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Entry version 160 (16 Oct 2019)
Sequence version 2 (27 Mar 2002)
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Protein

Zinc finger protein 70

Gene

ZNF70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 70
Alternative name(s):
Zinc finger protein N27C7-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13140 ZNF70

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
194544 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UC06

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000187792

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37714

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UC06

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF70

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141062

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473801 – 446Zinc finger protein 70Add BLAST446

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UC06

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UC06

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UC06

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UC06

PeptideAtlas

More...
PeptideAtlasi
Q9UC06

PRoteomics IDEntifications database

More...
PRIDEi
Q9UC06

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84108

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UC06

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UC06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187792 Expressed in 158 organ(s), highest expression level in tibia

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UC06 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018821

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113441, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UC06, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339314

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UC06

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163200

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UC06

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFVFEDR

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UC06

TreeFam database of animal gene trees

More...
TreeFami
TF337055

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UC06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE
60 70 80 90 100
IPLGEQDEEN DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD
110 120 130 140 150
LSMCQIIHSE EPSPCDCAET DRGDSGPNAP HRTPQPAKPY ACRECGKAFS
160 170 180 190 200
QSSHLLRHLV IHTGEKPYEC CECGKAFSQS SHLLRHQIIH TGEKPYECRE
210 220 230 240 250
CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR KHERIHTGER
260 270 280 290 300
PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR
310 320 330 340 350
IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS
360 370 380 390 400
LIEHQRIHTG EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF
410 420 430 440
RHRSALIEHY KTHTREKPYV CNLCGKSFRG SSHLIRHQKI HSGEKL
Length:446
Mass (Da):50,802
Last modified:March 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE79A25ED2BD816D9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB050771 Genomic DNA Translation: BAB83033.1
CR456615 mRNA Translation: CAG30501.1
BC040161 mRNA Translation: AAH40161.1
X60077 Genomic DNA Translation: CAC16148.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13812.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D42825

NCBI Reference Sequences

More...
RefSeqi
NP_068735.1, NM_021916.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341976; ENSP00000339314; ENSG00000187792

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7621

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7621

UCSC genome browser

More...
UCSCi
uc002zxs.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050771 Genomic DNA Translation: BAB83033.1
CR456615 mRNA Translation: CAG30501.1
BC040161 mRNA Translation: AAH40161.1
X60077 Genomic DNA Translation: CAC16148.1
CCDSiCCDS13812.1
PIRiD42825
RefSeqiNP_068735.1, NM_021916.3

3D structure databases

SMRiQ9UC06
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113441, 12 interactors
IntActiQ9UC06, 7 interactors
STRINGi9606.ENSP00000339314

PTM databases

iPTMnetiQ9UC06
PhosphoSitePlusiQ9UC06

Polymorphism and mutation databases

BioMutaiZNF70
DMDMi20141062

Proteomic databases

jPOSTiQ9UC06
MassIVEiQ9UC06
MaxQBiQ9UC06
PaxDbiQ9UC06
PeptideAtlasiQ9UC06
PRIDEiQ9UC06
ProteomicsDBi84108

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7621

Genome annotation databases

EnsembliENST00000341976; ENSP00000339314; ENSG00000187792
GeneIDi7621
KEGGihsa:7621
UCSCiuc002zxs.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7621

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF70
HGNCiHGNC:13140 ZNF70
HPAiHPA018821
MIMi194544 gene
neXtProtiNX_Q9UC06
OpenTargetsiENSG00000187792
PharmGKBiPA37714

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163200
HOGENOMiHOG000234617
InParanoidiQ9UC06
OMAiTFVFEDR
OrthoDBi1318335at2759
PhylomeDBiQ9UC06
TreeFamiTF337055

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF70 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7621
PharosiQ9UC06

Protein Ontology

More...
PROi
PR:Q9UC06

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187792 Expressed in 158 organ(s), highest expression level in tibia
GenevisibleiQ9UC06 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF70_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UC06
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: October 16, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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