CTSF

Functionⁱ

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Catalytic activityⁱ

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	295	1 Publication	1
Active siteⁱ	431	1 Publication	1
Active siteⁱ	451	By similarity	1

GO - Molecular functionⁱ

cysteine-type endopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
proteolysis
Source: ProtInc
Traceable author statementⁱ
- 9822672
proteolysis involved in cellular protein catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease

Molecular function

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAⁱ	3.4.22.41 2681
Reactomeⁱ	R-HSA-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C01.018

MEROPSⁱ

C01.018

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cathepsin F (EC:3.4.22.41) Short name: CATSF
Gene namesⁱ	Name:CTSF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174080.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2531 CTSF
MIMⁱ	603539 gene
neXtProtⁱ	NX_Q9UBX1

Keywords - Cellular componentⁱ

Lysosome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ceroid lipofuscinosis, neuronal, 13 (CLN13)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of neuronal ceroid lipofuscinosis characterized by adult onset of progressive cognitive decline and motor dysfunction leading to dementia and often early death. Some patients develop seizures. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_070159	231	Y → C in CLN13. 1 PublicationCorresponds to variant dbSNP:rs143889283EnsemblClinVar.	1
Natural variantⁱVAR_070160	321	Q → R in CLN13. 1 PublicationCorresponds to variant dbSNP:rs397514731EnsemblClinVar.	1
Natural variantⁱVAR_070161	458	G → A in CLN13. 1 PublicationCorresponds to variant dbSNP:rs397514732EnsemblClinVar.	1
Natural variantⁱVAR_070162	480	S → L in CLN13. 1 PublicationCorresponds to variant dbSNP:rs397514733EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation, Neurodegeneration, Neuronal ceroid lipofuscinosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8722
GeneReviewsⁱ	CTSF
MalaCards human disease database More...MalaCardsⁱ	CTSF
MIMⁱ	615362 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000174080
Orphanetⁱ	352709 CLN13 disease
PharmGKBⁱ	PA27031

Chemistry databases

ChEMBLⁱ	CHEMBL2517
Drug and drug target database More...DrugBankⁱ	DB02243 4-Morpholin-4-Yl-Piperidine-1-Carboxylic Acid [1-(3-Benzenesulfonyl-1-Propyl-Allylcarbamoyl)-2-Phenylethyl]-Amide DB01871 [1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester DB03536 Benzoyl-Arginine-Alanine-Methyl Ketone DB08775 BENZOYL-TYROSINE-ALANINE-METHYL KETONE DB07913 HOMOPHENYLALANINYLMETHANE DB03691 WRR-112 DB03573 WRR-99
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2347

Polymorphism and mutation databases

BioMutaⁱ	CTSF
DMDMⁱ	12643325

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST	19
PropeptideⁱPRO_0000026202	20 – 270	Activation peptideAdd BLAST	251
ChainⁱPRO_0000026203	271 – 484	Cathepsin FAdd BLAST	214

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	160	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	195	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	292 ↔ 333	1 Publication
Disulfide bondⁱ	326 ↔ 366	1 Publication
Glycosylationⁱ	367	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	378	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	424 ↔ 472	By similarity
Glycosylationⁱ	440	N-linked (GlcNAc...) asparagine1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDⁱ	Q9UBX1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UBX1
PaxDbⁱ	Q9UBX1
PeptideAtlas More...PeptideAtlasⁱ	Q9UBX1
PRIDEⁱ	Q9UBX1
ProteomicsDBⁱ	84089

PTM databases

GlyConnectⁱ	1080
iPTMnetⁱ	Q9UBX1
PhosphoSitePlusⁱ	Q9UBX1

Expressionⁱ

Tissue specificityⁱ

High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus.

