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Protein

SUN domain-containing ossification factor

Gene

SUCO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processOsteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing ossification factor
Alternative name(s):
Membrane protein CH1
Protein osteopotentia homolog
SUN-like protein 1
Gene namesi
Name:SUCO
Synonyms:C1orf9, CH1, OPT, SLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000094975.13
HGNCiHGNC:1240 SUCO
neXtProtiNX_Q9UBS9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1011 – 1031HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51430
OpenTargetsiENSG00000094975
PharmGKBiPA25621

Polymorphism and mutation databases

DMDMi74761893

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500006570730 – 1254SUN domain-containing ossification factorAdd BLAST1225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi524N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi928N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi955N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1081PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UBS9
PaxDbiQ9UBS9
PeptideAtlasiQ9UBS9
PRIDEiQ9UBS9
ProteomicsDBi84053
84054 [Q9UBS9-2]

PTM databases

GlyConnecti1775
iPTMnetiQ9UBS9
PhosphoSitePlusiQ9UBS9

Expressioni

Tissue specificityi

Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus, small intestine and spleen.1 Publication

Gene expression databases

BgeeiENSG00000094975 Expressed in 235 organ(s), highest expression level in caput epididymis
CleanExiHS_C1orf9
ExpressionAtlasiQ9UBS9 baseline and differential
GenevisibleiQ9UBS9 HS

Organism-specific databases

HPAiHPA047251

Interactioni

Protein-protein interaction databases

BioGridi119536, 24 interactors
IntActiQ9UBS9, 21 interactors
STRINGi9606.ENSP00000263688

Structurei

3D structure databases

ProteinModelPortaliQ9UBS9
SMRiQ9UBS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini284 – 453SUNPROSITE-ProRule annotationAdd BLAST170

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili909 – 1009Sequence analysisAdd BLAST101

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1396 Eukaryota
ENOG41116S0 LUCA
GeneTreeiENSGT00390000013502
HOGENOMiHOG000070169
HOVERGENiHBG107549
InParanoidiQ9UBS9
OMAiVKQFDIA
PhylomeDBiQ9UBS9
TreeFamiTF105817

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR012919 SUN_dom
PfamiView protein in Pfam
PF07738 Sad1_UNC, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS51469 SUN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKHRRALAL VSCLFLCSLV WLPSWRVCCK ESSSASASSY YSQDDNCALE
60 70 80 90 100
NEDVQFQKKD EREGPINAES LGKSGSNLPI SPKEHKLKDD SIVDVQNTES
110 120 130 140 150
KKLSPPVVET LPTVDLHEES SNAVVDSETV ENISSSSTSE ITPISKLDEI
160 170 180 190 200
EKSGTIPIAK PSETEQSETD CDVGEALDAS APIEQPSFVS PPDSLVGQHI
210 220 230 240 250
ENVSSSHGKG KITKSEFESK VSASEQGGGD PKSALNASDN LKNESSDYTK
260 270 280 290 300
PGDIDPTSVA SPKDPEDIPT FDEWKKKVME VEKEKSQSMH ASSNGGSHAT
310 320 330 340 350
KKVQKNRNNY ASVECGAKIL AANPEAKSTS AILIENMDLY MLNPCSTKIW
360 370 380 390 400
FVIELCEPIQ VKQLDIANYE LFSSTPKDFL VSISDRYPTN KWIKLGTFHG
410 420 430 440 450
RDERNVQSFP LDEQMYAKYV KMFIKYIKVE LLSHFGSEHF CPLSLIRVFG
460 470 480 490 500
TSMVEEYEEI ADSQYHSERQ ELFDEDYDYP LDYNTGEDKS SKNLLGSATN
510 520 530 540 550
AILNMVNIAA NILGAKTEDL TEGNKSISEN ATATAAPKMP ESTPVSTPVP
560 570 580 590 600
SPEYVTTEVH THDMEPSTPD TPKESPIVQL VQEEEEEASP STVTLLGSGE
610 620 630 640 650
QEDESSPWFE SETQIFCSEL TTICCISSFS EYIYKWCSVR VALYRQRSRT
660 670 680 690 700
ALSKGKDYLV LAQPPLLLPA ESVDVSVLQP LSGELENTNI EREAETVVLG
710 720 730 740 750
DLSSSMHQDD LVNHTVDAVE LEPSHSQTLS QSLLLDITPE INPLPKIEVS
760 770 780 790 800
ESVEYEAGHI PSPVIPQESS VEIDNETEQK SESFSSIEKP SITYETNKVN
810 820 830 840 850
ELMDNIIKED VNSMQIFTKL SETIVPPINT ATVPDNEDGE AKMNIADTAK
860 870 880 890 900
QTLISVVDSS SLPEVKEEEQ SPEDALLRGL QRTATDFYAE LQNSTDLGYA
910 920 930 940 950
NGNLVHGSNQ KESVFMRLNN RIKALEVNMS LSGRYLEELS QRYRKQMEEM
960 970 980 990 1000
QKAFNKTIVK LQNTSRIAEE QDQRQTEAIQ LLQAQLTNMT QLVSNLSATV
1010 1020 1030 1040 1050
AELKREVSDR QSYLVISLVL CVVLGLMLCM QRCRNTSQFD GDYISKLPKS
1060 1070 1080 1090 1100
NQYPSPKRCF SSYDDMNLKR RTSFPLMRSK SLQLTGKEVD PNDLYIVEPL
1110 1120 1130 1140 1150
KFSPEKKKKR CKYKIEKIET IKPEEPLHPI ANGDIKGRKP FTNQRDFSNM
1160 1170 1180 1190 1200
GEVYHSSYKG PPSEGSSETS SQSEESYFCG ISACTSLCNG QSQKTKTEKR
1210 1220 1230 1240 1250
ALKRRRSKVQ DQGKLIKTLI QTKSGSLPSL HDIIKGNKEI TVGTFGVTAV

