UniProtKB - Q9UBW8 (CSN7A_HUMAN)
COP9 signalosome complex subunit 7a
COPS7A
Functioni
GO - Biological processi
- COP9 signalosome assembly Source: InterPro
- nucleotide-excision repair, DNA damage recognition Source: Reactome
- post-translational protein modification Source: Reactome
- protein deneddylation Source: UniProtKB
- transcription-coupled nucleotide-excision repair Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q9UBW8 |
Reactomei | R-HSA-5696394, DNA Damage Recognition in GG-NER R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664, Neddylation |
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 7aShort name: SGN7a Short name: Signalosome subunit 7a Alternative name(s): Dermal papilla-derived protein 10 JAB1-containing signalosome subunit 7a |
Gene namesi | Name:COPS7A Synonyms:CSN7A, DERP10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16758, COPS7A |
MIMi | 616009, gene |
neXtProti | NX_Q9UBW8 |
VEuPathDBi | HostDB:ENSG00000111652.9 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- COP9 signalosome Source: UniProtKB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, Nucleus, SignalosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 50813 |
OpenTargetsi | ENSG00000111652 |
PharmGKBi | PA26758 |
Miscellaneous databases
Pharosi | Q9UBW8, Tbio |
Genetic variation databases
BioMutai | COPS7A |
DMDMi | 55976618 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000120996 | 2 – 275 | COP9 signalosome complex subunit 7aAdd BLAST | 274 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9UBW8 |
jPOSTi | Q9UBW8 |
MassIVEi | Q9UBW8 |
MaxQBi | Q9UBW8 |
PaxDbi | Q9UBW8 |
PeptideAtlasi | Q9UBW8 |
PRIDEi | Q9UBW8 |
ProteomicsDBi | 84087 |
PTM databases
iPTMneti | Q9UBW8 |
PhosphoSitePlusi | Q9UBW8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000111652, Expressed in prefrontal cortex and 245 other tissues |
ExpressionAtlasi | Q9UBW8, baseline and differential |
Genevisiblei | Q9UBW8, HS |
Organism-specific databases
HPAi | ENSG00000111652, Low tissue specificity |
Interactioni
Subunit structurei
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8.
Interacts with PMF1 (PubMed:12020345).
Interacts with the translation initiation factor EIF3S6 (PubMed:12220626).
Interacts with CK2 and PKD (PubMed:12628923).
Interacts directly with ID3 (By similarity).
By similarity6 Publications(Microbial infection) Interacts with vaccinia virus protein C9L.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 119130, 111 interactors |
ComplexPortali | CPX-1870, COP9 signalosome variant 1 |
CORUMi | Q9UBW8 |
DIPi | DIP-53412N |
IntActi | Q9UBW8, 71 interactors |
MINTi | Q9UBW8 |
STRINGi | 9606.ENSP00000438115 |
Miscellaneous databases
RNActi | Q9UBW8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 159 | PCIPROSITE-ProRule annotationAdd BLAST | 158 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 185 – 233 | Sequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3250, Eukaryota |
GeneTreei | ENSGT00940000159873 |
InParanoidi | Q9UBW8 |
OMAi | ANQYREN |
OrthoDBi | 1396757at2759 |
PhylomeDBi | Q9UBW8 |
TreeFami | TF101149 |
Family and domain databases
InterProi | View protein in InterPro IPR037757, COPS7A IPR041481, CSN7_helixI IPR000717, PCI_dom |
PANTHERi | PTHR15350:SF7, PTHR15350:SF7, 1 hit |
Pfami | View protein in Pfam PF18392, CSN7a_helixI, 1 hit PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP
60 70 80 90 100
NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS
110 120 130 140 150
VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ
160 170 180 190 200
RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG CEVVLSGIEE QVSRANQHKE
210 220 230 240 250
QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT ELREPAPGTN
260 270
QRQPSKKASK GKGLRGSAKI WSKSN
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H7C6 | F5H7C6_HUMAN | COP9 signalosome complex subunit 7a | COPS7A | 192 | Annotation score: | ||
F5H248 | F5H248_HUMAN | COP9 signalosome complex subunit 7a | COPS7A | 262 | Annotation score: | ||
F5GYF7 | F5GYF7_HUMAN | COP9 signalosome complex subunit 7a | COPS7A | 212 | Annotation score: | ||
F5H4U8 | F5H4U8_HUMAN | COP9 signalosome complex subunit 7a | COPS7A | 125 | Annotation score: | ||
G3XAP1 | G3XAP1_HUMAN | COP9 constitutive photomorphogenic ... | COPS7A hCG_25925 | 62 | Annotation score: | ||
F5GXT7 | F5GXT7_HUMAN | COP9 signalosome complex subunit 7a | COPS7A | 71 | Annotation score: | ||
F5H3M6 | F5H3M6_HUMAN | COP9 signalosome complex subunit 7a | COPS7A | 60 | Annotation score: | ||
