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UniProtKB - Q9UBU8 (MO4L1_HUMAN)

Entry version 210 (17 Jun 2020)
Sequence version 2 (15 Feb 2005)
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Protein

Mortality factor 4-like protein 1

Gene

MORF4L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA recombination, DNA repair, Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847 HATs acetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mortality factor 4-like protein 1
Alternative name(s):
MORF-related gene 15 protein
Protein MSL3-1
Transcription factor-like protein MRG15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MORF4L1
Synonyms:MRG15
ORF Names:FWP006, HSPC008, HSPC061, PP368
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000185787.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:16989 MORF4L1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607303 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UBU8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi208V → E: Abolishes binding to MRFAP1. 1 Publication1
Mutagenesisi234E → R: No effect on MRFAP1 binding. 1 Publication1
Mutagenesisi251Y → A: No effect on MRFAP1 binding. 1 Publication1
Mutagenesisi254N → C: Reduces binding to MRFAP1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10933

Open Targets

More...OpenTargetsi		ENSG00000185787

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134895182

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UBU8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MORF4L1

Domain mapping of disease mutations (DMDM)

More...DMDMi		59803121

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000887641 – 362Mortality factor 4-like protein 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei143N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UBU8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UBU8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UBU8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UBU8

PeptideAtlas

More...PeptideAtlasi		Q9UBU8

PRoteomics IDEntifications database

More...PRIDEi		Q9UBU8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		6799
84073 [Q9UBU8-1]
84074 [Q9UBU8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UBU8

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UBU8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UBU8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UBU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185787 Expressed in testis and 93 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UBU8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UBU8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185787 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP.

Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46.

Interacts with RB1 and KAT8. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors.

Interacts with the N-terminus of MRFAP1.

Found in a complex composed of MORF4L1, MRFAP1 and RB1.

Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51.

Interacts with PALB2.

Forms a complex with MSL1 and NUPR1.

