UniProtKB - Q9UBT7 (CTNL1_HUMAN)
Protein
Alpha-catulin
Gene
CTNNAL1
Organism
Homo sapiens (Human)
Status
Functioni
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
GO - Molecular functioni
- actin filament binding Source: InterPro
- cadherin binding Source: InterPro
GO - Biological processi
- cell adhesion Source: InterPro
- Rho protein signal transduction Source: MGI
Enzyme and pathway databases
PathwayCommonsi | Q9UBT7 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-catulinAlternative name(s): Alpha-catenin-related protein Short name: ACRP Catenin alpha-like protein 1 |
Gene namesi | Name:CTNNAL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2512, CTNNAL1 |
MIMi | 604785, gene |
neXtProti | NX_Q9UBT7 |
VEuPathDBi | HostDB:ENSG00000119326.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytoskeleton
- cytoskeleton 1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8727 |
OpenTargetsi | ENSG00000119326 |
PharmGKBi | PA27011 |
Miscellaneous databases
Pharosi | Q9UBT7, Tbio |
Genetic variation databases
BioMutai | CTNNAL1 |
DMDMi | 62901512 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064268 | 1 – 734 | Alpha-catulinAdd BLAST | 734 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 374 | PhosphoserineBy similarity | 1 | |
Modified residuei | 538 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UBT7 |
jPOSTi | Q9UBT7 |
MassIVEi | Q9UBT7 |
PaxDbi | Q9UBT7 |
PeptideAtlasi | Q9UBT7 |
PRIDEi | Q9UBT7 |
ProteomicsDBi | 84061 [Q9UBT7-1] 84062 [Q9UBT7-2] 84063 [Q9UBT7-3] |
PTM databases
iPTMneti | Q9UBT7 |
PhosphoSitePlusi | Q9UBT7 |
Expressioni
Tissue specificityi
Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.3 Publications
Inductioni
Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis.1 Publication
Gene expression databases
Bgeei | ENSG00000119326, Expressed in right adrenal gland cortex and 237 other tissues |
ExpressionAtlasi | Q9UBT7, baseline and differential |
Genevisiblei | Q9UBT7, HS |
Organism-specific databases
HPAi | ENSG00000119326, Tissue enhanced (adrenal) |
Interactioni
Subunit structurei
Interacts with ARHGEF1.
1 PublicationBinary interactionsi
Hide detailsQ9UBT7
GO - Molecular functioni
- actin filament binding Source: InterPro
- cadherin binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 114266, 28 interactors |
CORUMi | Q9UBT7 |
DIPi | DIP-33236N |
IntActi | Q9UBT7, 33 interactors |
MINTi | Q9UBT7 |
STRINGi | 9606.ENSP00000320434 |
Miscellaneous databases
RNActi | Q9UBT7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the vinculin/alpha-catenin family.Curated
Phylogenomic databases
eggNOGi | KOG3681, Eukaryota |
GeneTreei | ENSGT00990000203614 |
HOGENOMi | CLU_015314_4_0_1 |
InParanoidi | Q9UBT7 |
OMAi | NEIVQHG |
PhylomeDBi | Q9UBT7 |
TreeFami | TF313686 |
Family and domain databases
InterProi | View protein in InterPro IPR036723, Alpha-catenin/vinculin-like_sf IPR001033, Alpha_catenin IPR030045, CTNNAL1 IPR006077, Vinculin/catenin |
PANTHERi | PTHR46342, PTHR46342, 1 hit |
Pfami | View protein in Pfam PF01044, Vinculin, 1 hit |
PRINTSi | PR00805, ALPHACATENIN |
SUPFAMi | SSF47220, SSF47220, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UBT7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT
60 70 80 90 100
LINHKDNTKK SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI
110 120 130 140 150
NIACIEAKQA GETIAALTDI TNLNHLESDG QITIFTDKTG VIKAARLLLS
160 170 180 190 200
SVTKVLLLAD RVVIKQIITS RNKVLATMER LEKVNSFQEF VQIFSQFGNE
210 220 230 240 250
MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT ASKTCLRHPN
260 270 280 290 300
CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK
310 320 330 340 350
MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS
360 370 380 390 400
TQARMELQQL ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST
410 420 430 440 450
ATQLAADLLK YHADHVVLKA LKLTGVEGNL EALAEYACKL SEQKEQLVET
460 470 480 490 500
CRLLRHISGT EPLEITCIHA EETFQVTGQQ IISAAETLTL HPSSKIAKEN
510 520 530 540 550
LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP KPMKNNANLK
560 570 580 590 600
SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM
610 620 630 640 650
SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD
660 670 680 690 700
