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UniProtKB - Q9UDX4 (S14L3_HUMAN)

Entry version 152 (07 Apr 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

SEC14-like protein 3

Gene

SEC14L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UDX4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SEC14-like protein 3
Alternative name(s):
Tocopherol-associated protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC14L3
Synonyms:TAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18655, SEC14L3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612824, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UDX4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100012.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		266629

Open Targets

More...OpenTargetsi		ENSG00000100012

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134960743

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UDX4, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB14003, alpha-Tocopherol acetate
DB14001, alpha-Tocopherol succinate
DB14002, D-alpha-Tocopherol acetate
DB11635, Tocofersolan
DB11251, Tocopherol
DB00163, Vitamin E

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SEC14L3

Domain mapping of disease mutations (DMDM)

More...DMDMi		29428056

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002107581 – 400SEC14-like protein 3Add BLAST400

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UDX4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UDX4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UDX4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UDX4

PeptideAtlas

More...PeptideAtlasi		Q9UDX4

PRoteomics IDEntifications database

More...PRIDEi		Q9UDX4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17097
19815
84124 [Q9UDX4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UDX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UDX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100012, Expressed in bronchial epithelial cell and 45 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UDX4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UDX4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100012, Tissue enhanced (bone marrow, liver, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129297, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q9UDX4, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000215812

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UDX4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UDX4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 249CRAL-TRIOPROSITE-ProRule annotationAdd BLAST174
Domaini275 – 383GOLDPROSITE-ProRule annotationAdd BLAST109

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1471, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014001_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UDX4

Identification of Orthologs from Complete Genome Data

More...OMAi		EMARVAF

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UDX4

TreeFam database of animal gene trees

More...TreeFami		TF313988

Family and domain databases

Conserved Domains Database

More...CDDi		cd00170, SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR036865, CRAL-TRIO_dom_sf
IPR011074, CRAL/TRIO_N_dom
IPR036273, CRAL/TRIO_N_dom_sf
IPR009038, GOLD_dom
IPR036598, GOLD_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00650, CRAL_TRIO, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01100, CRAL_TRIO_N, 1 hit
SM00516, SEC14, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101576, SSF101576, 1 hit
SSF46938, SSF46938, 1 hit
SSF52087, SSF52087, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50191, CRAL_TRIO, 1 hit
PS50866, GOLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UDX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ 
        60         70         80         90        100
KSEALLRKYM EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY 
       110        120        130        140        150
DIIGPLDPKG LLFSVTKQDL LKTKMRDCER ILHECDLQTE RLGKKIETIV 
       160        170        180        190        200
MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE NYPETLKFML IVKATKLFPV 
       210        220        230        240        250
GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ FGGTLTDPDG 
       260        270        280        290        300
NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG 
       310        320        330        340        350
CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED 
       360        370        380        390        400
GNLTCSEAGV YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV
Length:400
Mass (Da):46,048
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07F880D25B66CC19
GO
Isoform 2 (identifier: Q9UDX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Show »
Length:341
Mass (Da):39,174
Checksum:i831C914C0A5FE469
GO
Isoform 3 (identifier: Q9UDX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MSGRVGDLSP...DHILDWQPPE → M

Show »
Length:323
Mass (Da):36,922
Checksum:i0F9B9BBD477DF986
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1Y0H7C1Y0_HUMAN
SEC14-like protein 3
SEC14L3
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MC44B5MC44_HUMAN
SEC14-like protein 3
SEC14L3
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB08F8WB08_HUMAN
SEC14-like protein 3
SEC14L3
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024627103I → T1 PublicationCorresponds to variant dbSNP:rs4820853Ensembl.1
Natural variantiVAR_024628214R → H. Corresponds to variant dbSNP:rs2269961Ensembl.1
Natural variantiVAR_022097335D → E1 PublicationCorresponds to variant dbSNP:rs2240345Ensembl.1
Natural variantiVAR_061787364R → C. Corresponds to variant dbSNP:rs35764129Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0455531 – 78MSGRV…WQPPE → M in isoform 3. CuratedAdd BLAST78
Alternative sequenceiVSP_0455541 – 59Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY158086 mRNA Translation: AAO21870.1
AC004832 Genomic DNA Translation: AAF19258.1
BC101001 mRNA Translation: AAI01002.1
BC101002 mRNA Translation: AAI01003.1
BC101004 mRNA Translation: AAI01005.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13877.1 [Q9UDX4-1]
CCDS58800.1 [Q9UDX4-3]
CCDS58801.1 [Q9UDX4-2]