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9UBU8
With#Exp.IntAct
ARRDC3 [Q96B67]3EBI-399246,EBI-2875665
BEND7 - isoform 2 [Q8N7W2-2]3EBI-399246,EBI-10181188
CAMK2B [Q13554]3EBI-399246,EBI-1058722
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-399246,EBI-10181988
FAM9B [Q8IZU0]3EBI-399246,EBI-10175124
FLJ13057 [Q53SE7]3EBI-399246,EBI-10172181
FXR2 [P51116]3EBI-399246,EBI-740459
GOLGA2 [Q08379]3EBI-399246,EBI-618309
HMBOX1 [Q6NT76]3EBI-399246,EBI-2549423
HMBOX1 - isoform 2 [Q6NT76-2]3EBI-399246,EBI-10212206
IKZF1 [Q13422]3EBI-399246,EBI-745305
L3MBTL3 [Q96JM7]3EBI-399246,EBI-2686809
LZTS2 [Q9BRK4]3EBI-399246,EBI-741037
MEOX1 [P50221]3EBI-399246,EBI-2864512
MRFAP1 [Q9Y605]6EBI-399246,EBI-995714
MRFAP1L1 [Q96HT8]8EBI-399246,EBI-748896
MRGBP [Q9NV56]6EBI-399246,EBI-399076
NAB2 [Q15742]3EBI-399246,EBI-8641936
NAV2 [Q8IVL1]3EBI-399246,EBI-741200
PBXIP1 [Q96AQ6]3EBI-399246,EBI-740845
RACGAP1 [Q9H0H5]3EBI-399246,EBI-717233
REL [Q04864]3EBI-399246,EBI-307352
TFCP2 [Q12800]3EBI-399246,EBI-717422
THAP1 [Q9NVV9]3EBI-399246,EBI-741515
TNIP1 [Q15025]4EBI-399246,EBI-357849
TNNT1 [P13805]3EBI-399246,EBI-726527
TRIM41 [Q8WV44]3EBI-399246,EBI-725997
ZBTB10 [Q96DT7]3EBI-399246,EBI-10235384
ZBTB9 [Q96C00]4EBI-399246,EBI-395708
Isoform 2 [Q9UBU8-2]
With#Exp.IntAct
ARID3A [Q99856]3EBI-10288852,EBI-5458244
ARRDC3 [Q96B67]3EBI-10288852,EBI-2875665
BEX5 [Q5H9J7]3EBI-10288852,EBI-10243741
CAMK2B [Q13554]3EBI-10288852,EBI-1058722
CAMK2B - isoform 2 [Q13554-3]3EBI-10288852,EBI-11523526
CWC27 - isoform 2 [Q6UX04-2]3EBI-10288852,EBI-18939574
DDIT4L [Q96D03]3EBI-10288852,EBI-742054
DMAP1 [Q9NPF5]4EBI-10288852,EBI-399105
DRAP1 [Q14919]3EBI-10288852,EBI-712941
FAM13C [Q8NE31]3EBI-10288852,EBI-751248
FBXO16 [Q8IX29]3EBI-10288852,EBI-12063229
FXR2 [P51116]3EBI-10288852,EBI-740459
GMCL1 [Q96IK5]3EBI-10288852,EBI-2548508
GOLGA2 [Q08379]3EBI-10288852,EBI-618309
GOLGA6A [Q9NYA3]3EBI-10288852,EBI-11163335
GSC2 [O15499]3EBI-10288852,EBI-19954058
HMBOX1 [Q6NT76]3EBI-10288852,EBI-2549423
HMG20A [Q9NP66]3EBI-10288852,EBI-740641
KPNA2 [P52292]3EBI-10288852,EBI-349938
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-10288852,EBI-11985629
LHX2 [P50458]3EBI-10288852,EBI-12179869
LZTS2 [Q9BRK4]3EBI-10288852,EBI-741037
MEOX2 [Q6FHY5]3EBI-10288852,EBI-16439278
MPHOSPH10 [O00566]3EBI-10288852,EBI-5235884
MRFAP1 [Q9Y605]15EBI-10288852,EBI-995714
MRFAP1L1 [Q96HT8]27EBI-10288852,EBI-748896
MRGBP [Q9NV56]18EBI-10288852,EBI-399076
MRPL12 [P52815]3EBI-10288852,EBI-358272
NAB2 [Q15742]3EBI-10288852,EBI-8641936
NECAB1 [Q8N987]3EBI-10288852,EBI-11956853
NKD1 [Q969G9]3EBI-10288852,EBI-1538217
PALB2 [Q86YC2]3EBI-10288852,EBI-1222653
PBXIP1 [Q96AQ6]3EBI-10288852,EBI-740845
PHF12 [Q96QT6]6EBI-10288852,EBI-2803760
PHF12 - isoform 2 [Q96QT6-2]3EBI-10288852,EBI-10293106
PIBF1 [Q4G0R1]3EBI-10288852,EBI-14066006
PICK1 [Q9NRD5]3EBI-10288852,EBI-79165
PLEKHA3 [Q9HB20]3EBI-10288852,EBI-11079894
RCBTB2 [O95199]3EBI-10288852,EBI-742404
SYN3 [Q17R54]3EBI-10288852,EBI-12820047
TEPSIN [Q96N21]3EBI-10288852,EBI-11139477
TFCP2 [Q12800]3EBI-10288852,EBI-717422
TLE5 - isoform 2 [Q08117-2]3EBI-10288852,EBI-11741437
TNNT2 - isoform 11 [P45379-11]3EBI-10288852,EBI-17559309
TRAF2 [Q12933]3EBI-10288852,EBI-355744
TRIM41 [Q8WV44]5EBI-10288852,EBI-725997
UBP1 [Q9NZI7]3EBI-10288852,EBI-2795133
VPS26A [O75436]3EBI-10288852,EBI-1043891
WBP11 [Q9Y2W2]3EBI-10288852,EBI-714455
ZBTB26 [Q9HCK0]3EBI-10288852,EBI-3918996
ZBTB43 [O43298]3EBI-10288852,EBI-740718
ZBTB8B [Q8NAP8]3EBI-10288852,EBI-17494306
ZBTB9 [Q96C00]3EBI-10288852,EBI-395708
ZC3H7A - isoform 2 [Q8IWR0-2]3EBI-10288852,EBI-12242934
ZNF276 [Q8N554]3EBI-10288852,EBI-750821
ZNF438 [Q7Z4V0]3EBI-10288852,EBI-11962468
ZNF449 [Q6P9G9]3EBI-10288852,EBI-10215956
Phf12 [Q5SPL2] from Mus musculus.2EBI-10288852,EBI-15963335

