B4GALT7

Functionⁱ

Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.1 Publication

Catalytic activityⁱ

UDP-alpha-D-galactose + O-beta-D-xylosyl-[protein] = UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein].1 Publication

Cofactorⁱ

Mn²⁺1 Publication

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	165	ManganeseCombined sources1 Publication	1
Binding siteⁱ	194	UDP-alpha-D-galactoseCombined sources1 Publication	1
Binding siteⁱ	224	UDP-alpha-D-galactoseCombined sources1 Publication	1
Metal bindingⁱ	257	Manganese; via tele nitrogenCombined sources1 Publication	1
Binding siteⁱ	266	UDP-alpha-D-galactoseCombined sources1 Publication	1

GO - Molecular functionⁱ

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24052259
galactosyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10506123
manganese ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24052259
xylosylprotein 4-beta-galactosyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10438455

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 10473568
glycosaminoglycan biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10438455
glycosaminoglycan metabolic process Source: Reactome
negative regulation of fibroblast proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16583246
protein N-linked glycosylation
Source: UniProtKB
Inferred from direct assayⁱ
- 24052259
proteoglycan metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16583246
supramolecular fiber organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16583246

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00459-MONOMER
BRENDAⁱ	2.4.1.133 2681
Reactomeⁱ	R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT7 Glycosyltransferase Family 7

CAZyⁱ

GT7 Glycosyltransferase Family 7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-1,4-galactosyltransferase 7 (EC:2.4.1.-) Short name: Beta-1,4-GalTase 7 Short name: Beta4Gal-T7 Short name: b4Gal-T7 Alternative name(s): UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7 Including the following 1 domains: Xylosylprotein 4-beta-galactosyltransferase (EC:2.4.1.133) Alternative name(s): Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I UDP-galactose:beta-xylose beta-1,4-galactosyltransferase XGPT XGalT-1 Xylosylprotein beta-1,4-galactosyltransferase
Gene namesⁱ	Name:B4GALT7 Synonyms:XGALT1 ORF Names:UNQ748/PRO1478
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000027847.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:930 B4GALT7
MIMⁱ	604327 gene
neXtProtⁱ	NX_Q9UBV7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 30	CytoplasmicSequence analysisAdd BLAST	30
Transmembraneⁱ	31 – 51	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	52 – 327	LumenalSequence analysisAdd BLAST	276

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ehlers-Danlos syndrome, spondylodysplastic type, 1 (EDSSPD1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSSPD1 is an autosomal recessive form characterized by short stature, developmental anomalies of the forearm bones and elbow, and bowing of extremities, in addition to the classic features of Ehlers-Danlos syndrome.

Keywords - Diseaseⁱ

Disease mutation, Dwarfism, Ehlers-Danlos syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11285
MalaCards human disease database More...MalaCardsⁱ	B4GALT7
MIMⁱ	130070 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000027847
Orphanetⁱ	75496 Ehlers-Danlos syndrome, progeroid type 294049 Reunion Island's Larsen syndrome
PharmGKBⁱ	PA25229

Polymorphism and mutation databases

BioMutaⁱ	B4GALT7
DMDMⁱ	13123990

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080550	1 – 327	Beta-1,4-galactosyltransferase 7Add BLAST		327

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	154	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	316 ↔ 324

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q9UBV7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UBV7
PaxDbⁱ	Q9UBV7
PeptideAtlas More...PeptideAtlasⁱ	Q9UBV7
PRIDEⁱ	Q9UBV7
ProteomicsDBⁱ	84081

PTM databases

SwissPalmⁱ	Q9UBV7

SwissPalmⁱ

Q9UBV7

Expressionⁱ

Tissue specificityⁱ

High expression in heart, pancreas and liver, medium in placenta and kidney, low in brain, skeletal muscle and lung.

