Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA repair protein REV1

Gene

REV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei357dCTPBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi423Magnesium 1PROSITE-ProRule annotation1
Metal bindingi423Magnesium 2PROSITE-ProRule annotation1
Binding sitei522dCTPBy similarity1
Metal bindingi570Magnesium 1PROSITE-ProRule annotation1
Binding sitei570dCTPBy similarity1
Metal bindingi571Magnesium 1PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi423 – 427dCTP bindingBy similarity5
Nucleotide bindingi510 – 516dCTP bindingBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • damaged DNA binding Source: ProtInc
  • deoxycytidyl transferase activity Source: Reactome
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA synthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-110312 Translesion synthesis by REV1
R-HSA-5655862 Translesion synthesis by POLK
R-HSA-5656121 Translesion synthesis by POLI
R-HSA-5656169 Termination of translesion DNA synthesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UBZ9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein REV1 (EC:2.7.7.-)
Alternative name(s):
Alpha integrin-binding protein 80
Short name:
AIBP80
Rev1-like terminal deoxycytidyl transferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REV1
Synonyms:REV1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135945.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14060 REV1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606134 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBZ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi570D → A: Abolishes transferase activity; when associated with A-571. 1 Publication1
Mutagenesisi571E → A: Abolishes transferase activity; when associated with A-570. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51455

Open Targets

More...
OpenTargetsi
ENSG00000135945

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162401120

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
REV1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59798439

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001739921 – 1251DNA repair protein REV1Add BLAST1251

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UBZ9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UBZ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBZ9

PeptideAtlas

More...
PeptideAtlasi
Q9UBZ9

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBZ9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84105
84106 [Q9UBZ9-2]
84107 [Q9UBZ9-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9UBZ9

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBZ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135945 Expressed in 227 organ(s), highest expression level in adrenal tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_REV1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UBZ9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBZ9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044534
HPA051036

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with the DNA polymerase zeta which is composed of REV3L and MAD2L2; the interaction with MAD2L2 is direct and requires that REV3L is in its closed conformation. Interacts with POLH, POLI and POLK. May bind ITGA3. Interacts with FAAP20/C1orf86.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei770Interaction with target DNABy similarity1
Sitei783Interaction with target DNABy similarity1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FAAP20Q6NZ362EBI-7353917,EBI-2817693

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119551, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UBZ9

Protein interaction database and analysis system

More...
IntActi
Q9UBZ9, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9UBZ9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258428

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBWNMR-A44-133[»]
2LSINMR-A1156-1251[»]
2LSKNMR-A1158-1251[»]
2LSYNMR-A1158-1251[»]
2N1GNMR-A1158-1251[»]
3GQCX-ray2.50A/B/C/D330-833[»]
3VU7X-ray2.80H1140-1251[»]
4BA9X-ray2.73A/B/C/D/E/F1158-1242[»]
4EXTX-ray1.90A1156-1251[»]
4GK0X-ray2.70E/F1117-1251[»]
4GK5X-ray3.21E/F1117-1251[»]
5VZMNMR-B933-1040[»]
6ASRX-ray2.36B998-1040[»]
6AXDNMR-A998-1040[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UBZ9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBZ9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UBZ9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 131BRCTPROSITE-ProRule annotationAdd BLAST88
Domaini419 – 653UmuCPROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni352 – 362Interaction with target DNABy similarityAdd BLAST11
Regioni653 – 656Interaction with target DNABy similarity4
Regioni709 – 717Interaction with target DNABy similarity9
Regioni1150 – 1249Protein interaction domain; mediates interaction with DNA polymerase zetaAdd BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1071 – 1078Nuclear localization signalSequence analysis8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain is necessary for protein interactions.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2093 Eukaryota
COG0389 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156374

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154094

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054140

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBZ9

KEGG Orthology (KO)

More...
KOi
K03515

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMAFDFI

Database of Orthologous Groups

More...
OrthoDBi
299766at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBZ9