DDKLMLLLEI NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL
710 720 730
VQLLSLCYKL LKKLQMENNG WVSVTNKDTM DSKT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JTQ6 | Q5JTQ6_HUMAN | Alpha-catulin | CTNNAL1 | 183 | Annotation score: | ||
Q5JTQ9 | Q5JTQ9_HUMAN | Alpha-catulin | CTNNAL1 | 135 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 504 | F → S in BAD96950 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020924 | 91 | N → T1 PublicationCorresponds to variant dbSNP:rs28361109Ensembl. | 1 | |
Natural variantiVAR_020925 | 203 | E → K1 PublicationCorresponds to variant dbSNP:rs28361118Ensembl. | 1 | |
Natural variantiVAR_033845 | 424 | T → S. Corresponds to variant dbSNP:rs16913734EnsemblClinVar. | 1 | |
Natural variantiVAR_020926 | 527 | E → Q1 PublicationCorresponds to variant dbSNP:rs7021366Ensembl. | 1 | |
Natural variantiVAR_053370 | 555 | D → E. Corresponds to variant dbSNP:rs34922868Ensembl. | 1 | |
Natural variantiVAR_020927 | 593 | I → N1 PublicationCorresponds to variant dbSNP:rs28361167Ensembl. | 1 | |
Natural variantiVAR_020928 | 716 | M → R1 PublicationCorresponds to variant dbSNP:rs28361182Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012582 | 397 – 480 | Missing in isoform 3. 1 PublicationAdd BLAST | 84 | |
Alternative sequenceiVSP_012583 | 714 – 734 | LQMEN…MDSKT → SETRY in isoform 2. 1 PublicationAdd BLAST | 21 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000325551; ENSP00000320434; ENSG00000119326 [Q9UBT7-1] ENST00000374595; ENSP00000363723; ENSG00000119326 [Q9UBT7-2] |
GeneIDi | 8727 |
KEGGi | hsa:8727 |
UCSCi | uc004bdo.3, human [Q9UBT7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
3D structure databases
SMRi | Q9UBT7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114266, 28 interactors |
CORUMi | Q9UBT7 |
DIPi | DIP-33236N |
IntActi | Q9UBT7, 33 interactors |
MINTi | Q9UBT7 |
STRINGi | 9606.ENSP00000320434 |
PTM databases
iPTMneti | Q9UBT7 |
PhosphoSitePlusi | Q9UBT7 |
Genetic variation databases
BioMutai | CTNNAL1 |
DMDMi | 62901512 |
Proteomic databases
EPDi | Q9UBT7 |
jPOSTi | Q9UBT7 |
MassIVEi | Q9UBT7 |
PaxDbi | Q9UBT7 |
PeptideAtlasi | Q9UBT7 |
PRIDEi | Q9UBT7 |
ProteomicsDBi | 84061 [Q9UBT7-1] 84062 [Q9UBT7-2] 84063 [Q9UBT7-3] |
Protocols and materials databases
Antibodypediai | 14981, 139 antibodies |
DNASUi | 8727 |
Genome annotation databases
Ensembli | ENST00000325551; ENSP00000320434; ENSG00000119326 [Q9UBT7-1] ENST00000374595; ENSP00000363723; ENSG00000119326 [Q9UBT7-2] |
GeneIDi | 8727 |
KEGGi | hsa:8727 |
UCSCi | uc004bdo.3, human [Q9UBT7-1] |
Organism-specific databases
CTDi | 8727 |
DisGeNETi | 8727 |
GeneCardsi | CTNNAL1 |
HGNCi | HGNC:2512, CTNNAL1 |
HPAi | ENSG00000119326, Tissue enhanced (adrenal) |
MIMi | 604785, gene |
neXtProti | NX_Q9UBT7 |
OpenTargetsi | ENSG00000119326 |
PharmGKBi | PA27011 |
VEuPathDBi | HostDB:ENSG00000119326.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3681, Eukaryota |
GeneTreei | ENSGT00990000203614 |
HOGENOMi | CLU_015314_4_0_1 |
InParanoidi | Q9UBT7 |
OMAi | NEIVQHG |
PhylomeDBi | Q9UBT7 |
TreeFami | TF313686 |
Enzyme and pathway databases
PathwayCommonsi | Q9UBT7 |
Miscellaneous databases
BioGRID-ORCSi | 8727, 7 hits in 878 CRISPR screens |
ChiTaRSi | CTNNAL1, human |
GeneWikii | CTNNAL1 |
GenomeRNAii | 8727 |
Pharosi | Q9UBT7, Tbio |
PROi | PR:Q9UBT7 |
RNActi | Q9UBT7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119326, Expressed in right adrenal gland cortex and 237 other tissues |
ExpressionAtlasi | Q9UBT7, baseline and differential |
Genevisiblei | Q9UBT7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036723, Alpha-catenin/vinculin-like_sf IPR001033, Alpha_catenin IPR030045, CTNNAL1 IPR006077, Vinculin/catenin |
PANTHERi | PTHR46342, PTHR46342, 1 hit |
Pfami | View protein in Pfam PF01044, Vinculin, 1 hit |
PRINTSi | PR00805, ALPHACATENIN |
SUPFAMi | SSF47220, SSF47220, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTNL1_HUMAN | |
Accessioni | Q9UBT7Primary (citable) accession number: Q9UBT7 Secondary accession number(s): B5BU47 Q9Y401 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | February 1, 2005 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM