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UniProtKB - Q9UBT7 (CTNL1_HUMAN)

Entry version 148 (10 Feb 2021)
Sequence version 2 (01 Feb 2005)
Previous versions | rss
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Protein

Alpha-catulin

Gene

CTNNAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UBT7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-catulin
Alternative name(s):
Alpha-catenin-related protein
Short name:
ACRP
Catenin alpha-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTNNAL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2512, CTNNAL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604785, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UBT7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000119326.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8727

Open Targets

More...OpenTargetsi		ENSG00000119326

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27011

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UBT7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CTNNAL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		62901512

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642681 – 734Alpha-catulinAdd BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei374PhosphoserineBy similarity1
Modified residuei538PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UBT7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UBT7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UBT7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UBT7

PeptideAtlas

More...PeptideAtlasi		Q9UBT7

PRoteomics IDEntifications database

More...PRIDEi		Q9UBT7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84061 [Q9UBT7-1]
84062 [Q9UBT7-2]
84063 [Q9UBT7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UBT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UBT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000119326, Expressed in right adrenal gland cortex and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UBT7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UBT7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000119326, Tissue enhanced (adrenal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARHGEF1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114266, 28 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UBT7

Database of interacting proteins

More...DIPi		DIP-33236N

Protein interaction database and analysis system

More...IntActi		Q9UBT7, 33 interactors

Molecular INTeraction database

More...MINTi		Q9UBT7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000320434

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UBT7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UBT7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3681, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015314_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UBT7

Identification of Orthologs from Complete Genome Data

More...OMAi		NEIVQHG

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UBT7

TreeFam database of animal gene trees

More...TreeFami		TF313686

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR001033, Alpha_catenin
IPR030045, CTNNAL1
IPR006077, Vinculin/catenin

The PANTHER Classification System

More...PANTHERi		PTHR46342, PTHR46342, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01044, Vinculin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00805, ALPHACATENIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47220, SSF47220, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT 
        60         70         80         90        100
LINHKDNTKK SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI 
       110        120        130        140        150
NIACIEAKQA GETIAALTDI TNLNHLESDG QITIFTDKTG VIKAARLLLS 
       160        170        180        190        200
SVTKVLLLAD RVVIKQIITS RNKVLATMER LEKVNSFQEF VQIFSQFGNE 
       210        220        230        240        250
MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT ASKTCLRHPN 
       260        270        280        290        300
CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 
       310        320        330        340        350
MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS 
       360        370        380        390        400
TQARMELQQL ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST 
       410        420        430        440        450
ATQLAADLLK YHADHVVLKA LKLTGVEGNL EALAEYACKL SEQKEQLVET 
       460        470        480        490        500
CRLLRHISGT EPLEITCIHA EETFQVTGQQ IISAAETLTL HPSSKIAKEN 
       510        520        530        540        550
LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP KPMKNNANLK 
       560        570        580        590        600
SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM 
       610        620        630        640        650
SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD 
       660        670        680        690        700
DDKLMLLLEI NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL 
       710        720        730 
VQLLSLCYKL LKKLQMENNG WVSVTNKDTM DSKT
Length:734
Mass (Da):81,896
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8756237C73AAEA31
GO
Isoform 2 (identifier: Q9UBT7-2) [UniParc]FASTAAdd to basket
Also known as: Alpha2-catulin

The sequence of this isoform differs from the canonical sequence as follows:
     714-734: LQMENNGWVSVTNKDTMDSKT → SETRY

Show »
Length:718
Mass (Da):80,152
Checksum:i3FDAAE7A79BBB43E
GO
Isoform 3 (identifier: Q9UBT7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-480: Missing.

Show »
Length:650
Mass (Da):72,616
Checksum:iF71E1D06CBF61593
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JTQ6Q5JTQ6_HUMAN
Alpha-catulin
CTNNAL1
183Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JTQ9Q5JTQ9_HUMAN
Alpha-catulin
CTNNAL1
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti504F → S in BAD96950 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02092491N → T1 PublicationCorresponds to variant dbSNP:rs28361109Ensembl.1
Natural variantiVAR_020925203E → K1 PublicationCorresponds to variant dbSNP:rs28361118Ensembl.1
Natural variantiVAR_033845424T → S. Corresponds to variant dbSNP:rs16913734EnsemblClinVar.1
Natural variantiVAR_020926527E → Q1 PublicationCorresponds to variant dbSNP:rs7021366Ensembl.1
Natural variantiVAR_053370555D → E. Corresponds to variant dbSNP:rs34922868Ensembl.1
Natural variantiVAR_020927593I → N1 PublicationCorresponds to variant dbSNP:rs28361167Ensembl.1
Natural variantiVAR_020928716M → R1 PublicationCorresponds to variant dbSNP:rs28361182Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012582397 – 480Missing in isoform 3. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_012583714 – 734LQMEN…MDSKT → SETRY in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF030233 mRNA Translation: AAC83460.1
U97067 mRNA Translation: AAC27693.1
AF134888 AF134876 Genomic DNA Translation: AAF07820.1
AF134888 AF134873 Genomic DNA Translation: AAF07821.1
AF135021 mRNA Translation: AAF07819.1
AF006070 mRNA Translation: AAC26011.1
AF080071 mRNA Translation: AAC69576.1
AK223230 mRNA Translation: BAD96950.1
AY523969 Genomic DNA Translation: AAR92479.1
AB451283 mRNA Translation: BAG70097.1
AB451415 mRNA Translation: BAG70229.1
AL354797 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59036.1
BC117208 mRNA Translation: AAI17209.1
BC117234 mRNA Translation: AAI17235.1
AL050016 mRNA Translation: CAB43238.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6775.1 [Q9UBT7-1]
CCDS69638.1 [Q9UBT7-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T08703