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116134, 129 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-978 NuA4 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UBU8

Database of interacting proteins

More...DIPi		DIP-29017N

Protein interaction database and analysis system

More...IntActi		Q9UBU8, 118 interactors

Molecular INTeraction database

More...MINTi		Q9UBU8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000331310

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UBU8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UBU8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UBU8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 362MRGPROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 62Interaction with KAT81 PublicationAdd BLAST37
Regioni133 – 266Sufficient for interaction with SIN3A1 PublicationAdd BLAST134
Regioni164 – 230Interaction with RB1-1Add BLAST67
Regioni188 – 342Sufficient for interaction with PHF121 PublicationAdd BLAST155
Regioni323 – 344Interaction with RB1-2Add BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi135 – 146Nuclear localization signalSequence analysisAdd BLAST12

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3001 Eukaryota
ENOG410XR9F LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182965

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UBU8

KEGG Orthology (KO)

More...KOi		K11339

Database of Orthologous Groups

More...OrthoDBi		1624495at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UBU8

TreeFam database of animal gene trees

More...TreeFami		TF323400

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.274.30, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00330

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR008676 MRG
IPR038011 MRG15
IPR038217 MRG_C_sf
IPR026541 MRG_dom
IPR025995 Tudor-knot

The PANTHER Classification System

More...PANTHERi		PTHR10880 PTHR10880, 1 hit
PTHR10880:SF29 PTHR10880:SF29, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05712 MRG, 1 hit
PF11717 Tudor-knot, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038133 HAT_Nua4_EAF3/MRG15, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54160 SSF54160, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51640 MRG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN 
        60         70         80         90        100
KKSAVRPRRS EKSLKTHEDI VALFPVPEGA PSVHHPLLTS SWDEWVPESR 
       110        120        130        140        150
VLKYVDTNLQ KQRELQKANQ EQYAEGKMRG AAPGKKTSGL QQKNVEVKTK 
       160        170        180        190        200
KNKQKTPGNG DGGSTSETPQ PPRKKRARVD PTVENEETFM NRVEVKVKIP 
       210        220        230        240        250
EELKPWLVDD WDLITRQKQL FYLPAKKNVD SILEDYANYK KSRGNTDNKE 
       260        270        280        290        300
YAVNEVVAGI KEYFNVMLGT QLLYKFERPQ YAEILADHPD APMSQVYGAP 
       310        320        330        340        350
HLLRLFVRIG AMLAYTPLDE KSLALLLNYL HDFLKYLAKN SATLFSASDY 
       360 
EVAPPEYHRK AV
Length:362
Mass (Da):41,474
Last modified:February 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96B76BCA801F1187
GO
Isoform 2 (identifier: Q9UBU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-91: KSAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSS → N

