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Protein

COP9 signalosome complex subunit 7a

Gene

COPS7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.5 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 7a
Short name:
SGN7a
Short name:
Signalosome subunit 7a
Alternative name(s):
Dermal papilla-derived protein 10
JAB1-containing signalosome subunit 7a
Gene namesi
Name:COPS7A
Synonyms:CSN7A, DERP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111652.9
HGNCiHGNC:16758 COPS7A
MIMi616009 gene
neXtProtiNX_Q9UBW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi50813
OpenTargetsiENSG00000111652
PharmGKBiPA26758

Polymorphism and mutation databases

BioMutaiCOPS7A
DMDMi55976618

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001209962 – 275COP9 signalosome complex subunit 7aAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Post-translational modificationi

Phosphorylated by CK2 and PKD kinases.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UBW8
MaxQBiQ9UBW8
PaxDbiQ9UBW8
PeptideAtlasiQ9UBW8
PRIDEiQ9UBW8
ProteomicsDBi84087

PTM databases

iPTMnetiQ9UBW8
PhosphoSitePlusiQ9UBW8

Expressioni

Tissue specificityi

Widely expressed. Expressed at high level in brain, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000111652 Expressed in 232 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_COPS7A
ExpressionAtlasiQ9UBW8 baseline and differential
GenevisibleiQ9UBW8 HS

Organism-specific databases

HPAiHPA026915

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1 (PubMed:12020345). Interacts with the translation initiation factor EIF3S6 (PubMed:12220626). Interacts with CK2 and PKD (PubMed:12628923). Interacts directly with ID3 (By similarity).By similarity6 Publications
(Microbial infection) Interacts with vaccinia virus protein C9L.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
COPS3Q9UNS29EBI-712982,EBI-350590

Protein-protein interaction databases

BioGridi119130, 99 interactors
ComplexPortaliCPX-1870 COP9 signalosome variant 1
CORUMiQ9UBW8
DIPiDIP-53412N
IntActiQ9UBW8, 50 interactors
MINTiQ9UBW8
STRINGi9606.ENSP00000229251

Structurei

3D structure databases

ProteinModelPortaliQ9UBW8
SMRiQ9UBW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 159PCIPROSITE-ProRule annotationAdd BLAST158

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili185 – 233Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3250 Eukaryota
ENOG410XP7W LUCA
GeneTreeiENSGT00390000013069
HOGENOMiHOG000006003
HOVERGENiHBG051138
InParanoidiQ9UBW8
KOiK12180
OMAiDQRNQQV
OrthoDBiEOG091G0I8H
PhylomeDBiQ9UBW8
TreeFamiTF101149

Family and domain databases

InterProiView protein in InterPro
IPR037757 COPS7A
IPR000717 PCI_dom
PANTHERiPTHR15350:SF7 PTHR15350:SF7, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9UBW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP
60 70 80 90 100
NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS
110 120 130 140 150
VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ
160 170 180 190 200
RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG CEVVLSGIEE QVSRANQHKE
210 220 230 240 250
QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT ELREPAPGTN
260 270
QRQPSKKASK GKGLRGSAKI WSKSN
Length:275
Mass (Da):30,277
Last modified:May 1, 2000 - v1
Checksum:i20888B35BFFF6326
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H7C6F5H7C6_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
192Annotation score:
F5H248F5H248_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
262Annotation score:
F5GYF7F5GYF7_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
212Annotation score:
F5H4U8F5H4U8_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
125Annotation score:
F5H3M6F5H3M6_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
60Annotation score:
F5H4Z0F5H4Z0_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
56Annotation score:
F5GXT7F5GXT7_HUMAN
COP9 signalosome complex subunit 7a
COPS7A
71Annotation score:
G3XAP1G3XAP1_HUMAN
COP9 constitutive photomorphogenic ...
COPS7A hCG_25925
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218K → E in BAA91620 (PubMed:14702039).Curated1
Sequence conflicti253Q → H in AAF04307 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210052 mRNA Translation: AAF19205.1
AB014764 mRNA Translation: BAB87805.1
AB033603 mRNA Translation: BAA85390.1
AF193844 mRNA Translation: AAF04307.1
AK001318 mRNA Translation: BAA91620.1
AK021721 mRNA Translation: BAG51042.1
AK022488 mRNA Translation: BAB14052.1
AK292621 mRNA Translation: BAF85310.1
CH471116 Genomic DNA Translation: EAW88745.1
CH471116 Genomic DNA Translation: EAW88747.1
CH471116 Genomic DNA Translation: EAW88748.1
BC011789 mRNA Translation: AAH11789.1
CCDSiCCDS8558.1
RefSeqiNP_001157565.1, NM_001164093.1
NP_001157566.1, NM_001164094.1
NP_001157567.1, NM_001164095.2
NP_057403.1, NM_016319.3
XP_005253751.1, XM_005253694.2
UniGeneiHs.530823

