COPS7A

Functionⁱ

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.5 Publications

GO - Biological processⁱ

nucleotide-excision repair, DNA damage recognition Source: Reactome
post-translational protein modification Source: Reactome
protein deneddylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19141280
transcription-coupled nucleotide-excision repair Source: Reactome
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction

Biological process

Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5696394 DNA Damage Recognition in GG-NER R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664 Neddylation

Reactomeⁱ

R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: COP9 signalosome complex subunit 7a Short name: SGN7a Short name: Signalosome subunit 7a Alternative name(s): Dermal papilla-derived protein 10 JAB1-containing signalosome subunit 7a
Gene namesⁱ	Name:COPS7A Synonyms:CSN7A, DERP10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111652.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16758 COPS7A
MIMⁱ	616009 gene
neXtProtⁱ	NX_Q9UBW8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50813
Open Targets More...OpenTargetsⁱ	ENSG00000111652
PharmGKBⁱ	PA26758

Polymorphism and mutation databases

BioMutaⁱ	COPS7A
DMDMⁱ	55976618

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000120996	2 – 275	COP9 signalosome complex subunit 7aAdd BLAST		274

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserine1 Publication		1

Post-translational modificationⁱ

Phosphorylated by CK2 and PKD kinases.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UBW8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UBW8
PaxDbⁱ	Q9UBW8
PeptideAtlas More...PeptideAtlasⁱ	Q9UBW8
PRIDEⁱ	Q9UBW8
ProteomicsDBⁱ	84087

PTM databases

iPTMnetⁱ	Q9UBW8
PhosphoSitePlusⁱ	Q9UBW8

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Expressed at high level in brain, heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000111652 Expressed in 232 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_COPS7A
ExpressionAtlasⁱ	Q9UBW8 baseline and differential
Genevisibleⁱ	Q9UBW8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026915

HPAⁱ

HPA026915

Interactionⁱ

Subunit structureⁱ

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1 (PubMed:12020345). Interacts with the translation initiation factor EIF3S6 (PubMed:12220626). Interacts with CK2 and PKD (PubMed:12628923). Interacts directly with ID3 (By similarity).By similarity6 Publications

(Microbial infection) Interacts with vaccinia virus protein C9L.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
COPS3	Q9UNS2	9	EBI-712982,EBI-350590

With

Entry

#Exp.

IntAct

Notes

COPS3

Q9UNS2

9

EBI-712982,EBI-350590

Protein-protein interaction databases

BioGridⁱ	119130, 99 interactors
ComplexPortalⁱ	CPX-1870 COP9 signalosome variant 1
CORUMⁱ	Q9UBW8
Database of interacting proteins More...DIPⁱ	DIP-53412N
IntActⁱ	Q9UBW8, 50 interactors
Molecular INTeraction database More...MINTⁱ	Q9UBW8
STRINGⁱ	9606.ENSP00000229251

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UBW8
SMRⁱ	Q9UBW8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 159	PCIPROSITE-ProRule annotationAdd BLAST		158

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	185 – 233	Sequence analysisAdd BLAST		49

Sequence similaritiesⁱ

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3250 Eukaryota ENOG410XP7W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013069
HOGENOMⁱ	HOG000006003
HOVERGENⁱ	HBG051138
InParanoidⁱ	Q9UBW8
KEGG Orthology (KO) More...KOⁱ	K12180
OMAⁱ	DQRNQQV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I8H
PhylomeDBⁱ	Q9UBW8
TreeFamⁱ	TF101149

Family and domain databases

InterProⁱ	View protein in InterPro IPR037757 COPS7A IPR000717 PCI_dom
PANTHERⁱ	PTHR15350:SF7 PTHR15350:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

Q9UBW8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP 
        60         70         80         90        100
NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS 
       110        120        130        140        150
VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ 
       160        170        180        190        200
RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG CEVVLSGIEE QVSRANQHKE 
       210        220        230        240        250
QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT ELREPAPGTN 
       260        270 
QRQPSKKASK GKGLRGSAKI WSKSN