SGHI
Length:1,254
Mass (Da):139,430
Last modified:May 1, 2000 - v1
Checksum:i4EBA1ABCC27DAAB1
GO
Isoform 2 (identifier: Q9UBS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGFLARPFL...SGRGKKEEKM
     60-96: Missing.
     421-427: Missing.

Note: No experimental confirmation available.
Show »
Length:1,405
Mass (Da):156,418
Checksum:iFA5EB6BA78F4A6DD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DYM4B4DYM4_HUMAN
SUN domain-containing ossification ...
SUCO
883Annotation score:
A0A087WV04A0A087WV04_HUMAN
SUN domain-containing ossification ...
SUCO
691Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti452S → N in AAF04619 (Ref. 2) Curated1
Sequence conflicti811V → M in AAF04619 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0279211M → MRGFLARPFLSTNQHLAQWG SPLPQGKGLVQLPSQHTRHS RPFHELCSKEENSATVPKLI SLVVSSETIDFSNKTMDSRR DWEREKRILEGKLQLPKALA RTQRARDEGRAWTSRWLQRR RSPESCEAPLSAPLWGPQRG LPGREPLRSRSASAIALRTI GHILALLLRLLHLGLGSGGC REDVPPSGRGKKEEKM in isoform 2. 1 Publication1
Alternative sequenceiVSP_02792260 – 96Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_027923421 – 427Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250075 mRNA Translation: CAB57360.1
AF097535 mRNA Translation: AAF04619.1
AL035291 mRNA Translation: CAA22894.1
Z96050 Genomic DNA No translation available.
Z94054 Genomic DNA No translation available.
BC137125 mRNA Translation: AAI37126.1
CH471067 Genomic DNA Translation: EAW90931.1
AF310265 Genomic DNA Translation: AAK28742.1
AF310266 Genomic DNA Translation: AAK28743.1
AF310267 Genomic DNA Translation: AAK28744.1
AF310268 Genomic DNA Translation: AAK28745.1
AF310269 Genomic DNA Translation: AAK28746.1
AF310270 Genomic DNA Translation: AAK28747.1
AF310271 Genomic DNA Translation: AAK28748.1
AF310272 Genomic DNA Translation: AAK28749.1
AF310273 Genomic DNA Translation: AAK28750.1
AF310274 Genomic DNA Translation: AAK28751.1
AF310275 Genomic DNA Translation: AAK28752.1
AF310276 Genomic DNA Translation: AAK28753.1
AF310277 Genomic DNA Translation: AAK28754.1
AF310278 Genomic DNA Translation: AAK28755.1
AF310279 Genomic DNA Translation: AAK28756.1
AF310280 Genomic DNA Translation: AAK28757.1
AF310281 Genomic DNA Translation: AAK28758.1
AF310282 Genomic DNA Translation: AAK28759.1
AF310283 Genomic DNA Translation: AAK28760.1
AF310284 Genomic DNA Translation: AAK28761.1
AF310285 Genomic DNA Translation: AAK28762.1
AF310286 Genomic DNA Translation: AAK28763.1
AF310287 Genomic DNA Translation: AAK28764.1
AF310288 Genomic DNA Translation: AAK28765.1
AF310289 Genomic DNA Translation: AAK28766.1
AF310290 Genomic DNA Translation: AAK28767.1
AF310291 Genomic DNA Translation: AAK28768.1
AF310292 Genomic DNA Translation: AAK28769.1
AF310293 Genomic DNA Translation: AAK28770.1
AF310294 Genomic DNA Translation: AAK28771.1
AF310295 Genomic DNA Translation: AAK28772.1
AF310296 Genomic DNA Translation: AAK28773.1
AF310297 Genomic DNA Translation: AAK28774.1
AF310298 Genomic DNA Translation: AAK28775.1
AF310299 Genomic DNA Translation: AAK28776.1
AF310300 Genomic DNA Translation: AAK28777.1
AF310301 Genomic DNA Translation: AAK28778.1
AF310302 Genomic DNA Translation: AAK28779.1
AF310303 Genomic DNA Translation: AAK28780.1
AF310304 Genomic DNA Translation: AAK28781.1
AF310305 Genomic DNA Translation: AAK28782.1
AF310306 Genomic DNA Translation: AAK28783.1
AF310307 Genomic DNA Translation: AAK28784.1
AF310308 Genomic DNA Translation: AAK28785.1
AF310309 Genomic DNA Translation: AAK28786.1
AF310310 Genomic DNA Translation: AAK28787.1
AF310311 Genomic DNA Translation: AAK28788.1
AF310312 Genomic DNA Translation: AAK28789.1
AF310313 Genomic DNA Translation: AAK28790.1
AF310314 Genomic DNA Translation: AAK28791.1
AF310315 Genomic DNA Translation: AAK28792.1
AF310316 Genomic DNA Translation: AAK28793.1
AF310317 Genomic DNA Translation: AAK28794.1
AF310318 Genomic DNA Translation: AAK28795.1
AF310319 Genomic DNA Translation: AAK28796.1
AF310320 Genomic DNA Translation: AAK28797.1
AF310321 Genomic DNA Translation: AAK28798.1
AF310322 Genomic DNA Translation: AAK28799.1
AF310323 Genomic DNA Translation: AAK28800.1
AF310324 Genomic DNA Translation: AAK28801.1
AF310325 Genomic DNA Translation: AAK28802.1
CCDSiCCDS1303.1 [Q9UBS9-1]
CCDS65726.1 [Q9UBS9-2]
PIRiJC7185
RefSeqiNP_001269679.1, NM_001282750.1
NP_001269680.1, NM_001282751.1
NP_055098.1, NM_014283.4 [Q9UBS9-1]
NP_057311.3, NM_016227.3 [Q9UBS9-2]
UniGeneiHs.204559