F5H4Z0 | F5H4Z0_HUMAN | COP9 signalosome complex subunit 7a | COPS7A | 56 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 218 | K → E in BAA91620 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 253 | Q → H in AAF04307 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF210052 mRNA Translation: AAF19205.1 AB014764 mRNA Translation: BAB87805.1 AB033603 mRNA Translation: BAA85390.1 AF193844 mRNA Translation: AAF04307.1 AK001318 mRNA Translation: BAA91620.1 AK021721 mRNA Translation: BAG51042.1 AK022488 mRNA Translation: BAB14052.1 AK292621 mRNA Translation: BAF85310.1 CH471116 Genomic DNA Translation: EAW88745.1 CH471116 Genomic DNA Translation: EAW88747.1 CH471116 Genomic DNA Translation: EAW88748.1 BC011789 mRNA Translation: AAH11789.1 |
CCDSi | CCDS8558.1 |
RefSeqi | NP_001157565.1, NM_001164093.1 NP_001157566.1, NM_001164094.1 NP_001157567.1, NM_001164095.2 NP_057403.1, NM_016319.3 XP_005253751.1, XM_005253694.2 |
Genome annotation databases
Ensembli | ENST00000229251; ENSP00000229251; ENSG00000111652 ENST00000534877; ENSP00000438363; ENSG00000111652 ENST00000534947; ENSP00000446039; ENSG00000111652 ENST00000539735; ENSP00000441852; ENSG00000111652 ENST00000543155; ENSP00000438115; ENSG00000111652 |
GeneIDi | 50813 |
KEGGi | hsa:50813 |
UCSCi | uc001qqh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF210052 mRNA Translation: AAF19205.1 AB014764 mRNA Translation: BAB87805.1 AB033603 mRNA Translation: BAA85390.1 AF193844 mRNA Translation: AAF04307.1 AK001318 mRNA Translation: BAA91620.1 AK021721 mRNA Translation: BAG51042.1 AK022488 mRNA Translation: BAB14052.1 AK292621 mRNA Translation: BAF85310.1 CH471116 Genomic DNA Translation: EAW88745.1 CH471116 Genomic DNA Translation: EAW88747.1 CH471116 Genomic DNA Translation: EAW88748.1 BC011789 mRNA Translation: AAH11789.1 |
CCDSi | CCDS8558.1 |
RefSeqi | NP_001157565.1, NM_001164093.1 NP_001157566.1, NM_001164094.1 NP_001157567.1, NM_001164095.2 NP_057403.1, NM_016319.3 XP_005253751.1, XM_005253694.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4D10 | X-ray | 3.80 | G/O | 1-218 | [»] | |
4D18 | X-ray | 4.08 | G/O | 1-218 | [»] | |
4WSN | X-ray | 5.50 | G/O/W/e/m/u | 1-218 | [»] | |
SMRi | Q9UBW8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119130, 111 interactors |
ComplexPortali | CPX-1870, COP9 signalosome variant 1 |
CORUMi | Q9UBW8 |
DIPi | DIP-53412N |
IntActi | Q9UBW8, 71 interactors |
MINTi | Q9UBW8 |
STRINGi | 9606.ENSP00000438115 |
PTM databases
iPTMneti | Q9UBW8 |
PhosphoSitePlusi | Q9UBW8 |
Genetic variation databases
BioMutai | COPS7A |
DMDMi | 55976618 |
Proteomic databases
EPDi | Q9UBW8 |
jPOSTi | Q9UBW8 |
MassIVEi | Q9UBW8 |
MaxQBi | Q9UBW8 |
PaxDbi | Q9UBW8 |
PeptideAtlasi | Q9UBW8 |
PRIDEi | Q9UBW8 |
ProteomicsDBi | 84087 |
Protocols and materials databases
Antibodypediai | 11091, 206 antibodies |
DNASUi | 50813 |
Genome annotation databases
Ensembli | ENST00000229251; ENSP00000229251; ENSG00000111652 ENST00000534877; ENSP00000438363; ENSG00000111652 ENST00000534947; ENSP00000446039; ENSG00000111652 ENST00000539735; ENSP00000441852; ENSG00000111652 ENST00000543155; ENSP00000438115; ENSG00000111652 |
GeneIDi | 50813 |
KEGGi | hsa:50813 |
UCSCi | uc001qqh.4, human |
Organism-specific databases
CTDi | 50813 |
DisGeNETi | 50813 |
GeneCardsi | COPS7A |
HGNCi | HGNC:16758, COPS7A |
HPAi | ENSG00000111652, Low tissue specificity |
MIMi | 616009, gene |
neXtProti | NX_Q9UBW8 |
OpenTargetsi | ENSG00000111652 |
PharmGKBi | PA26758 |
VEuPathDBi | HostDB:ENSG00000111652.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3250, Eukaryota |
GeneTreei | ENSGT00940000159873 |
InParanoidi | Q9UBW8 |
OMAi | ANQYREN |
OrthoDBi | 1396757at2759 |
PhylomeDBi | Q9UBW8 |
TreeFami | TF101149 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBW8 |
Reactomei | R-HSA-5696394, DNA Damage Recognition in GG-NER R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664, Neddylation |
Miscellaneous databases
BioGRID-ORCSi | 50813, 6 hits in 880 CRISPR screens |
ChiTaRSi | COPS7A, human |
GeneWikii | COPS7A |
GenomeRNAii | 50813 |
Pharosi | Q9UBW8, Tbio |
PROi | PR:Q9UBW8 |
RNActi | Q9UBW8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111652, Expressed in prefrontal cortex and 245 other tissues |
ExpressionAtlasi | Q9UBW8, baseline and differential |
Genevisiblei | Q9UBW8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037757, COPS7A IPR041481, CSN7_helixI IPR000717, PCI_dom |
PANTHERi | PTHR15350:SF7, PTHR15350:SF7, 1 hit |
Pfami | View protein in Pfam PF18392, CSN7a_helixI, 1 hit PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSN7A_HUMAN | |
Accessioni | Q9UBW8Primary (citable) accession number: Q9UBW8 Secondary accession number(s): A8K9A6, Q9NVX3, Q9UJW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families