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Protein

Heat shock protein beta-7

Gene

HSPB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • filamin binding Source: Ensembl
  • protein C-terminus binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-7
Short name:
HspB7
Alternative name(s):
Cardiovascular heat shock protein
Short name:
cvHsp
Gene namesi
Name:HSPB7
Synonyms:CVHSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173641.17
HGNCiHGNC:5249 HSPB7
MIMi610692 gene
neXtProtiNX_Q9UBY9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27129
OpenTargetsiENSG00000173641
PharmGKBiPA29514

Polymorphism and mutation databases

BioMutaiHSPB7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259411 – 170Heat shock protein beta-7Add BLAST170

Proteomic databases

PaxDbiQ9UBY9
PeptideAtlasiQ9UBY9
PRIDEiQ9UBY9
ProteomicsDBi84101
84102 [Q9UBY9-2]
84103 [Q9UBY9-3]

2D gel databases

UCD-2DPAGEiQ9UBY9

PTM databases

iPTMnetiQ9UBY9
PhosphoSitePlusiQ9UBY9

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.

Gene expression databases

BgeeiENSG00000173641 Expressed in 162 organ(s), highest expression level in heart left ventricle
CleanExiHS_HSPB7
ExpressionAtlasiQ9UBY9 baseline and differential
GenevisibleiQ9UBY9 HS

Organism-specific databases

HPAiHPA027639

Interactioni

Subunit structurei

Interacts with C-terminal domain of actin-binding protein 280.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118020, 14 interactors
IntActiQ9UBY9, 18 interactors
STRINGi9606.ENSP00000310111

Structurei

3D structure databases

ProteinModelPortaliQ9UBY9
SMRiQ9UBY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 170sHSPPROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 71Required for localization to SC35 splicing specklesAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 31Poly-SerAdd BLAST15

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00390000010674
HOGENOMiHOG000072715
HOVERGENiHBG052040
InParanoidiQ9UBY9
KOiK09546
OMAiMNTFTHK
PhylomeDBiQ9UBY9
TreeFamiTF350564

Family and domain databases

CDDicd06479 ACD_HspB7_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037885 ACD_HspB7
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSHRTSSTFR AERSFHSSSS SSSSSTSSSA SRALPAQDPP MEKALSMFSD
60 70 80 90 100
DFGSFMRPHS EPLAFPARPG GAGNIKTLGD AYEFAVDVRD FSPEDIIVTT
110 120 130 140 150
SNNHIEVRAE KLAADGTVMN TFAHKCQLPE DVDPTSVTSA LREDGSLTIR
160 170
ARRHPHTEHV QQTFRTEIKI
Length:170
Mass (Da):18,611
Last modified:May 1, 2000 - v1
Checksum:i0A6F47931AE67B3E
GO
Isoform 2 (identifier: Q9UBY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-67: A → AAHPTA

Show »
Length:175
Mass (Da):19,088
Checksum:iE8A9AC71D6DA9069
GO
Isoform 3 (identifier: Q9UBY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: R → K
     69-170: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:68
Mass (Da):7,344
Checksum:i83465ACD0B48C6FF
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q68DG0Q68DG0_HUMAN
Heat shock protein beta-7
HSPB7 DKFZp779D0968
174Annotation score:
Q8N241Q8N241_HUMAN
Heat shock 27kDa protein family, me...
HSPB7 hCG_23506
245Annotation score:
D3YTC6D3YTC6_HUMAN
Heat shock protein beta-7
HSPB7
165Annotation score:
C9J5A3C9J5A3_HUMAN
Heat shock protein beta-7
HSPB7
124Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00242467A → AAHPTA in isoform 2. 2 Publications1
Alternative sequenceiVSP_00242568R → K in isoform 3. 1 Publication1
Alternative sequenceiVSP_00242669 – 170Missing in isoform 3. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243191 mRNA Translation: CAB63258.1
AF155908 mRNA Translation: AAF20022.1
AK057295 mRNA Translation: BAG51899.1
CR749298 mRNA Translation: CAH18153.1
AL096775 Genomic DNA Translation: CAB86671.1
AL355994 Genomic DNA No translation available.
BC006319 mRNA Translation: AAH06319.1
CCDSiCCDS30611.1 [Q9UBY9-1]
CCDS85932.1 [Q9UBY9-2]
RefSeqiNP_055239.1, NM_014424.4 [Q9UBY9-1]
UniGeneiHs.502612

Genome annotation databases

EnsembliENST00000311890; ENSP00000310111; ENSG00000173641 [Q9UBY9-1]
ENST00000487046; ENSP00000419477; ENSG00000173641 [Q9UBY9-2]
GeneIDi27129
KEGGihsa:27129
UCSCiuc001axo.2 human [Q9UBY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243191 mRNA Translation: CAB63258.1
AF155908 mRNA Translation: AAF20022.1
AK057295 mRNA Translation: BAG51899.1
CR749298 mRNA Translation: CAH18153.1
AL096775 Genomic DNA Translation: CAB86671.1
AL355994 Genomic DNA No translation available.
BC006319 mRNA Translation: AAH06319.1
CCDSiCCDS30611.1 [Q9UBY9-1]
CCDS85932.1 [Q9UBY9-2]
RefSeqiNP_055239.1, NM_014424.4 [Q9UBY9-1]
UniGeneiHs.502612

3D structure databases

ProteinModelPortaliQ9UBY9
SMRiQ9UBY9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118020, 14 interactors
IntActiQ9UBY9, 18 interactors
STRINGi9606.ENSP00000310111

PTM databases

iPTMnetiQ9UBY9
PhosphoSitePlusiQ9UBY9

Polymorphism and mutation databases

BioMutaiHSPB7

2D gel databases

UCD-2DPAGEiQ9UBY9

Proteomic databases

PaxDbiQ9UBY9
PeptideAtlasiQ9UBY9
PRIDEiQ9UBY9
ProteomicsDBi84101
84102 [Q9UBY9-2]
84103 [Q9UBY9-3]

Protocols and materials databases

DNASUi27129
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311890; ENSP00000310111; ENSG00000173641 [Q9UBY9-1]
ENST00000487046; ENSP00000419477; ENSG00000173641 [Q9UBY9-2]
GeneIDi27129
KEGGihsa:27129
UCSCiuc001axo.2 human [Q9UBY9-1]

Organism-specific databases

CTDi27129
DisGeNETi27129
EuPathDBiHostDB:ENSG00000173641.17
GeneCardsiHSPB7
HGNCiHGNC:5249 HSPB7
HPAiHPA027639
MIMi610692 gene
neXtProtiNX_Q9UBY9
OpenTargetsiENSG00000173641
PharmGKBiPA29514
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00390000010674
HOGENOMiHOG000072715
HOVERGENiHBG052040
InParanoidiQ9UBY9
KOiK09546
OMAiMNTFTHK
PhylomeDBiQ9UBY9
TreeFamiTF350564

Miscellaneous databases

ChiTaRSiHSPB7 human
GenomeRNAii27129
PROiPR:Q9UBY9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173641 Expressed in 162 organ(s), highest expression level in heart left ventricle
CleanExiHS_HSPB7
ExpressionAtlasiQ9UBY9 baseline and differential
GenevisibleiQ9UBY9 HS

Family and domain databases

CDDicd06479 ACD_HspB7_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037885 ACD_HspB7
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB7_HUMAN
AccessioniPrimary (citable) accession number: Q9UBY9
Secondary accession number(s): B3KQ37, C9K0Y0, Q9NU17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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