Genome annotation databases

EnsembliENST00000263688; ENSP00000263688; ENSG00000094975 [Q9UBS9-1]
ENST00000367723; ENSP00000356696; ENSG00000094975 [Q9UBS9-2]
ENST00000608151; ENSP00000477484; ENSG00000094975 [Q9UBS9-2]
GeneIDi51430
KEGGihsa:51430
UCSCiuc001giq.6 human [Q9UBS9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250075 mRNA Translation: CAB57360.1
AF097535 mRNA Translation: AAF04619.1
AL035291 mRNA Translation: CAA22894.1
Z96050 Genomic DNA No translation available.
Z94054 Genomic DNA No translation available.
BC137125 mRNA Translation: AAI37126.1
CH471067 Genomic DNA Translation: EAW90931.1
AF310265 Genomic DNA Translation: AAK28742.1
AF310266 Genomic DNA Translation: AAK28743.1
AF310267 Genomic DNA Translation: AAK28744.1
AF310268 Genomic DNA Translation: AAK28745.1
AF310269 Genomic DNA Translation: AAK28746.1
AF310270 Genomic DNA Translation: AAK28747.1
AF310271 Genomic DNA Translation: AAK28748.1
AF310272 Genomic DNA Translation: AAK28749.1
AF310273 Genomic DNA Translation: AAK28750.1
AF310274 Genomic DNA Translation: AAK28751.1
AF310275 Genomic DNA Translation: AAK28752.1
AF310276 Genomic DNA Translation: AAK28753.1
AF310277 Genomic DNA Translation: AAK28754.1
AF310278 Genomic DNA Translation: AAK28755.1
AF310279 Genomic DNA Translation: AAK28756.1
AF310280 Genomic DNA Translation: AAK28757.1
AF310281 Genomic DNA Translation: AAK28758.1
AF310282 Genomic DNA Translation: AAK28759.1
AF310283 Genomic DNA Translation: AAK28760.1
AF310284 Genomic DNA Translation: AAK28761.1
AF310285 Genomic DNA Translation: AAK28762.1
AF310286 Genomic DNA Translation: AAK28763.1
AF310287 Genomic DNA Translation: AAK28764.1
AF310288 Genomic DNA Translation: AAK28765.1
AF310289 Genomic DNA Translation: AAK28766.1
AF310290 Genomic DNA Translation: AAK28767.1
AF310291 Genomic DNA Translation: AAK28768.1
AF310292 Genomic DNA Translation: AAK28769.1
AF310293 Genomic DNA Translation: AAK28770.1
AF310294 Genomic DNA Translation: AAK28771.1
AF310295 Genomic DNA Translation: AAK28772.1
AF310296 Genomic DNA Translation: AAK28773.1
AF310297 Genomic DNA Translation: AAK28774.1
AF310298 Genomic DNA Translation: AAK28775.1
AF310299 Genomic DNA Translation: AAK28776.1
AF310300 Genomic DNA Translation: AAK28777.1
AF310301 Genomic DNA Translation: AAK28778.1
AF310302 Genomic DNA Translation: AAK28779.1
AF310303 Genomic DNA Translation: AAK28780.1
AF310304 Genomic DNA Translation: AAK28781.1
AF310305 Genomic DNA Translation: AAK28782.1
AF310306 Genomic DNA Translation: AAK28783.1
AF310307 Genomic DNA Translation: AAK28784.1
AF310308 Genomic DNA Translation: AAK28785.1
AF310309 Genomic DNA Translation: AAK28786.1
AF310310 Genomic DNA Translation: AAK28787.1
AF310311 Genomic DNA Translation: AAK28788.1
AF310312 Genomic DNA Translation: AAK28789.1
AF310313 Genomic DNA Translation: AAK28790.1
AF310314 Genomic DNA Translation: AAK28791.1
AF310315 Genomic DNA Translation: AAK28792.1
AF310316 Genomic DNA Translation: AAK28793.1
AF310317 Genomic DNA Translation: AAK28794.1
AF310318 Genomic DNA Translation: AAK28795.1
AF310319 Genomic DNA Translation: AAK28796.1
AF310320 Genomic DNA Translation: AAK28797.1
AF310321 Genomic DNA Translation: AAK28798.1
AF310322 Genomic DNA Translation: AAK28799.1
AF310323 Genomic DNA Translation: AAK28800.1
AF310324 Genomic DNA Translation: AAK28801.1
AF310325 Genomic DNA Translation: AAK28802.1
CCDSiCCDS1303.1 [Q9UBS9-1]
CCDS65726.1 [Q9UBS9-2]
PIRiJC7185
RefSeqiNP_001269679.1, NM_001282750.1
NP_001269680.1, NM_001282751.1
NP_055098.1, NM_014283.4 [Q9UBS9-1]
NP_057311.3, NM_016227.3 [Q9UBS9-2]
UniGeneiHs.204559

