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Protein

Nuclear RNA export factor 1

Gene

NXF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mRNA export from nucleus Source: UniProtKB
  • poly(A)+ mRNA export from nucleus Source: GO_Central
  • RNA export from nucleus Source: Reactome
  • viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, mRNA transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9UBU9

Protein family/group databases

Transport Classification Database

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TCDBi
3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear RNA export factor 1
Alternative name(s):
Tip-associated protein
Tip-associating protein
mRNA export factor TAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NXF1
Synonyms:TAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000162231.13

Human Gene Nomenclature Database

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HGNCi
HGNC:8071 NXF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602647 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBU9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi71R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-78, A-81, A-82, A-89, A-91, A-97, A-98, A-100 and A-105. 1 Publication1
Mutagenesisi78R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-81, A-82, A-89, A-91, A-97, A-98, A-100 and A-105. 1 Publication1
Mutagenesisi81R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-82, A-89, A-91, A-97, A-98, A-100 and A-105. 1 Publication1
Mutagenesisi82R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-89, A-91, A-97, A-98, A-100 and A-105. 1 Publication1
Mutagenesisi89R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-91, A-97, A-98, A-100 and A-105. 1 Publication1
Mutagenesisi91R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-97, A-98, A-100 and A-105. 1 Publication1
Mutagenesisi97R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-91, A-98, A-100 and A-105. 1 Publication1
Mutagenesisi98R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-91, A-97, A-100 and A-105. 1 Publication1
Mutagenesisi100R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-91, A-97, A-98 and A-105. 1 Publication1
Mutagenesisi105R → A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-91, A-97, A-98 and A-100. 1 Publication1
Mutagenesisi306 – 308ERE → AAA: Decreases the export of mRNAs from the nucleus. 3
Mutagenesisi383L → R: Diminishes nuclear rim staining and 80% reduction in mRNA export activity; when associated with R-386. Complete loss of nuclear rim staining and mRNA export activity; when associated with R-386 and A-594. 1 Publication1
Mutagenesisi386L → R: Diminishes nuclear rim staining and 80% reduction in mRNA export activity; when associated with R-383. Complete loss of nuclear rim staining and mRNA export activity; when associated with R-383 and A-594. 1 Publication1
Mutagenesisi399D → A: 60% reduction in mRNA export activity. 1 Publication1
Mutagenesisi450 – 453LRFR → AAAA: Abolishes interaction with THOC5 and CHTOP. 1 Publication4
Mutagenesisi453R → A: Impairs intramolecular interaction between RBD and NTF2. 1 Publication1
Mutagenesisi456 – 459KHTR → AAAA: Abolishes interaction with THOC5 and CHTOP, no effect on interaction with NXT1; enhances intramolecular interaction between RBD and NTF2, reduces RNA binding and mRNA export. 2 Publications4
Mutagenesisi456K → D: Impairs intramolecular interaction between RBD and NTF2; when associated with D-459. 1
Mutagenesisi459R → D: Impairs intramolecular interaction between RBD and NTF2; when associated with D-456. 1
Mutagenesisi482D → R: 90% reduction in mRNA export activity. 1 Publication1
Mutagenesisi518I → R: 98% reduction in mRNA export activity. 1 Publication1
Mutagenesisi521P → Q: 35% reduction in mRNA export activity. 1 Publication1
Mutagenesisi594W → A: Suppresses FG-nucleoporin binding. Diminishes nuclear rim staining and 88% reduction in mRNA export activity. Complete loss of nuclear rim staining and mRNA export activity; when associated with R-383 and R-386. 1 Publication1
Mutagenesisi595D → R: Suppresses FG-nucleoporin binding. 1
Mutagenesisi617F → A: Suppresses FG-nucleoporin binding. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
10482

Open Targets

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OpenTargetsi
ENSG00000162231

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31858

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NXF1

Domain mapping of disease mutations (DMDM)

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DMDMi
20139282

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205292 – 619Nuclear RNA export factor 1Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei42Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei42Omega-N-methylarginine; alternateBy similarity1
Modified residuei126Nitrated tyrosineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Nitration, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBU9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBU9

PeptideAtlas

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PeptideAtlasi
Q9UBU9

PRoteomics IDEntifications database

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PRIDEi
Q9UBU9

ProteomicsDB human proteome resource

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ProteomicsDBi
84075
84076 [Q9UBU9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UBU9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UBU9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162231 Expressed in 97 organ(s), highest expression level in pituitary gland

