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UniProtKB - Q9UBW8 (CSN7A_HUMAN)

Entry version 158 (10 Feb 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

COP9 signalosome complex subunit 7a

Gene

COPS7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UBW8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5696394, DNA Damage Recognition in GG-NER
R-HSA-6781823, Formation of TC-NER Pre-Incision Complex
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664, Neddylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
COP9 signalosome complex subunit 7a
Short name:
SGN7a
Short name:
Signalosome subunit 7a
Alternative name(s):
Dermal papilla-derived protein 10
JAB1-containing signalosome subunit 7a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COPS7A
Synonyms:CSN7A, DERP10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16758, COPS7A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616009, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UBW8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111652.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		50813

Open Targets

More...OpenTargetsi		ENSG00000111652

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26758

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UBW8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		COPS7A

Domain mapping of disease mutations (DMDM)

More...DMDMi		55976618

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001209962 – 275COP9 signalosome complex subunit 7aAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CK2 and PKD kinases.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UBW8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UBW8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UBW8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UBW8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UBW8

PeptideAtlas

More...PeptideAtlasi		Q9UBW8

PRoteomics IDEntifications database

More...PRIDEi		Q9UBW8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84087

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UBW8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UBW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at high level in brain, heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111652, Expressed in prefrontal cortex and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UBW8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UBW8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111652, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8.

Interacts with PMF1 (PubMed:12020345).

Interacts with the translation initiation factor EIF3S6 (PubMed:12220626).

Interacts with CK2 and PKD (PubMed:12628923).

Interacts directly with ID3 (By similarity).

By similarity6 Publications

(Microbial infection) Interacts with vaccinia virus protein C9L.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119130, 111 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1870, COP9 signalosome variant 1

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UBW8

Database of interacting proteins

More...DIPi		DIP-53412N

Protein interaction database and analysis system

More...IntActi		Q9UBW8, 71 interactors

Molecular INTeraction database

More...MINTi		Q9UBW8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000438115

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UBW8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UBW8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 159PCIPROSITE-ProRule annotationAdd BLAST158

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili185 – 233Sequence analysisAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3250, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159873

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UBW8

Identification of Orthologs from Complete Genome Data

More...OMAi		ANQYREN

Database of Orthologous Groups

More...OrthoDBi		1396757at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UBW8

TreeFam database of animal gene trees

More...TreeFami		TF101149

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037757, COPS7A
IPR041481, CSN7_helixI
IPR000717, PCI_dom

The PANTHER Classification System

More...PANTHERi		PTHR15350:SF7, PTHR15350:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18392, CSN7a_helixI, 1 hit
PF01399, PCI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00088, PINT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50250, PCI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9UBW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP 
        60         70         80         90        100
NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS 
       110        120        130        140        150
VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ 
       160        170        180        190        200
RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG CEVVLSGIEE QVSRANQHKE 
       210        220        230        240        250
QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT ELREPAPGTN 
       260        270 
QRQPSKKASK GKGLRGSAKI WSKSN
Length:275
Mass (Da):30,277
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20888B35BFFF6326
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H7C6F5H7C6_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
192Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H248F5H248_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
262Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYF7F5GYF7_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
212Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4U8F5H4U8_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XAP1G3XAP1_HUMAN
COP9 constitutive photomorphogenic ...
COPS7A hCG_25925
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXT7F5GXT7_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3M6F5H3M6_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4Z0F5H4Z0_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218K → E in BAA91620 (PubMed:14702039).Curated1
Sequence conflicti253Q → H in AAF04307 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF210052 mRNA Translation: AAF19205.1
AB014764 mRNA Translation: BAB87805.1
AB033603 mRNA Translation: BAA85390.1
AF193844 mRNA Translation: AAF04307.1
AK001318 mRNA Translation: BAA91620.1
AK021721 mRNA Translation: BAG51042.1
AK022488 mRNA Translation: BAB14052.1
AK292621 mRNA Translation: BAF85310.1
CH471116 Genomic DNA Translation: EAW88745.1
CH471116 Genomic DNA Translation: EAW88747.1
CH471116 Genomic DNA Translation: EAW88748.1
BC011789 mRNA Translation: AAH11789.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8558.1

NCBI Reference Sequences

More...RefSeqi		NP_001157565.1, NM_001164093.1
NP_001157566.1, NM_001164094.1
NP_001157567.1, NM_001164095.2
NP_057403.1, NM_016319.3
XP_005253751.1, XM_005253694.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229251; ENSP00000229251; ENSG00000111652
ENST00000534877; ENSP00000438363; ENSG00000111652
ENST00000534947; ENSP00000446039; ENSG00000111652
ENST00000539735; ENSP00000441852; ENSG00000111652
ENST00000543155; ENSP00000438115; ENSG00000111652

