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Entry version 160 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

Lysophosphatidic acid receptor 3

Gene

LPAR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UBY5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events
R-HSA-419408, Lysosphingolipid and LPA receptors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UBY5

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001572

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophosphatidic acid receptor 3
Short name:
LPA receptor 3
Short name:
LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPAR3
Synonyms:EDG7, LPA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171517.5

Human Gene Nomenclature Database

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HGNCi
HGNC:14298, LPAR3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605106, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBY5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 67CytoplasmicSequence analysisAdd BLAST15
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 101ExtracellularSequence analysisAdd BLAST13
Transmembranei102 – 124Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini125 – 146CytoplasmicSequence analysisAdd BLAST22
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 186ExtracellularSequence analysisAdd BLAST19
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 240CytoplasmicSequence analysisAdd BLAST33
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 353CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23566

Open Targets

More...
OpenTargetsi
ENSG00000171517

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394213

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBY5, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3250

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
274

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LPAR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
26393418

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694331 – 353Lysophosphatidic acid receptor 3Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi309S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UBY5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBY5

PeptideAtlas

More...
PeptideAtlasi
Q9UBY5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBY5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84099

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9UBY5, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBY5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBY5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171517, Expressed in oviduct epithelium and 149 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBY5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171517, Tissue enhanced (fallopian)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9UBY5
With#Exp.IntAct
AQP6 [Q13520]3EBI-12033434,EBI-13059134
ARL13B [Q3SXY8]3EBI-12033434,EBI-11343438
ASZ1 [Q8WWH4]3EBI-12033434,EBI-12239061
BCL2L13 [Q9BXK5]3EBI-12033434,EBI-747430
C16orf54 [Q6UWD8]3EBI-12033434,EBI-18041102
CD53 [P19397]3EBI-12033434,EBI-6657396
CD74 - isoform 2 [P04233-2]4EBI-12033434,EBI-12222807
CD79A [P11912]3EBI-12033434,EBI-7797864
CLDN2 [P57739]3EBI-12033434,EBI-751440
CLDN7 [O95471]3EBI-12033434,EBI-740744
CLDN9 [O95484]3EBI-12033434,EBI-18341636
CLEC12B - isoform 2 [Q2HXU8-2]3EBI-12033434,EBI-12811991
CPLX4 [Q7Z7G2]3EBI-12033434,EBI-18013275
CREB3L1 [Q96BA8]5EBI-12033434,EBI-6942903
CYB561 [P49447]3EBI-12033434,EBI-8646596
CYBRD1 [Q53TN4]3EBI-12033434,EBI-8637742
EDA [Q92838]3EBI-12033434,EBI-529425
ERGIC3 [Q9Y282]3EBI-12033434,EBI-781551
FAM209A [Q5JX71]3EBI-12033434,EBI-18304435
FAM210B [Q96KR6]3EBI-12033434,EBI-18938272
FFAR2 [O15552]3EBI-12033434,EBI-2833872
FNDC9 [Q8TBE3]3EBI-12033434,EBI-12142257
GJB5 [O95377]3EBI-12033434,EBI-3909454
GORAB [Q5T7V8]3EBI-12033434,EBI-3917143
GPX8 [Q8TED1]3EBI-12033434,EBI-11721746
JAGN1 [Q8N5M9]3EBI-12033434,EBI-10266796
KCNC1 [P48547]3EBI-12033434,EBI-12830942
KCNJ6 [P48051]3EBI-12033434,EBI-12017638
LEPROTL1 [O95214]3EBI-12033434,EBI-750776
LHFPL5 [Q8TAF8]3EBI-12033434,EBI-2820517
LIME1 [Q9H400]3EBI-12033434,EBI-2830566
MFF - isoform 5 [Q9GZY8-5]3EBI-12033434,EBI-11956541
MGST3 [O14880]3EBI-12033434,EBI-724754
MRM1 [Q6IN84]3EBI-12033434,EBI-5454865
MS4A4A [Q96JQ5]3EBI-12033434,EBI-12820341
NDUFAF2 [Q8N183]3EBI-12033434,EBI-2682365
OPRM1 - isoform 10 [P35372-10]3EBI-12033434,EBI-12807478
PGRMC2 [O15173]3EBI-12033434,EBI-1050125
RELL2 [Q8NC24]3EBI-12033434,EBI-10269209
RETREG3 [Q86VR2]5EBI-12033434,EBI-10192441
SCN3B [Q9NY72]3EBI-12033434,EBI-17247926
SGMS2 [Q8NHU3]3EBI-12033434,EBI-10977284
SHISAL1 [Q3SXP7]3EBI-12033434,EBI-18037857
SLC10A6 [Q3KNW5]3EBI-12033434,EBI-18159983
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-12033434,EBI-17295964
TFEC - isoform 3 [O14948-3]3EBI-12033434,EBI-12246506
THAP4 [Q8WY91]3EBI-12033434,EBI-726691
TMEM14B [Q9NUH8]3EBI-12033434,EBI-8638294
TMEM237 - isoform 2 [Q96Q45-2]3EBI-12033434,EBI-10982110
TMEM41A [Q96HV5]3EBI-12033434,EBI-10288884
TMEM52B [Q4KMG9]3EBI-12033434,EBI-18178701
TMEM70 [Q9BUB7]3EBI-12033434,EBI-726363
TMEM79 [Q9BSE2]3EBI-12033434,EBI-8649725