CleanEx database of gene expression profiles

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CleanExi
HS_NXF1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBU9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBU9 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB016327
HPA061593

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer (via NTF2 domain) with NXT1 (PubMed:11583626). The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export (PubMed:11583626). Forms a complex with RANBP2/NUP358, NXT1 and RANGAP1 (PubMed:14729961). Associates with the exon junction complex (EJC) and with the transcription/export (TREX) complex (PubMed:11707413, PubMed:22893130). Found in a mRNA complex with UPF3A and UPF3B (PubMed:11546873). Found in a post-splicing complex with RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1 (PubMed:11546874). Interacts (via N-terminus) with DHX9 (via N-terminus); this interaction is direct and negatively regulates NXF1-mediated nuclear export of constitutive transport element (CTE)-containing cellular mRNAs (PubMed:10924507). Interacts with ALYREF/THOC4 (PubMed:11707413, PubMed:14730019, PubMed:19165146, PubMed:23299939). Interacts with FYTTD1/UIF (PubMed:19836239). Interacts with EIF4A3 (PubMed:14730019). Interacts with NUPL2 (PubMed:10228171). Interacts with THOC5 (PubMed:19165146, PubMed:23299939). Interacts with CHTOP (PubMed:23299939, PubMed:23826332). Interacts with FRG1 (via N-terminus) (PubMed:21699900). Interacts with LUZP4 (PubMed:25662211). Interacts with FMR1; the interaction occurs in a mRNA-dependent and polyribosomes-independent manner in the nucleus (PubMed:18936162). Interacts with CPSF6 (via N-terminus); this interaction is direct (PubMed:19864460). Interacts with RBM15 (PubMed:17001072). Interacts with RBM15B (PubMed:19586903).22 Publications
(Microbial infection) Interacts with Saimiriine herpesvirus 2 TIP protein.1 Publication
(Microbial infection) Interacts with human herpes virus 1 (HHV-1) ICP27 protein; this interaction allows efficient export of HHV-1 early and late transcripts.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115745, 1132 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UBU9

Database of interacting proteins

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DIPi
DIP-31789N

Protein interaction database and analysis system

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IntActi
Q9UBU9, 138 interactors

Molecular INTeraction database

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MINTi
Q9UBU9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000294172

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1619
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UBU9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBU9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9UBU9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 198RRMAdd BLAST80
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati266 – 291LRR 1Add BLAST26
Repeati292 – 315LRR 2Add BLAST24
Repeati316 – 343LRR 3Add BLAST28
Repeati344 – 371LRR 4Add BLAST28
Domaini386 – 536NTF2PROSITE-ProRule annotationAdd BLAST151
Domaini565 – 619TAP-CPROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 198Interaction with ALYREF/THOC4 and LUZP41 PublicationAdd BLAST197
Regioni2 – 118RNA-binding (RBD)Add BLAST117
Regioni2 – 60Minor non-specific RNA-bindingAdd BLAST59
Regioni61 – 118Major non-specific RNA-bindingAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi67 – 100Nuclear localization signalAdd BLAST34
Motifi83 – 110Nuclear export signalAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi551 – 561Pro-richAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats.1 Publication
The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs.1 Publication
The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from the nucleus. It inhibits RNA binding activity through an intramolecular interaction with the N-terminal RNA binding domain (RBD); the inhibition is removed by an association with the TREX complex, specifically involving ALYREF/THOC4 and THOC5.1 Publication
The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in the interaction with nucleoporins.1 Publication
The leucine-rich repeats are essential for the export of mRNA from the nucleus.1 Publication
The RNA-binding domain is a non-canonical RNP-type domain.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NXF family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3763 Eukaryota
ENOG410XR55 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000236269

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG013199

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBU9

KEGG Orthology (KO)

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KOi
K14284

Identification of Orthologs from Complete Genome Data

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OMAi
SYFGTET

Database of Orthologous Groups

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OrthoDBi
EOG091G04QA

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBU9

TreeFam database of animal gene trees

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TreeFami
TF314566

Family and domain databases

Conserved Domains Database

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CDDi
cd00780 NTF2, 1 hit
cd14342 UBA_TAP-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR030217 NXF_fam
IPR035979 RBD_domain_sf
IPR005637 TAP_C_dom
IPR015245 Tap_RNA-bd
IPR009060 UBA-like_sf

The PANTHER Classification System

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PANTHERi
PTHR10662 PTHR10662, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02136 NTF2, 1 hit
PF09162 Tap-RNA_bind, 1 hit
PF03943 TAP_C, 1 hit

