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Protein

Gamma-aminobutyric acid type B receptor subunit 1

Gene

GABBR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054).By similarityCurated10 Publications
Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei247Agonist1
Binding sitei270Agonist1
Binding sitei287Agonist1
Binding sitei367Agonist1
Binding sitei395Agonist1
Binding sitei466Agonist1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-977444 GABA B receptor activation
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SIGNORiQ9UBS5

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid type B receptor subunit 1
Short name:
GABA-B receptor 1
Short name:
GABA-B-R1
Short name:
GABA-BR1
Short name:
GABABR1
Short name:
Gb1
Gene namesi
Name:GABBR1
Synonyms:GPRC3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204681.10
HGNCiHGNC:4070 GABBR1
MIMi603540 gene
neXtProtiNX_Q9UBS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 591ExtracellularSequence analysisAdd BLAST577
Transmembranei592 – 612Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini613 – 631CytoplasmicSequence analysisAdd BLAST19
Transmembranei632 – 652Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini653 – 667ExtracellularSequence analysisAdd BLAST15
Transmembranei668 – 688Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini689 – 710CytoplasmicSequence analysisAdd BLAST22
Transmembranei711 – 731Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini732 – 768ExtracellularSequence analysisAdd BLAST37
Transmembranei769 – 789Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini790 – 804CytoplasmicSequence analysisAdd BLAST15
Transmembranei805 – 825Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini826 – 833ExtracellularSequence analysis8
Transmembranei834 – 854Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini855 – 961CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Secreted, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi182W → A: Abolishes signaling via G-proteins. Abolishes antagonist binding. 1 Publication1
Mutagenesisi230Y → A: Slightly decreases signaling via G-proteins. 1 Publication1
Mutagenesisi234Y → A: Decreases signaling via G-proteins. 1 Publication1
Mutagenesisi287H → A: Strongly reduces signaling via G-proteins. Abolishes antagonist binding. 1 Publication1
Mutagenesisi367Y → A: Strongly reduces signaling via G-proteins. No effect on antagonist binding. 1 Publication1
Mutagenesisi395W → A: Strongly reduces signaling via G-proteins. Strongly reduces antagonist binding. 1 Publication1

Organism-specific databases

DisGeNETi2550
OpenTargetsiENSG00000204681
PharmGKBiPA28484

Chemistry databases

ChEMBLiCHEMBL2064
DrugBankiDB08891 Arbaclofen
DB08892 Arbaclofen Placarbil
DB00181 Baclofen
DB00837 Progabide
DB05010 SGS742
DB01080 Vigabatrin
GuidetoPHARMACOLOGYi240

Polymorphism and mutation databases

BioMutaiGABBR1
DMDMi12643873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000001294915 – 961Gamma-aminobutyric acid type B receptor subunit 1Add BLAST947

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 145PROSITE-ProRule annotation
Disulfide bondi131 ↔ 157PROSITE-ProRule annotation
Disulfide bondi220 ↔ 246PROSITE-ProRule annotation1 Publication
Disulfide bondi376 ↔ 410PROSITE-ProRule annotation1 Publication
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi482N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei873PhosphothreonineBy similarity1
Modified residuei930PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UBS5
PeptideAtlasiQ9UBS5
PRIDEiQ9UBS5
ProteomicsDBi84047
84048 [Q9UBS5-2]
84049 [Q9UBS5-3]
84050 [Q9UBS5-4]
84051 [Q9UBS5-5]

PTM databases

iPTMnetiQ9UBS5
PhosphoSitePlusiQ9UBS5

Expressioni

Tissue specificityi

Highly expressed in brain (PubMed:9844003, PubMed:9753614, PubMed:9872744). Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer (PubMed:9844003). Isoform 1B: Mainly expressed in Purkinje cells (PubMed:9844003). Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland (PubMed:10906333).4 Publications

Gene expression databases

BgeeiENSG00000204681 Expressed in 206 organ(s), highest expression level in paraflocculus
CleanExiHS_GABBR1
ExpressionAtlasiQ9UBS5 baseline and differential
GenevisibleiQ9UBS5 HS

