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Protein

Sodium/hydrogen exchanger 2

Gene

SLC9A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-425986 Sodium/Proton exchangers

Protein family/group databases

TCDBi2.A.36.1.17 the monovalent cation:proton antiporter-1 (cpa1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 2
Alternative name(s):
Na(+)/H(+) exchanger 2
Short name:
NHE-2
Solute carrier family 9 member 2
Gene namesi
Name:SLC9A2
Synonyms:NHE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115616.2
HGNCiHGNC:11072 SLC9A2
MIMi600530 gene
neXtProtiNX_Q9UBY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Intramembranei14 – 33Name=A/M1By similarityAdd BLAST20
Topological domaini34 – 79CytoplasmicSequence analysisAdd BLAST46
Intramembranei80 – 100Name=B/M2By similarityAdd BLAST21
Topological domaini101 – 106CytoplasmicSequence analysis6
Transmembranei107 – 127Helical; Name=C/M3Sequence analysisAdd BLAST21
Topological domaini128 – 138ExtracellularSequence analysisAdd BLAST11
Transmembranei139 – 159Helical; Name=D/M4Sequence analysisAdd BLAST21
Topological domaini160 – 168CytoplasmicSequence analysis9
Transmembranei169 – 189Helical; Name=E/M5Sequence analysisAdd BLAST21
Topological domaini190 – 208ExtracellularSequence analysisAdd BLAST19
Transmembranei209 – 229Helical; Name=F/M5ASequence analysisAdd BLAST21
Topological domaini230 – 236CytoplasmicSequence analysis7
Transmembranei237 – 257Helical; Name=G/M5BSequence analysisAdd BLAST21
Topological domaini258 – 277ExtracellularSequence analysisAdd BLAST20
Transmembranei278 – 298Helical; Name=H/M6Sequence analysisAdd BLAST21
Topological domaini299 – 307CytoplasmicSequence analysis9
Transmembranei308 – 328Helical; Name=I/M7Sequence analysisAdd BLAST21
Topological domaini329 – 360ExtracellularSequence analysisAdd BLAST32
Transmembranei361 – 381Helical; Name=J/M8Sequence analysisAdd BLAST21
Topological domaini382 – 391CytoplasmicSequence analysis10
Transmembranei392 – 412Helical; Name=K/M9Sequence analysisAdd BLAST21
Topological domaini413 – 429ExtracellularSequence analysisAdd BLAST17
Intramembranei430 – 450Name=LBy similarityAdd BLAST21
Topological domaini451 – 458ExtracellularSequence analysis8
Transmembranei459 – 479Helical; Name=M13Sequence analysisAdd BLAST21
Topological domaini480 – 812CytoplasmicSequence analysisAdd BLAST333

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6549
OpenTargetsiENSG00000115616
PharmGKBiPA35929

Chemistry databases

ChEMBLiCHEMBL3133

Polymorphism and mutation databases

BioMutaiSLC9A2
DMDMi19924293

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523521 – 812Sodium/hydrogen exchanger 2Add BLAST812

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated (Possible).

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UBY0
MaxQBiQ9UBY0
PaxDbiQ9UBY0
PeptideAtlasiQ9UBY0
PRIDEiQ9UBY0
ProteomicsDBi84098

PTM databases

iPTMnetiQ9UBY0
PhosphoSitePlusiQ9UBY0

Expressioni

Tissue specificityi

Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.

Gene expression databases

BgeeiENSG00000115616 Expressed in 86 organ(s), highest expression level in stomach
CleanExiHS_SLC9A2
GenevisibleiQ9UBY0 HS

Organism-specific databases

HPAiHPA035121
HPA035122

Interactioni

Subunit structurei

Interacts with CHP1 and CHP2.By similarity

Protein-protein interaction databases

BioGridi112439, 6 interactors
IntActiQ9UBY0, 1 interactor
STRINGi9606.ENSP00000233969

Chemistry databases

BindingDBiQ9UBY0

Structurei

3D structure databases

ProteinModelPortaliQ9UBY0
SMRiQ9UBY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000247044
HOVERGENiHBG052615
InParanoidiQ9UBY0
KOiK14722
OMAiAYKMEWK
OrthoDBiEOG091G02Q0
PhylomeDBiQ9UBY0
TreeFamiTF317212

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001953 Na/H_exchanger_2
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01086 NAHEXCHNGR2
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UBY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLGNWRSL RAPLPPMLLL LLLQVAGPVG ALAETLLNAP RAMGTSSSPP
60 70 80 90 100
SPASVVAPGT TLFEESRLPV FTLDYPHVQI PFEITLWILL ASLAKIGFHL
110 120 130 140 150
YHKLPTIVPE SCLLIMVGLL LGGIIFGVDE KSPPAMKTDV FFLYLLPPIV
160 170 180 190 200
LDAGYFMPTR PFFENIGTIF WYAVVGTLWN SIGIGVSLFG ICQIEAFGLS
210 220 230 240 250
DITLLQNLLF GSLISAVDPV AVLAVFENIH VNEQLYILVF GESLLNDAVT
260 270 280 290 300
VVLYNLFKSF CQMKTIETID VFAGIANFFV VGIGGVLIGI FLGFIAAFTT
310 320 330 340 350
RFTHNIRVIE PLFVFLYSYL SYITAEMFHL SGIMAITACA MTMNKYVEEN
360 370 380 390 400
VSQKSYTTIK YFMKMLSSVS ETLIFIFMGV STVGKNHEWN WAFVCFTLAF
410 420 430 440 450
CLMWRALGVF VLTQVINRFR TIPLTFKDQF IIAYGGLRGA ICFALVFLLP
460 470 480 490 500
AAVFPRKKLF ITAAIVVIFF TVFILGITIR PLVEFLDVKR SNKKQQAVSE
510 520 530 540 550
EIYCRLFDHV KTGIEDVCGH WGHNFWRDKF KKFDDKYLRK LLIRENQPKS
560 570 580 590 600
SIVSLYKKLE IKHAIEMAET GMISTVPTFA SLNDCREEKI RKVTSSETDE
610 620 630 640 650
IRELLSRNLY QIRQRTLSYN RHSLTADTSE RQAKEILIRR RHSLRESIRK
660 670 680 690 700
DSSLNREHRA STSTSRYLSL PKNTKLPEKL QKRRTISIAD GNSSDSDADA
710 720 730 740 750
GTTVLNLQPR ARRFLPEQFS KKSPQSYKME WKNEVDVDSG RDMPSTPPTP
760 770 780 790 800
HSREKGTQTS GLLQQPLLSK DQSGSEREDS LTEGIPPKPP PRLVWRASEP
810
GSRKARFGSE KP
Length:812
Mass (Da):91,520
Last modified:May 1, 2000 - v1
Checksum:i17EE177DC3830D0A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035964299T → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035965806R → Q in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073299 mRNA Translation: AAD41635.1
AC007239 Genomic DNA Translation: AAF19248.1
CH471127 Genomic DNA Translation: EAX01789.1
BC136377 mRNA Translation: AAI36378.1
BC136378 mRNA Translation: AAI36379.1
CCDSiCCDS2062.1
RefSeqiNP_003039.2, NM_003048.5
UniGeneiHs.250083

Genome annotation databases

EnsembliENST00000233969; ENSP00000233969; ENSG00000115616
GeneIDi6549
KEGGihsa:6549
UCSCiuc002tca.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSL9A2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBY0
Secondary accession number(s): B2RMS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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