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UniProtKB - Q9UD71 (PPR1B_HUMAN)

Entry version 162 (07 Apr 2021)
Sequence version 2 (10 Oct 2002)
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Protein

Protein phosphatase 1 regulatory subunit 1B

Gene

PPP1R1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of protein-phosphatase 1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein phosphatase inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UD71

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-180024, DARPP-32 events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UD71

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UD71

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1B
Alternative name(s):
DARPP-32
Dopamine- and cAMP-regulated neuronal phosphoprotein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R1B
Synonyms:DARPP32
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9287, PPP1R1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604399, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UD71

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131771.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84152

Open Targets

More...OpenTargetsi		ENSG00000131771

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33639

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UD71, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPP1R1B

Domain mapping of disease mutations (DMDM)

More...DMDMi		23831292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000714731 – 204Protein phosphatase 1 regulatory subunit 1BAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei34Phosphothreonine; by PKABy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei75Phosphothreonine; by CDK51 Publication1
Modified residuei102PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
Phosphorylation of Thr-34 is required for activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UD71

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UD71

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UD71

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UD71

PeptideAtlas

More...PeptideAtlasi		Q9UD71

PRoteomics IDEntifications database

More...PRIDEi		Q9UD71

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84112 [Q9UD71-1]
84113 [Q9UD71-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UD71

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UD71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131771, Expressed in caudate nucleus and 166 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UD71, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UD71, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131771, Tissue enhanced (brain, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123915, 7 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9UD71

Protein interaction database and analysis system

More...IntActi		Q9UD71, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000254079

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UD71, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi119 – 136Asp/Glu-rich (acidic)Add BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein phosphatase inhibitor 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S19Z, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111283

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UD71

Identification of Orthologs from Complete Genome Data

More...OMAi		SNPCAYT

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UD71

TreeFam database of animal gene trees

More...TreeFami		TF332576

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015670, DARPP-32
IPR008466, PPP1R1A/B/C

The PANTHER Classification System

More...PANTHERi		PTHR15417, PTHR15417, 1 hit
PTHR15417:SF2, PTHR15417:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05395, DARPP-32, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UD71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR LSEHSSPEEE 
        60         70         80         90        100
ASPHQRASGE GHHLKSKRPN PCAYTPPSLK AVQRIAESHL QSISNLNENQ 
       110        120        130        140        150
ASEEEDELGE LRELGYPREE DEEEEEDDEE EEEEEDSQAE VLKVIRQSAG 
       160        170        180        190        200
QKTTCGQGLE GPWERPPPLD ESERDGGSED QVEDPALSEP GEEPQRPSPS 

EPGT
Length:204
Mass (Da):22,963
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1CE7DDD29D2D4FB
GO
Isoform 2 (identifier: Q9UD71-2) [UniParc]FASTAAdd to basket
Also known as: t-DARPP

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:168
Mass (Da):18,738
Checksum:iF139B0673543BFE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KSJ8J3KSJ8_HUMAN
DARPP-32
PPP1R1B
144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT77J3KT77_HUMAN
DARPP-32
PPP1R1B
171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155 – 157CGQ → RGL (PubMed:8120638).Curated3
Sequence conflicti204T → R (PubMed:8120638).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0051171 – 36Missing in isoform 2. 5 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF464196 mRNA Translation: AAM76683.1
AY070271 mRNA Translation: AAL59016.1
AF435972 mRNA Translation: AAP35094.1
AF435973 mRNA Translation: AAP35095.1
AF435974 mRNA Translation: AAP35096.1
AF435975 Genomic DNA Translation: AAP35097.1
AF435975 Genomic DNA Translation: AAP35098.1
AK024593 mRNA Translation: BAB14931.1
BT007076 mRNA Translation: AAP35739.1
BC001519 mRNA Translation: AAH01519.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11339.1 [Q9UD71-1]
CCDS11340.1 [Q9UD71-2]

NCBI Reference Sequences

More...RefSeqi		NP_001229393.1, NM_001242464.1 [Q9UD71-2]
NP_115568.2, NM_032192.3 [Q9UD71-1]
NP_852606.1, NM_181505.3 [Q9UD71-2]
XP_016880705.1, XM_017025216.1 [Q9UD71-1]
XP_016880706.1, XM_017025217.1 [Q9UD71-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000254079; ENSP00000254079; ENSG00000131771 [Q9UD71-1]
ENST00000394265; ENSP00000377808; ENSG00000131771 [Q9UD71-2]
ENST00000394267; ENSP00000377810; ENSG00000131771 [Q9UD71-2]
ENST00000580825; ENSP00000462137; ENSG00000131771 [Q9UD71-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84152