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD043466 Tap_RNA_bd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00804 TAP_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46934 SSF46934, 1 hit
SSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51450 LRR, 3 hits
PS50177 NTF2_DOMAIN, 1 hit
PS51281 TAP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEGKSYSE HDDERVNFPQ RKKKGRGPFR WKYGEGNRRS GRGGSGIRSS
60 70 80 90 100
RLEEDDGDVA MSDAQDGPRV RYNPYTTRPN RRGDTWHDRD RIHVTVRRDR
110 120 130 140 150
APPERGGAGT SQDGTSKNWF KITIPYGRKY DKAWLLSMIQ SKCSVPFTPI
160 170 180 190 200
EFHYENTRAQ FFVEDASTAS ALKAVNYKIL DRENRRISII INSSAPPHTI
210 220 230 240 250
LNELKPEQVE QLKLIMSKRY DGSQQALDLK GLRSDPDLVA QNIDVVLNRR
260 270 280 290 300
SCMAATLRII EENIPELLSL NLSNNRLYRL DDMSSIVQKA PNLKILNLSG
310 320 330 340 350
NELKSERELD KIKGLKLEEL WLDGNSLCDT FRDQSTYISA IRERFPKLLR
360 370 380 390 400
LDGHELPPPI AFDVEAPTTL PPCKGSYFGT ENLKSLVLHF LQQYYAIYDS
410 420 430 440 450
GDRQGLLDAY HDGACCSLSI PFIPQNPARS SLAEYFKDSR NVKKLKDPTL
460 470 480 490 500
RFRLLKHTRL NVVAFLNELP KTQHDVNSFV VDISAQTSTL LCFSVNGVFK
510 520 530 540 550
EVDGKSRDSL RAFTRTFIAV PASNSGLCIV NDELFVRNAS SEEIQRAFAM
560 570 580 590 600
PAPTPSSSPV PTLSPEQQEM LQAFSTQSGM NLEWSQKCLQ DNNWDYTRSA
610
QAFTHLKAKG EIPEVAFMK
Length:619
Mass (Da):70,182
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i338872AADA789FBF
GO
Isoform 2 (identifier: Q9UBU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     339-356: SAIRERFPKLLRLDGHEL → RSVVACVSPPGDLHPLGG
     357-619: Missing.

Show »
Length:356
Mass (Da):40,476
Checksum:i470701F5324EC0B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIN3E9PIN3_HUMAN
Nuclear RNA export factor 1
NXF1
603Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLA7E9PLA7_HUMAN
Nuclear RNA export factor 1
NXF1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E227B4E227_HUMAN
cDNA FLJ61053, highly similar to Nu...
NXF1
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMV7E9PMV7_HUMAN
Nuclear RNA export factor 1
NXF1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDU0H0YDU0_HUMAN
Nuclear RNA export factor 1
NXF1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQA4E9PQA4_HUMAN
Nuclear RNA export factor 1
NXF1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119W → C in AAB81111 (PubMed:9175835).Curated1
Sequence conflicti256T → N in AAD20016 (PubMed:10454577).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041427339 – 356SAIRE…DGHEL → RSVVACVSPPGDLHPLGG in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_041428357 – 619Missing in isoform 2. 1 PublicationAdd BLAST263

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ132712 mRNA Translation: CAA10753.1
AF112880 mRNA Translation: AAD39102.1
AF126246 mRNA Translation: AAD20016.1
AK304137 mRNA Translation: BAG65031.1
AK027192 mRNA No translation available.
AP001160 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74105.1
BC004904 mRNA Translation: AAH04904.1
BC028041 mRNA Translation: AAH28041.1
U80073 mRNA Translation: AAB81111.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44629.1 [Q9UBU9-2]
CCDS8037.1 [Q9UBU9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074960.1, NM_001081491.1 [Q9UBU9-2]
NP_006353.2, NM_006362.4 [Q9UBU9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.523739
Hs.601546

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294172; ENSP00000294172; ENSG00000162231 [Q9UBU9-1]
ENST00000531709; ENSP00000453885; ENSG00000162231 [Q9UBU9-2]
ENST00000532297; ENSP00000436679; ENSG00000162231 [Q9UBU9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10482

