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Protein

Kallikrein-11

Gene

KLK11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Charge relay systemBy similarity1
Active sitei142Charge relay systemBy similarity1
Active sitei235Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.35 2681
3.4.21.B42 2681

Protein family/group databases

MEROPSiS01.257

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-11 (EC:3.4.21.-)
Short name:
hK11
Alternative name(s):
Hippostasin
Serine protease 20
Trypsin-like protease
Cleaved into the following 2 chains:
Gene namesi
Name:KLK11
Synonyms:PRSS20, TLSP
ORF Names:UNQ649/PRO1279
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167757.13
HGNCiHGNC:6359 KLK11
MIMi604434 gene
neXtProtiNX_Q9UBX7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11012
OpenTargetsiENSG00000167757
PharmGKBiPA30148

Polymorphism and mutation databases

BioMutaiKLK11
DMDMi88984315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50Sequence analysisAdd BLAST50
PropeptideiPRO_000002795451 – 53Activation peptideSequence analysis3
ChainiPRO_000002795554 – 282Kallikrein-11Add BLAST229
ChainiPRO_000030206154 – 188Kallikrein-11 inactive chain 1Add BLAST135
ChainiPRO_0000302062189 – 282Kallikrein-11 inactive chain 2Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 195PROSITE-ProRule annotation
Disulfide bondi79 ↔ 95PROSITE-ProRule annotation
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi167 ↔ 269PROSITE-ProRule annotation
Disulfide bondi174 ↔ 241PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 220PROSITE-ProRule annotation
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi231 ↔ 256PROSITE-ProRule annotation
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9UBX7
PeptideAtlasiQ9UBX7
PRIDEiQ9UBX7
ProteomicsDBi84094
84095 [Q9UBX7-1]
84096 [Q9UBX7-3]

PTM databases

iPTMnetiQ9UBX7
PhosphoSitePlusiQ9UBX7

Miscellaneous databases

PMAP-CutDBiQ9UBX7

Expressioni

Tissue specificityi

Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000167757 Expressed in 136 organ(s), highest expression level in ectocervix
CleanExiHS_KLK11
ExpressionAtlasiQ9UBX7 baseline and differential
GenevisibleiQ9UBX7 HS

Organism-specific databases

HPAiCAB026340

Interactioni

Protein-protein interaction databases

BioGridi116202, 28 interactors
STRINGi9606.ENSP00000473047

Structurei

3D structure databases

ProteinModelPortaliQ9UBX7
SMRiQ9UBX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 280Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9UBX7
KOiK09620
OMAiIKGYECS
OrthoDBiEOG091G0DF7
PhylomeDBiQ9UBX7
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9UBX7-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG
60 70 80 90 100
ETRIIKGFEC KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY
110 120 130 140 150
IVHLGQHNLQ KEEGCEQTRT ATESFPHPGF NNSLPNKDHR NDIMLVKMAS
160 170 180 190 200
PVSITWAVRP LTLSSRCVTA GTSCLISGWG STSSPQLRLP HTLRCANITI
210 220 230 240 250
IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV CNQSLQGIIS
260 270 280
WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN
Length:282
Mass (Da):31,059
Last modified:February 21, 2006 - v2
Checksum:iB442DDE613EE0A17
GO
Isoform 1 (identifier: Q9UBX7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:250
Mass (Da):27,466
Checksum:i192D910BBCDC7A56
GO
Isoform 3 (identifier: Q9UBX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-98: P → PWVSLTSPTHVSPDLSSSNYCLSHLS

Note: Localized in the prostate secretory epithelium.
Show »
Length:307
Mass (Da):33,759
Checksum:iE5C0EE949DBAFA2B
GO
Isoform 4 (identifier: Q9UBX7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     98-98: P → PWVSLTSPTHVSPDLSSSNYCLSHLS

Show »
Length:275
Mass (Da):30,166
Checksum:i257A42B28F40E2C4
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZI8M0QZI8_HUMAN
Kallikrein-11
KLK11
170Annotation score:
M0R151M0R151_HUMAN
Kallikrein related peptidase 11 iso...
KLK11 TLSP
109Annotation score:
M0QZV0M0QZV0_HUMAN
Kallikrein-11
KLK11
68Annotation score:
M0QYW4M0QYW4_HUMAN
Kallikrein-11
KLK11
141Annotation score:
A0A0A0MR55A0A0A0MR55_HUMAN
Kallikrein-11
KLK11
116Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05185632A → T. Corresponds to variant dbSNP:rs2288892Ensembl.1
Natural variantiVAR_02194349G → E. Corresponds to variant dbSNP:rs3745539Ensembl.1
Natural variantiVAR_024296166R → C. Corresponds to variant dbSNP:rs1048328Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0054021 – 32Missing in isoform 1 and isoform 4. 4 PublicationsAdd BLAST32
Alternative sequenceiVSP_04332698P → PWVSLTSPTHVSPDLSSSNY CLSHLS in isoform 3 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012917 mRNA Translation: BAA33404.1
AB013730 mRNA Translation: BAA88713.1
AB041036 mRNA Translation: BAA96797.1
AF164623 Genomic DNA Translation: AAD47815.1
AF243527 Genomic DNA Translation: AAG33364.1
AB078780 mRNA Translation: BAC54105.1
AB261897 mRNA Translation: BAE95335.1
AB259014 mRNA Translation: BAF02733.1
AY359014 mRNA Translation: AAQ89373.1
AC011473 Genomic DNA Translation: AAG23257.1
CH471135 Genomic DNA Translation: EAW71971.1
BC022068 mRNA Translation: AAH22068.1
CCDSiCCDS12818.1 [Q9UBX7-2]
CCDS12819.1 [Q9UBX7-1]
CCDS54297.1 [Q9UBX7-4]
RefSeqiNP_001129504.1, NM_001136032.2 [Q9UBX7-1]
NP_001161077.1, NM_001167605.1 [Q9UBX7-4]
NP_006844.1, NM_006853.2 [Q9UBX7-1]
NP_659196.1, NM_144947.2 [Q9UBX7-2]
XP_011524671.1, XM_011526369.1 [Q9UBX7-3]
XP_011524672.1, XM_011526370.2 [Q9UBX7-4]
XP_011524673.1, XM_011526371.2 [Q9UBX7-4]
XP_011524674.1, XM_011526372.2 [Q9UBX7-4]
XP_011524675.1, XM_011526373.1 [Q9UBX7-4]
UniGeneiHs.57771

