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Protein

SUMO-activating enzyme subunit 2

Gene

UBA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei48ATP1 Publication1
Binding sitei72ATP1 Publication1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi158Zinc1
Metal bindingi161Zinc1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei173Glycyl thioester intermediatePROSITE-ProRule annotation2 Publications1
Metal bindingi441Zinc1
Metal bindingi444Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi24 – 29ATP1 Publication6
Nucleotide bindingi56 – 59ATP1 Publication4
Nucleotide bindingi95 – 96ATP1 Publication2
Nucleotide bindingi117 – 122ATP1 Publication6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acid-amino acid ligase activity Source: InterPro
  • ATP binding Source: CAFA
  • enzyme activator activity Source: ProtInc
  • magnesium ion binding Source: CAFA
  • protein heterodimerization activity Source: CAFA
  • small protein activating enzyme binding Source: CAFA
  • SUMO activating enzyme activity Source: UniProtKB
  • SUMO binding Source: CAFA
  • transcription factor binding Source: Ensembl
  • transferase activity Source: UniProtKB-KW
  • ubiquitin-like protein conjugating enzyme binding Source: CAFA

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00886

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SUMO-activating enzyme subunit 2 (EC:2.3.2.-)
Alternative name(s):
Anthracycline-associated resistance ARX
Ubiquitin-like 1-activating enzyme E1B
Ubiquitin-like modifier-activating enzyme 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBA2
Synonyms:SAE2, UBLE1B
ORF Names:HRIHFB2115
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000126261.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30661 UBA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613295 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi56N → A: Abolishes ATP-dependent activation of SUMO proteins. 1 Publication1
Mutagenesisi57L → A: Strongly reduces ATP-dependent activation of SUMO proteins. 1 Publication1
Mutagenesisi59R → A: Strongly reduces ATP-dependent activation of SUMO proteins. 1 Publication1
Mutagenesisi72K → A: Abolishes ATP-dependent activation of SUMO proteins. 1 Publication1
Mutagenesisi117D → A: Abolishes ATP-dependent activation of SUMO proteins. 1 Publication1
Mutagenesisi173C → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi174T → A: Slightly reduced enzyme activity. 1 Publication1
Mutagenesisi184H → Q: No effect on enzyme activity. 1 Publication1
Mutagenesisi235I → A: Strongly reduced interaction with UBE2I; when associated with A-238. 1 Publication1
Mutagenesisi238I → A: Strongly reduced interaction with UBE2I; when associated with A-235. 1 Publication1
Mutagenesisi484Missing : Strongly reduced interaction with UBE2I. 1 Publication1
Mutagenesisi485G → GGGG: Strongly reduced interaction with UBE2I. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10054

Open Targets

More...
OpenTargetsi
ENSG00000126261

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162407583

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3137290

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UBA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
42559898

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949681 – 640SUMO-activating enzyme subunit 2Add BLAST640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki164Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei207PhosphoserineCombined sources1
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki257Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki257Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei271N6-acetyllysine; alternateCombined sources1
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki420Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki420Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei507PhosphoserineCombined sources1
Cross-linki540Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei592PhosphoserineCombined sources1
Cross-linki611Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei613N6-acetyllysine; alternateBy similarity1
Cross-linki613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki623Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UBT2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBT2

PeptideAtlas

More...
PeptideAtlasi
Q9UBT2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBT2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84055

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBT2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UBT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126261 Expressed in 158 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_UBA2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UBT2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBT2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041436

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115365, 169 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2161 SUMO activating enzyme complex
CPX-3042 activated SUMO1-E1 ligase complex
CPX-3044 activated SUMO2-E1 ligase complex
CPX-3045 activated SUMO3-E1 ligase complex
CPX-3076 activated SUMO4-E1 ligase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UBT2

Database of interacting proteins

More...
DIPi
DIP-35136N

Protein interaction database and analysis system

More...
IntActi
Q9UBT2, 18 interactors

Molecular INTeraction database

More...
MINTi
Q9UBT2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000246548

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UBT2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1640
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

More...
DisProti
DP00486

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UBT2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBT2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UBT2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2013 Eukaryota
COG0476 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00550000074924

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216514

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG060266

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBT2

KEGG Orthology (KO)

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KOi
K10685

Identification of Orthologs from Complete Genome Data

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OMAi
YECTPKA

Database of Orthologous Groups

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OrthoDBi
EOG091G07PV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBT2

TreeFam database of animal gene trees

More...
TreeFami
TF300765

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.520, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000594 ThiF_NAD_FAD-bd
IPR028077 UAE_UbL_dom
IPR023318 Ub_act_enz_dom_a_sf
IPR030661 Uba2
IPR032426 UBA2_C
IPR035985 Ubiquitin-activating_enz
IPR018074 UBQ-activ_enz_E1_CS
IPR033127 UBQ-activ_enz_E1_Cys_AS

