FAM8A1

Functionⁱ

Protein family/group databases

TCDBⁱ	1.E.43.3.4 the putative transglycosylase-associated holin (t-a hol) family

TCDBⁱ

1.E.43.3.4 the putative transglycosylase-associated holin (t-a hol) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM8A1 Alternative name(s): Autosomal highly conserved protein
Gene namesⁱ	Name:FAM8A1 Synonyms:AHCP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137414.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16372 FAM8A1
neXtProtⁱ	NX_Q9UBU6

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	257 – 277	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	304 – 324	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	371 – 391	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000137414
PharmGKBⁱ	PA27986

Polymorphism and mutation databases

BioMutaⁱ	FAM8A1
DMDMⁱ	74753230

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000087167	1 – 413	Protein FAM8A1Add BLAST		413

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	229	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UBU6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UBU6
PaxDbⁱ	Q9UBU6
PeptideAtlas More...PeptideAtlasⁱ	Q9UBU6
PRIDEⁱ	Q9UBU6
ProteomicsDBⁱ	84070

PTM databases

iPTMnetⁱ	Q9UBU6
PhosphoSitePlusⁱ	Q9UBU6

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed, with a higher level of expression in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000137414 Expressed in 236 organ(s), highest expression level in Brodmann (1909) area 23
CleanExⁱ	HS_FAM8A1
ExpressionAtlasⁱ	Q9UBU6 baseline and differential
Genevisibleⁱ	Q9UBU6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044698 HPA073675

HPAⁱ

HPA044698
HPA073675

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119541, 45 interactors
CORUMⁱ	Q9UBU6
IntActⁱ	Q9UBU6, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q9UBU6
STRINGⁱ	9606.ENSP00000259963

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UBU6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	242 – 408	RDDAdd BLAST		167

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	59 – 64	Poly-Ala		6
Compositional biasⁱ	164 – 167	Poly-Pro		4

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4647 Eukaryota ENOG4111F0T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007346
HOGENOMⁱ	HOG000220846
HOVERGENⁱ	HBG054566
InParanoidⁱ	Q9UBU6
OMAⁱ	AAFPAYC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N0J
PhylomeDBⁱ	Q9UBU6
TreeFamⁱ	TF314024

Family and domain databases

InterProⁱ	View protein in InterPro IPR010432 RDD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06271 RDD, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9UBU6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEGPEEARG HPPGQDDGGG DHEPVPSLRG PPTTAVPCPR DDPQAEPQAP 
        60         70         80         90        100
GRPTAPGLAA AAAADKLEPP RELRKRGEAA SGSGAELQEQ AGCEAPEAAA 
       110        120        130        140        150
PRERPARLSA REYSRQVHEW LWQSYCGYLT WHSGLAAFPA YCSPQPSPQS 
       160        170        180        190        200
FPSGGAAVPQ AAAPPPPQLG YYNPFYFLSP GAAGPDPRTA AGISTPAPVA 
       210        220        230        240        250
GLGPRAPHVQ ASVRATPVTR VGSAAPSRSP SETGRQAGRE YVIPSLAHRF 
       260        270        280        290        300
MAEMVDFFIL FFIKATIVLS IMHLSGIKDI SKFAMHYIIE EIDEDTSMED 
       310        320        330        340        350
LQKMMVVALI YRLLVCFYEI ICIWGAGGAT PGKFLLGLRV VTCDTSVLIA 
       360        370        380        390        400
PSRVLVIPSS NVSITTSTIR ALIKNFSIAS FFPAFITLLF FQHNRTAYDI 
       410 
VAGTIVVKRN GVR

Length:413

Mass (Da):44,123

Last modified:May 1, 2000 - v1

Checksum:ⁱ35B92497907CCD2E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF097027 mRNA Translation: AAF07850.1 AK312814 mRNA Translation: BAG35672.1 AL138824 Genomic DNA No translation available. AF097026 Genomic DNA Translation: AAF07849.1 CH471087 Genomic DNA Translation: EAW55382.1 BC047881 mRNA Translation: AAH47881.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4540.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057339.1, NM_016255.2
UniGeneⁱ	Hs.95260

Genome annotation databases

Ensemblⁱ	ENST00000259963; ENSP00000259963; ENSG00000137414
GeneIDⁱ	51439
KEGGⁱ	hsa:51439
UCSC genome browser More...UCSCⁱ	uc003ncc.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UBU6	Family with sequence similarity 8, member A1, isoform CRA_a		HUMAN		413	UniRef100_Q9UBU6