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117108, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UBY5, 53 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000395389

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UBY5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UBY5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBY5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214362

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047979_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBY5

KEGG Orthology (KO)

More...
KOi
K04294

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIYSYKD

Database of Orthologous Groups

More...
OrthoDBi
1366218at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBY5

TreeFam database of animal gene trees

More...
TreeFami
TF330052

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR004065, LPA_rcpt
IPR005385, LPA_rcpt_EDG7

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01560, EDG7RECEPTOR
PR00237, GPCRRHODOPSN
PR01527, LPARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UBY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL
60 70 80 90 100
VIAAVIKNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN
110 120 130 140 150
RWFLRQGLLD SSLTASLTNL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL
160 170 180 190 200
LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLVF WTVSNLMAFL
210 220 230 240 250
IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT VMTVLGAFVV
260 270 280 290 300
CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM
310 320 330 340 350
YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK

STS
Length:353
Mass (Da):40,128
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i105DC9DD185E2CE7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049415231R → Q. Corresponds to variant dbSNP:rs35745543Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF127138 mRNA Translation: AAD56311.1
AF186380 mRNA Translation: AAF00530.1
AY322547 mRNA Translation: AAP84360.1
BC126268 mRNA Translation: AAI26269.1
BC126270 mRNA Translation: AAI26271.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS700.1

NCBI Reference Sequences

More...
RefSeqi
NP_036284.1, NM_012152.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370611; ENSP00000359643; ENSG00000171517
ENST00000440886; ENSP00000395389; ENSG00000171517

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23566

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23566

UCSC genome browser

More...
UCSCi
uc001dkl.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127138 mRNA Translation: AAD56311.1
AF186380 mRNA Translation: AAF00530.1
AY322547 mRNA Translation: AAP84360.1
BC126268 mRNA Translation: AAI26269.1
BC126270 mRNA Translation: AAI26271.1
CCDSiCCDS700.1
RefSeqiNP_036284.1, NM_012152.2

3D structure databases

SMRiQ9UBY5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117108, 4 interactors
IntActiQ9UBY5, 53 interactors
STRINGi9606.ENSP00000395389

Chemistry databases

BindingDBiQ9UBY5
ChEMBLiCHEMBL3250
GuidetoPHARMACOLOGYi274
SwissLipidsiSLP:000001572

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

GlyGeniQ9UBY5, 2 sites
iPTMnetiQ9UBY5
PhosphoSitePlusiQ9UBY5

Polymorphism and mutation databases

BioMutaiLPAR3
DMDMi26393418

Proteomic databases

MassIVEiQ9UBY5
PaxDbiQ9UBY5
PeptideAtlasiQ9UBY5
PRIDEiQ9UBY5
ProteomicsDBi84099

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2955, 319 antibodies

Genome annotation databases

EnsembliENST00000370611; ENSP00000359643; ENSG00000171517
ENST00000440886; ENSP00000395389; ENSG00000171517
GeneIDi23566
KEGGihsa:23566
UCSCiuc001dkl.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23566
DisGeNETi23566
EuPathDBiHostDB:ENSG00000171517.5

GeneCards: human genes, protein and diseases

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GeneCardsi
LPAR3
HGNCiHGNC:14298, LPAR3
HPAiENSG00000171517, Tissue enhanced (fallopian)
MIMi605106, gene
neXtProtiNX_Q9UBY5
OpenTargetsiENSG00000171517
PharmGKBiPA162394213

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01000000214362
HOGENOMiCLU_047979_0_0_1
InParanoidiQ9UBY5
KOiK04294
OMAiCIYSYKD
OrthoDBi1366218at2759
PhylomeDBiQ9UBY5
TreeFamiTF330052

Enzyme and pathway databases

PathwayCommonsiQ9UBY5
ReactomeiR-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events
R-HSA-419408, Lysosphingolipid and LPA receptors
SIGNORiQ9UBY5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23566, 4 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LPAR3, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LPAR3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23566
PharosiQ9UBY5, Tchem

Protein Ontology

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PROi
PR:Q9UBY5
RNActiQ9UBY5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000171517, Expressed in oviduct epithelium and 149 other tissues
GenevisibleiQ9UBY5, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR004065, LPA_rcpt
IPR005385, LPA_rcpt_EDG7
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR01560, EDG7RECEPTOR
PR00237, GPCRRHODOPSN
PR01527, LPARECEPTOR
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPAR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBY5
Secondary accession number(s): A0AVA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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