Length:275

Mass (Da):30,277

Last modified:May 1, 2000 - v1

Checksum:ⁱ20888B35BFFF6326

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H7C6	F5H7C6_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	192	Annotation score:
F5H248	F5H248_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	262	Annotation score:
F5GYF7	F5GYF7_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	212	Annotation score:
F5H4U8	F5H4U8_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	125	Annotation score:
F5H3M6	F5H3M6_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	60	Annotation score:
F5H4Z0	F5H4Z0_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	56	Annotation score:
F5GXT7	F5GXT7_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	71	Annotation score:
G3XAP1	G3XAP1_HUMAN	COP9 constitutive photomorphogenic ... COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis), isoform CRA_b (COP9 signalosome complex subunit 7a)	COPS7A hCG_25925	62	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	218	K → E in BAA91620 (PubMed:14702039).Curated		1
Sequence conflictⁱ	253	Q → H in AAF04307 (Ref. 4) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF210052 mRNA Translation: AAF19205.1 AB014764 mRNA Translation: BAB87805.1 AB033603 mRNA Translation: BAA85390.1 AF193844 mRNA Translation: AAF04307.1 AK001318 mRNA Translation: BAA91620.1 AK021721 mRNA Translation: BAG51042.1 AK022488 mRNA Translation: BAB14052.1 AK292621 mRNA Translation: BAF85310.1 CH471116 Genomic DNA Translation: EAW88745.1 CH471116 Genomic DNA Translation: EAW88747.1 CH471116 Genomic DNA Translation: EAW88748.1 BC011789 mRNA Translation: AAH11789.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8558.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001157565.1, NM_001164093.1 NP_001157566.1, NM_001164094.1 NP_001157567.1, NM_001164095.2 NP_057403.1, NM_016319.3 XP_005253751.1, XM_005253694.2
UniGeneⁱ	Hs.530823

Genome annotation databases

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UBW8	COP9 signalosome complex subunit 7a		PONAB		275	UniRef100_Q9UBW8
COP9 signalosome complex subunit 7a		CALJA		275
COP9 constitutive photomorphogenic homolog subunit 7A		PANTR		275
COP9 signalosome complex subunit 7a		URSMA		275
COP9 signalosome complex subunit 7a		Enhydra lutris kenyoni		275
+17

Protein	Similar proteins		Species	Score	Length	Source
Q9UBW8	COP9 signalosome complex subunit 7a		PONAB		275	UniRef90_Q9UBW8
COP9 signalosome complex subunit 7a		MOUSE		275
COP9 signalosome complex subunit 7a		CALJA		275
COP9 constitutive photomorphogenic homolog subunit 7A		PANTR		275
COP9 signalosome complex subunit 7a		URSMA		275
+83

Protein	Similar proteins		Species	Score	Length	Source
Q9UBW8	COP9 signalosome complex subunit 7a		PONAB		275	UniRef50_Q9UBW8
COP9 signalosome complex subunit 7a		MOUSE		275
COP9 signalosome complex subunit 7b		BOVIN		264
COP9 signalosome complex subunit 7b		HUMAN		264
COP9 signalosome complex subunit 7a		CALJA		275
+264

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF210052 mRNA Translation: AAF19205.1 AB014764 mRNA Translation: BAB87805.1 AB033603 mRNA Translation: BAA85390.1 AF193844 mRNA Translation: AAF04307.1 AK001318 mRNA Translation: BAA91620.1 AK021721 mRNA Translation: BAG51042.1 AK022488 mRNA Translation: BAB14052.1 AK292621 mRNA Translation: BAF85310.1 CH471116 Genomic DNA Translation: EAW88745.1 CH471116 Genomic DNA Translation: EAW88747.1 CH471116 Genomic DNA Translation: EAW88748.1 BC011789 mRNA Translation: AAH11789.1
CCDSⁱ	CCDS8558.1
RefSeqⁱ	NP_001157565.1, NM_001164093.1 NP_001157566.1, NM_001164094.1 NP_001157567.1, NM_001164095.2 NP_057403.1, NM_016319.3 XP_005253751.1, XM_005253694.2
UniGeneⁱ	Hs.530823