Organism-specific databases

HPAiHPA050483
HPA058459

Interactioni

Subunit structurei

Heterodimer of GABBR1 and GABBR2 (PubMed:9872316, PubMed:10773016, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Homodimers may form, but are inactive (PubMed:9872316, PubMed:15617512). Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABBR2 (PubMed:10906333). Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity). Interacts with JAKMIP1 (PubMed:14718537).By similarity9 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi108825, 23 interactors
ComplexPortaliCPX-2955 GABA-B receptor complex
CORUMiQ9UBS5
DIPiDIP-38394N
IntActiQ9UBS5, 11 interactors
MINTiQ9UBS5
STRINGi9606.ENSP00000366233

Structurei

Secondary structure

1961
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UBS5
SMRiQ9UBS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 96Sushi 1PROSITE-ProRule annotationAdd BLAST67
Domaini98 – 159Sushi 2PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni888 – 916Interaction with ATF4By similarityAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili869 – 925Sequence analysisAdd BLAST57

Domaini

Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR2 (PubMed:9872744). The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably plays a role in the specificity for G-protein coupling (PubMed:9844003).2 Publications

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1055 Eukaryota
ENOG410XNN1 LUCA
GeneTreeiENSGT00530000063129
HOGENOMiHOG000171607
HOVERGENiHBG051688
InParanoidiQ9UBS5
KOiK04615
OMAiPKICQAR
OrthoDBiEOG091G01WG
PhylomeDBiQ9UBS5
TreeFamiTF313965

Family and domain databases

CDDicd15291 7tmC_GABA-B-R1, 1 hit
cd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR002455 GPCR3_GABA-B
IPR017978 GPCR_3_C
IPR002456 GPCR_3_GABA_rcpt_B1
IPR028082 Peripla_BP_I
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10519 PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF53822 SSF53822, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
PS50923 SUSHI, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms corresponding to the full receptor are essentially found in the central nervous system (CNS).

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1A (identifier: Q9UBS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLLLLLAPL FLRPPGAGGA QTPNATSEGC QIIHPPWEGG IRYRGLTRDQ
60 70 80 90 100
VKAINFLPVD YEIEYVCRGE REVVGPKVRK CLANGSWTDM DTPSRCVRIC
110 120 130 140 150
SKSYLTLENG KVFLTGGDLP ALDGARVDFR CDPDFHLVGS SRSICSQGQW
160 170 180 190 200
STPKPHCQVN RTPHSERRAV YIGALFPMSG GWPGGQACQP AVEMALEDVN
210 220 230 240 250
SRRDILPDYE LKLIHHDSKC DPGQATKYLY ELLYNDPIKI ILMPGCSSVS
260 270 280 290 300
TLVAEAARMW NLIVLSYGSS SPALSNRQRF PTFFRTHPSA TLHNPTRVKL
310 320 330 340 350
FEKWGWKKIA TIQQTTEVFT STLDDLEERV KEAGIEITFR QSFFSDPAVP
360 370 380 390 400
VKNLKRQDAR IIVGLFYETE ARKVFCEVYK ERLFGKKYVW FLIGWYADNW
410 420 430 440 450
FKIYDPSINC TVDEMTEAVE GHITTEIVML NPANTRSISN MTSQEFVEKL
460 470 480 490 500
TKRLKRHPEE TGGFQEAPLA YDAIWALALA LNKTSGGGGR SGVRLEDFNY
510 520 530 540 550
NNQTITDQIY RAMNSSSFEG VSGHVVFDAS GSRMAWTLIE QLQGGSYKKI
560 570 580 590 600
GYYDSTKDDL SWSKTDKWIG GSPPADQTLV IKTFRFLSQK LFISVSVLSS
610 620 630 640 650
LGIVLAVVCL SFNIYNSHVR YIQNSQPNLN NLTAVGCSLA LAAVFPLGLD
660 670 680 690 700
GYHIGRNQFP FVCQARLWLL GLGFSLGYGS MFTKIWWVHT VFTKKEEKKE
710 720 730 740 750
WRKTLEPWKL YATVGLLVGM DVLTLAIWQI VDPLHRTIET FAKEEPKEDI
760 770 780 790 800
DVSILPQLEH CSSRKMNTWL GIFYGYKGLL LLLGIFLAYE TKSVSTEKIN
810 820 830 840 850
DHRAVGMAIY NVAVLCLITA PVTMILSSQQ DAAFAFASLA IVFSSYITLV
860 870 880 890 900
VLFVPKMRRL ITRGEWQSEA QDTMKTGSST NNNEEEKSRL LEKENRELEK
910 920 930 940 950
IIAEKEERVS ELRHQLQSRQ QLRSRRHPPT PPEPSGGLPR GPPEPPDRLS
960
CDGSRVHLLY K
Length:961
Mass (Da):108,320
Last modified:May 1, 2000 - v1
Checksum:i54E7349CD02B633F
GO
Isoform 1B (identifier: Q9UBS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: MLLLLLLAPL...PHCQVNRTPH → MGPGAPFARV...PHSRVPPHPS