Gene expression databases

Bgeeⁱ	ENSG00000174080 Expressed in 233 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CTSF
ExpressionAtlasⁱ	Q9UBX1 baseline and differential
Genevisibleⁱ	Q9UBX1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002141 HPA031431 HPA055610

HPAⁱ

CAB002141
HPA031431
HPA055610

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114261, 18 interactors
STRINGⁱ	9606.ENSP00000310832

Chemistry databases

BindingDBⁱ

Q9UBX1

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	277 – 280	Combined sources	4
Beta strandⁱ	291 – 293	Combined sources	3
Helixⁱ	295 – 312	Combined sources	18
Helixⁱ	320 – 326	Combined sources	7
Beta strandⁱ	328 – 330	Combined sources	3
Helixⁱ	338 – 348	Combined sources	11
Turnⁱ	354 – 356	Combined sources	3
Helixⁱ	370 – 372	Combined sources	3
Beta strandⁱ	378 – 382	Combined sources	5
Helixⁱ	387 – 397	Combined sources	11
Beta strandⁱ	400 – 404	Combined sources	5
Helixⁱ	407 – 411	Combined sources	5
Beta strandⁱ	414 – 417	Combined sources	4
Helixⁱ	421 – 423	Combined sources	3
Beta strandⁱ	431 – 441	Combined sources	11
Beta strandⁱ	444 – 450	Combined sources	7
Beta strandⁱ	462 – 469	Combined sources	8
Helixⁱ	471 – 473	Combined sources	3
Turnⁱ	474 – 477	Combined sources	4
Beta strandⁱ	479 – 482	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UBX1
SMRⁱ	Q9UBX1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UBX1

EvolutionaryTraceⁱ

Q9UBX1

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1542 Eukaryota COG4870 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140823
HOGENOMⁱ	HOG000230774
HOVERGENⁱ	HBG011513
InParanoidⁱ	Q9UBX1
KEGG Orthology (KO) More...KOⁱ	K01373
OMAⁱ	SGIPFWA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05SD
PhylomeDBⁱ	Q9UBX1
TreeFamⁱ	TF314550

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02248 Peptidase_C1A, 1 hit
InterProⁱ	View protein in InterPro IPR038765 Papain_like_cys_pep_sf IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR013128 Peptidase_C1A IPR000668 Peptidase_C1A_C IPR039417 Peptidase_C1A_papain-like IPR013201 Prot_inhib_I29
PANTHERⁱ	PTHR12411 PTHR12411, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08246 Inhibitor_I29, 1 hit PF00112 Peptidase_C1, 1 hit
PRINTSⁱ	PR00705 PAPAIN
SMARTⁱ	View protein in SMART SM00848 Inhibitor_I29, 1 hit SM00645 Pept_C1, 1 hit
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9UBX1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPWLQLLSL LGLLPGAVAA PAQPRAASFQ AWGPPSPELL APTRFALEMF 
        60         70         80         90        100
NRGRAAGTRA VLGLVRGRVR RAGQGSLYSL EATLEEPPCN DPMVCRLPVS 
       110        120        130        140        150
KKTLLCSFQV LDELGRHVLL RKDCGPVDTK VPGAGEPKSA FTQGSAMISS 
       160        170        180        190        200
LSQNHPDNRN ETFSSVISLL NEDPLSQDLP VKMASIFKNF VITYNRTYES 
       210        220        230        240        250
KEEARWRLSV FVNNMVRAQK IQALDRGTAQ YGVTKFSDLT EEEFRTIYLN 
       260        270        280        290        300
TLLRKEPGNK MKQAKSVGDL APPEWDWRSK GAVTKVKDQG MCGSCWAFSV 
       310        320        330        340        350
TGNVEGQWFL NQGTLLSLSE QELLDCDKMD KACMGGLPSN AYSAIKNLGG 
       360        370        380        390        400
LETEDDYSYQ GHMQSCNFSA EKAKVYINDS VELSQNEQKL AAWLAKRGPI 
       410        420        430        440        450
SVAINAFGMQ FYRHGISRPL RPLCSPWLID HAVLLVGYGN RSDVPFWAIK 
       460        470        480 
NSWGTDWGEK GYYYLHRGSG ACGVNTMASS AVVD