TreeFam database of animal gene trees

More...
TreeFami
TF314488

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00027 BRCT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.1280, 1 hit
3.30.1490.100, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR025527 HUWE1/Rev1_UBM
IPR012112 REV1
IPR031991 Rev1_C
IPR038401 Rev1_C_sf
IPR001126 UmuC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16589 BRCT_2, 1 hit
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
PF16727 REV1_C, 1 hit
PF14377 UBM, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036573 REV1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100879 SSF100879, 1 hit
SSF52113 SSF52113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS50173 UMUC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBZ9-1) [UniParc]FASTAAdd to basket
Also known as: REV1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRGGWRKRA ENDGWETWGG YMAAKVQKLE EQFRSDAAMQ KDGTSSTIFS
60 70 80 90 100
GVAIYVNGYT DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI
110 120 130 140 150
KELKGEKVIR PEWIVESIKA GRLLSYIPYQ LYTKQSSVQK GLSFNPVCRP
160 170 180 190 200
EDPLPGPSNI AKQLNNRVNH IVKKIETENE VKVNGMNSWN EEDENNDFSF
210 220 230 240 250
VDLEQTSPGR KQNGIPHPRG STAIFNGHTP SSNGALKTQD CLVPMVNSVA
260 270 280 290 300
SRLSPAFSQE EDKAEKSSTD FRDCTLQQLQ QSTRNTDALR NPHRTNSFSL
310 320 330 340 350
SPLHSNTKIN GAHHSTVQGP SSTKSTSSVS TFSKAAPSVP SKPSDCNFIS
360 370 380 390 400
NFYSHSRLHH ISMWKCELTE FVNTLQRQSN GIFPGREKLK KMKTGRSALV
410 420 430 440 450
VTDTGDMSVL NSPRHQSCIM HVDMDCFFVS VGIRNRPDLK GKPVAVTSNR
460 470 480 490 500
GTGRAPLRPG ANPQLEWQYY QNKILKGKAA DIPDSSLWEN PDSAQANGID
510 520 530 540 550
SVLSRAEIAS CSYEARQLGI KNGMFFGHAK QLCPNLQAVP YDFHAYKEVA
560 570 580 590 600
QTLYETLASY THNIEAVSCD EALVDITEIL AETKLTPDEF ANAVRMEIKD
610 620 630 640 650
QTKCAASVGI GSNILLARMA TRKAKPDGQY HLKPEEVDDF IRGQLVTNLP
660 670 680 690 700
GVGHSMESKL ASLGIKTCGD LQYMTMAKLQ KEFGPKTGQM LYRFCRGLDD
710 720 730 740 750
RPVRTEKERK SVSAEINYGI RFTQPKEAEA FLLSLSEEIQ RRLEATGMKG
760 770 780 790 800
KRLTLKIMVR KPGAPVETAK FGGHGICDNI ARTVTLDQAT DNAKIIGKAM
810 820 830 840 850
LNMFHTMKLN ISDMRGVGIH VNQLVPTNLN PSTCPSRPSV QSSHFPSGSY
860 870 880 890 900
SVRDVFQVQK AKKSTEEEHK EVFRAAVDLE ISSASRTCTF LPPFPAHLPT
910 920 930 940 950
SPDTNKAESS GKWNGLHTPV SVQSRLNLSI EVPSPSQLDQ SVLEALPPDL
960 970 980 990 1000
REQVEQVCAV QQAESHGDKK KEPVNGCNTG ILPQPVGTVL LQIPEPQESN
1010 1020 1030 1040 1050
SDAGINLIAL PAFSQVDPEV FAALPAELQR ELKAAYDQRQ RQGENSTHQQ
1060 1070 1080 1090 1100
SASASVPKNP LLHLKAAVKE KKRNKKKKTI GSPKRIQSPL NNKLLNSPAK
1110 1120 1130 1140 1150
TLPGACGSPQ KLIDGFLKHE GPPAEKPLEE LSASTSGVPG LSSLQSDPAG
1160 1170 1180 1190 1200
CVRPPAPNLA GAVEFNDVKT LLREWITTIS DPMEEDILQV VKYCTDLIEE
1210 1220 1230 1240 1250
KDLEKLDLVI KYMKRLMQQS VESVWNMAFD FILDNVQVVL QQTYGSTLKV

T
Length:1,251
Mass (Da):138,248
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i010E261D537DBA80
GO
Isoform 2 (identifier: Q9UBZ9-2) [UniParc]FASTAAdd to basket
Also known as: REV1S

The sequence of this isoform differs from the canonical sequence as follows:
     479-479: Missing.