Database of genes from NCBI RefSeq genomes

More...GeneIDi		50813

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:50813

UCSC genome browser

More...UCSCi		uc001qqh.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210052 mRNA Translation: AAF19205.1
AB014764 mRNA Translation: BAB87805.1
AB033603 mRNA Translation: BAA85390.1
AF193844 mRNA Translation: AAF04307.1
AK001318 mRNA Translation: BAA91620.1
AK021721 mRNA Translation: BAG51042.1
AK022488 mRNA Translation: BAB14052.1
AK292621 mRNA Translation: BAF85310.1
CH471116 Genomic DNA Translation: EAW88745.1
CH471116 Genomic DNA Translation: EAW88747.1
CH471116 Genomic DNA Translation: EAW88748.1
BC011789 mRNA Translation: AAH11789.1
CCDSiCCDS8558.1
RefSeqiNP_001157565.1, NM_001164093.1
NP_001157566.1, NM_001164094.1
NP_001157567.1, NM_001164095.2
NP_057403.1, NM_016319.3
XP_005253751.1, XM_005253694.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80G/O1-218[»]
4D18X-ray4.08G/O1-218[»]
4WSNX-ray5.50G/O/W/e/m/u1-218[»]
SMRiQ9UBW8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119130, 111 interactors
ComplexPortaliCPX-1870, COP9 signalosome variant 1
CORUMiQ9UBW8
DIPiDIP-53412N
IntActiQ9UBW8, 71 interactors
MINTiQ9UBW8
STRINGi9606.ENSP00000438115

PTM databases

iPTMnetiQ9UBW8
PhosphoSitePlusiQ9UBW8

Genetic variation databases

BioMutaiCOPS7A
DMDMi55976618

Proteomic databases

EPDiQ9UBW8
jPOSTiQ9UBW8
MassIVEiQ9UBW8
MaxQBiQ9UBW8
PaxDbiQ9UBW8
PeptideAtlasiQ9UBW8
PRIDEiQ9UBW8
ProteomicsDBi84087

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11091, 206 antibodies

The DNASU plasmid repository

More...DNASUi		50813

Genome annotation databases

EnsembliENST00000229251; ENSP00000229251; ENSG00000111652
ENST00000534877; ENSP00000438363; ENSG00000111652
ENST00000534947; ENSP00000446039; ENSG00000111652
ENST00000539735; ENSP00000441852; ENSG00000111652
ENST00000543155; ENSP00000438115; ENSG00000111652
GeneIDi50813
KEGGihsa:50813
UCSCiuc001qqh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		50813
DisGeNETi50813

GeneCards: human genes, protein and diseases

More...GeneCardsi		COPS7A
HGNCiHGNC:16758, COPS7A
HPAiENSG00000111652, Low tissue specificity
MIMi616009, gene
neXtProtiNX_Q9UBW8
OpenTargetsiENSG00000111652
PharmGKBiPA26758
VEuPathDBiHostDB:ENSG00000111652.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3250, Eukaryota
GeneTreeiENSGT00940000159873
InParanoidiQ9UBW8
OMAiANQYREN
OrthoDBi1396757at2759
PhylomeDBiQ9UBW8
TreeFamiTF101149

Enzyme and pathway databases

PathwayCommonsiQ9UBW8
ReactomeiR-HSA-5696394, DNA Damage Recognition in GG-NER
R-HSA-6781823, Formation of TC-NER Pre-Incision Complex
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664, Neddylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		50813, 6 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		COPS7A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		COPS7A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		50813
PharosiQ9UBW8, Tbio

Protein Ontology

More...PROi		PR:Q9UBW8
RNActiQ9UBW8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111652, Expressed in prefrontal cortex and 245 other tissues
ExpressionAtlasiQ9UBW8, baseline and differential
GenevisibleiQ9UBW8, HS

Family and domain databases

InterProiView protein in InterPro
IPR037757, COPS7A
IPR041481, CSN7_helixI
IPR000717, PCI_dom
PANTHERiPTHR15350:SF7, PTHR15350:SF7, 1 hit
PfamiView protein in Pfam
PF18392, CSN7a_helixI, 1 hit
PF01399, PCI, 1 hit
SMARTiView protein in SMART
SM00088, PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250, PCI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSN7A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBW8
Secondary accession number(s): A8K9A6, Q9NVX3, Q9UJW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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