The PANTHER Classification System

More...
PANTHERi
PTHR10953:SF5 PTHR10953:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00899 ThiF, 1 hit
PF14732 UAE_UbL, 1 hit
PF16195 UBA2_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039133 SUMO_E1B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69572 SSF69572, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00536 UBIQUITIN_ACTIVAT_1, 1 hit
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSRGLPRE LAEAVAGGRV LVVGAGGIGC ELLKNLVLTG FSHIDLIDLD
60 70 80 90 100
TIDVSNLNRQ FLFQKKHVGR SKAQVAKESV LQFYPKANIV AYHDSIMNPD
110 120 130 140 150
YNVEFFRQFI LVMNALDNRA ARNHVNRMCL AADVPLIESG TAGYLGQVTT
160 170 180 190 200
IKKGVTECYE CHPKPTQRTF PGCTIRNTPS EPIHCIVWAK YLFNQLFGEE
210 220 230 240 250
DADQEVSPDR ADPEAAWEPT EAEARARASN EDGDIKRIST KEWAKSTGYD
260 270 280 290 300
PVKLFTKLFK DDIRYLLTMD KLWRKRKPPV PLDWAEVQSQ GEETNASDQQ
310 320 330 340 350
NEPQLGLKDQ QVLDVKSYAR LFSKSIETLR VHLAEKGDGA ELIWDKDDPS
360 370 380 390 400
AMDFVTSAAN LRMHIFSMNM KSRFDIKSMA GNIIPAIATT NAVIAGLIVL
410 420 430 440 450
EGLKILSGKI DQCRTIFLNK QPNPRKKLLV PCALDPPNPN CYVCASKPEV
460 470 480 490 500
TVRLNVHKVT VLTLQDKIVK EKFAMVAPDV QIEDGKGTIL ISSEEGETEA
510 520 530 540 550
NNHKKLSEFG IRNGSRLQAD DFLQDYTLLI NILHSEDLGK DVEFEVVGDA
560 570 580 590 600
PEKVGPKQAE DAAKSITNGS DDGAQPSTST AQEQDDVLIV DSDEEDSSNN
610 620 630 640
ADVSEEERSR KRKLDEKENL SAKRSRIEQK EELDDVIALD
Length:640
Mass (Da):71,224
Last modified:February 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC12D15293BBF90EB
GO
Isoform 2 (identifier: Q9UBT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Note: No experimental confirmation available.
Show »
Length:544
Mass (Da):60,839
Checksum:i24F5E43AB6FA2B05
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPL2K7EPL2_HUMAN
SUMO-activating enzyme subunit 2
UBA2
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ93U3KQ93_HUMAN
SUMO-activating enzyme subunit 2
UBA2
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESK7K7ESK7_HUMAN
SUMO-activating enzyme subunit 2
UBA2
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ55U3KQ55_HUMAN
SUMO-activating enzyme subunit 2
UBA2
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES38K7ES38_HUMAN
SUMO-activating enzyme subunit 2
UBA2
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229S → C in AAD12784 (PubMed:9920803).Curated1
Sequence conflicti229S → C in AAD23914 (PubMed:10217437).Curated1
Sequence conflicti341E → G in CAB66839 (PubMed:11230166).Curated1
Sequence conflicti456V → L in BAD92109 (Ref. 11) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017689307L → R2 PublicationsCorresponds to variant dbSNP:rs1043062Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0561641 – 96Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF090384 mRNA Translation: AAD12784.1
AF079566 mRNA Translation: AAD23914.1
AF110957 mRNA Translation: AAD24434.1
U35832 mRNA Translation: AAC99992.1
AL136905 mRNA Translation: CAB66839.1
AK124730 mRNA Translation: BAG54081.1
BT009781 mRNA Translation: AAP88783.1
CR456756 mRNA Translation: CAG33037.1
AC008747 Genomic DNA No translation available.
BC003153 mRNA Translation: AAH03153.1
AB208872 mRNA Translation: BAD92109.1
AB015337 mRNA Translation: BAA34795.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12439.1 [Q9UBT2-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46936

NCBI Reference Sequences

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RefSeqi
NP_005490.1, NM_005499.2 [Q9UBT2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.631580

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000246548; ENSP00000246548; ENSG00000126261 [Q9UBT2-1]
ENST00000439527; ENSP00000437484; ENSG00000126261 [Q9UBT2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10054