Show »
Length:844
Mass (Da):95,148
Checksum:iD926376823699485
GO
Isoform 1C (identifier: Q9UBS5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-159: Missing.

Show »
Length:899
Mass (Da):101,543
Checksum:i65DD7A31D68114AE
GO
Isoform 1D (identifier: Q9UBS5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     905-961: KEERVSELRH...DGSRVHLLYK → SGGLPRGPPEPPDRLSCDGSRVHLLYK

Show »
Length:931
Mass (Da):104,665
Checksum:i6FD16A36835AAB34
GO
Isoform 1E (identifier: Q9UBS5-5) [UniParc]FASTAAdd to basket
Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     570-961: GGSPPADQTL...DGSRVHLLYK → VISRTHSPT

Note: Major isoform in almost all peripheral tissues, although containing a premature stop codon in the mRNA and thus being a potential target for nonsense-mediated mRNA decay. May act as an antagonist of GABA-B receptors, being able to disrupt the normal association between isoform 1A and GABBR2.1 Publication
Show »
Length:578
Mass (Da):65,082
Checksum:i9B15DFD4E097428F
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JKF9A0A0G2JKF9_HUMAN
GABBR1
GABBR1
961Annotation score:
A0A140T9S4A0A140T9S4_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
899Annotation score:
A0A140TA42A0A140TA42_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
578Annotation score:
C9JZG6C9JZG6_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
156Annotation score:
F8WDC0F8WDC0_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
193Annotation score:
F8WAV2F8WAV2_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
137Annotation score:
C9J342C9J342_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
133Annotation score:
F8WAS6F8WAS6_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
97Annotation score:
F8WF38F8WF38_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
131Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2L → M in Y11044 (PubMed:9753614).Curated1
Sequence conflicti21Q → H in CAA09939 (PubMed:9872316).Curated1
Sequence conflicti21Q → H in CAA09941 (PubMed:9872316).Curated1
Sequence conflicti93P → L in AAC98508 (Ref. 3) Curated1
Sequence conflicti127V → A in CAA09939 (PubMed:9872316).Curated1
Sequence conflicti322Missing in CAA09031 (PubMed:9933300).Curated1
Sequence conflicti542L → P in Y11044 (PubMed:9753614).Curated1
Sequence conflicti691V → G in Y11044 (PubMed:9753614).Curated1
Sequence conflicti905 – 934Missing in CAA09031 (PubMed:9933300).CuratedAdd BLAST30

