Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mortality factor 4-like protein 1

Gene

MORF4L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.2 Publications

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

  • cell proliferation Source: Ensembl
  • chromatin remodeling Source: GO_Central
  • chromatin silencing Source: GO_Central
  • double-strand break repair via homologous recombination Source: UniProtKB
  • histone deacetylation Source: UniProtKB
  • histone H2A acetylation Source: UniProtKB
  • histone H4 acetylation Source: UniProtKB
  • regulation of growth Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA recombination, DNA repair, Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Mortality factor 4-like protein 1
Alternative name(s):
MORF-related gene 15 protein
Protein MSL3-1
Transcription factor-like protein MRG15
Gene namesi
Name:MORF4L1
Synonyms:MRG15
ORF Names:FWP006, HSPC008, HSPC061, PP368
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000185787.14
HGNCiHGNC:16989 MORF4L1
MIMi607303 gene
neXtProtiNX_Q9UBU8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi208V → E: Abolishes binding to MRFAP1. 1 Publication1
Mutagenesisi234E → R: No effect on MRFAP1 binding. 1 Publication1
Mutagenesisi251Y → A: No effect on MRFAP1 binding. 1 Publication1
Mutagenesisi254N → C: Reduces binding to MRFAP1. 1 Publication1

Organism-specific databases

DisGeNETi10933
OpenTargetsiENSG00000185787
PharmGKBiPA134895182

Polymorphism and mutation databases

BioMutaiMORF4L1
DMDMi59803121

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887641 – 362Mortality factor 4-like protein 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UBU8
PaxDbiQ9UBU8
PeptideAtlasiQ9UBU8
PRIDEiQ9UBU8
ProteomicsDBi84073
84074 [Q9UBU8-2]

PTM databases

iPTMnetiQ9UBU8
PhosphoSitePlusiQ9UBU8

Expressioni

Gene expression databases

BgeeiENSG00000185787
CleanExiHS_MORF4L1
ExpressionAtlasiQ9UBU8 baseline and differential
GenevisibleiQ9UBU8 HS

Organism-specific databases

HPAiHPA042360
HPA062010

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and KAT8. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2. Forms a complex with MSL1 and NUPR1.8 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116134, 115 interactors
ComplexPortaliCPX-978 NuA4 histone acetyltransferase complex
CORUMiQ9UBU8
DIPiDIP-29017N
IntActiQ9UBU8, 87 interactors
MINTiQ9UBU8
STRINGi9606.ENSP00000331310

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi16 – 36Combined sources21
Beta strandi39 – 46Combined sources8
Beta strandi47 – 49Combined sources3
Beta strandi94 – 97Combined sources4
Helixi98 – 100Combined sources3
Beta strandi101 – 105Combined sources5
Helixi106 – 125Combined sources20
Helixi201 – 203Combined sources3
Helixi204 – 215Combined sources12
Beta strandi219 – 221Combined sources3
Beta strandi226 – 228Combined sources3
Helixi229 – 241Combined sources13
Beta strandi244 – 246Combined sources3
Helixi252 – 271Combined sources20
Helixi275 – 277Combined sources3
Helixi278 – 287Combined sources10
Helixi293 – 296Combined sources4
Helixi299 – 313Combined sources15
Helixi320 – 339Combined sources20
Helixi341 – 344Combined sources4
Helixi347 – 349Combined sources3
Beta strandi350 – 352Combined sources3
Helixi355 – 358Combined sources4
Turni359 – 361Combined sources3

3D structure databases

ProteinModelPortaliQ9UBU8
SMRiQ9UBU8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UBU8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 362MRGPROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 62Interaction with KAT81 PublicationAdd BLAST37
Regioni133 – 266Sufficient for interaction with SIN3A1 PublicationAdd BLAST134
Regioni164 – 230Interaction with RB1-1Add BLAST67
Regioni188 – 342Sufficient for interaction with PHF121 PublicationAdd BLAST155
Regioni323 – 344Interaction with RB1-2Add BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi135 – 146Nuclear localization signalSequence analysisAdd BLAST12

Phylogenomic databases

eggNOGiKOG3001 Eukaryota
ENOG410XR9F LUCA
GeneTreeiENSGT00530000063018
HOVERGENiHBG052487
InParanoidiQ9UBU8
KOiK11339
OrthoDBiEOG091G0J32
PhylomeDBiQ9UBU8
TreeFamiTF323400

