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Protein

NK1 transcription factor-related protein 2

Gene

NKX1-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function in cell specification, particularly in the CNS.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi163 – 222HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NK1 transcription factor-related protein 2
Alternative name(s):
Homeobox protein SAX-1
NKX-1.1
Gene namesi
Name:NKX1-2
Synonyms:C10orf121, NKX1.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000229544.8
HGNCiHGNC:31652 NKX1-2
neXtProtiNX_Q9UD57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000229544
PharmGKBiPA134977174

Polymorphism and mutation databases

BioMutaiNKX1-2
DMDMi338817978

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003259721 – 310NK1 transcription factor-related protein 2Add BLAST310

Proteomic databases

EPDiQ9UD57
PeptideAtlasiQ9UD57
PRIDEiQ9UD57
ProteomicsDBi84111

Expressioni

Gene expression databases

BgeeiENSG00000229544
CleanExiHS_NKX1-2
GenevisibleiQ9UD57 HS

Organism-specific databases

HPAiHPA029367

Structurei

3D structure databases

ProteinModelPortaliQ9UD57
SMRiQ9UD57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 93Poly-Glu6
Compositional biasi134 – 137Poly-Gly4
Compositional biasi150 – 155Poly-Arg6
Compositional biasi224 – 259Gly-richAdd BLAST36

Sequence similaritiesi

Belongs to the NK-1 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00910000144024
HOVERGENiHBG052632
InParanoidiQ9UD57
KOiK09309
OMAiGPSYLTP
OrthoDBiEOG091G0SCQ
TreeFamiTF316128

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UD57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAWQDGGAK AAPSHHKISF SVLDILDPQK FTRAALPAVR PAPREARKSL
60 70 80 90 100
AEVEAGKDAS SRDPVRQLET PDAAGPGAGQ ASPLEGSEAE EEEDAEDPRR
110 120 130 140 150
PRLRERAARL LPGLARSPDA PAGALASGEP CEDGGGGPVR SPPGSPGSPR
160 170 180 190 200
PRRRRLEPNC AKPRRARTAF TYEQLVALEN KFRATRYLSV CERLNLALSL
210 220 230 240 250
SLTETQVKIW FQNRRTKWKK QNPGADGAAQ VGGGAPQPGA AGGGGGGGSG
260 270 280 290 300
GSPGPPGTGA LHFQTFPSYS AANVLFPSAA SFPLTAAAPG SPFAPFLGPS
310
YLTPFYAPRL
Length:310
Mass (Da):32,381
Last modified:June 28, 2011 - v3
Checksum:iFF2D02B4DCFC5689
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445237 Genomic DNA No translation available.
CCDSiCCDS59221.1
RefSeqiNP_001139812.1, NM_001146340.1
UniGeneiHs.290255

Genome annotation databases

EnsembliENST00000451024; ENSP00000451945; ENSG00000229544
GeneIDi390010
KEGGihsa:390010
UCSCiuc010quf.3 human

Similar proteinsi

Entry informationi

Entry nameiNKX12_HUMAN
AccessioniPrimary (citable) accession number: Q9UD57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 28, 2011
Last modified: June 20, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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