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4D10	X-ray	3.80	G/O	1-218	[»]
	4D18	X-ray	4.08	G/O	1-218	[»]
	4WSN	X-ray	5.50	G/O/W/e/m/u	1-218	[»]
ProteinModelPortalⁱ	Q9UBW8
SMRⁱ	Q9UBW8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119130, 99 interactors
ComplexPortalⁱ	CPX-1870 COP9 signalosome variant 1
CORUMⁱ	Q9UBW8
DIPⁱ	DIP-53412N
IntActⁱ	Q9UBW8, 50 interactors
MINTⁱ	Q9UBW8
STRINGⁱ	9606.ENSP00000229251

PTM databases

iPTMnetⁱ	Q9UBW8
PhosphoSitePlusⁱ	Q9UBW8

Polymorphism and mutation databases

BioMutaⁱ	COPS7A
DMDMⁱ	55976618

Proteomic databases

EPDⁱ	Q9UBW8
MaxQBⁱ	Q9UBW8
PaxDbⁱ	Q9UBW8
PeptideAtlasⁱ	Q9UBW8
PRIDEⁱ	Q9UBW8
ProteomicsDBⁱ	84087

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50813
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000229251; ENSP00000229251; ENSG00000111652 ENST00000534877; ENSP00000438363; ENSG00000111652 ENST00000534947; ENSP00000446039; ENSG00000111652 ENST00000539735; ENSP00000441852; ENSG00000111652 ENST00000543155; ENSP00000438115; ENSG00000111652
GeneIDⁱ	50813
KEGGⁱ	hsa:50813
UCSCⁱ	uc001qqh.4 human

Organism-specific databases

CTDⁱ	50813
DisGeNETⁱ	50813
EuPathDBⁱ	HostDB:ENSG00000111652.9
GeneCardsⁱ	COPS7A
HGNCⁱ	HGNC:16758 COPS7A
HPAⁱ	HPA026915
MIMⁱ	616009 gene
neXtProtⁱ	NX_Q9UBW8
OpenTargetsⁱ	ENSG00000111652
PharmGKBⁱ	PA26758
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3250 Eukaryota ENOG410XP7W LUCA
GeneTreeⁱ	ENSGT00390000013069
HOGENOMⁱ	HOG000006003
HOVERGENⁱ	HBG051138
InParanoidⁱ	Q9UBW8
KOⁱ	K12180
OMAⁱ	DQRNQQV
OrthoDBⁱ	EOG091G0I8H
PhylomeDBⁱ	Q9UBW8
TreeFamⁱ	TF101149

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5696394 DNA Damage Recognition in GG-NER R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664 Neddylation

Reactomeⁱ

R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSⁱ	COPS7A human
GeneWikiⁱ	COPS7A
GenomeRNAiⁱ	50813
Protein Ontology More...PROⁱ	PR:Q9UBW8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111652 Expressed in 232 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_COPS7A
ExpressionAtlasⁱ	Q9UBW8 baseline and differential
Genevisibleⁱ	Q9UBW8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR037757 COPS7A IPR000717 PCI_dom
PANTHERⁱ	PTHR15350:SF7 PTHR15350:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSN7A_HUMAN
Accessionⁱ	Q9UBW8Primary (citable) accession number: Q9UBW8 Secondary accession number(s): A8K9A6, Q9NVX3, Q9UJW4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q9UBW8 (CSN7A_HUMAN)

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COP9 signalosome complex subunit 7a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