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01014620A → V3 PublicationsCorresponds to variant dbSNP:rs1805056Ensembl.1
Natural variantiVAR_010147489G → S3 PublicationsCorresponds to variant dbSNP:rs1805057Ensembl.1
Natural variantiVAR_049279645F → L. Corresponds to variant dbSNP:rs2076489Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0020371 – 164MLLLL…NRTPH → MGPGAPFARVGWPLPLLVVM AAGVAPVWASHSPHLPRPHS RVPPHPS in isoform 1B. 3 PublicationsAdd BLAST164
Alternative sequenceiVSP_00203898 – 159Missing in isoform 1C. 2 PublicationsAdd BLAST62
Alternative sequenceiVSP_002039570 – 961GGSPP…HLLYK → VISRTHSPT in isoform 1E. CuratedAdd BLAST392
Alternative sequenceiVSP_002040905 – 961KEERV…HLLYK → SGGLPRGPPEPPDRLSCDGS RVHLLYK in isoform 1D. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225028 mRNA Translation: CAA12359.1
AJ225029 mRNA Translation: CAA12360.1
AJ012185 mRNA Translation: CAA09939.1
AJ012186 mRNA Translation: CAA09940.1
AF099148 mRNA Translation: AAC98508.1
Y11044 mRNA No translation available.
AJ012187 mRNA Translation: CAA09941.1
AJ010170
, AJ010171, AJ010172, AJ010173, AJ010174, AJ010175, AJ010176, AJ010177, AJ010178, AJ010179, AJ010180, AJ010181, AJ010182, AJ010183, AJ010184, AJ010185, AJ010186, AJ010187, AJ010188, AJ010189, AJ010190, AJ010191 Genomic DNA Translation: CAA09031.1
AJ012288 mRNA Translation: CAA09980.1
AF301005 mRNA Translation: AAG23962.1
AL031983 Genomic DNA Translation: CAA21453.1
AL031983 Genomic DNA Translation: CAA21454.1
AL645936 Genomic DNA No translation available.
AL662826 Genomic DNA No translation available.
BX000688 Genomic DNA No translation available.
CR388210 Genomic DNA No translation available.
CR759766 Genomic DNA No translation available.
CR759870 Genomic DNA No translation available.
CR788300 Genomic DNA No translation available.
CR936483 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03205.1
CH471081 Genomic DNA Translation: EAX03210.1
BC042598 mRNA Translation: AAH42598.1
BC050532 mRNA Translation: AAH50532.2
CCDSiCCDS4663.1 [Q9UBS5-1]
CCDS4664.1 [Q9UBS5-3]
CCDS4665.1 [Q9UBS5-2]
PIRiJE0356
RefSeqiNP_001305982.1, NM_001319053.1
NP_001461.1, NM_001470.3 [Q9UBS5-1]
NP_068703.1, NM_021903.2 [Q9UBS5-2]
NP_068704.2, NM_021904.3 [Q9UBS5-3]
UniGeneiHs.167017

Genome annotation databases

EnsembliENST00000355973; ENSP00000348248; ENSG00000204681 [Q9UBS5-2]
ENST00000376977; ENSP00000366176; ENSG00000204681 [Q9UBS5-5]
ENST00000377012; ENSP00000366211; ENSG00000204681 [Q9UBS5-2]
ENST00000377016; ENSP00000366215; ENSG00000204681 [Q9UBS5-3]
ENST00000377034; ENSP00000366233; ENSG00000204681 [Q9UBS5-1]
ENST00000383537; ENSP00000373029; ENSG00000206466 [Q9UBS5-2]
ENST00000383541; ENSP00000373033; ENSG00000206466 [Q9UBS5-3]
ENST00000383542; ENSP00000373034; ENSG00000206466 [Q9UBS5-1]
ENST00000383543; ENSP00000373035; ENSG00000206466 [Q9UBS5-2]
ENST00000383636; ENSP00000373132; ENSG00000206511 [Q9UBS5-2]
ENST00000383637; ENSP00000373133; ENSG00000206511 [Q9UBS5-3]
ENST00000383638; ENSP00000373134; ENSG00000206511 [Q9UBS5-1]
ENST00000383639; ENSP00000373135; ENSG00000206511 [Q9UBS5-2]
ENST00000414980; ENSP00000406499; ENSG00000232632 [Q9UBS5-2]
ENST00000417759; ENSP00000391572; ENSG00000237112 [Q9UBS5-2]
ENST00000419674; ENSP00000399861; ENSG00000232569 [Q9UBS5-3]
ENST00000423604; ENSP00000388035; ENSG00000232632 [Q9UBS5-1]
ENST00000425097; ENSP00000411286; ENSG00000237112 [Q9UBS5-1]
ENST00000434660; ENSP00000412167; ENSG00000232632 [Q9UBS5-3]
ENST00000438094; ENSP00000406285; ENSG00000232632 [Q9UBS5-2]
ENST00000439457; ENSP00000406066; ENSG00000232569 [Q9UBS5-1]
ENST00000443440; ENSP00000399318; ENSG00000237112 [Q9UBS5-3]
ENST00000446436; ENSP00000394528; ENSG00000237112 [Q9UBS5-2]
ENST00000448754; ENSP00000405709; ENSG00000237051 [Q9UBS5-2]
ENST00000449163; ENSP00000411263; ENSG00000232569 [Q9UBS5-2]
ENST00000452300; ENSP00000408938; ENSG00000232569 [Q9UBS5-2]
ENST00000458612; ENSP00000416903; ENSG00000237051 [Q9UBS5-2]
ENST00000494877; ENSP00000419061; ENSG00000204681 [Q9UBS5-5]
ENST00000546913; ENSP00000448999; ENSG00000232569 [Q9UBS5-1]
ENST00000547410; ENSP00000448531; ENSG00000232569 [Q9UBS5-5]
ENST00000548767; ENSP00000446983; ENSG00000232632 [Q9UBS5-5]
ENST00000551140; ENSP00000448654; ENSG00000237112 [Q9UBS5-5]
ENST00000551423; ENSP00000449342; ENSG00000206511 [Q9UBS5-5]
ENST00000552399; ENSP00000449449; ENSG00000206466 [Q9UBS5-5]
GeneIDi2550
KEGGihsa:2550
UCSCiuc003nmp.5 human [Q9UBS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225028 mRNA Translation: CAA12359.1
AJ225029 mRNA Translation: CAA12360.1
AJ012185 mRNA Translation: CAA09939.1
AJ012186 mRNA Translation: CAA09940.1
AF099148 mRNA Translation: AAC98508.1
Y11044 mRNA No translation available.
AJ012187 mRNA Translation: CAA09941.1
AJ010170
, AJ010171, AJ010172, AJ010173, AJ010174, AJ010175, AJ010176, AJ010177, AJ010178, AJ010179, AJ010180, AJ010181, AJ010182, AJ010183, AJ010184, AJ010185, AJ010186, AJ010187, AJ010188, AJ010189, AJ010190, AJ010191 Genomic DNA Translation: CAA09031.1
AJ012288 mRNA Translation: CAA09980.1
AF301005 mRNA Translation: AAG23962.1
AL031983 Genomic DNA Translation: CAA21453.1
AL031983 Genomic DNA Translation: CAA21454.1
AL645936 Genomic DNA No translation available.
AL662826 Genomic DNA No translation available.
BX000688 Genomic DNA No translation available.
CR388210 Genomic DNA No translation available.
CR759766 Genomic DNA No translation available.
CR759870 Genomic DNA No translation available.
CR788300 Genomic DNA No translation available.
CR936483 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03205.1
CH471081 Genomic DNA Translation: EAX03210.1
BC042598 mRNA Translation: AAH42598.1
BC050532 mRNA Translation: AAH50532.2
CCDSiCCDS4663.1 [Q9UBS5-1]
CCDS4664.1 [Q9UBS5-3]
CCDS4665.1 [Q9UBS5-2]
PIRiJE0356
RefSeqiNP_001305982.1, NM_001319053.1
NP_001461.1, NM_001470.3 [Q9UBS5-1]
NP_068703.1, NM_021903.2 [Q9UBS5-2]
NP_068704.2, NM_021904.3 [Q9UBS5-3]
UniGeneiHs.167017

