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Entry version 159 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

Sodium/hydrogen exchanger 2

Gene

SLC9A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425986 Sodium/Proton exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.36.1.17 the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 2
Alternative name(s):
Na(+)/H(+) exchanger 2
Short name:
NHE-2
Solute carrier family 9 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC9A2
Synonyms:NHE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11072 SLC9A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600530 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBY0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei14 – 33Name=A/M1By similarityAdd BLAST20
Topological domaini34 – 79CytoplasmicSequence analysisAdd BLAST46
Intramembranei80 – 100Name=B/M2By similarityAdd BLAST21
Topological domaini101 – 106CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei107 – 127Helical; Name=C/M3Sequence analysisAdd BLAST21
Topological domaini128 – 138ExtracellularSequence analysisAdd BLAST11
Transmembranei139 – 159Helical; Name=D/M4Sequence analysisAdd BLAST21
Topological domaini160 – 168CytoplasmicSequence analysis9
Transmembranei169 – 189Helical; Name=E/M5Sequence analysisAdd BLAST21
Topological domaini190 – 208ExtracellularSequence analysisAdd BLAST19
Transmembranei209 – 229Helical; Name=F/M5ASequence analysisAdd BLAST21
Topological domaini230 – 236CytoplasmicSequence analysis7
Transmembranei237 – 257Helical; Name=G/M5BSequence analysisAdd BLAST21
Topological domaini258 – 277ExtracellularSequence analysisAdd BLAST20
Transmembranei278 – 298Helical; Name=H/M6Sequence analysisAdd BLAST21
Topological domaini299 – 307CytoplasmicSequence analysis9
Transmembranei308 – 328Helical; Name=I/M7Sequence analysisAdd BLAST21
Topological domaini329 – 360ExtracellularSequence analysisAdd BLAST32
Transmembranei361 – 381Helical; Name=J/M8Sequence analysisAdd BLAST21
Topological domaini382 – 391CytoplasmicSequence analysis10
Transmembranei392 – 412Helical; Name=K/M9Sequence analysisAdd BLAST21
Topological domaini413 – 429ExtracellularSequence analysisAdd BLAST17
Intramembranei430 – 450Name=LBy similarityAdd BLAST21
Topological domaini451 – 458ExtracellularSequence analysis8
Transmembranei459 – 479Helical; Name=M13Sequence analysisAdd BLAST21
Topological domaini480 – 812CytoplasmicSequence analysisAdd BLAST333

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6549

Open Targets

More...
OpenTargetsi
ENSG00000115616

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35929

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBY0

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3133

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC9A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
19924293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523521 – 812Sodium/hydrogen exchanger 2Add BLAST812

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated (Possible).

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UBY0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UBY0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UBY0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBY0

PeptideAtlas

More...
PeptideAtlasi
Q9UBY0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBY0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84098

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBY0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115616 Expressed in 86 organ(s), highest expression level in stomach

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBY0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035121
HPA035122

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHP1 and CHP2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112439, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UBY0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233969

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UBY0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBY0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1966 Eukaryota
COG0025 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156807

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247044

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBY0

KEGG Orthology (KO)

More...
KOi
K14722

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIPFNMK

Database of Orthologous Groups

More...
OrthoDBi
316731at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBY0

TreeFam database of animal gene trees

More...
TreeFami
TF317212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001953 Na/H_exchanger_2
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10110 PTHR10110, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084 NAHEXCHNGR
PR01086 NAHEXCHNGR2