NCBI Reference Sequences

More...RefSeqi		NP_001273903.1, NM_001286974.1 [Q9UBT7-2]
NP_003789.1, NM_003798.3 [Q9UBT7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000325551; ENSP00000320434; ENSG00000119326 [Q9UBT7-1]
ENST00000374595; ENSP00000363723; ENSG00000119326 [Q9UBT7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8727

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8727

UCSC genome browser

More...UCSCi		uc004bdo.3, human [Q9UBT7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030233 mRNA Translation: AAC83460.1
U97067 mRNA Translation: AAC27693.1
AF134888 AF134876 Genomic DNA Translation: AAF07820.1
AF134888 AF134873 Genomic DNA Translation: AAF07821.1
AF135021 mRNA Translation: AAF07819.1
AF006070 mRNA Translation: AAC26011.1
AF080071 mRNA Translation: AAC69576.1
AK223230 mRNA Translation: BAD96950.1
AY523969 Genomic DNA Translation: AAR92479.1
AB451283 mRNA Translation: BAG70097.1
AB451415 mRNA Translation: BAG70229.1
AL354797 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59036.1
BC117208 mRNA Translation: AAI17209.1
BC117234 mRNA Translation: AAI17235.1
AL050016 mRNA Translation: CAB43238.1
CCDSiCCDS6775.1 [Q9UBT7-1]
CCDS69638.1 [Q9UBT7-2]
PIRiT08703
RefSeqiNP_001273903.1, NM_001286974.1 [Q9UBT7-2]
NP_003789.1, NM_003798.3 [Q9UBT7-1]

3D structure databases

SMRiQ9UBT7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114266, 28 interactors
CORUMiQ9UBT7
DIPiDIP-33236N
IntActiQ9UBT7, 33 interactors
MINTiQ9UBT7
STRINGi9606.ENSP00000320434

PTM databases

iPTMnetiQ9UBT7
PhosphoSitePlusiQ9UBT7

Genetic variation databases

BioMutaiCTNNAL1
DMDMi62901512

Proteomic databases

EPDiQ9UBT7
jPOSTiQ9UBT7
MassIVEiQ9UBT7
PaxDbiQ9UBT7
PeptideAtlasiQ9UBT7
PRIDEiQ9UBT7
ProteomicsDBi84061 [Q9UBT7-1]
84062 [Q9UBT7-2]
84063 [Q9UBT7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14981, 139 antibodies

The DNASU plasmid repository

More...DNASUi		8727

Genome annotation databases

EnsembliENST00000325551; ENSP00000320434; ENSG00000119326 [Q9UBT7-1]
ENST00000374595; ENSP00000363723; ENSG00000119326 [Q9UBT7-2]
GeneIDi8727
KEGGihsa:8727
UCSCiuc004bdo.3, human [Q9UBT7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8727
DisGeNETi8727

GeneCards: human genes, protein and diseases

More...GeneCardsi		CTNNAL1
HGNCiHGNC:2512, CTNNAL1
HPAiENSG00000119326, Tissue enhanced (adrenal)
MIMi604785, gene
neXtProtiNX_Q9UBT7
OpenTargetsiENSG00000119326
PharmGKBiPA27011
VEuPathDBiHostDB:ENSG00000119326.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3681, Eukaryota
GeneTreeiENSGT00990000203614
HOGENOMiCLU_015314_4_0_1
InParanoidiQ9UBT7
OMAiNEIVQHG
PhylomeDBiQ9UBT7
TreeFamiTF313686

Enzyme and pathway databases

PathwayCommonsiQ9UBT7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8727, 7 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CTNNAL1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CTNNAL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8727
PharosiQ9UBT7, Tbio

Protein Ontology

More...PROi		PR:Q9UBT7
RNActiQ9UBT7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000119326, Expressed in right adrenal gland cortex and 237 other tissues
ExpressionAtlasiQ9UBT7, baseline and differential
GenevisibleiQ9UBT7, HS

Family and domain databases

InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR001033, Alpha_catenin
IPR030045, CTNNAL1
IPR006077, Vinculin/catenin
PANTHERiPTHR46342, PTHR46342, 1 hit
PfamiView protein in Pfam
PF01044, Vinculin, 1 hit
PRINTSiPR00805, ALPHACATENIN
SUPFAMiSSF47220, SSF47220, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTNL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBT7
Secondary accession number(s): B5BU47
, O76084, Q53FQ2, Q5JTQ7, Q5JTQ8, Q9Y401
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: February 10, 2021
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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