Genome annotation databases

EnsembliENST00000229251; ENSP00000229251; ENSG00000111652
ENST00000534877; ENSP00000438363; ENSG00000111652
ENST00000534947; ENSP00000446039; ENSG00000111652
ENST00000539735; ENSP00000441852; ENSG00000111652
ENST00000543155; ENSP00000438115; ENSG00000111652
GeneIDi50813
KEGGihsa:50813
UCSCiuc001qqh.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210052 mRNA Translation: AAF19205.1
AB014764 mRNA Translation: BAB87805.1
AB033603 mRNA Translation: BAA85390.1
AF193844 mRNA Translation: AAF04307.1
AK001318 mRNA Translation: BAA91620.1
AK021721 mRNA Translation: BAG51042.1
AK022488 mRNA Translation: BAB14052.1
AK292621 mRNA Translation: BAF85310.1
CH471116 Genomic DNA Translation: EAW88745.1
CH471116 Genomic DNA Translation: EAW88747.1
CH471116 Genomic DNA Translation: EAW88748.1
BC011789 mRNA Translation: AAH11789.1
CCDSiCCDS8558.1
RefSeqiNP_001157565.1, NM_001164093.1
NP_001157566.1, NM_001164094.1
NP_001157567.1, NM_001164095.2
NP_057403.1, NM_016319.3
XP_005253751.1, XM_005253694.2
UniGeneiHs.530823

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80G/O1-218[»]
4D18X-ray4.08G/O1-218[»]
4WSNX-ray5.50G/O/W/e/m/u1-218[»]
ProteinModelPortaliQ9UBW8
SMRiQ9UBW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119130, 99 interactors
ComplexPortaliCPX-1870 COP9 signalosome variant 1
CORUMiQ9UBW8
DIPiDIP-53412N
IntActiQ9UBW8, 50 interactors
MINTiQ9UBW8
STRINGi9606.ENSP00000229251

PTM databases

iPTMnetiQ9UBW8
PhosphoSitePlusiQ9UBW8

Polymorphism and mutation databases

BioMutaiCOPS7A
DMDMi55976618

Proteomic databases

EPDiQ9UBW8
MaxQBiQ9UBW8
PaxDbiQ9UBW8
PeptideAtlasiQ9UBW8
PRIDEiQ9UBW8
ProteomicsDBi84087

Protocols and materials databases

DNASUi50813
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229251; ENSP00000229251; ENSG00000111652
ENST00000534877; ENSP00000438363; ENSG00000111652
ENST00000534947; ENSP00000446039; ENSG00000111652
ENST00000539735; ENSP00000441852; ENSG00000111652
ENST00000543155; ENSP00000438115; ENSG00000111652
GeneIDi50813
KEGGihsa:50813
UCSCiuc001qqh.4 human

Organism-specific databases

CTDi50813
DisGeNETi50813
EuPathDBiHostDB:ENSG00000111652.9
GeneCardsiCOPS7A
HGNCiHGNC:16758 COPS7A
HPAiHPA026915
MIMi616009 gene
neXtProtiNX_Q9UBW8
OpenTargetsiENSG00000111652
PharmGKBiPA26758
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3250 Eukaryota
ENOG410XP7W LUCA
GeneTreeiENSGT00390000013069
HOGENOMiHOG000006003
HOVERGENiHBG051138
InParanoidiQ9UBW8
KOiK12180
OMAiDQRNQQV
OrthoDBiEOG091G0I8H
PhylomeDBiQ9UBW8
TreeFamiTF101149

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSiCOPS7A human
GeneWikiiCOPS7A
GenomeRNAii50813
PROiPR:Q9UBW8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111652 Expressed in 232 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_COPS7A
ExpressionAtlasiQ9UBW8 baseline and differential
GenevisibleiQ9UBW8 HS

Family and domain databases

InterProiView protein in InterPro
IPR037757 COPS7A
IPR000717 PCI_dom
PANTHERiPTHR15350:SF7 PTHR15350:SF7, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSN7A_HUMAN
AccessioniPrimary (citable) accession number: Q9UBW8
Secondary accession number(s): A8K9A6, Q9NVX3, Q9UJW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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