Family and domain databases

Gene3Di1.10.274.30, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR008676 MRG
IPR038011 MRG15
IPR038217 MRG_C_sf
IPR026541 MRG_dom
IPR025995 Tudor-knot
PANTHERiPTHR10880 PTHR10880, 1 hit
PTHR10880:SF29 PTHR10880:SF29, 1 hit
PfamiView protein in Pfam
PF05712 MRG, 1 hit
PF11717 Tudor-knot, 1 hit
PIRSFiPIRSF038133 HAT_Nua4_EAF3/MRG15, 1 hit
SUPFAMiSSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS51640 MRG, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN
60 70 80 90 100
KKSAVRPRRS EKSLKTHEDI VALFPVPEGA PSVHHPLLTS SWDEWVPESR
110 120 130 140 150
VLKYVDTNLQ KQRELQKANQ EQYAEGKMRG AAPGKKTSGL QQKNVEVKTK
160 170 180 190 200
KNKQKTPGNG DGGSTSETPQ PPRKKRARVD PTVENEETFM NRVEVKVKIP
210 220 230 240 250
EELKPWLVDD WDLITRQKQL FYLPAKKNVD SILEDYANYK KSRGNTDNKE
260 270 280 290 300
YAVNEVVAGI KEYFNVMLGT QLLYKFERPQ YAEILADHPD APMSQVYGAP
310 320 330 340 350
HLLRLFVRIG AMLAYTPLDE KSLALLLNYL HDFLKYLAKN SATLFSASDY
360
EVAPPEYHRK AV
Length:362
Mass (Da):41,474
Last modified:February 15, 2005 - v2
Checksum:i96B76BCA801F1187
GO
Isoform 2 (identifier: Q9UBU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-91: KSAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSS → N

Show »
Length:323
Mass (Da):37,231
Checksum:i33CDBEC7D9CF513F
GO
Isoform 3 (identifier: Q9UBU8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Show »
Length:235
Mass (Da):26,750
Checksum:i04AA4B2175DF583E
GO

Sequence cautioni

The sequence AAG17253 differs from that shown. Reason: Frameshift at positions 348 and 360.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224P → R in AAH67826 (PubMed:15489334).Curated1
Sequence conflicti261K → KK in CAB70879 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0460161 – 127Missing in isoform 3. 2 PublicationsAdd BLAST127
Alternative sequenceiVSP_01288952 – 91KSAVR…LLTSS → N in isoform 2. 6 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100615 mRNA Translation: AAD29872.1
AF167173 mRNA Translation: AAF80854.1
AF218011 mRNA Translation: AAG17253.1 Frameshift.
AY148481 mRNA Translation: AAN65338.1
AF070664 mRNA Translation: AAD20970.1
AF161546 mRNA Translation: AAF29033.1
AF109188 mRNA Translation: AAQ13497.1
AK296650 mRNA Translation: BAG59248.1
AK300789 mRNA Translation: BAH13347.1
AL137697 mRNA Translation: CAB70879.2
AC011944 Genomic DNA No translation available.
AC022748 Genomic DNA No translation available.
AC103975 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99145.1
CH471136 Genomic DNA Translation: EAW99144.1
CH471136 Genomic DNA Translation: EAW99146.1
CH471136 Genomic DNA Translation: EAW99147.1
BC022845 mRNA Translation: AAH22845.1
BC002936 mRNA Translation: AAH02936.1
BC067826 mRNA Translation: AAH67826.1
CX165647 mRNA No translation available.
AF131847 mRNA Translation: AAD20058.1
CCDSiCCDS10307.1 [Q9UBU8-1]
CCDS32304.1 [Q9UBU8-2]
CCDS58393.1 [Q9UBU8-3]
PIRiT46285
RefSeqiNP_001252532.1, NM_001265603.1 [Q9UBU8-3]
NP_001252533.1, NM_001265604.1 [Q9UBU8-3]
NP_001252534.1, NM_001265605.1 [Q9UBU8-3]
NP_006782.1, NM_006791.3 [Q9UBU8-2]
NP_996670.1, NM_206839.2 [Q9UBU8-1]
UniGeneiHs.374503

Genome annotation databases

EnsembliENST00000331268; ENSP00000331310; ENSG00000185787 [Q9UBU8-1]
ENST00000426013; ENSP00000408880; ENSG00000185787 [Q9UBU8-2]
ENST00000558502; ENSP00000452808; ENSG00000185787 [Q9UBU8-3]
ENST00000559345; ENSP00000452717; ENSG00000185787 [Q9UBU8-3]
GeneIDi10933
KEGGihsa:10933
UCSCiuc002bel.5 human [Q9UBU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMO4L1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBU8
Secondary accession number(s): B4DKN6
, B7Z6R1, D3DW88, O95899, Q5QTS1, Q6NVX8, Q86YT7, Q9HBP6, Q9NSW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 15, 2005
Last modified: July 18, 2018
This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health