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Entry version 166 (13 Feb 2019)
Sequence version 1 (01 May 2000)
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Protein

Homeobox expressed in ES cells 1

Gene

HESX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi108 – 167HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox expressed in ES cells 1
Alternative name(s):
Homeobox protein ANF
Short name:
hAnf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HESX1
Synonyms:HANF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163666.8

Human Gene Nomenclature Database

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HGNCi
HGNC:4877 HESX1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601802 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBX0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Septooptic dysplasia (SOD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA clinically heterogeneous disorder defined by any combination of optic nerve hypoplasia, pituitary gland hypoplasia with panhypopopituitarism, and midline abnormalities of the brain, including absence of the corpus callosum and septum pellucidum.
See also OMIM:182230
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_010225160R → C in SOD; loss of DNA-binding. 1 PublicationCorresponds to variant dbSNP:rs28936702EnsemblClinVar.1
Natural variantiVAR_063233170S → L in SOD; mild. 1 PublicationCorresponds to variant dbSNP:rs28936703EnsemblClinVar.1
Growth hormone deficiency with pituitary anomalies (GHDPA)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by low or absent growth hormone levels, in the presence of a hypoplastic anterior pituitary lobe and ectopic or absent posterior pituitary lobe.
See also OMIM:182230
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063232149E → K in GHDPA; unable to repress PROP1-mediated activation. 1 PublicationCorresponds to variant dbSNP:rs104893742EnsemblClinVar.1
Natural variantiVAR_063234181T → A in GHDPA. 1 PublicationCorresponds to variant dbSNP:rs28936704EnsemblClinVar.1
Pituitary hormone deficiency, combined, 5 (CPHD5)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCombined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD5 is characterized by complete or partial deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone.
See also OMIM:182230
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0632306Q → H in CPHD5. 1 PublicationCorresponds to variant dbSNP:rs121909173EnsemblClinVar.1
Natural variantiVAR_06323126I → T in CPHD5; the mutated protein is associated with impaired transcriptional repression but not DNA binding. 1 PublicationCorresponds to variant dbSNP:rs28936416EnsemblClinVar.1
Natural variantiVAR_078488109R → Q in CPHD5; unknown pathological significance; loss of DNA binding ability; unable to repress PROP1-mediated activation; no effect on nuclear location; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs768165720EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
8820

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
HESX1

MalaCards human disease database

More...
MalaCardsi
HESX1
MIMi182230 phenotype
262600 phenotype

Open Targets

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OpenTargetsi
ENSG00000163666

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
95494 Combined pituitary hormone deficiencies, genetic forms
226307 Hypothyroidism due to deficient transcription factors involved in pituitary development or function
478 Kallmann syndrome
95496 Pituitary stalk interruption syndrome
3157 Septo-optic dysplasia spectrum

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29255

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HESX1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12230168

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000489221 – 185Homeobox expressed in ES cells 1Add BLAST185

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UBX0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBX0

PeptideAtlas

More...
PeptideAtlasi
Q9UBX0

PRoteomics IDEntifications database

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PRIDEi
Q9UBX0

ProteomicsDB human proteome resource

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ProteomicsDBi
84088

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBX0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBX0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Strongly expressed in Rathke pouch in seven-week-old embryo.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163666 Expressed in 92 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBX0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBX0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024187

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form heterodimers with PROP1 in binding to DNA (By similarity). Interacts with TLE1.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114347, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UBX0

Protein interaction database and analysis system

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IntActi
Q9UBX0, 8 interactors

Molecular INTeraction database

More...
MINTi
Q9UBX0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295934

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K40NMR-A108-174[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UBX0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBX0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UBX0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ANF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0490 Eukaryota
ENOG410YIJ3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156780

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112889

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004226

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBX0

KEGG Orthology (KO)

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KOi
K09354

Identification of Orthologs from Complete Genome Data

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OMAi
FKMNSYP

Database of Orthologous Groups

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OrthoDBi
388324at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBX0