Length:484

Mass (Da):53,366

Last modified:May 1, 2000 - v1

Checksum:ⁱ1D5D551B489D822B

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YD65	H0YD65_HUMAN	Cathepsin F Cathepsin F	CTSF	282	Annotation score:
H0YE42	H0YE42_HUMAN	Cathepsin F Cathepsin F	CTSF	82	Annotation score:
E9PSC2	E9PSC2_HUMAN	Cathepsin F Cathepsin F	CTSF	120	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	305	E → K in AAF13146 (Ref. 5) Curated		1
Sequence conflictⁱ	442 – 484	SDVPF…SAVVD → EFRCLSCIQPGHRQGWDHSI SGPLEGK (PubMed:17974005).CuratedAdd BLAST		43

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_051513	153	Q → R. Corresponds to variant dbSNP:rs11550508EnsemblClinVar.	1
Natural variantⁱVAR_070159	231	Y → C in CLN13. 1 PublicationCorresponds to variant dbSNP:rs143889283EnsemblClinVar.	1
Natural variantⁱVAR_070160	321	Q → R in CLN13. 1 PublicationCorresponds to variant dbSNP:rs397514731EnsemblClinVar.	1
Natural variantⁱVAR_070161	458	G → A in CLN13. 1 PublicationCorresponds to variant dbSNP:rs397514732EnsemblClinVar.	1
Natural variantⁱVAR_070162	480	S → L in CLN13. 1 PublicationCorresponds to variant dbSNP:rs397514733EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ007331 mRNA Translation: CAB42883.1 AF088886 mRNA Translation: AAD26616.2 AF132894 Genomic DNA Translation: AAD41790.1 AF136279 mRNA Translation: AAF13146.1 AF071748 mRNA Translation: AAC78838.1 AF071749 mRNA Translation: AAC78839.1 AK313657 mRNA Translation: BAG36411.1 BC011682 mRNA Translation: AAH11682.1 BC036451 mRNA Translation: AAH36451.1 AL137742 mRNA Translation: CAB70900.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8144.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003784.2, NM_003793.3
UniGeneⁱ	Hs.11590

Genome annotation databases

Ensemblⁱ	ENST00000310325; ENSP00000310832; ENSG00000174080
GeneIDⁱ	8722
KEGGⁱ	hsa:8722
UCSC genome browser More...UCSCⁱ	uc001oip.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UBX1	Cathepsin F (Fragment)		HUMAN		120	UniRef100_Q9UBX1
Cathepsin F, isoform CRA_a		HUMAN		392

Protein	Similar proteins		Species	Score	Length	Source
Q9UBX1	Cathepsin F (Fragment)		HUMAN		120	UniRef90_Q9UBX1
Cathepsin F		CALJA		489
Cathepsin F		PANTR		485
Cathepsin F		MACMU		484
CTSF isoform 1		PONAB		484
+18

Protein	Similar proteins		Species	Score	Length	Source
Q9UBX1	Cathepsin F (Fragment)		HUMAN		120	UniRef50_Q9UBX1
Cathepsin F		CALJA		489
Cathepsin F		PANTR		485
Uncharacterized protein		MACFA		484
Uncharacterized protein		RHIBE		484
+75

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ007331 mRNA Translation: CAB42883.1 AF088886 mRNA Translation: AAD26616.2 AF132894 Genomic DNA Translation: AAD41790.1 AF136279 mRNA Translation: AAF13146.1 AF071748 mRNA Translation: AAC78838.1 AF071749 mRNA Translation: AAC78839.1 AK313657 mRNA Translation: BAG36411.1 BC011682 mRNA Translation: AAH11682.1 BC036451 mRNA Translation: AAH36451.1 AL137742 mRNA Translation: CAB70900.1
CCDSⁱ	CCDS8144.1
RefSeqⁱ	NP_003784.2, NM_003793.3
UniGeneⁱ	Hs.11590

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1D5U	model	-	A	271-484	[»]
	1M6D	X-ray	1.70	A/B	271-484	[»]
ProteinModelPortalⁱ	Q9UBX1
SMRⁱ	Q9UBX1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114261, 18 interactors
STRINGⁱ	9606.ENSP00000310832