Show »
Length:323
Mass (Da):37,231
Checksum:i33CDBEC7D9CF513F
GO
Isoform 3 (identifier: Q9UBU8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Show »
Length:235
Mass (Da):26,750
Checksum:i04AA4B2175DF583E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMJ0H0YMJ0_HUMAN
Mortality factor 4-like protein 1
MORF4L1
245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNE0H0YNE0_HUMAN
Mortality factor 4-like protein 1
MORF4L1
213Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KTM8B3KTM8_HUMAN
Mortality factor 4-like protein 1
MORF4L1
348Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLJ3H0YLJ3_HUMAN
Mortality factor 4-like protein 1
MORF4L1
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM21H0YM21_HUMAN
Mortality factor 4-like protein 1
MORF4L1
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLV1H0YLV1_HUMAN
Mortality factor 4-like protein 1
MORF4L1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMT8H0YMT8_HUMAN
Mortality factor 4-like protein 1
MORF4L1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNX3H0YNX3_HUMAN
Mortality factor 4-like protein 1
MORF4L1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNI8H0YNI8_HUMAN
Mortality factor 4-like protein 1
MORF4L1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG17253 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti224P → R in AAH67826 (PubMed:15489334).Curated1
Sequence conflicti261K → KK in CAB70879 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0460161 – 127Missing in isoform 3. 2 PublicationsAdd BLAST127
Alternative sequenceiVSP_01288952 – 91KSAVR…LLTSS → N in isoform 2. 6 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF100615 mRNA Translation: AAD29872.1
AF167173 mRNA Translation: AAF80854.1
AF218011 mRNA Translation: AAG17253.1 Frameshift.
AY148481 mRNA Translation: AAN65338.1
AF070664 mRNA Translation: AAD20970.1
AF161546 mRNA Translation: AAF29033.1
AF109188 mRNA Translation: AAQ13497.1
AK296650 mRNA Translation: BAG59248.1
AK300789 mRNA Translation: BAH13347.1
AL137697 mRNA Translation: CAB70879.2
AC011944 Genomic DNA No translation available.
AC022748 Genomic DNA No translation available.
AC103975 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99145.1
CH471136 Genomic DNA Translation: EAW99144.1
CH471136 Genomic DNA Translation: EAW99146.1
CH471136 Genomic DNA Translation: EAW99147.1
BC022845 mRNA Translation: AAH22845.1
BC002936 mRNA Translation: AAH02936.1
BC067826 mRNA Translation: AAH67826.1
CX165647 mRNA No translation available.
AF131847 mRNA Translation: AAD20058.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10307.1 [Q9UBU8-1]
CCDS32304.1 [Q9UBU8-2]
CCDS58393.1 [Q9UBU8-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T46285

NCBI Reference Sequences

More...RefSeqi		NP_001252532.1, NM_001265603.1 [Q9UBU8-3]
NP_001252533.1, NM_001265604.1 [Q9UBU8-3]
NP_001252534.1, NM_001265605.1 [Q9UBU8-3]
NP_006782.1, NM_006791.3 [Q9UBU8-2]
NP_996670.1, NM_206839.2 [Q9UBU8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000331268; ENSP00000331310; ENSG00000185787 [Q9UBU8-1]
ENST00000426013; ENSP00000408880; ENSG00000185787 [Q9UBU8-2]
ENST00000558502; ENSP00000452808; ENSG00000185787 [Q9UBU8-3]
ENST00000559345; ENSP00000452717; ENSG00000185787 [Q9UBU8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10933

UCSC genome browser

More...UCSCi		uc002bel.5 human [Q9UBU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100615 mRNA Translation: AAD29872.1
AF167173 mRNA Translation: AAF80854.1
AF218011 mRNA Translation: AAG17253.1 Frameshift.
AY148481 mRNA Translation: AAN65338.1
AF070664 mRNA Translation: AAD20970.1
AF161546 mRNA Translation: AAF29033.1
AF109188 mRNA Translation: AAQ13497.1
AK296650 mRNA Translation: BAG59248.1
AK300789 mRNA Translation: BAH13347.1
AL137697 mRNA Translation: CAB70879.2
AC011944 Genomic DNA No translation available.
AC022748 Genomic DNA No translation available.
AC103975 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99145.1
CH471136 Genomic DNA Translation: EAW99144.1
CH471136 Genomic DNA Translation: EAW99146.1
CH471136 Genomic DNA Translation: EAW99147.1
BC022845 mRNA Translation: AAH22845.1
BC002936 mRNA Translation: AAH02936.1
BC067826 mRNA Translation: AAH67826.1
CX165647 mRNA No translation available.
AF131847 mRNA Translation: AAD20058.1
CCDSiCCDS10307.1 [Q9UBU8-1]
CCDS32304.1 [Q9UBU8-2]
CCDS58393.1 [Q9UBU8-3]
PIRiT46285
RefSeqiNP_001252532.1, NM_001265603.1 [Q9UBU8-3]
NP_001252533.1, NM_001265604.1 [Q9UBU8-3]
NP_001252534.1, NM_001265605.1 [Q9UBU8-3]
NP_006782.1, NM_006791.3 [Q9UBU8-2]
NP_996670.1, NM_206839.2 [Q9UBU8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AQLX-ray2.30A/B190-362[»]
2EFINMR-A1-132[»]
2F5JX-ray2.20A/B190-360[»]
2F5KX-ray2.20A/B/C/D/E/F1-129[»]
2LKMNMR-B194-362[»]
2N1DNMR-B194-362[»]
6AGOX-ray3.10C/D190-361[»]
6INEX-ray2.60B190-362[»]
SMRiQ9UBU8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116134, 129 interactors
ComplexPortaliCPX-978 NuA4 histone acetyltransferase complex
CORUMiQ9UBU8
DIPiDIP-29017N
IntActiQ9UBU8, 118 interactors
MINTiQ9UBU8
STRINGi9606.ENSP00000331310