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10482

UCSC genome browser

More...
UCSCi
uc001nvf.1 human [Q9UBU9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132712 mRNA Translation: CAA10753.1
AF112880 mRNA Translation: AAD39102.1
AF126246 mRNA Translation: AAD20016.1
AK304137 mRNA Translation: BAG65031.1
AK027192 mRNA No translation available.
AP001160 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74105.1
BC004904 mRNA Translation: AAH04904.1
BC028041 mRNA Translation: AAH28041.1
U80073 mRNA Translation: AAB81111.1
CCDSiCCDS44629.1 [Q9UBU9-2]
CCDS8037.1 [Q9UBU9-1]
RefSeqiNP_001074960.1, NM_001081491.1 [Q9UBU9-2]
NP_006353.2, NM_006362.4 [Q9UBU9-1]
UniGeneiHs.523739
Hs.601546

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FO1X-ray2.90A/B102-372[»]
1FT8X-ray3.15A/B/C/D/E102-372[»]
1GO5NMR-A551-619[»]
1JKGX-ray1.90B371-619[»]
1JN5X-ray2.80B371-619[»]
1KOHX-ray3.80A/B/C/D96-372[»]
1KOOX-ray3.80A/B/C/D96-372[»]
1OAIX-ray1.00A561-619[»]
2Z5KX-ray2.60B53-82[»]
2Z5MX-ray3.00B53-82[»]
3RW6X-ray2.30A/B96-362[»]
3RW7X-ray3.00A/B/C/D96-362[»]
4WYKX-ray3.40A/C96-555[»]
ProteinModelPortaliQ9UBU9
SMRiQ9UBU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115745, 1132 interactors
CORUMiQ9UBU9
DIPiDIP-31789N
IntActiQ9UBU9, 138 interactors
MINTiQ9UBU9
STRINGi9606.ENSP00000294172

Protein family/group databases

TCDBi3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetiQ9UBU9
PhosphoSitePlusiQ9UBU9

Polymorphism and mutation databases

BioMutaiNXF1
DMDMi20139282

Proteomic databases

EPDiQ9UBU9
PaxDbiQ9UBU9
PeptideAtlasiQ9UBU9
PRIDEiQ9UBU9
ProteomicsDBi84075
84076 [Q9UBU9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10482
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294172; ENSP00000294172; ENSG00000162231 [Q9UBU9-1]
ENST00000531709; ENSP00000453885; ENSG00000162231 [Q9UBU9-2]
ENST00000532297; ENSP00000436679; ENSG00000162231 [Q9UBU9-1]
GeneIDi10482
KEGGihsa:10482
UCSCiuc001nvf.1 human [Q9UBU9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10482
DisGeNETi10482
EuPathDBiHostDB:ENSG00000162231.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NXF1
HGNCiHGNC:8071 NXF1
HPAiCAB016327
HPA061593
MIMi602647 gene
neXtProtiNX_Q9UBU9
OpenTargetsiENSG00000162231
PharmGKBiPA31858

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3763 Eukaryota
ENOG410XR55 LUCA
GeneTreeiENSGT00390000007539
HOGENOMiHOG000236269
HOVERGENiHBG013199
InParanoidiQ9UBU9
KOiK14284
OMAiSYFGTET
OrthoDBiEOG091G04QA
PhylomeDBiQ9UBU9
TreeFamiTF314566

Enzyme and pathway databases

ReactomeiR-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
SIGNORiQ9UBU9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NXF1 human
EvolutionaryTraceiQ9UBU9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NXF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10482

Protein Ontology

More...
PROi
PR:Q9UBU9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162231 Expressed in 97 organ(s), highest expression level in pituitary gland
CleanExiHS_NXF1
ExpressionAtlasiQ9UBU9 baseline and differential
GenevisibleiQ9UBU9 HS

Family and domain databases

CDDicd00780 NTF2, 1 hit
cd14342 UBA_TAP-C, 1 hit
Gene3Di3.30.70.330, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR030217 NXF_fam
IPR035979 RBD_domain_sf
IPR005637 TAP_C_dom
IPR015245 Tap_RNA-bd
IPR009060 UBA-like_sf
PANTHERiPTHR10662 PTHR10662, 1 hit
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
PF09162 Tap-RNA_bind, 1 hit
PF03943 TAP_C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD043466 Tap_RNA_bd, 1 hit
SMARTiView protein in SMART
SM00804 TAP_C, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 3 hits
PS50177 NTF2_DOMAIN, 1 hit
PS51281 TAP_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNXF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBU9
Secondary accession number(s): B4E269, Q99799, Q9UQL2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: December 5, 2018
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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