Chemistry databases

BindingDBⁱ	Q9UBX1
ChEMBLⁱ	CHEMBL2517
DrugBankⁱ	DB02243 4-Morpholin-4-Yl-Piperidine-1-Carboxylic Acid [1-(3-Benzenesulfonyl-1-Propyl-Allylcarbamoyl)-2-Phenylethyl]-Amide DB01871 [1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester DB03536 Benzoyl-Arginine-Alanine-Methyl Ketone DB08775 BENZOYL-TYROSINE-ALANINE-METHYL KETONE DB07913 HOMOPHENYLALANINYLMETHANE DB03691 WRR-112 DB03573 WRR-99
GuidetoPHARMACOLOGYⁱ	2347

Protein family/group databases

MEROPSⁱ	C01.018

MEROPSⁱ

C01.018

PTM databases

GlyConnectⁱ	1080
iPTMnetⁱ	Q9UBX1
PhosphoSitePlusⁱ	Q9UBX1

Polymorphism and mutation databases

BioMutaⁱ	CTSF
DMDMⁱ	12643325

Proteomic databases

EPDⁱ	Q9UBX1
MaxQBⁱ	Q9UBX1
PaxDbⁱ	Q9UBX1
PeptideAtlasⁱ	Q9UBX1
PRIDEⁱ	Q9UBX1
ProteomicsDBⁱ	84089

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8722
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000310325; ENSP00000310832; ENSG00000174080
GeneIDⁱ	8722
KEGGⁱ	hsa:8722
UCSCⁱ	uc001oip.4 human

Organism-specific databases

CTDⁱ	8722
DisGeNETⁱ	8722
EuPathDBⁱ	HostDB:ENSG00000174080.10
GeneCardsⁱ	CTSF
GeneReviewsⁱ	CTSF
HGNCⁱ	HGNC:2531 CTSF
HPAⁱ	CAB002141 HPA031431 HPA055610
MalaCardsⁱ	CTSF
MIMⁱ	603539 gene 615362 phenotype
neXtProtⁱ	NX_Q9UBX1
OpenTargetsⁱ	ENSG00000174080
Orphanetⁱ	352709 CLN13 disease
PharmGKBⁱ	PA27031
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1542 Eukaryota COG4870 LUCA
GeneTreeⁱ	ENSGT00900000140823
HOGENOMⁱ	HOG000230774
HOVERGENⁱ	HBG011513
InParanoidⁱ	Q9UBX1
KOⁱ	K01373
OMAⁱ	SGIPFWA
OrthoDBⁱ	EOG091G05SD
PhylomeDBⁱ	Q9UBX1
TreeFamⁱ	TF314550

Enzyme and pathway databases

BRENDAⁱ	3.4.22.41 2681
Reactomeⁱ	R-HSA-2132295 MHC class II antigen presentation

Miscellaneous databases

ChiTaRSⁱ	CTSF human
EvolutionaryTraceⁱ	Q9UBX1
GeneWikiⁱ	Cathepsin_F
GenomeRNAiⁱ	8722
Protein Ontology More...PROⁱ	PR:Q9UBX1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174080 Expressed in 233 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CTSF
ExpressionAtlasⁱ	Q9UBX1 baseline and differential
Genevisibleⁱ	Q9UBX1 HS

Family and domain databases

CDDⁱ	cd02248 Peptidase_C1A, 1 hit
InterProⁱ	View protein in InterPro IPR038765 Papain_like_cys_pep_sf IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR013128 Peptidase_C1A IPR000668 Peptidase_C1A_C IPR039417 Peptidase_C1A_papain-like IPR013201 Prot_inhib_I29
PANTHERⁱ	PTHR12411 PTHR12411, 1 hit
Pfamⁱ	View protein in Pfam PF08246 Inhibitor_I29, 1 hit PF00112 Peptidase_C1, 1 hit
PRINTSⁱ	PR00705 PAPAIN
SMARTⁱ	View protein in SMART SM00848 Inhibitor_I29, 1 hit SM00645 Pept_C1, 1 hit
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CATF_HUMAN
Accessionⁱ	Q9UBX1Primary (citable) accession number: Q9UBX1 Secondary accession number(s): B2R964 , O95240, Q9NSU4, Q9UKQ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Peptidase families
Classification of peptidase families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UBX1 (CATF_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cathepsin F

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Extracellular region or secreted

Lysosome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