UniProtKB - Q9UBX2 (DUX4_HUMAN)
Protein
Double homeobox protein 4
Gene
DUX4
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that is selectively and transiently expressed in cleavage-stage embryos (PubMed:28459457). Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3' (PubMed:28459457, PubMed:28459454, PubMed:29572508, PubMed:30540931, PubMed:30315230). Binds to chromatin containing histone H3 acetylated at 'Lys-27' (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, binds to chromatin that lacks histone H3 acetylation at 'Lys-27' (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at 'Lys-27' at new sites (PubMed:26951377). Involved in transcriptional regulation of numerous genes, primarily as transcriptional activator, but mediates also repression of a set of target genes (PubMed:17984056, PubMed:27378237, PubMed:26951377, PubMed:28459457, PubMed:28459454, PubMed:29618456, PubMed:30540931, PubMed:29572508). Promotes expression of ZSCAN4 and KDM4E, two proteins with essential roles during early embryogenesis (PubMed:27378237, PubMed:26951377, PubMed:28459457, PubMed:29618456). Heterologous expression in cultured embryonic stem cells mediates also transcription of HERVL retrotransposons and transcripts derived from ACRO1 and HSATII satellite repeats (PubMed:28459457). May activate expression of PITX1 (PubMed:17984056). May regulate microRNA (miRNA) expression (PubMed:24145033). Inappropriate expression can inhibit myogenesis and promote apoptosis (PubMed:26951377, PubMed:28935672, PubMed:29618456).11 Publications
Probably inactive as a transcriptional activator, due to the absence of the C-terminal region that is important for transcriptional activation. Can inhibit transcriptional activation mediated by isoform 1. Heterologous expression of isoform 2 has no deleterious effect on cell survival.1 Publication
Miscellaneous
DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes.4 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 19 – 78 | Homeobox 1PROSITE-ProRule annotation1 PublicationAdd BLAST | 60 | |
DNA bindingi | 94 – 153 | Homeobox 2PROSITE-ProRule annotation1 PublicationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: UniProtKB
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB
- multicellular organism development Source: UniProtKB-KW
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of G0 to G1 transition Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9UBX2 |
SIGNORi | Q9UBX2 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Double homeobox protein 4ImportedAlternative name(s): Double homeobox protein 10Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000260596.5 |
HGNCi | HGNC:50800, DUX4 |
MIMi | 606009, gene |
neXtProti | NX_Q9UBX2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation7 Publications
Note: Actively transported through the nuclear pore complex (NPC).1 Publication
Nucleus
- Nucleus 1 Publication1 Publication
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nuclear membrane Source: UniProtKB
- nucleolus Source: HPA
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Facioscapulohumeral muscular dystrophy 1 (FSHD1)2 Publications
The gene represented in this entry is involved in disease pathogenesis. The disease is caused by deletion of an integral number of units of a 3.3-kb tandem repeats, termed D4Z4 macrosatellite, located on chromosome 4q35. In unaffected subjects, the D4Z4 array consists of 11-150 repeats, while in FSHD1 patients, the array is reduced to 1-10 repeats (PubMed:19320656). DUX4 is located in D4Z4 macrosatellite which is epigenetically repressed in somatic tissues. D4Z4 chromatin relaxation in FSHD1 results in inefficient epigenetic repression of DUX4 and a variegated pattern of DUX4 protein expression in a subset of skeletal muscle nuclei. Ectopic expression of DUX4 in skeletal muscle activates the expression of stem cell and germline genes, and, when overexpressed in somatic cells, DUX4 can ultimately lead to cell death.1 Publication