Show »
Length:1,250
Mass (Da):138,177
Checksum:iB4B1606DB6E866F2
GO
Isoform 3 (identifier: Q9UBZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     406-413: DMSVLNSP → RYLLKLSS
     414-1251: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):43,649
Checksum:iA0EA83A568AD74F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C263H7C263_HUMAN
DNA repair protein REV1
REV1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPS2C9JPS2_HUMAN
DNA repair protein REV1
REV1
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCR0F8WCR0_HUMAN
DNA repair protein REV1
REV1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK43708 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021249138V → M. Corresponds to variant dbSNP:rs3087403Ensembl.1
Natural variantiVAR_021250257F → S. Corresponds to variant dbSNP:rs3087386Ensembl.1
Natural variantiVAR_029193306N → D. Corresponds to variant dbSNP:rs28382882Ensembl.1
Natural variantiVAR_021251373N → S. Corresponds to variant dbSNP:rs3087399Ensembl.1
Natural variantiVAR_029194656M → V. Corresponds to variant dbSNP:rs3087394Ensembl.1
Natural variantiVAR_029195660L → W. Corresponds to variant dbSNP:rs3087398Ensembl.1
Natural variantiVAR_029196700D → N. Corresponds to variant dbSNP:rs28382941Ensembl.1
Natural variantiVAR_029197704R → Q. Corresponds to variant dbSNP:rs28382942Ensembl.1
Natural variantiVAR_029199902P → H. Corresponds to variant dbSNP:rs28382961Ensembl.1
Natural variantiVAR_029198902P → S. Corresponds to variant dbSNP:rs28382960Ensembl.1
Natural variantiVAR_029200921S → I. Corresponds to variant dbSNP:rs3087396Ensembl.1
Natural variantiVAR_0244361003A → T. Corresponds to variant dbSNP:rs3087401Ensembl.1
Natural variantiVAR_0292011060P → T. Corresponds to variant dbSNP:rs3087388Ensembl.1
Natural variantiVAR_0292021074N → K. Corresponds to variant dbSNP:rs3087393Ensembl.1
Natural variantiVAR_0292031091N → T. Corresponds to variant dbSNP:rs3087392Ensembl.1
Natural variantiVAR_0292041102L → P. Corresponds to variant dbSNP:rs3087400Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0128091 – 21Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_012810406 – 413DMSVLNSP → RYLLKLSS in isoform 3. 1 Publication8
Alternative sequenceiVSP_012811414 – 1251Missing in isoform 3. 1 PublicationAdd BLAST838
Alternative sequenceiVSP_012812479Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF151538 mRNA Translation: AAF06731.1
AF206019 mRNA Translation: AAF18986.1
AB047646 mRNA Translation: BAB21441.1
AF357886 mRNA Translation: AAK43708.1 Different initiation.
AK002087 mRNA Translation: BAA92079.1
AC018690 Genomic DNA Translation: AAY24314.1
AJ131720 mRNA Translation: CAB38231.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2045.1 [Q9UBZ9-1]
CCDS42722.1 [Q9UBZ9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001032961.1, NM_001037872.2 [Q9UBZ9-2]
NP_001308383.1, NM_001321454.1
NP_001308384.1, NM_001321455.1
NP_001308387.1, NM_001321458.1
NP_001308388.1, NM_001321459.1
NP_001308389.1, NM_001321460.1
NP_057400.1, NM_016316.3 [Q9UBZ9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.443077

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258428; ENSP00000258428; ENSG00000135945 [Q9UBZ9-1]
ENST00000393445; ENSP00000377091; ENSG00000135945 [Q9UBZ9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51455

UCSC genome browser

More...
UCSCi
uc002tac.4 human [Q9UBZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151538 mRNA Translation: AAF06731.1
AF206019 mRNA Translation: AAF18986.1
AB047646 mRNA Translation: BAB21441.1
AF357886 mRNA Translation: AAK43708.1 Different initiation.
AK002087 mRNA Translation: BAA92079.1
AC018690 Genomic DNA Translation: AAY24314.1
AJ131720 mRNA Translation: CAB38231.1
CCDSiCCDS2045.1 [Q9UBZ9-1]
CCDS42722.1 [Q9UBZ9-2]
RefSeqiNP_001032961.1, NM_001037872.2 [Q9UBZ9-2]
NP_001308383.1, NM_001321454.1
NP_001308384.1, NM_001321455.1
NP_001308387.1, NM_001321458.1
NP_001308388.1, NM_001321459.1
NP_001308389.1, NM_001321460.1
NP_057400.1, NM_016316.3 [Q9UBZ9-1]
UniGeneiHs.443077