Gene expression databases

Bgeeⁱ	ENSG00000027847 Expressed in 201 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_B4GALT7
ExpressionAtlasⁱ	Q9UBV7 baseline and differential
Genevisibleⁱ	Q9UBV7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042330

HPAⁱ

HPA042330

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KRTAP10-7	P60409	3	EBI-10319970,EBI-10172290
RABGGTB	P53611	5	EBI-10319970,EBI-536715

Protein-protein interaction databases

BioGridⁱ	116441, 36 interactors
IntActⁱ	Q9UBV7, 19 interactors
STRINGⁱ	9606.ENSP00000029410

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	82 – 84	Combined sources	3
Helixⁱ	88 – 90	Combined sources	3
Beta strandⁱ	95 – 103	Combined sources	9
Helixⁱ	105 – 121	Combined sources	17
Beta strandⁱ	126 – 133	Combined sources	8
Beta strandⁱ	135 – 137	Combined sources	3
Helixⁱ	141 – 151	Combined sources	11
Beta strandⁱ	158 – 162	Combined sources	5
Beta strandⁱ	166 – 168	Combined sources	3
Beta strandⁱ	183 – 186	Combined sources	4
Turnⁱ	188 – 190	Combined sources	3
Beta strandⁱ	191 – 193	Combined sources	3
Beta strandⁱ	202 – 207	Combined sources	6
Helixⁱ	208 – 213	Combined sources	6
Beta strandⁱ	223 – 226	Combined sources	4
Helixⁱ	227 – 237	Combined sources	11
Helixⁱ	251 – 253	Combined sources	3
Beta strandⁱ	254 – 257	Combined sources	4
Turnⁱ	261 – 263	Combined sources	3
Helixⁱ	274 – 277	Combined sources	4
Turnⁱ	287 – 289	Combined sources	3
Beta strandⁱ	292 – 302	Combined sources	11
Beta strandⁱ	305 – 314	Combined sources	10
Turnⁱ	318 – 320	Combined sources	3
Helixⁱ	322 – 325	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UBV7
SMRⁱ	Q9UBV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	100 – 104	UDP-alpha-D-galactose bindingCombined sources1 Publication	5
Regionⁱ	139 – 141	UDP-alpha-D-galactose binding1 Publication	3
Regionⁱ	164 – 165	UDP-alpha-D-galactose bindingCombined sources1 Publication	2
Regionⁱ	226 – 229	N-acetyl-D-glucosamine bindingCurated	4
Regionⁱ	257 – 259	UDP-alpha-D-galactose bindingCombined sources1 Publication	3

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 7 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3917 Eukaryota ENOG410Z0TP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119140
HOGENOMⁱ	HOG000286021
HOVERGENⁱ	HBG050654
InParanoidⁱ	Q9UBV7
KEGG Orthology (KO) More...KOⁱ	K00733
OMAⁱ	KAATPWC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HCH
PhylomeDBⁱ	Q9UBV7
TreeFamⁱ	TF312834

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR003859 Galactosyl_T IPR027791 Galactosyl_T_C IPR027995 Galactosyl_T_N IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR19300 PTHR19300, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02709 Glyco_transf_7C, 1 hit PF13733 Glyco_transf_7N, 1 hit
PRINTSⁱ	PR02050 B14GALTRFASE
SUPFAMⁱ	SSF53448 SSF53448, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q9UBV7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFPSRRKAAQ LPWEDGRSGL LSGGLPRKCS VFHLFVACLS LGFFSLLWLQ 
        60         70         80         90        100
LSCSGDVARA VRGQGQETSG PPRACPPEPP PEHWEEDASW GPHRLAVLVP 
       110        120        130        140        150
FRERFEELLV FVPHMRRFLS RKKIRHHIYV LNQVDHFRFN RAALINVGFL 
       160        170        180        190        200
ESSNSTDYIA MHDVDLLPLN EELDYGFPEA GPFHVASPEL HPLYHYKTYV 
       210        220        230        240        250
GGILLLSKQH YRLCNGMSNR FWGWGREDDE FYRRIKGAGL QLFRPSGITT 
       260        270        280        290        300
GYKTFRHLHD PAWRKRDQKR IAAQKQEQFK VDREGGLNTV KYHVASRTAL 
       310        320 
SVGGAPCTVL NIMLDCDKTA TPWCTFS