Disease descriptionA degenerative muscle disease characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. The onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with impairment of upper extremity elevation. This tends to be followed by facial weakness, primarily involving the orbicularis oris and orbicularis oculi muscles.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 20 | R → A: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 23 | R → A: Mildly decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 26 | W → A: No effect on DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 69 | N → A: Mildly decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 95 | R → A: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 95 | R → A: No effect on DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 96 | R → A: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 97 | K → A: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 98 | R → A: Decreased DNA binding affinity. 2 Publications | 1 | |
Mutagenesisi | 143 | Q → E: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 144 | N → A: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 144 | N → E: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 145 | R → E: Altered sequence specificity, with increased affinity for the DNA sequence 5'-TAATCTAATTA-3'. 1 Publication | 1 | |
Mutagenesisi | 147 | A → S: Altered sequence specificity, with increased affinity for the DNA sequence 5'-TAATCTAATTA-3'. 1 Publication | 1 | |
Mutagenesisi | 148 | R → A: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 148 | R → E: Decreased DNA binding affinity. 1 Publication | 1 | |
Mutagenesisi | 159 – 371 | Missing : Decreased activity as transcriptional activator. 1 PublicationAdd BLAST | 213 | |
Mutagenesisi | 159 – 326 | Missing : No effect on activity as transcriptional activator. 1 PublicationAdd BLAST | 168 | |
Mutagenesisi | 160 – 342 | Missing : No effect on activity as transcriptional activator. 1 PublicationAdd BLAST | 183 | |
Mutagenesisi | 327 – 424 | Missing : Loss of interaction with EP300 and CREBBP. 1 PublicationAdd BLAST | 98 | |
Mutagenesisi | 374 – 424 | Missing : Abolishes activity as transcriptional activator. 1 PublicationAdd BLAST | 51 | |
Mutagenesisi | 405 – 424 | Missing : Reduced activity as transcriptional activator. 1 PublicationAdd BLAST | 20 |
Organism-specific databases
DisGeNETi | 100288687 |
GeneReviewsi | DUX4 |
MalaCardsi | DUX4 |
MIMi | 158900, phenotype |
OpenTargetsi | ENSG00000260596 |
Orphaneti | 269, Facioscapulohumeral dystrophy |
Miscellaneous databases
Pharosi | Q9UBX2, Tbio |
Polymorphism and mutation databases
BioMutai | DUX4 |
DMDMi | 74720085 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252413 | 1 – 424 | Double homeobox protein 4Add BLAST | 424 |
Proteomic databases
MassIVEi | Q9UBX2 |
PeptideAtlasi | Q9UBX2 |
ProteomicsDBi | 84090 |
PTM databases
iPTMneti | Q9UBX2 |
PhosphoSitePlusi | Q9UBX2 |
Expressioni
Tissue specificityi
Isoform 1: Does not seem to be expressed in normal muscle, but is detected in muscle of individuals with FSHD, and also in testis (at protein level) (PubMed:21060811, PubMed:17984056). Isoform 1: Does not seem to be expressed in normal muscle, but in muscle of individuals with FSHD, where it may be toxic to cells (PubMed:21060811, PubMed:17984056). Isoform 2: Detected in skeletal muscle, fibroblasts and testis from healthy individuals (PubMed:21060811).2 Publications
Developmental stagei
Isoform 1: Detected in embryos at the 4-cell stage. Not detected in embryos at the 2-cell stage, or at the 8-cell stage (at protein level). Detected in embryos at the 4-cell stage. Not detected in embryos at the 2-cell stage, or at the 8-cell stage (PubMed:28459457). Detected in induced pluripotent (iPS) cells, but expression is suppressed upon differentiation to embryoid bodies. Isoform 2: Detected in embryoid bodies derived from induced pluripotent (iPS) cells, but not in the induced pluripotent (iPS) cells themselves (PubMed:21060811).2 Publications