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBWNMR-A44-133[»]
2LSINMR-A1156-1251[»]
2LSKNMR-A1158-1251[»]
2LSYNMR-A1158-1251[»]
2N1GNMR-A1158-1251[»]
3GQCX-ray2.50A/B/C/D330-833[»]
3VU7X-ray2.80H1140-1251[»]
4BA9X-ray2.73A/B/C/D/E/F1158-1242[»]
4EXTX-ray1.90A1156-1251[»]
4GK0X-ray2.70E/F1117-1251[»]
4GK5X-ray3.21E/F1117-1251[»]
5VZMNMR-B933-1040[»]
6ASRX-ray2.36B998-1040[»]
6AXDNMR-A998-1040[»]
ProteinModelPortaliQ9UBZ9
SMRiQ9UBZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119551, 27 interactors
CORUMiQ9UBZ9
IntActiQ9UBZ9, 4 interactors
MINTiQ9UBZ9
STRINGi9606.ENSP00000258428

PTM databases

CarbonylDBiQ9UBZ9
iPTMnetiQ9UBZ9
PhosphoSitePlusiQ9UBZ9

Polymorphism and mutation databases

BioMutaiREV1
DMDMi59798439

Proteomic databases

EPDiQ9UBZ9
jPOSTiQ9UBZ9
PaxDbiQ9UBZ9
PeptideAtlasiQ9UBZ9
PRIDEiQ9UBZ9
ProteomicsDBi84105
84106 [Q9UBZ9-2]
84107 [Q9UBZ9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258428; ENSP00000258428; ENSG00000135945 [Q9UBZ9-1]
ENST00000393445; ENSP00000377091; ENSG00000135945 [Q9UBZ9-2]
GeneIDi51455
KEGGihsa:51455
UCSCiuc002tac.4 human [Q9UBZ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51455
DisGeNETi51455
EuPathDBiHostDB:ENSG00000135945.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
REV1
HGNCiHGNC:14060 REV1
HPAiHPA044534
HPA051036
MIMi606134 gene
neXtProtiNX_Q9UBZ9
OpenTargetsiENSG00000135945
PharmGKBiPA162401120

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2093 Eukaryota
COG0389 LUCA
GeneTreeiENSGT00940000156374
HOGENOMiHOG000154094
HOVERGENiHBG054140
InParanoidiQ9UBZ9
KOiK03515
OMAiNMAFDFI
OrthoDBi299766at2759
PhylomeDBiQ9UBZ9
TreeFamiTF314488

Enzyme and pathway databases

ReactomeiR-HSA-110312 Translesion synthesis by REV1
R-HSA-5655862 Translesion synthesis by POLK
R-HSA-5656121 Translesion synthesis by POLI
R-HSA-5656169 Termination of translesion DNA synthesis
SignaLinkiQ9UBZ9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
REV1 human
EvolutionaryTraceiQ9UBZ9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
REV1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51455

Protein Ontology

More...
PROi
PR:Q9UBZ9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135945 Expressed in 227 organ(s), highest expression level in adrenal tissue
CleanExiHS_REV1
ExpressionAtlasiQ9UBZ9 baseline and differential
GenevisibleiQ9UBZ9 HS

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.20.58.1280, 1 hit
3.30.1490.100, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR025527 HUWE1/Rev1_UBM
IPR012112 REV1
IPR031991 Rev1_C
IPR038401 Rev1_C_sf
IPR001126 UmuC
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
PF16727 REV1_C, 1 hit
PF14377 UBM, 2 hits
PIRSFiPIRSF036573 REV1, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50173 UMUC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREV1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBZ9
Secondary accession number(s): O95941
, Q53SI7, Q9C0J4, Q9NUP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: January 16, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again