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Protein

Protein phosphatase 1 regulatory subunit 1B

Gene

PPP1R1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-180024 DARPP-32 events
SignaLinkiQ9UD71
SIGNORiQ9UD71

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1B
Alternative name(s):
DARPP-32
Dopamine- and cAMP-regulated neuronal phosphoprotein
Gene namesi
Name:PPP1R1B
Synonyms:DARPP32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131771.13
HGNCiHGNC:9287 PPP1R1B
MIMi604399 gene
neXtProtiNX_Q9UD71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi84152
OpenTargetsiENSG00000131771
PharmGKBiPA33639

Polymorphism and mutation databases

BioMutaiPPP1R1B
DMDMi23831292

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714731 – 204Protein phosphatase 1 regulatory subunit 1BAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei34Phosphothreonine; by PKABy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei75Phosphothreonine; by CDK51 Publication1
Modified residuei102PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1

Post-translational modificationi

Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
Phosphorylation of Thr-34 is required for activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UD71
PaxDbiQ9UD71
PeptideAtlasiQ9UD71
PRIDEiQ9UD71
ProteomicsDBi84112
84113 [Q9UD71-2]

PTM databases

iPTMnetiQ9UD71
PhosphoSitePlusiQ9UD71

Expressioni

Gene expression databases

BgeeiENSG00000131771
CleanExiHS_PPP1R1B
ExpressionAtlasiQ9UD71 baseline and differential
GenevisibleiQ9UD71 HS

Organism-specific databases

HPAiCAB004026
HPA048630
HPA061142

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123915, 7 interactors
ELMiQ9UD71
IntActiQ9UD71, 4 interactors
STRINGi9606.ENSP00000254079

Structurei

3D structure databases

ProteinModelPortaliQ9UD71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 136Asp/Glu-rich (acidic)Add BLAST18

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J1BH Eukaryota
ENOG4111TN1 LUCA
GeneTreeiENSGT00730000111283
HOGENOMiHOG000290193
HOVERGENiHBG099182
InParanoidiQ9UD71
KOiK15494
OMAiANPCAYT
OrthoDBiEOG091G0NO6
PhylomeDBiQ9UD71
TreeFamiTF332576

Family and domain databases

InterProiView protein in InterPro
IPR015670 DARPP-32
IPR008466 PPP1R1A/B/C
PANTHERiPTHR15417 PTHR15417, 1 hit
PTHR15417:SF2 PTHR15417:SF2, 1 hit
PfamiView protein in Pfam
PF05395 DARPP-32, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UD71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR LSEHSSPEEE
60 70 80 90 100
ASPHQRASGE GHHLKSKRPN PCAYTPPSLK AVQRIAESHL QSISNLNENQ
110 120 130 140 150
ASEEEDELGE LRELGYPREE DEEEEEDDEE EEEEEDSQAE VLKVIRQSAG
160 170 180 190 200
QKTTCGQGLE GPWERPPPLD ESERDGGSED QVEDPALSEP GEEPQRPSPS

EPGT
Length:204
Mass (Da):22,963
Last modified:October 10, 2002 - v2
Checksum:iE1CE7DDD29D2D4FB
GO
Isoform 2 (identifier: Q9UD71-2) [UniParc]FASTAAdd to basket
Also known as: t-DARPP

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:168
Mass (Da):18,738
Checksum:iF139B0673543BFE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155 – 157CGQ → RGL (PubMed:8120638).Curated3
Sequence conflicti204T → R (PubMed:8120638).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0051171 – 36Missing in isoform 2. 5 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464196 mRNA Translation: AAM76683.1
AY070271 mRNA Translation: AAL59016.1
AF435972 mRNA Translation: AAP35094.1
AF435973 mRNA Translation: AAP35095.1
AF435974 mRNA Translation: AAP35096.1
AF435975 Genomic DNA Translation: AAP35097.1
AF435975 Genomic DNA Translation: AAP35098.1
AK024593 mRNA Translation: BAB14931.1
BT007076 mRNA Translation: AAP35739.1
BC001519 mRNA Translation: AAH01519.1
CCDSiCCDS11339.1 [Q9UD71-1]
CCDS11340.1 [Q9UD71-2]
RefSeqiNP_001229393.1, NM_001242464.1 [Q9UD71-2]
NP_115568.2, NM_032192.3 [Q9UD71-1]
NP_852606.1, NM_181505.3 [Q9UD71-2]
XP_016880705.1, XM_017025216.1 [Q9UD71-1]
XP_016880706.1, XM_017025217.1 [Q9UD71-2]
UniGeneiHs.286192

Genome annotation databases

EnsembliENST00000254079; ENSP00000254079; ENSG00000131771 [Q9UD71-1]
ENST00000394265; ENSP00000377808; ENSG00000131771 [Q9UD71-2]
ENST00000394267; ENSP00000377810; ENSG00000131771 [Q9UD71-2]
ENST00000580825; ENSP00000462137; ENSG00000131771 [Q9UD71-1]
GeneIDi84152
KEGGihsa:84152
UCSCiuc002hrz.4 human [Q9UD71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiPPR1B_HUMAN
AccessioniPrimary (citable) accession number: Q9UD71
Secondary accession number(s): Q547V9, Q547W0, Q9H7G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 10, 2002
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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