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Protein

Protein FAM8A1

Gene

FAM8A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi1.E.43.3.4 the putative transglycosylase-associated holin (t-a hol) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM8A1
Alternative name(s):
Autosomal highly conserved protein
Gene namesi
Name:FAM8A1
Synonyms:AHCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137414.5
HGNCiHGNC:16372 FAM8A1
neXtProtiNX_Q9UBU6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137414
PharmGKBiPA27986

Polymorphism and mutation databases

BioMutaiFAM8A1
DMDMi74753230

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000871671 – 413Protein FAM8A1Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBU6
MaxQBiQ9UBU6
PaxDbiQ9UBU6
PeptideAtlasiQ9UBU6
PRIDEiQ9UBU6
ProteomicsDBi84070

PTM databases

iPTMnetiQ9UBU6
PhosphoSitePlusiQ9UBU6

Expressioni

Tissue specificityi

Ubiquitously expressed, with a higher level of expression in testis.1 Publication

Gene expression databases

BgeeiENSG00000137414 Expressed in 236 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_FAM8A1
ExpressionAtlasiQ9UBU6 baseline and differential
GenevisibleiQ9UBU6 HS

Organism-specific databases

HPAiHPA044698
HPA073675

Interactioni

Protein-protein interaction databases

BioGridi119541, 45 interactors
CORUMiQ9UBU6
IntActiQ9UBU6, 9 interactors
MINTiQ9UBU6
STRINGi9606.ENSP00000259963

Structurei

3D structure databases

ProteinModelPortaliQ9UBU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 408RDDAdd BLAST167

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 64Poly-Ala6
Compositional biasi164 – 167Poly-Pro4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4647 Eukaryota
ENOG4111F0T LUCA
GeneTreeiENSGT00390000007346
HOGENOMiHOG000220846
HOVERGENiHBG054566
InParanoidiQ9UBU6
OMAiAAFPAYC
OrthoDBiEOG091G0N0J
PhylomeDBiQ9UBU6
TreeFamiTF314024

Family and domain databases

InterProiView protein in InterPro
IPR010432 RDD
PfamiView protein in Pfam
PF06271 RDD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UBU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGPEEARG HPPGQDDGGG DHEPVPSLRG PPTTAVPCPR DDPQAEPQAP
60 70 80 90 100
GRPTAPGLAA AAAADKLEPP RELRKRGEAA SGSGAELQEQ AGCEAPEAAA
110 120 130 140 150
PRERPARLSA REYSRQVHEW LWQSYCGYLT WHSGLAAFPA YCSPQPSPQS
160 170 180 190 200
FPSGGAAVPQ AAAPPPPQLG YYNPFYFLSP GAAGPDPRTA AGISTPAPVA
210 220 230 240 250
GLGPRAPHVQ ASVRATPVTR VGSAAPSRSP SETGRQAGRE YVIPSLAHRF
260 270 280 290 300
MAEMVDFFIL FFIKATIVLS IMHLSGIKDI SKFAMHYIIE EIDEDTSMED
310 320 330 340 350
LQKMMVVALI YRLLVCFYEI ICIWGAGGAT PGKFLLGLRV VTCDTSVLIA
360 370 380 390 400
PSRVLVIPSS NVSITTSTIR ALIKNFSIAS FFPAFITLLF FQHNRTAYDI
410
VAGTIVVKRN GVR
Length:413
Mass (Da):44,123
Last modified:May 1, 2000 - v1
Checksum:i35B92497907CCD2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097027 mRNA Translation: AAF07850.1
AK312814 mRNA Translation: BAG35672.1
AL138824 Genomic DNA No translation available.
AF097026 Genomic DNA Translation: AAF07849.1
CH471087 Genomic DNA Translation: EAW55382.1
BC047881 mRNA Translation: AAH47881.1
CCDSiCCDS4540.1
RefSeqiNP_057339.1, NM_016255.2
UniGeneiHs.95260

Genome annotation databases

EnsembliENST00000259963; ENSP00000259963; ENSG00000137414
GeneIDi51439
KEGGihsa:51439
UCSCiuc003ncc.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097027 mRNA Translation: AAF07850.1
AK312814 mRNA Translation: BAG35672.1
AL138824 Genomic DNA No translation available.
AF097026 Genomic DNA Translation: AAF07849.1
CH471087 Genomic DNA Translation: EAW55382.1
BC047881 mRNA Translation: AAH47881.1
CCDSiCCDS4540.1
RefSeqiNP_057339.1, NM_016255.2
UniGeneiHs.95260

3D structure databases

ProteinModelPortaliQ9UBU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119541, 45 interactors
CORUMiQ9UBU6
IntActiQ9UBU6, 9 interactors
MINTiQ9UBU6
STRINGi9606.ENSP00000259963

Protein family/group databases

TCDBi1.E.43.3.4 the putative transglycosylase-associated holin (t-a hol) family

PTM databases

iPTMnetiQ9UBU6
PhosphoSitePlusiQ9UBU6

Polymorphism and mutation databases

BioMutaiFAM8A1
DMDMi74753230

Proteomic databases

EPDiQ9UBU6
MaxQBiQ9UBU6
PaxDbiQ9UBU6
PeptideAtlasiQ9UBU6
PRIDEiQ9UBU6
ProteomicsDBi84070

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259963; ENSP00000259963; ENSG00000137414
GeneIDi51439
KEGGihsa:51439
UCSCiuc003ncc.4 human

Organism-specific databases

CTDi51439
EuPathDBiHostDB:ENSG00000137414.5
GeneCardsiFAM8A1
HGNCiHGNC:16372 FAM8A1
HPAiHPA044698
HPA073675
neXtProtiNX_Q9UBU6
OpenTargetsiENSG00000137414
PharmGKBiPA27986
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4647 Eukaryota
ENOG4111F0T LUCA
GeneTreeiENSGT00390000007346
HOGENOMiHOG000220846
HOVERGENiHBG054566
InParanoidiQ9UBU6
OMAiAAFPAYC
OrthoDBiEOG091G0N0J
PhylomeDBiQ9UBU6
TreeFamiTF314024

Miscellaneous databases

ChiTaRSiFAM8A1 human
GenomeRNAii51439
PROiPR:Q9UBU6

Gene expression databases

BgeeiENSG00000137414 Expressed in 236 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_FAM8A1
ExpressionAtlasiQ9UBU6 baseline and differential
GenevisibleiQ9UBU6 HS

Family and domain databases

InterProiView protein in InterPro
IPR010432 RDD
PfamiView protein in Pfam
PF06271 RDD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA8A1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBU6
Secondary accession number(s): B2R725
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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