Length:327

Mass (Da):37,406

Last modified:May 1, 2000 - v1

Checksum:ⁱ2EDF51A2F8143135

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RJI5	D6RJI5_HUMAN	Beta-1,4-galactosyltransferase 7 Beta-1,4-galactosyltransferase 7	B4GALT7	170	Annotation score:
H0Y9D6	H0Y9D6_HUMAN	Beta-1,4-galactosyltransferase 7 Beta-1,4-galactosyltransferase 7	B4GALT7	77	Annotation score:
D6RDJ8	D6RDJ8_HUMAN	Beta-1,4-galactosyltransferase 7 Beta-1,4-galactosyltransferase 7	B4GALT7	36	Annotation score:
D6RA33	D6RA33_HUMAN	Beta-1,4-galactosyltransferase 7 Beta-1,4-galactosyltransferase 7	B4GALT7	42	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	147	V → L in AAF22225 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_010293	186	A → D in EDSSPD1. 1 PublicationCorresponds to variant dbSNP:rs121917817EnsemblClinVar.		1
Natural variantⁱVAR_010294	206	L → P in EDSSPD1. 1 PublicationCorresponds to variant dbSNP:rs121917818EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ005382 mRNA Translation: CAB56424.1 AB028600 mRNA Translation: BAA83414.1 AF142675 mRNA Translation: AAF22225.1 AY358578 mRNA Translation: AAQ88941.1 AK023506 mRNA Translation: BAG51201.1 CH471195 Genomic DNA Translation: EAW84965.1 BC007317 mRNA Translation: AAH07317.1 BC062983 mRNA Translation: AAH62983.1 BC072403 mRNA Translation: AAH72403.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4429.1
NCBI Reference Sequences More...RefSeqⁱ	NP_009186.1, NM_007255.2
UniGeneⁱ	Hs.455109

Genome annotation databases

Ensemblⁱ	ENST00000029410; ENSP00000029410; ENSG00000027847
GeneIDⁱ	11285
KEGGⁱ	hsa:11285
UCSC genome browser More...UCSCⁱ	uc003mhy.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UBV7	B4GALT7 isoform 2		PANTR		327	UniRef100_Q9UBV7
Uncharacterized protein		PANPA		327

Protein	Similar proteins		Species	Score	Length	Source
Q9UBV7	B4GALT7 isoform 2		PANTR		327	UniRef90_Q9UBV7
Uncharacterized protein		PANPA		327
beta-1,4-galactosyltransferase 7 isoform X1		Florida manatee		329
Putative beta-14-galactosyltransferase		DESRO		327
UPI000DF68784		VULVU		402
+7

Protein	Similar proteins		Species	Score	Length	Source
Q9UBV7	Beta-1,4-galactosyltransferase 7		MOUSE		327	UniRef50_Q9UBV7
B4GALT7 isoform 2		PANTR		327
Uncharacterized protein		PANPA		327
beta-1,4-galactosyltransferase 7 isoform X1		Florida manatee		329
Putative beta-14-galactosyltransferase		DESRO		327
+212

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - GTase

Beta-1,4-galactosyltransferase 7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ005382 mRNA Translation: CAB56424.1 AB028600 mRNA Translation: BAA83414.1 AF142675 mRNA Translation: AAF22225.1 AY358578 mRNA Translation: AAQ88941.1 AK023506 mRNA Translation: BAG51201.1 CH471195 Genomic DNA Translation: EAW84965.1 BC007317 mRNA Translation: AAH07317.1 BC062983 mRNA Translation: AAH62983.1 BC072403 mRNA Translation: AAH72403.1
CCDSⁱ	CCDS4429.1
RefSeqⁱ	NP_009186.1, NM_007255.2
UniGeneⁱ	Hs.455109