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MQEX-ray2.35A165-576[»]
4MQFX-ray2.22A165-576[»]
4MR7X-ray2.15A165-576[»]
4MR8X-ray2.15A165-576[»]
4MR9X-ray2.35A165-576[»]
4MRMX-ray2.86A165-576[»]
4MS1X-ray2.25A165-576[»]
4MS3X-ray2.50A165-576[»]
4MS4X-ray1.90A165-576[»]
4PASX-ray1.62A879-919[»]
ProteinModelPortaliQ9UBS5
SMRiQ9UBS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108825, 23 interactors
ComplexPortaliCPX-2955 GABA-B receptor complex
CORUMiQ9UBS5
DIPiDIP-38394N
IntActiQ9UBS5, 11 interactors
MINTiQ9UBS5
STRINGi9606.ENSP00000366233

Chemistry databases

ChEMBLiCHEMBL2064
DrugBankiDB08891 Arbaclofen
DB08892 Arbaclofen Placarbil
DB00181 Baclofen
DB00837 Progabide
DB05010 SGS742
DB01080 Vigabatrin
GuidetoPHARMACOLOGYi240

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9UBS5
PhosphoSitePlusiQ9UBS5

Polymorphism and mutation databases

BioMutaiGABBR1
DMDMi12643873

Proteomic databases

PaxDbiQ9UBS5
PeptideAtlasiQ9UBS5
PRIDEiQ9UBS5
ProteomicsDBi84047
84048 [Q9UBS5-2]
84049 [Q9UBS5-3]
84050 [Q9UBS5-4]
84051 [Q9UBS5-5]