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840 b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UBY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLGNWRSL RAPLPPMLLL LLLQVAGPVG ALAETLLNAP RAMGTSSSPP
60 70 80 90 100
SPASVVAPGT TLFEESRLPV FTLDYPHVQI PFEITLWILL ASLAKIGFHL
110 120 130 140 150
YHKLPTIVPE SCLLIMVGLL LGGIIFGVDE KSPPAMKTDV FFLYLLPPIV
160 170 180 190 200
LDAGYFMPTR PFFENIGTIF WYAVVGTLWN SIGIGVSLFG ICQIEAFGLS
210 220 230 240 250
DITLLQNLLF GSLISAVDPV AVLAVFENIH VNEQLYILVF GESLLNDAVT
260 270 280 290 300
VVLYNLFKSF CQMKTIETID VFAGIANFFV VGIGGVLIGI FLGFIAAFTT
310 320 330 340 350
RFTHNIRVIE PLFVFLYSYL SYITAEMFHL SGIMAITACA MTMNKYVEEN
360 370 380 390 400
VSQKSYTTIK YFMKMLSSVS ETLIFIFMGV STVGKNHEWN WAFVCFTLAF
410 420 430 440 450
CLMWRALGVF VLTQVINRFR TIPLTFKDQF IIAYGGLRGA ICFALVFLLP
460 470 480 490 500
AAVFPRKKLF ITAAIVVIFF TVFILGITIR PLVEFLDVKR SNKKQQAVSE
510 520 530 540 550
EIYCRLFDHV KTGIEDVCGH WGHNFWRDKF KKFDDKYLRK LLIRENQPKS
560 570 580 590 600
SIVSLYKKLE IKHAIEMAET GMISTVPTFA SLNDCREEKI RKVTSSETDE
610 620 630 640 650
IRELLSRNLY QIRQRTLSYN RHSLTADTSE RQAKEILIRR RHSLRESIRK
660 670 680 690 700
DSSLNREHRA STSTSRYLSL PKNTKLPEKL QKRRTISIAD GNSSDSDADA
710 720 730 740 750
GTTVLNLQPR ARRFLPEQFS KKSPQSYKME WKNEVDVDSG RDMPSTPPTP
760 770 780 790 800
HSREKGTQTS GLLQQPLLSK DQSGSEREDS LTEGIPPKPP PRLVWRASEP
810
GSRKARFGSE KP
Length:812
Mass (Da):91,520
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17EE177DC3830D0A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035964299T → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1386751319Ensembl.1
Natural variantiVAR_035965806R → Q in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF073299 mRNA Translation: AAD41635.1
AC007239 Genomic DNA Translation: AAF19248.1
CH471127 Genomic DNA Translation: EAX01789.1
BC136377 mRNA Translation: AAI36378.1
BC136378 mRNA Translation: AAI36379.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2062.1

NCBI Reference Sequences

More...
RefSeqi
NP_003039.2, NM_003048.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233969; ENSP00000233969; ENSG00000115616

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6549

UCSC genome browser

More...
UCSCi
uc002tca.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073299 mRNA Translation: AAD41635.1
AC007239 Genomic DNA Translation: AAF19248.1
CH471127 Genomic DNA Translation: EAX01789.1
BC136377 mRNA Translation: AAI36378.1
BC136378 mRNA Translation: AAI36379.1
CCDSiCCDS2062.1
RefSeqiNP_003039.2, NM_003048.5

3D structure databases

SMRiQ9UBY0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112439, 6 interactors
IntActiQ9UBY0, 2 interactors
STRINGi9606.ENSP00000233969

Chemistry databases

BindingDBiQ9UBY0
ChEMBLiCHEMBL3133

Protein family/group databases

TCDBi2.A.36.1.17 the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

iPTMnetiQ9UBY0
PhosphoSitePlusiQ9UBY0

Polymorphism and mutation databases

BioMutaiSLC9A2
DMDMi19924293

Proteomic databases

jPOSTiQ9UBY0
MassIVEiQ9UBY0
MaxQBiQ9UBY0
PaxDbiQ9UBY0
PeptideAtlasiQ9UBY0
PRIDEiQ9UBY0
ProteomicsDBi84098

Genome annotation databases

EnsembliENST00000233969; ENSP00000233969; ENSG00000115616
GeneIDi6549
KEGGihsa:6549
UCSCiuc002tca.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6549
DisGeNETi6549

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC9A2
HGNCiHGNC:11072 SLC9A2
HPAiHPA035121
HPA035122
MIMi600530 gene
neXtProtiNX_Q9UBY0
OpenTargetsiENSG00000115616
PharmGKBiPA35929

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00940000156807
HOGENOMiHOG000247044
InParanoidiQ9UBY0
KOiK14722
OMAiTIPFNMK
OrthoDBi316731at2759
PhylomeDBiQ9UBY0
TreeFamiTF317212

Enzyme and pathway databases

ReactomeiR-HSA-425986 Sodium/Proton exchangers

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC9A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6549
PharosiQ9UBY0

Protein Ontology

More...
PROi
PR:Q9UBY0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115616 Expressed in 86 organ(s), highest expression level in stomach
GenevisibleiQ9UBY0 HS

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001953 Na/H_exchanger_2
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01086 NAHEXCHNGR2
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBY0
Secondary accession number(s): B2RMS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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