Gene expression databases
Bgeei | ENSG00000260596, Expressed in sural nerve and 57 other tissues |
ExpressionAtlasi | Q9UBX2, baseline and differential |
Genevisiblei | Q9UBX2, HS |
Organism-specific databases
HPAi | ENSG00000260596, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ9UBX2
With | #Exp. | IntAct |
---|---|---|
DES [P17661] | 3 | EBI-11600078,EBI-1055572 |
IPO13 [O94829] | 2 | EBI-11600078,EBI-747310 |
Des [P31001] from Mus musculus. | 2 | EBI-11600078,EBI-298565 |
Protein-protein interaction databases
BioGRIDi | 940343, 2 interactors |
IntActi | Q9UBX2, 284 interactors |
STRINGi | 9606.ENSP00000485452 |
Miscellaneous databases
RNActi | Q9UBX2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UBX2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 327 – 424 | Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes1 PublicationAdd BLAST | 98 | |
Regioni | 405 – 424 | Important for transcriptional activation of target genes1 PublicationAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 16 – 98 | Arg-richAdd BLAST | 83 | |
Compositional biasi | 156 – 245 | Ala-richAdd BLAST | 90 |
Domaini
The two homeobox domains are arranged in a head-to-head orientation when bound to double-stranded DNA, each domain binding to one of the two DNA strands. Together, the homeobox domains can be considered to bind DNA with the consensus sequence 5'-TAATCTAATCA-3', but due to the head-to-head orientation of the DNA-bound domains, the first homeobox domain binds to the consensus sequence 5'-TAAT-3', and the second homeobox domain binds DNA on the opposite strand, with the consensus sequence 5'-TGAT-3' (PubMed:30322619, PubMed:30540931). Both homeobox domains confer nuclear targeting (PubMed:15709750).3 Publications
The C-terminal region is required for efficient activation of transcription from target promoters (PubMed:26951377, PubMed:29618456). It mediates interaction with EP300 and CREBBP (PubMed:26951377).2 Publications
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
Homeobox, RepeatPhylogenomic databases
eggNOGi | KOG0849, Eukaryota |
GeneTreei | ENSGT00940000154537 |
HOGENOMi | CLU_045070_0_0_1 |
InParanoidi | Q9UBX2 |
OMAi | ARQGQMQ |
OrthoDBi | 390511at2759 |
PhylomeDBi | Q9UBX2 |
Family and domain databases
CDDi | cd00086, homeodomain, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 2 hits |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9UBX2-1) [UniParc]FASTAAdd to basket
Also known as: DUX4-fl1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE
60 70 80 90 100
RLAQAIGIPE PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA
110 120 130 140 150
VTGSQTALLL RAFEKDRFPG IAAREELARE TGLPESRIQI WFQNRRARHP
160 170 180 190 200
GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF AHTGAWGTGL PAPHVPCAPG
210 220 230 240 250
ALPQGAFVSQ AARAAPALQP SQAAPAEGIS QPAPARGDFA YAAPAPPDGA
260 270 280 290 300
LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA
310 320 330 340 350
PPTSQGSPWW GWGRGPQVAG AAWEPQAGAA PPPQPAPPDA SASARQGQMQ
360 370 380 390 400
GIPAPSQALQ EPAPWSALPC GLLLDELLAS PEFLQQAQPL LETEAPGELE
410 420
ASEEAASLEA PLSEEEYRAL LEEL
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060075 | 160 | A → V in isoform 2. | 1 | |
Alternative sequenceiVSP_060076 | 161 – 424 | Missing in isoform 2. Add BLAST | 264 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117653 Genomic DNA Translation: AAD54067.2 HQ266762 mRNA Translation: ADN68617.1 AF117653 Genomic DNA Translation: AAD54068.2 AY044051 Genomic DNA Translation: AAK91509.1 AC215524 Genomic DNA No translation available. |
CCDSi | CCDS77990.1 [Q9UBX2-1] |
RefSeqi | NP_001280727.1, NM_001293798.2 [Q9UBX2-1] NP_001292997.1, NM_001306068.2 [Q9UBX2-1] XP_011529816.1, XM_011531514.2 XP_016885822.1, XM_017030333.1 XP_016885823.1, XM_017030334.1 XP_016885824.1, XM_017030335.1 XP_016885825.1, XM_017030336.1 XP_016885826.1, XM_017030337.1 XP_016885827.1, XM_017030338.1 XP_016885828.1, XM_017030339.1 XP_016885829.1, XM_017030340.1 |
