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UniProtKB - Q9UD71 (PPR1B_HUMAN)
Protein
Protein phosphatase 1 regulatory subunit 1B
Gene
PPP1R1B
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitor of protein-phosphatase 1.
GO - Molecular functioni
- cAMP-dependent protein kinase inhibitor activity Source: Reactome
- protein kinase inhibitor activity Source: UniProtKB
- protein phosphatase inhibitor activity Source: CAFA
- protein phosphatase regulator activity Source: Reactome
GO - Biological processi
- behavioral response to cocaine Source: Ensembl
- cellular response to cocaine Source: Ensembl
- intracellular signal transduction Source: GO_Central
- locomotory behavior Source: Ensembl
- negative regulation of female receptivity Source: Ensembl
- negative regulation of phosphoprotein phosphatase activity Source: CAFA
- response to amphetamine Source: Ensembl
- response to morphine Source: Ensembl
- signal transduction Source: UniProtKB
- transcription, DNA-templated Source: Ensembl
- visual learning Source: Ensembl
Keywordsi
Molecular function | Protein phosphatase inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q9UD71 |
Reactomei | R-HSA-180024, DARPP-32 events |
SignaLinki | Q9UD71 |
SIGNORi | Q9UD71 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 1BAlternative name(s): DARPP-32 Dopamine- and cAMP-regulated neuronal phosphoprotein |
Gene namesi | Name:PPP1R1B Synonyms:DARPP32 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9287, PPP1R1B |
MIMi | 604399, gene |
neXtProti | NX_Q9UD71 |
VEuPathDBi | HostDB:ENSG00000131771 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
- neuronal cell body Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 84152 |
OpenTargetsi | ENSG00000131771 |
PharmGKBi | PA33639 |
Miscellaneous databases
Pharosi | Q9UD71, Tbio |
Genetic variation databases
BioMutai | PPP1R1B |
DMDMi | 23831292 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071473 | 1 – 204 | Protein phosphatase 1 regulatory subunit 1BAdd BLAST | 204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 34 | Phosphothreonine; by PKABy similarity | 1 | |
Modified residuei | 45 | PhosphoserineBy similarity | 1 | |
Modified residuei | 46 | PhosphoserineBy similarity | 1 | |
Modified residuei | 75 | Phosphothreonine; by CDK51 Publication | 1 | |
Modified residuei | 102 | PhosphoserineBy similarity | 1 | |
Modified residuei | 137 | PhosphoserineBy similarity | 1 | |
Modified residuei | 198 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
Phosphorylation of Thr-34 is required for activity.By similarity
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9UD71 |
jPOSTi | Q9UD71 |
MassIVEi | Q9UD71 |
MaxQBi | Q9UD71 |
PaxDbi | Q9UD71 |
PeptideAtlasi | Q9UD71 |
PRIDEi | Q9UD71 |
ProteomicsDBi | 84112 [Q9UD71-1] 84113 [Q9UD71-2] |
PTM databases
iPTMneti | Q9UD71 |
PhosphoSitePlusi | Q9UD71 |
Expressioni
Gene expression databases
Bgeei | ENSG00000131771, Expressed in caudate nucleus and 166 other tissues |
ExpressionAtlasi | Q9UD71, baseline and differential |
Genevisiblei | Q9UD71, HS |
Organism-specific databases
HPAi | ENSG00000131771, Group enriched (brain, choroid plexus, intestine, salivary gland) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 123915, 7 interactors |
ELMi | Q9UD71 |
IntActi | Q9UD71, 5 interactors |
STRINGi | 9606.ENSP00000254079 |
Miscellaneous databases
RNActi | Q9UD71, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 204 | DisorderedSequence analysisAdd BLAST | 204 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 67 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 85 – 99 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 117 – 138 | Acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 166 – 181 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the protein phosphatase inhibitor 1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S19Z, Eukaryota |
GeneTreei | ENSGT00730000111283 |
InParanoidi | Q9UD71 |
OMAi | EDPCEGD |
PhylomeDBi | Q9UD71 |
TreeFami | TF332576 |
Family and domain databases
InterProi | View protein in InterPro IPR015670, DARPP-32 IPR008466, PPP1R1A/B/C |
PANTHERi | PTHR15417, PTHR15417, 1 hit PTHR15417:SF2, PTHR15417:SF2, 1 hit |
Pfami | View protein in Pfam PF05395, DARPP-32, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UD71-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR LSEHSSPEEE
60 70 80 90 100
ASPHQRASGE GHHLKSKRPN PCAYTPPSLK AVQRIAESHL QSISNLNENQ
110 120 130 140 150
ASEEEDELGE LRELGYPREE DEEEEEDDEE EEEEEDSQAE VLKVIRQSAG
160 170 180 190 200
QKTTCGQGLE GPWERPPPLD ESERDGGSED QVEDPALSEP GEEPQRPSPS
EPGT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KSJ8 | J3KSJ8_HUMAN | DARPP-32 | PPP1R1B | 144 | Annotation score: | ||
