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Protein

Zinc finger protein 212

Gene

ZNF212

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri316 – 338C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 212
Alternative name(s):
Zinc finger protein C2H2-150
Gene namesi
Name:ZNF212
Synonyms:ZNFC150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000170260.8
HGNCiHGNC:13004 ZNF212
MIMi602386 gene
neXtProtiNX_Q9UDV6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37583

Polymorphism and mutation databases

BioMutaiZNF212
DMDMi55977888

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474561 – 495Zinc finger protein 212Add BLAST495

Proteomic databases

EPDiQ9UDV6
MaxQBiQ9UDV6
PaxDbiQ9UDV6
PeptideAtlasiQ9UDV6
PRIDEiQ9UDV6
ProteomicsDBi84118

PTM databases

iPTMnetiQ9UDV6
PhosphoSitePlusiQ9UDV6

Expressioni

Gene expression databases

BgeeiENSG00000170260
CleanExiHS_ZNF212
ExpressionAtlasiQ9UDV6 baseline and differential
GenevisibleiQ9UDV6 HS

Organism-specific databases

HPAiHPA049807
HPA054178

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi113698, 35 interactors
IntActiQ9UDV6, 32 interactors
MINTiQ9UDV6

Structurei

3D structure databases

ProteinModelPortaliQ9UDV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 219KRABPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri316 – 338C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
ENOG41112W3 LUCA
GeneTreeiENSGT00530000063032
HOGENOMiHOG000013125
HOVERGENiHBG055724
InParanoidiQ9UDV6
KOiK09228
OMAiGQECGQG
OrthoDBiEOG091G0P6J
PhylomeDBiQ9UDV6
TreeFamiTF337777

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR022137 DUF3669_Znf
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF12417 DUF3669, 1 hit
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q9UDV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESAPARHR RKRRSTPLTS STLPSQATEK SSYFQTTEIS LWTVVAAIQA
60 70 80 90 100
VEKKMESQAA RLQSLEGRTG TAEKKLADCE KMAVEFGNQL EGKWAVLGTL
110 120 130 140 150
LQEYGLLQRR LENVENLLRN RNFWILRLPP GSKGEAPKVS RSLENDGVCF
160 170 180 190 200
TEQEWENLED WQKELYRNVM ESNYETLVSL KVLGQTEGEA ELGTEMLGDL
210 220 230 240 250
EEEGPGGAHP AGGVMIKQEL QYTQEGPADL PGEFSCIAEE QAFLSPEQTE
260 270 280 290 300
LWGGQGSSVL LETGPGDSTL EEPVGSRVPS SSRTVGCPKQ KSHRQVQLDQ
310 320 330 340 350
ECGQGLKLKK DTSRPYECSE CEITFRYKQQ LATHLRSHSG WGSCTPEEPE
360 370 380 390 400
ESLRPRPRLK PQTKKAKLHQ CDVCLRSFSC KVSLVTHQRC HLQEGPSAGQ
410 420 430 440 450
HVQERFSPNS LVALPGHIPW RKSRSSLICG YCGKSFSHPS DLVRHQRIHT
460 470 480 490
GERPYSCTEC EKSFVQKQHL LQHQKIHQRE RGGLALEPGR PNGLL
Length:495
Mass (Da):55,447
Last modified:November 23, 2004 - v3
Checksum:iAF0F7EEC8A482F8A
GO

Sequence cautioni

The sequence AAC51296 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAD45826 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052794293H → Y. Corresponds to variant dbSNP:rs34185245Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315086 mRNA Translation: BAG37551.1
AC004890 Genomic DNA Translation: AAD45826.2 Different initiation.
CH471146 Genomic DNA Translation: EAW80054.1
BC022785 mRNA Translation: AAH22785.2
U38864 mRNA Translation: AAC51296.1 Different initiation.
CCDSiCCDS5896.1
PIRiI39199
RefSeqiNP_036388.2, NM_012256.3
UniGeneiHs.490510

Genome annotation databases

EnsembliENST00000335870; ENSP00000338572; ENSG00000170260
GeneIDi7988
KEGGihsa:7988
UCSCiuc003wfp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN212_HUMAN
AccessioniPrimary (citable) accession number: Q9UDV6
Secondary accession number(s): B2RCF4, Q13396, Q8N664
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: July 18, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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