Genome annotation databases

EnsembliENST00000319720; ENSP00000324269; ENSG00000167757 [Q9UBX7-1]
ENST00000391804; ENSP00000375680; ENSG00000167757 [Q9UBX7-4]
ENST00000453757; ENSP00000413958; ENSG00000167757 [Q9UBX7-1]
ENST00000594768; ENSP00000473047; ENSG00000167757 [Q9UBX7-2]
GeneIDi11012
KEGGihsa:11012
UCSCiuc002pvb.3 human [Q9UBX7-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012917 mRNA Translation: BAA33404.1
AB013730 mRNA Translation: BAA88713.1
AB041036 mRNA Translation: BAA96797.1
AF164623 Genomic DNA Translation: AAD47815.1
AF243527 Genomic DNA Translation: AAG33364.1
AB078780 mRNA Translation: BAC54105.1
AB261897 mRNA Translation: BAE95335.1
AB259014 mRNA Translation: BAF02733.1
AY359014 mRNA Translation: AAQ89373.1
AC011473 Genomic DNA Translation: AAG23257.1
CH471135 Genomic DNA Translation: EAW71971.1
BC022068 mRNA Translation: AAH22068.1
CCDSiCCDS12818.1 [Q9UBX7-2]
CCDS12819.1 [Q9UBX7-1]
CCDS54297.1 [Q9UBX7-4]
RefSeqiNP_001129504.1, NM_001136032.2 [Q9UBX7-1]
NP_001161077.1, NM_001167605.1 [Q9UBX7-4]
NP_006844.1, NM_006853.2 [Q9UBX7-1]
NP_659196.1, NM_144947.2 [Q9UBX7-2]
XP_011524671.1, XM_011526369.1 [Q9UBX7-3]
XP_011524672.1, XM_011526370.2 [Q9UBX7-4]
XP_011524673.1, XM_011526371.2 [Q9UBX7-4]
XP_011524674.1, XM_011526372.2 [Q9UBX7-4]
XP_011524675.1, XM_011526373.1 [Q9UBX7-4]
UniGeneiHs.57771

3D structure databases

ProteinModelPortaliQ9UBX7
SMRiQ9UBX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116202, 28 interactors
STRINGi9606.ENSP00000473047

Protein family/group databases

MEROPSiS01.257

PTM databases

iPTMnetiQ9UBX7
PhosphoSitePlusiQ9UBX7

Polymorphism and mutation databases

BioMutaiKLK11
DMDMi88984315

Proteomic databases

PaxDbiQ9UBX7
PeptideAtlasiQ9UBX7
PRIDEiQ9UBX7
ProteomicsDBi84094
84095 [Q9UBX7-1]
84096 [Q9UBX7-3]

Protocols and materials databases

DNASUi11012
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319720; ENSP00000324269; ENSG00000167757 [Q9UBX7-1]
ENST00000391804; ENSP00000375680; ENSG00000167757 [Q9UBX7-4]
ENST00000453757; ENSP00000413958; ENSG00000167757 [Q9UBX7-1]
ENST00000594768; ENSP00000473047; ENSG00000167757 [Q9UBX7-2]
GeneIDi11012
KEGGihsa:11012
UCSCiuc002pvb.3 human [Q9UBX7-2]

Organism-specific databases

CTDi11012
DisGeNETi11012
EuPathDBiHostDB:ENSG00000167757.13
GeneCardsiKLK11
HGNCiHGNC:6359 KLK11
HPAiCAB026340
MIMi604434 gene
neXtProtiNX_Q9UBX7
OpenTargetsiENSG00000167757
PharmGKBiPA30148
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9UBX7
KOiK09620
OMAiIKGYECS
OrthoDBiEOG091G0DF7
PhylomeDBiQ9UBX7
TreeFamiTF331065

Enzyme and pathway databases

BRENDAi3.4.21.35 2681
3.4.21.B42 2681

Miscellaneous databases

ChiTaRSiKLK11 human
GeneWikiiKLK11
GenomeRNAii11012
PMAP-CutDBiQ9UBX7
PROiPR:Q9UBX7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167757 Expressed in 136 organ(s), highest expression level in ectocervix
CleanExiHS_KLK11
ExpressionAtlasiQ9UBX7 baseline and differential
GenevisibleiQ9UBX7 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLK11_HUMAN
AccessioniPrimary (citable) accession number: Q9UBX7
Secondary accession number(s): O75837
, Q0WXX5, Q8IXD7, Q9NS65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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