PTM databases

iPTMnetiQ9UBU8
MetOSiteiQ9UBU8
PhosphoSitePlusiQ9UBU8
SwissPalmiQ9UBU8

Polymorphism and mutation databases

BioMutaiMORF4L1
DMDMi59803121

Proteomic databases

EPDiQ9UBU8
jPOSTiQ9UBU8
MassIVEiQ9UBU8
PaxDbiQ9UBU8
PeptideAtlasiQ9UBU8
PRIDEiQ9UBU8
ProteomicsDBi6799
84073 [Q9UBU8-1]
84074 [Q9UBU8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27748 365 antibodies

The DNASU plasmid repository

More...DNASUi		10933

Genome annotation databases

EnsembliENST00000331268; ENSP00000331310; ENSG00000185787 [Q9UBU8-1]
ENST00000426013; ENSP00000408880; ENSG00000185787 [Q9UBU8-2]
ENST00000558502; ENSP00000452808; ENSG00000185787 [Q9UBU8-3]
ENST00000559345; ENSP00000452717; ENSG00000185787 [Q9UBU8-3]
GeneIDi10933
KEGGihsa:10933
UCSCiuc002bel.5 human [Q9UBU8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10933
DisGeNETi10933
EuPathDBiHostDB:ENSG00000185787.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		MORF4L1
HGNCiHGNC:16989 MORF4L1
HPAiENSG00000185787 Low tissue specificity
MIMi607303 gene
neXtProtiNX_Q9UBU8
OpenTargetsiENSG00000185787
PharmGKBiPA134895182

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3001 Eukaryota
ENOG410XR9F LUCA
GeneTreeiENSGT00950000182965
InParanoidiQ9UBU8
KOiK11339
OrthoDBi1624495at2759
PhylomeDBiQ9UBU8
TreeFamiTF323400

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10933 18 hits in 791 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MORF4L1 human
EvolutionaryTraceiQ9UBU8

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MORF4L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10933
PharosiQ9UBU8 Tbio

Protein Ontology

More...PROi		PR:Q9UBU8
RNActiQ9UBU8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185787 Expressed in testis and 93 other tissues
ExpressionAtlasiQ9UBU8 baseline and differential
GenevisibleiQ9UBU8 HS

Family and domain databases

Gene3Di1.10.274.30, 1 hit
IDEALiIID00330
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR008676 MRG
IPR038011 MRG15
IPR038217 MRG_C_sf
IPR026541 MRG_dom
IPR025995 Tudor-knot
PANTHERiPTHR10880 PTHR10880, 1 hit
PTHR10880:SF29 PTHR10880:SF29, 1 hit
PfamiView protein in Pfam
PF05712 MRG, 1 hit
PF11717 Tudor-knot, 1 hit
PIRSFiPIRSF038133 HAT_Nua4_EAF3/MRG15, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51640 MRG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMO4L1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBU8
Secondary accession number(s): B4DKN6
, B7Z6R1, D3DW88, O95899, Q5QTS1, Q6NVX8, Q86YT7, Q9HBP6, Q9NSW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 15, 2005
Last modified: June 17, 2020
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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