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10054

UCSC genome browser

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UCSCi
uc002nvk.4 human [Q9UBT2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090384 mRNA Translation: AAD12784.1
AF079566 mRNA Translation: AAD23914.1
AF110957 mRNA Translation: AAD24434.1
U35832 mRNA Translation: AAC99992.1
AL136905 mRNA Translation: CAB66839.1
AK124730 mRNA Translation: BAG54081.1
BT009781 mRNA Translation: AAP88783.1
CR456756 mRNA Translation: CAG33037.1
AC008747 Genomic DNA No translation available.
BC003153 mRNA Translation: AAH03153.1
AB208872 mRNA Translation: BAD92109.1
AB015337 mRNA Translation: BAA34795.1
CCDSiCCDS12439.1 [Q9UBT2-1]
PIRiT46936
RefSeqiNP_005490.1, NM_005499.2 [Q9UBT2-1]
UniGeneiHs.631580

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y8QX-ray2.25B/D1-640[»]
1Y8RX-ray2.75B/E1-640[»]
2PX9NMR-A166-382[»]
3KYCX-ray2.45B1-640[»]
3KYDX-ray2.61B1-549[»]
4W5VX-ray2.50B445-561[»]
5FQ2X-ray2.20B446-547[»]
DisProtiDP00486
ProteinModelPortaliQ9UBT2
SMRiQ9UBT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115365, 169 interactors
ComplexPortaliCPX-2161 SUMO activating enzyme complex
CPX-3042 activated SUMO1-E1 ligase complex
CPX-3044 activated SUMO2-E1 ligase complex
CPX-3045 activated SUMO3-E1 ligase complex
CPX-3076 activated SUMO4-E1 ligase complex
CORUMiQ9UBT2
DIPiDIP-35136N
IntActiQ9UBT2, 18 interactors
MINTiQ9UBT2
STRINGi9606.ENSP00000246548

Chemistry databases

BindingDBiQ9UBT2
ChEMBLiCHEMBL3137290

PTM databases

iPTMnetiQ9UBT2
PhosphoSitePlusiQ9UBT2
SwissPalmiQ9UBT2

Polymorphism and mutation databases

BioMutaiUBA2
DMDMi42559898

Proteomic databases

EPDiQ9UBT2
PaxDbiQ9UBT2
PeptideAtlasiQ9UBT2
PRIDEiQ9UBT2
ProteomicsDBi84055

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10054
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246548; ENSP00000246548; ENSG00000126261 [Q9UBT2-1]
ENST00000439527; ENSP00000437484; ENSG00000126261 [Q9UBT2-2]
GeneIDi10054
KEGGihsa:10054
UCSCiuc002nvk.4 human [Q9UBT2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10054
DisGeNETi10054
EuPathDBiHostDB:ENSG00000126261.12

GeneCards: human genes, protein and diseases

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GeneCardsi
UBA2
HGNCiHGNC:30661 UBA2
HPAiHPA041436
MIMi613295 gene
neXtProtiNX_Q9UBT2
OpenTargetsiENSG00000126261
PharmGKBiPA162407583

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2013 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00550000074924
HOGENOMiHOG000216514
HOVERGENiHBG060266
InParanoidiQ9UBT2
KOiK10685
OMAiYECTPKA
OrthoDBiEOG091G07PV
PhylomeDBiQ9UBT2
TreeFamiTF300765

Enzyme and pathway databases

UniPathwayi
UPA00886

ReactomeiR-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UBA2 human
EvolutionaryTraceiQ9UBT2

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
UBA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10054

Protein Ontology

More...
PROi
PR:Q9UBT2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126261 Expressed in 158 organ(s), highest expression level in kidney
CleanExiHS_UBA2
ExpressionAtlasiQ9UBT2 baseline and differential
GenevisibleiQ9UBT2 HS

Family and domain databases

Gene3Di1.10.10.520, 1 hit
InterProiView protein in InterPro
IPR000594 ThiF_NAD_FAD-bd
IPR028077 UAE_UbL_dom
IPR023318 Ub_act_enz_dom_a_sf
IPR030661 Uba2
IPR032426 UBA2_C
IPR035985 Ubiquitin-activating_enz
IPR018074 UBQ-activ_enz_E1_CS
IPR033127 UBQ-activ_enz_E1_Cys_AS
PANTHERiPTHR10953:SF5 PTHR10953:SF5, 1 hit
PfamiView protein in Pfam
PF00899 ThiF, 1 hit
PF14732 UAE_UbL, 1 hit
PF16195 UBA2_C, 1 hit
PIRSFiPIRSF039133 SUMO_E1B, 1 hit
SUPFAMiSSF69572 SSF69572, 1 hit
PROSITEiView protein in PROSITE
PS00536 UBIQUITIN_ACTIVAT_1, 1 hit
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAE2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBT2
Secondary accession number(s): B3KWB9
, O95605, Q59H87, Q6IBP6, Q9NTJ1, Q9UED2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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