UCSC genome browser

More...UCSCi		uc002hrz.4, human [Q9UD71-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464196 mRNA Translation: AAM76683.1
AY070271 mRNA Translation: AAL59016.1
AF435972 mRNA Translation: AAP35094.1
AF435973 mRNA Translation: AAP35095.1
AF435974 mRNA Translation: AAP35096.1
AF435975 Genomic DNA Translation: AAP35097.1
AF435975 Genomic DNA Translation: AAP35098.1
AK024593 mRNA Translation: BAB14931.1
BT007076 mRNA Translation: AAP35739.1
BC001519 mRNA Translation: AAH01519.1
CCDSiCCDS11339.1 [Q9UD71-1]
CCDS11340.1 [Q9UD71-2]
RefSeqiNP_001229393.1, NM_001242464.1 [Q9UD71-2]
NP_115568.2, NM_032192.3 [Q9UD71-1]
NP_852606.1, NM_181505.3 [Q9UD71-2]
XP_016880705.1, XM_017025216.1 [Q9UD71-1]
XP_016880706.1, XM_017025217.1 [Q9UD71-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123915, 7 interactors
ELMiQ9UD71
IntActiQ9UD71, 5 interactors
STRINGi9606.ENSP00000254079

PTM databases

iPTMnetiQ9UD71
PhosphoSitePlusiQ9UD71

Genetic variation databases

BioMutaiPPP1R1B
DMDMi23831292

Proteomic databases

EPDiQ9UD71
jPOSTiQ9UD71
MassIVEiQ9UD71
PaxDbiQ9UD71
PeptideAtlasiQ9UD71
PRIDEiQ9UD71
ProteomicsDBi84112 [Q9UD71-1]
84113 [Q9UD71-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28294, 744 antibodies

The DNASU plasmid repository

More...DNASUi		84152

Genome annotation databases

EnsembliENST00000254079; ENSP00000254079; ENSG00000131771 [Q9UD71-1]
ENST00000394265; ENSP00000377808; ENSG00000131771 [Q9UD71-2]
ENST00000394267; ENSP00000377810; ENSG00000131771 [Q9UD71-2]
ENST00000580825; ENSP00000462137; ENSG00000131771 [Q9UD71-1]
GeneIDi84152
KEGGihsa:84152
UCSCiuc002hrz.4, human [Q9UD71-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84152
DisGeNETi84152

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPP1R1B
HGNCiHGNC:9287, PPP1R1B
HPAiENSG00000131771, Tissue enhanced (brain, salivary gland)
MIMi604399, gene
neXtProtiNX_Q9UD71
OpenTargetsiENSG00000131771
PharmGKBiPA33639
VEuPathDBiHostDB:ENSG00000131771.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S19Z, Eukaryota
GeneTreeiENSGT00730000111283
InParanoidiQ9UD71
OMAiSNPCAYT
PhylomeDBiQ9UD71
TreeFamiTF332576

Enzyme and pathway databases

PathwayCommonsiQ9UD71
ReactomeiR-HSA-180024, DARPP-32 events
SignaLinkiQ9UD71
SIGNORiQ9UD71

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84152, 10 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPP1R1B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PPP1R1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84152
PharosiQ9UD71, Tbio

Protein Ontology

More...PROi		PR:Q9UD71
RNActiQ9UD71, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131771, Expressed in caudate nucleus and 166 other tissues
ExpressionAtlasiQ9UD71, baseline and differential
GenevisibleiQ9UD71, HS

Family and domain databases

InterProiView protein in InterPro
IPR015670, DARPP-32
IPR008466, PPP1R1A/B/C
PANTHERiPTHR15417, PTHR15417, 1 hit
PTHR15417:SF2, PTHR15417:SF2, 1 hit
PfamiView protein in Pfam
PF05395, DARPP-32, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPR1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UD71
Secondary accession number(s): Q547V9, Q547W0, Q9H7G1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 10, 2002
Last modified: April 7, 2021
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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