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4IRP	X-ray	2.10	A/B	81-327	[»]
	4IRQ	X-ray	2.30	A/B/C/D	81-327	[»]
ProteinModelPortalⁱ	Q9UBV7
SMRⁱ	Q9UBV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116441, 36 interactors
IntActⁱ	Q9UBV7, 19 interactors
STRINGⁱ	9606.ENSP00000029410

Protein family/group databases

CAZyⁱ	GT7 Glycosyltransferase Family 7

CAZyⁱ

GT7 Glycosyltransferase Family 7

PTM databases

SwissPalmⁱ	Q9UBV7

SwissPalmⁱ

Q9UBV7

Polymorphism and mutation databases

BioMutaⁱ	B4GALT7
DMDMⁱ	13123990

Proteomic databases

EPDⁱ	Q9UBV7
MaxQBⁱ	Q9UBV7
PaxDbⁱ	Q9UBV7
PeptideAtlasⁱ	Q9UBV7
PRIDEⁱ	Q9UBV7
ProteomicsDBⁱ	84081

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11285
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000029410; ENSP00000029410; ENSG00000027847
GeneIDⁱ	11285
KEGGⁱ	hsa:11285
UCSCⁱ	uc003mhy.4 human

Organism-specific databases

CTDⁱ	11285
DisGeNETⁱ	11285
EuPathDBⁱ	HostDB:ENSG00000027847.13
GeneCardsⁱ	B4GALT7
HGNCⁱ	HGNC:930 B4GALT7
HPAⁱ	HPA042330
MalaCardsⁱ	B4GALT7
MIMⁱ	130070 phenotype 604327 gene
neXtProtⁱ	NX_Q9UBV7
OpenTargetsⁱ	ENSG00000027847
Orphanetⁱ	75496 Ehlers-Danlos syndrome, progeroid type 294049 Reunion Island's Larsen syndrome
PharmGKBⁱ	PA25229
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3917 Eukaryota ENOG410Z0TP LUCA
GeneTreeⁱ	ENSGT00760000119140
HOGENOMⁱ	HOG000286021
HOVERGENⁱ	HBG050654
InParanoidⁱ	Q9UBV7
KOⁱ	K00733
OMAⁱ	KAATPWC
OrthoDBⁱ	EOG091G0HCH
PhylomeDBⁱ	Q9UBV7
TreeFamⁱ	TF312834

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
BioCycⁱ	MetaCyc:HS00459-MONOMER
BRENDAⁱ	2.4.1.133 2681
Reactomeⁱ	R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type

Miscellaneous databases

ChiTaRSⁱ	B4GALT7 human
GeneWikiⁱ	B4GALT7
GenomeRNAiⁱ	11285
Protein Ontology More...PROⁱ	PR:Q9UBV7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000027847 Expressed in 201 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_B4GALT7
ExpressionAtlasⁱ	Q9UBV7 baseline and differential
Genevisibleⁱ	Q9UBV7 HS

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR003859 Galactosyl_T IPR027791 Galactosyl_T_C IPR027995 Galactosyl_T_N IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR19300 PTHR19300, 1 hit
Pfamⁱ	View protein in Pfam PF02709 Glyco_transf_7C, 1 hit PF13733 Glyco_transf_7N, 1 hit
PRINTSⁱ	PR02050 B14GALTRFASE
SUPFAMⁱ	SSF53448 SSF53448, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B4GT7_HUMAN
Accessionⁱ	Q9UBV7Primary (citable) accession number: Q9UBV7 Secondary accession number(s): B3KN39, Q9UHN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	May 1, 2000
	Last modified:	October 10, 2018
	This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UBV7 (B4GT7_HUMAN)

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Beta-1,4-galactosyltransferase 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