NCBI Reference Sequences

More...RefSeqi		NP_001244307.1, NM_001257378.1 [Q9UDX4-3]
NP_001244308.1, NM_001257379.1 [Q9UDX4-2]
NP_001244311.1, NM_001257382.1 [Q9UDX4-2]
NP_777635.1, NM_174975.4 [Q9UDX4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000215812; ENSP00000215812; ENSG00000100012 [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012 [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012 [Q9UDX4-3]
ENST00000540910; ENSP00000439752; ENSG00000100012 [Q9UDX4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		266629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:266629

UCSC genome browser

More...UCSCi		uc003ahy.4, human [Q9UDX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158086 mRNA Translation: AAO21870.1
AC004832 Genomic DNA Translation: AAF19258.1
BC101001 mRNA Translation: AAI01002.1
BC101002 mRNA Translation: AAI01003.1
BC101004 mRNA Translation: AAI01005.1
CCDSiCCDS13877.1 [Q9UDX4-1]
CCDS58800.1 [Q9UDX4-3]
CCDS58801.1 [Q9UDX4-2]
RefSeqiNP_001244307.1, NM_001257378.1 [Q9UDX4-3]
NP_001244308.1, NM_001257379.1 [Q9UDX4-2]
NP_001244311.1, NM_001257382.1 [Q9UDX4-2]
NP_777635.1, NM_174975.4 [Q9UDX4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UYBX-ray1.50A1-400[»]
SMRiQ9UDX4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi129297, 5 interactors
IntActiQ9UDX4, 3 interactors
STRINGi9606.ENSP00000215812

Chemistry databases

DrugBankiDB14003, alpha-Tocopherol acetate
DB14001, alpha-Tocopherol succinate
DB14002, D-alpha-Tocopherol acetate
DB11635, Tocofersolan
DB11251, Tocopherol
DB00163, Vitamin E

PTM databases

iPTMnetiQ9UDX4
PhosphoSitePlusiQ9UDX4

Genetic variation databases

BioMutaiSEC14L3
DMDMi29428056

Proteomic databases

EPDiQ9UDX4
jPOSTiQ9UDX4
MassIVEiQ9UDX4
PaxDbiQ9UDX4
PeptideAtlasiQ9UDX4
PRIDEiQ9UDX4
ProteomicsDBi17097
19815
84124 [Q9UDX4-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		59073, 42 antibodies

Genome annotation databases

EnsembliENST00000215812; ENSP00000215812; ENSG00000100012 [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012 [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012 [Q9UDX4-3]
ENST00000540910; ENSP00000439752; ENSG00000100012 [Q9UDX4-3]
GeneIDi266629
KEGGihsa:266629
UCSCiuc003ahy.4, human [Q9UDX4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		266629
DisGeNETi266629

GeneCards: human genes, protein and diseases

More...GeneCardsi		SEC14L3
HGNCiHGNC:18655, SEC14L3
HPAiENSG00000100012, Tissue enhanced (bone marrow, liver, thyroid gland)
MIMi612824, gene
neXtProtiNX_Q9UDX4
OpenTargetsiENSG00000100012
PharmGKBiPA134960743
VEuPathDBiHostDB:ENSG00000100012.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1471, Eukaryota
GeneTreeiENSGT00940000162077
HOGENOMiCLU_014001_2_1_1
InParanoidiQ9UDX4
OMAiEMARVAF
PhylomeDBiQ9UDX4
TreeFamiTF313988

Enzyme and pathway databases

PathwayCommonsiQ9UDX4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		266629, 6 hits in 982 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		266629
PharosiQ9UDX4, Tbio

Protein Ontology

More...PROi		PR:Q9UDX4
RNActiQ9UDX4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100012, Expressed in bronchial epithelial cell and 45 other tissues
ExpressionAtlasiQ9UDX4, baseline and differential
GenevisibleiQ9UDX4, HS

Family and domain databases

CDDicd00170, SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR036865, CRAL-TRIO_dom_sf
IPR011074, CRAL/TRIO_N_dom
IPR036273, CRAL/TRIO_N_dom_sf
IPR009038, GOLD_dom
IPR036598, GOLD_dom_sf
PfamiView protein in Pfam
PF00650, CRAL_TRIO, 1 hit
SMARTiView protein in SMART
SM01100, CRAL_TRIO_N, 1 hit
SM00516, SEC14, 1 hit
SUPFAMiSSF101576, SSF101576, 1 hit
SSF46938, SSF46938, 1 hit
SSF52087, SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191, CRAL_TRIO, 1 hit
PS50866, GOLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS14L3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UDX4
Secondary accession number(s): E7EN74
, E9PE57, Q495V8, Q495W0, Q495W1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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