Genome annotation databases
Ensembli | ENST00000565211; ENSP00000458065; ENSG00000260596 [Q9UBX2-1] ENST00000569241; ENSP00000456539; ENSG00000260596 [Q9UBX2-1] ENST00000570263; ENSP00000455112; ENSG00000260596 [Q9UBX2-2] ENST00000616166; ENSP00000483555; ENSG00000260596 [Q9UBX2-1] |
GeneIDi | 100288687 |
KEGGi | hsa:100288687 |
UCSCi | uc031tgs.2, human [Q9UBX2-1] uc063bru.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117653 Genomic DNA Translation: AAD54067.2 HQ266762 mRNA Translation: ADN68617.1 AF117653 Genomic DNA Translation: AAD54068.2 AY044051 Genomic DNA Translation: AAK91509.1 AC215524 Genomic DNA No translation available. |
CCDSi | CCDS77990.1 [Q9UBX2-1] |
RefSeqi | NP_001280727.1, NM_001293798.2 [Q9UBX2-1] NP_001292997.1, NM_001306068.2 [Q9UBX2-1] XP_011529816.1, XM_011531514.2 XP_016885822.1, XM_017030333.1 XP_016885823.1, XM_017030334.1 XP_016885824.1, XM_017030335.1 XP_016885825.1, XM_017030336.1 XP_016885826.1, XM_017030337.1 XP_016885827.1, XM_017030338.1 XP_016885828.1, XM_017030339.1 XP_016885829.1, XM_017030340.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5Z2S | X-ray | 1.50 | A | 100-150 | [»] | |
5Z2T | X-ray | 2.62 | C/D | 94-153 | [»] | |
5Z6Z | X-ray | 2.30 | A | 1-153 | [»] | |
5ZFW | X-ray | 2.10 | A | 1-149 | [»] | |
5ZFY | X-ray | 2.30 | A | 1-149 | [»] | |
5ZFZ | X-ray | 1.90 | A | 1-149 | [»] | |
6A8R | X-ray | 1.60 | A/B | 94-153 | [»] | |
6DFY | X-ray | 2.62 | C/D | 94-153 | [»] | |
6E8C | X-ray | 2.12 | A | 17-155 | [»] | |
6U81 | X-ray | 2.34 | A | 19-150 | [»] | |
6U82 | X-ray | 3.21 | A/D | 17-150 | [»] | |
SMRi | Q9UBX2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 940343, 2 interactors |
IntActi | Q9UBX2, 284 interactors |
STRINGi | 9606.ENSP00000485452 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | Q9UBX2 |
PhosphoSitePlusi | Q9UBX2 |
Polymorphism and mutation databases
BioMutai | DUX4 |
DMDMi | 74720085 |
Proteomic databases
MassIVEi | Q9UBX2 |
PeptideAtlasi | Q9UBX2 |
ProteomicsDBi | 84090 |
Protocols and materials databases
Antibodypediai | 73101, 267 antibodies |
Genome annotation databases
Ensembli | ENST00000565211; ENSP00000458065; ENSG00000260596 [Q9UBX2-1] ENST00000569241; ENSP00000456539; ENSG00000260596 [Q9UBX2-1] ENST00000570263; ENSP00000455112; ENSG00000260596 [Q9UBX2-2] ENST00000616166; ENSP00000483555; ENSG00000260596 [Q9UBX2-1] |
GeneIDi | 100288687 |
KEGGi | hsa:100288687 |
UCSCi | uc031tgs.2, human [Q9UBX2-1] uc063bru.1, human |
Organism-specific databases
CTDi | 100288687 |
DisGeNETi | 100288687 |
EuPathDBi | HostDB:ENSG00000260596.5 |
GeneCardsi | DUX4 |
GeneReviewsi | DUX4 |
HGNCi | HGNC:50800, DUX4 |
HPAi | ENSG00000260596, Tissue enhanced (testis) |
MalaCardsi | DUX4 |
MIMi | 158900, phenotype 606009, gene |
neXtProti | NX_Q9UBX2 |
OpenTargetsi | ENSG00000260596 |
Orphaneti | 269, Facioscapulohumeral dystrophy |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0849, Eukaryota |
GeneTreei | ENSGT00940000154537 |
HOGENOMi | CLU_045070_0_0_1 |
InParanoidi | Q9UBX2 |
OMAi | ARQGQMQ |
OrthoDBi | 390511at2759 |
PhylomeDBi | Q9UBX2 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBX2 |
SIGNORi | Q9UBX2 |
Miscellaneous databases
BioGRID-ORCSi | 100288687, 1 hit in 16 CRISPR screens |
ChiTaRSi | DUX4, human |
GenomeRNAii | 100288687 |
Pharosi | Q9UBX2, Tbio |
PROi | PR:Q9UBX2 |
RNActi | Q9UBX2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000260596, Expressed in sural nerve and 57 other tissues |
ExpressionAtlasi | Q9UBX2, baseline and differential |
Genevisiblei | Q9UBX2, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 2 hits |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DUX4_HUMAN | |
Accessioni | Q9UBX2Primary (citable) accession number: Q9UBX2 Secondary accession number(s): E2JJS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | October 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families