TreeFam database of animal gene trees

More...
TreeFami
TF335506

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UBX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPSLQEGAQ LGENKPSTCS FSIERILGLD QKKDCVPLMK PHRPWADTCS
60 70 80 90 100
SSGKDGNLCL HVPNPPSGIS FPSVVDHPMP EERASKYENY FSASERLSLK
110 120 130 140 150
RELSWYRGRR PRTAFTQNQI EVLENVFRVN CYPGIDIRED LAQKLNLEED
160 170 180
RIQIWFQNRR AKLKRSHRES QFLMAKKNFN TNLLE
Length:185
Mass (Da):21,409
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F23D319EB4FDBF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0A9C9J0A9_HUMAN
Homeobox-expressed in ES cells 1
HESX1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KR67J3KR67_HUMAN
Homeobox-expressed in ES cells 1
HESX1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0632306Q → H in CPHD5. 1 PublicationCorresponds to variant dbSNP:rs121909173EnsemblClinVar.1
Natural variantiVAR_06323126I → T in CPHD5; the mutated protein is associated with impaired transcriptional repression but not DNA binding. 1 PublicationCorresponds to variant dbSNP:rs28936416EnsemblClinVar.1
Natural variantiVAR_078488109R → Q in CPHD5; unknown pathological significance; loss of DNA binding ability; unable to repress PROP1-mediated activation; no effect on nuclear location; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs768165720EnsemblClinVar.1
Natural variantiVAR_010400125N → S1 PublicationCorresponds to variant dbSNP:rs9878928EnsemblClinVar.1
Natural variantiVAR_063232149E → K in GHDPA; unable to repress PROP1-mediated activation. 1 PublicationCorresponds to variant dbSNP:rs104893742EnsemblClinVar.1
Natural variantiVAR_010225160R → C in SOD; loss of DNA-binding. 1 PublicationCorresponds to variant dbSNP:rs28936702EnsemblClinVar.1
Natural variantiVAR_063233170S → L in SOD; mild. 1 PublicationCorresponds to variant dbSNP:rs28936703EnsemblClinVar.1
Natural variantiVAR_063234181T → A in GHDPA. 1 PublicationCorresponds to variant dbSNP:rs28936704EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF059734 Genomic DNA Translation: AAC24523.1
U82811 mRNA Translation: AAB88275.1
U65437 Genomic DNA Translation: AAB39561.1
BC069515 mRNA Translation: AAH69515.1
BC093979 mRNA Translation: AAH93979.1
BC112089 mRNA Translation: AAI12090.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2881.1

NCBI Reference Sequences

More...
RefSeqi
NP_003856.1, NM_003865.2
XP_005265583.1, XM_005265526.4
XP_006713442.1, XM_006713379.3
XP_011532506.1, XM_011534204.2
XP_011532507.1, XM_011534205.2
XP_016862910.1, XM_017007421.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.171980

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295934; ENSP00000295934; ENSG00000163666
ENST00000647958; ENSP00000498190; ENSG00000163666

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8820

UCSC genome browser

More...
UCSCi
uc003din.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059734 Genomic DNA Translation: AAC24523.1
U82811 mRNA Translation: AAB88275.1
U65437 Genomic DNA Translation: AAB39561.1
BC069515 mRNA Translation: AAH69515.1
BC093979 mRNA Translation: AAH93979.1
BC112089 mRNA Translation: AAI12090.1
CCDSiCCDS2881.1
RefSeqiNP_003856.1, NM_003865.2
XP_005265583.1, XM_005265526.4
XP_006713442.1, XM_006713379.3
XP_011532506.1, XM_011534204.2
XP_011532507.1, XM_011534205.2
XP_016862910.1, XM_017007421.1
UniGeneiHs.171980

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K40NMR-A108-174[»]
ProteinModelPortaliQ9UBX0
SMRiQ9UBX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114347, 7 interactors
CORUMiQ9UBX0
IntActiQ9UBX0, 8 interactors
MINTiQ9UBX0
STRINGi9606.ENSP00000295934

PTM databases

iPTMnetiQ9UBX0
PhosphoSitePlusiQ9UBX0

Polymorphism and mutation databases

BioMutaiHESX1
DMDMi12230168

Proteomic databases

jPOSTiQ9UBX0
PaxDbiQ9UBX0
PeptideAtlasiQ9UBX0
PRIDEiQ9UBX0
ProteomicsDBi84088

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8820
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295934; ENSP00000295934; ENSG00000163666
ENST00000647958; ENSP00000498190; ENSG00000163666
GeneIDi8820
KEGGihsa:8820
UCSCiuc003din.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8820
DisGeNETi8820
EuPathDBiHostDB:ENSG00000163666.8

GeneCards: human genes, protein and diseases

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GeneCardsi
HESX1
GeneReviewsiHESX1
HGNCiHGNC:4877 HESX1
HPAiHPA024187
MalaCardsiHESX1
MIMi182230 phenotype
262600 phenotype
601802 gene
neXtProtiNX_Q9UBX0
OpenTargetsiENSG00000163666
Orphaneti95494 Combined pituitary hormone deficiencies, genetic forms
226307 Hypothyroidism due to deficient transcription factors involved in pituitary development or function
478 Kallmann syndrome
95496 Pituitary stalk interruption syndrome
3157 Septo-optic dysplasia spectrum
PharmGKBiPA29255

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00940000156780
HOGENOMiHOG000112889
HOVERGENiHBG004226
InParanoidiQ9UBX0
KOiK09354
OMAiFKMNSYP
OrthoDBi388324at2759
PhylomeDBiQ9UBX0
TreeFamiTF335506

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HESX1 human
EvolutionaryTraceiQ9UBX0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HESX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8820

Protein Ontology

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PROi
PR:Q9UBX0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163666 Expressed in 92 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ9UBX0 baseline and differential
GenevisibleiQ9UBX0 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHESX1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBX0
Secondary accession number(s): Q52LC5, Q99667
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: February 13, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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