Protein	Similar proteins		Species	Score	Length	Source
Q9UBU6	Family with sequence similarity 8, member A1, isoform CRA_a		HUMAN		413	UniRef90_Q9UBU6
Uncharacterized protein		NOMLE		414
Protein FAM8A1		CALJA		413
Family with sequence similarity 8, member A1		MACMU		413
Uncharacterized protein		Cebus capucinus imitator		413
+19

Protein	Similar proteins		Species	Score	Length	Source
Q9UBU6	Family with sequence similarity 8, member A1, isoform CRA_a		HUMAN		413	UniRef50_Q9UBU6
Uncharacterized protein		NOMLE		414
Uncharacterized protein		Cebus capucinus imitator		413
Uncharacterized protein		AOTNA		413
Uncharacterized protein		PAPAN		413
+126

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF097027 mRNA Translation: AAF07850.1 AK312814 mRNA Translation: BAG35672.1 AL138824 Genomic DNA No translation available. AF097026 Genomic DNA Translation: AAF07849.1 CH471087 Genomic DNA Translation: EAW55382.1 BC047881 mRNA Translation: AAH47881.1
CCDSⁱ	CCDS4540.1
RefSeqⁱ	NP_057339.1, NM_016255.2
UniGeneⁱ	Hs.95260

3D structure databases

ProteinModelPortalⁱ	Q9UBU6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119541, 45 interactors
CORUMⁱ	Q9UBU6
IntActⁱ	Q9UBU6, 9 interactors
MINTⁱ	Q9UBU6
STRINGⁱ	9606.ENSP00000259963

Protein family/group databases

TCDBⁱ	1.E.43.3.4 the putative transglycosylase-associated holin (t-a hol) family

TCDBⁱ

1.E.43.3.4 the putative transglycosylase-associated holin (t-a hol) family

PTM databases

iPTMnetⁱ	Q9UBU6
PhosphoSitePlusⁱ	Q9UBU6

Polymorphism and mutation databases

BioMutaⁱ	FAM8A1
DMDMⁱ	74753230

Proteomic databases

EPDⁱ	Q9UBU6
MaxQBⁱ	Q9UBU6
PaxDbⁱ	Q9UBU6
PeptideAtlasⁱ	Q9UBU6
PRIDEⁱ	Q9UBU6
ProteomicsDBⁱ	84070

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000259963; ENSP00000259963; ENSG00000137414
GeneIDⁱ	51439
KEGGⁱ	hsa:51439
UCSCⁱ	uc003ncc.4 human

Organism-specific databases

CTDⁱ	51439
EuPathDBⁱ	HostDB:ENSG00000137414.5
GeneCardsⁱ	FAM8A1
HGNCⁱ	HGNC:16372 FAM8A1
HPAⁱ	HPA044698 HPA073675
neXtProtⁱ	NX_Q9UBU6
OpenTargetsⁱ	ENSG00000137414
PharmGKBⁱ	PA27986
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4647 Eukaryota ENOG4111F0T LUCA
GeneTreeⁱ	ENSGT00390000007346
HOGENOMⁱ	HOG000220846
HOVERGENⁱ	HBG054566
InParanoidⁱ	Q9UBU6
OMAⁱ	AAFPAYC
OrthoDBⁱ	EOG091G0N0J
PhylomeDBⁱ	Q9UBU6
TreeFamⁱ	TF314024

Miscellaneous databases

ChiTaRSⁱ	FAM8A1 human
GenomeRNAiⁱ	51439
Protein Ontology More...PROⁱ	PR:Q9UBU6

Gene expression databases

Bgeeⁱ	ENSG00000137414 Expressed in 236 organ(s), highest expression level in Brodmann (1909) area 23
CleanExⁱ	HS_FAM8A1
ExpressionAtlasⁱ	Q9UBU6 baseline and differential
Genevisibleⁱ	Q9UBU6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR010432 RDD
Pfamⁱ	View protein in Pfam PF06271 RDD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FA8A1_HUMAN
Accessionⁱ	Q9UBU6Primary (citable) accession number: Q9UBU6 Secondary accession number(s): B2R725
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
	Last sequence update:	May 1, 2000
	Last modified:	September 12, 2018
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UBU6 (FA8A1_HUMAN)

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Protein FAM8A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