J3KT77 | J3KT77_HUMAN | DARPP-32 | PPP1R1B | 171 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 155 – 157 | CGQ → RGL (PubMed:8120638).Curated | 3 | |
Sequence conflicti | 204 | T → R (PubMed:8120638).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005117 | 1 – 36 | Missing in isoform 2. 5 PublicationsAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF464196 mRNA Translation: AAM76683.1 AY070271 mRNA Translation: AAL59016.1 AF435972 mRNA Translation: AAP35094.1 AF435973 mRNA Translation: AAP35095.1 AF435974 mRNA Translation: AAP35096.1 AF435975 Genomic DNA Translation: AAP35097.1 AF435975 Genomic DNA Translation: AAP35098.1 AK024593 mRNA Translation: BAB14931.1 BT007076 mRNA Translation: AAP35739.1 BC001519 mRNA Translation: AAH01519.1 |
CCDSi | CCDS11339.1 [Q9UD71-1] CCDS11340.1 [Q9UD71-2] |
RefSeqi | NP_001229393.1, NM_001242464.1 [Q9UD71-2] NP_115568.2, NM_032192.3 [Q9UD71-1] NP_852606.1, NM_181505.3 [Q9UD71-2] XP_016880705.1, XM_017025216.1 [Q9UD71-1] XP_016880706.1, XM_017025217.1 [Q9UD71-2] |
Genome annotation databases
Ensembli | ENST00000254079; ENSP00000254079; ENSG00000131771 ENST00000394265; ENSP00000377808; ENSG00000131771 [Q9UD71-2] ENST00000394267; ENSP00000377810; ENSG00000131771 [Q9UD71-2] ENST00000580825; ENSP00000462137; ENSG00000131771 |
GeneIDi | 84152 |
KEGGi | hsa:84152 |
MANE-Selecti | ENST00000254079.9; ENSP00000254079.4; NM_032192.4; NP_115568.2 |
UCSCi | uc002hrz.4, human [Q9UD71-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF464196 mRNA Translation: AAM76683.1 AY070271 mRNA Translation: AAL59016.1 AF435972 mRNA Translation: AAP35094.1 AF435973 mRNA Translation: AAP35095.1 AF435974 mRNA Translation: AAP35096.1 AF435975 Genomic DNA Translation: AAP35097.1 AF435975 Genomic DNA Translation: AAP35098.1 AK024593 mRNA Translation: BAB14931.1 BT007076 mRNA Translation: AAP35739.1 BC001519 mRNA Translation: AAH01519.1 |
CCDSi | CCDS11339.1 [Q9UD71-1] CCDS11340.1 [Q9UD71-2] |
RefSeqi | NP_001229393.1, NM_001242464.1 [Q9UD71-2] NP_115568.2, NM_032192.3 [Q9UD71-1] NP_852606.1, NM_181505.3 [Q9UD71-2] XP_016880705.1, XM_017025216.1 [Q9UD71-1] XP_016880706.1, XM_017025217.1 [Q9UD71-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123915, 7 interactors |
ELMi | Q9UD71 |
IntActi | Q9UD71, 5 interactors |
STRINGi | 9606.ENSP00000254079 |
PTM databases
iPTMneti | Q9UD71 |
PhosphoSitePlusi | Q9UD71 |
Genetic variation databases
BioMutai | PPP1R1B |
DMDMi | 23831292 |
Proteomic databases
EPDi | Q9UD71 |
jPOSTi | Q9UD71 |
MassIVEi | Q9UD71 |
MaxQBi | Q9UD71 |
PaxDbi | Q9UD71 |
PeptideAtlasi | Q9UD71 |
PRIDEi | Q9UD71 |
ProteomicsDBi | 84112 [Q9UD71-1] 84113 [Q9UD71-2] |
Protocols and materials databases
Antibodypediai | 28294, 762 antibodies from 41 providers |
DNASUi | 84152 |
Genome annotation databases
Ensembli | ENST00000254079; ENSP00000254079; ENSG00000131771 ENST00000394265; ENSP00000377808; ENSG00000131771 [Q9UD71-2] ENST00000394267; ENSP00000377810; ENSG00000131771 [Q9UD71-2] ENST00000580825; ENSP00000462137; ENSG00000131771 |
GeneIDi | 84152 |
KEGGi | hsa:84152 |
MANE-Selecti | ENST00000254079.9; ENSP00000254079.4; NM_032192.4; NP_115568.2 |
UCSCi | uc002hrz.4, human [Q9UD71-1] |
Organism-specific databases
CTDi | 84152 |
DisGeNETi | 84152 |
GeneCardsi | PPP1R1B |
HGNCi | HGNC:9287, PPP1R1B |
HPAi | ENSG00000131771, Group enriched (brain, choroid plexus, intestine, salivary gland) |
MIMi | 604399, gene |
neXtProti | NX_Q9UD71 |
OpenTargetsi | ENSG00000131771 |
PharmGKBi | PA33639 |
VEuPathDBi | HostDB:ENSG00000131771 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S19Z, Eukaryota |
GeneTreei | ENSGT00730000111283 |
InParanoidi | Q9UD71 |
OMAi | EDPCEGD |
PhylomeDBi | Q9UD71 |
TreeFami | TF332576 |
Enzyme and pathway databases
PathwayCommonsi | Q9UD71 |
Reactomei | R-HSA-180024, DARPP-32 events |
SignaLinki | Q9UD71 |
SIGNORi | Q9UD71 |
Miscellaneous databases
BioGRID-ORCSi | 84152, 10 hits in 1041 CRISPR screens |
ChiTaRSi | PPP1R1B, human |
GeneWikii | PPP1R1B |
GenomeRNAii | 84152 |
Pharosi | Q9UD71, Tbio |
PROi | PR:Q9UD71 |
RNActi | Q9UD71, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131771, Expressed in caudate nucleus and 166 other tissues |
ExpressionAtlasi | Q9UD71, baseline and differential |
Genevisiblei | Q9UD71, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015670, DARPP-32 IPR008466, PPP1R1A/B/C |
PANTHERi | PTHR15417, PTHR15417, 1 hit PTHR15417:SF2, PTHR15417:SF2, 1 hit |
Pfami | View protein in Pfam PF05395, DARPP-32, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PPR1B_HUMAN | |
Accessioni | Q9UD71Primary (citable) accession number: Q9UD71 Secondary accession number(s): Q547V9, Q547W0, Q9H7G1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | October 10, 2002 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families