1 PublicationCorresponds to variant dbSNP:rs4820853Ensembl. | 1 | |
Natural variantiVAR_024628 | 214 | R → H. Corresponds to variant dbSNP:rs2269961Ensembl. | 1 | |
Natural variantiVAR_022097 | 335 | D → E1 PublicationCorresponds to variant dbSNP:rs2240345Ensembl. | 1 | |
Natural variantiVAR_061787 | 364 | R → C. Corresponds to variant dbSNP:rs35764129Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045553 | 1 – 78 | MSGRV…WQPPE → M in isoform 3. CuratedAdd BLAST | 78 | |
Alternative sequenceiVSP_045554 | 1 – 59 | Missing in isoform 2. 1 PublicationAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY158086 mRNA Translation: AAO21870.1 AC004832 Genomic DNA Translation: AAF19258.1 BC101001 mRNA Translation: AAI01002.1 BC101002 mRNA Translation: AAI01003.1 BC101004 mRNA Translation: AAI01005.1 |
CCDSi | CCDS13877.1 [Q9UDX4-1] CCDS58800.1 [Q9UDX4-3] CCDS58801.1 [Q9UDX4-2] |
RefSeqi | NP_001244307.1, NM_001257378.1 [Q9UDX4-3] NP_001244308.1, NM_001257379.1 [Q9UDX4-2] NP_001244311.1, NM_001257382.1 [Q9UDX4-2] NP_777635.1, NM_174975.4 [Q9UDX4-1] |
Genome annotation databases
Ensembli | ENST00000215812; ENSP00000215812; ENSG00000100012 [Q9UDX4-1] ENST00000401751; ENSP00000383896; ENSG00000100012 [Q9UDX4-2] ENST00000402286; ENSP00000385004; ENSG00000100012 [Q9UDX4-3] ENST00000540910; ENSP00000439752; ENSG00000100012 [Q9UDX4-3] |
GeneIDi | 266629 |
KEGGi | hsa:266629 |
UCSCi | uc003ahy.4, human [Q9UDX4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY158086 mRNA Translation: AAO21870.1 AC004832 Genomic DNA Translation: AAF19258.1 BC101001 mRNA Translation: AAI01002.1 BC101002 mRNA Translation: AAI01003.1 BC101004 mRNA Translation: AAI01005.1 |
CCDSi | CCDS13877.1 [Q9UDX4-1] CCDS58800.1 [Q9UDX4-3] CCDS58801.1 [Q9UDX4-2] |
RefSeqi | NP_001244307.1, NM_001257378.1 [Q9UDX4-3] NP_001244308.1, NM_001257379.1 [Q9UDX4-2] NP_001244311.1, NM_001257382.1 [Q9UDX4-2] NP_777635.1, NM_174975.4 [Q9UDX4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UYB | X-ray | 1.50 | A | 1-400 | [»] | |
SMRi | Q9UDX4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 129297, 5 interactors |
IntActi | Q9UDX4, 3 interactors |
STRINGi | 9606.ENSP00000215812 |
Chemistry databases
DrugBanki | DB14003, alpha-Tocopherol acetate DB14001, alpha-Tocopherol succinate DB14002, D-alpha-Tocopherol acetate DB11635, Tocofersolan DB11251, Tocopherol DB00163, Vitamin E |
PTM databases
iPTMneti | Q9UDX4 |
PhosphoSitePlusi | Q9UDX4 |
Genetic variation databases
BioMutai | SEC14L3 |
DMDMi | 29428056 |
Proteomic databases
EPDi | Q9UDX4 |
jPOSTi | Q9UDX4 |
MassIVEi | Q9UDX4 |
PaxDbi | Q9UDX4 |
PeptideAtlasi | Q9UDX4 |
PRIDEi | Q9UDX4 |
ProteomicsDBi | 17097 19815 84124 [Q9UDX4-1] |
Protocols and materials databases
Antibodypediai | 59073, 42 antibodies |
Genome annotation databases
Ensembli | ENST00000215812; ENSP00000215812; ENSG00000100012 [Q9UDX4-1] ENST00000401751; ENSP00000383896; ENSG00000100012 [Q9UDX4-2] ENST00000402286; ENSP00000385004; ENSG00000100012 [Q9UDX4-3] ENST00000540910; ENSP00000439752; ENSG00000100012 [Q9UDX4-3] |
GeneIDi | 266629 |
KEGGi | hsa:266629 |
UCSCi | uc003ahy.4, human [Q9UDX4-1] |
Organism-specific databases
CTDi | 266629 |
DisGeNETi | 266629 |
GeneCardsi | SEC14L3 |
HGNCi | HGNC:18655, SEC14L3 |
HPAi | ENSG00000100012, Tissue enhanced (bone marrow, liver, thyroid gland) |
MIMi | 612824, gene |
neXtProti | NX_Q9UDX4 |
OpenTargetsi | ENSG00000100012 |
PharmGKBi | PA134960743 |
VEuPathDBi | HostDB:ENSG00000100012.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000162077 |
HOGENOMi | CLU_014001_2_1_1 |
InParanoidi | Q9UDX4 |
OMAi | EMARVAF |
PhylomeDBi | Q9UDX4 |
TreeFami | TF313988 |
Enzyme and pathway databases
PathwayCommonsi | Q9UDX4 |
Miscellaneous databases
BioGRID-ORCSi | 266629, 6 hits in 982 CRISPR screens |
GenomeRNAii | 266629 |
Pharosi | Q9UDX4, Tbio |
PROi | PR:Q9UDX4 |
RNActi | Q9UDX4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100012, Expressed in bronchial epithelial cell and 45 other tissues |
ExpressionAtlasi | Q9UDX4, baseline and differential |
Genevisiblei | Q9UDX4, HS |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf IPR009038, GOLD_dom IPR036598, GOLD_dom_sf |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF101576, SSF101576, 1 hit SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit PS50866, GOLD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S14L3_HUMAN | |
Accessioni | Q9UDX4Primary (citable) accession number: Q9UDX4 Secondary accession number(s): E7EN74 Q495W1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 28, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references