3D structure databases

ProteinModelPortaliQ9UBS9
SMRiQ9UBS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119536, 24 interactors
IntActiQ9UBS9, 21 interactors
STRINGi9606.ENSP00000263688

PTM databases

GlyConnecti1775
iPTMnetiQ9UBS9
PhosphoSitePlusiQ9UBS9

Polymorphism and mutation databases

DMDMi74761893

Proteomic databases

EPDiQ9UBS9
PaxDbiQ9UBS9
PeptideAtlasiQ9UBS9
PRIDEiQ9UBS9
ProteomicsDBi84053
84054 [Q9UBS9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263688; ENSP00000263688; ENSG00000094975 [Q9UBS9-1]
ENST00000367723; ENSP00000356696; ENSG00000094975 [Q9UBS9-2]
ENST00000608151; ENSP00000477484; ENSG00000094975 [Q9UBS9-2]
GeneIDi51430
KEGGihsa:51430
UCSCiuc001giq.6 human [Q9UBS9-1]

Organism-specific databases

CTDi51430
DisGeNETi51430
EuPathDBiHostDB:ENSG00000094975.13
GeneCardsiSUCO
HGNCiHGNC:1240 SUCO
HPAiHPA047251
neXtProtiNX_Q9UBS9
OpenTargetsiENSG00000094975
PharmGKBiPA25621
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1396 Eukaryota
ENOG41116S0 LUCA
GeneTreeiENSGT00390000013502
HOGENOMiHOG000070169
HOVERGENiHBG107549
InParanoidiQ9UBS9
OMAiVKQFDIA
PhylomeDBiQ9UBS9
TreeFamiTF105817

Miscellaneous databases

ChiTaRSiSUCO human
GenomeRNAii51430
PROiPR:Q9UBS9

Gene expression databases

BgeeiENSG00000094975 Expressed in 235 organ(s), highest expression level in caput epididymis
CleanExiHS_C1orf9
ExpressionAtlasiQ9UBS9 baseline and differential
GenevisibleiQ9UBS9 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR012919 SUN_dom
PfamiView protein in Pfam
PF07738 Sad1_UNC, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS51469 SUN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUCO_HUMAN
AccessioniPrimary (citable) accession number: Q9UBS9
Secondary accession number(s): B2RNU4
, Q9BQB9, Q9BXQ2, Q9UL04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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