Protocols and materials databases

DNASUi2550
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355973; ENSP00000348248; ENSG00000204681 [Q9UBS5-2]
ENST00000376977; ENSP00000366176; ENSG00000204681 [Q9UBS5-5]
ENST00000377012; ENSP00000366211; ENSG00000204681 [Q9UBS5-2]
ENST00000377016; ENSP00000366215; ENSG00000204681 [Q9UBS5-3]
ENST00000377034; ENSP00000366233; ENSG00000204681 [Q9UBS5-1]
ENST00000383537; ENSP00000373029; ENSG00000206466 [Q9UBS5-2]
ENST00000383541; ENSP00000373033; ENSG00000206466 [Q9UBS5-3]
ENST00000383542; ENSP00000373034; ENSG00000206466 [Q9UBS5-1]
ENST00000383543; ENSP00000373035; ENSG00000206466 [Q9UBS5-2]
ENST00000383636; ENSP00000373132; ENSG00000206511 [Q9UBS5-2]
ENST00000383637; ENSP00000373133; ENSG00000206511 [Q9UBS5-3]
ENST00000383638; ENSP00000373134; ENSG00000206511 [Q9UBS5-1]
ENST00000383639; ENSP00000373135; ENSG00000206511 [Q9UBS5-2]
ENST00000414980; ENSP00000406499; ENSG00000232632 [Q9UBS5-2]
ENST00000417759; ENSP00000391572; ENSG00000237112 [Q9UBS5-2]
ENST00000419674; ENSP00000399861; ENSG00000232569 [Q9UBS5-3]
ENST00000423604; ENSP00000388035; ENSG00000232632 [Q9UBS5-1]
ENST00000425097; ENSP00000411286; ENSG00000237112 [Q9UBS5-1]
ENST00000434660; ENSP00000412167; ENSG00000232632 [Q9UBS5-3]
ENST00000438094; ENSP00000406285; ENSG00000232632 [Q9UBS5-2]
ENST00000439457; ENSP00000406066; ENSG00000232569 [Q9UBS5-1]
ENST00000443440; ENSP00000399318; ENSG00000237112 [Q9UBS5-3]
ENST00000446436; ENSP00000394528; ENSG00000237112 [Q9UBS5-2]
ENST00000448754; ENSP00000405709; ENSG00000237051 [Q9UBS5-2]
ENST00000449163; ENSP00000411263; ENSG00000232569 [Q9UBS5-2]
ENST00000452300; ENSP00000408938; ENSG00000232569 [Q9UBS5-2]
ENST00000458612; ENSP00000416903; ENSG00000237051 [Q9UBS5-2]
ENST00000494877; ENSP00000419061; ENSG00000204681 [Q9UBS5-5]
ENST00000546913; ENSP00000448999; ENSG00000232569 [Q9UBS5-1]
ENST00000547410; ENSP00000448531; ENSG00000232569 [Q9UBS5-5]
ENST00000548767; ENSP00000446983; ENSG00000232632 [Q9UBS5-5]
ENST00000551140; ENSP00000448654; ENSG00000237112 [Q9UBS5-5]
ENST00000551423; ENSP00000449342; ENSG00000206511 [Q9UBS5-5]
ENST00000552399; ENSP00000449449; ENSG00000206466 [Q9UBS5-5]
GeneIDi2550
KEGGihsa:2550
UCSCiuc003nmp.5 human [Q9UBS5-1]

Organism-specific databases

CTDi2550
DisGeNETi2550
EuPathDBiHostDB:ENSG00000204681.10
GeneCardsiGABBR1
HGNCiHGNC:4070 GABBR1
HPAiHPA050483
HPA058459
MIMi603540 gene
neXtProtiNX_Q9UBS5
OpenTargetsiENSG00000204681
PharmGKBiPA28484
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1055 Eukaryota
ENOG410XNN1 LUCA
GeneTreeiENSGT00530000063129
HOGENOMiHOG000171607
HOVERGENiHBG051688
InParanoidiQ9UBS5
KOiK04615
OMAiPKICQAR
OrthoDBiEOG091G01WG
PhylomeDBiQ9UBS5
TreeFamiTF313965

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-977444 GABA B receptor activation
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SIGNORiQ9UBS5

Miscellaneous databases

ChiTaRSiGABBR1 human
GeneWikiiGABBR1
GenomeRNAii2550
PROiPR:Q9UBS5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204681 Expressed in 206 organ(s), highest expression level in paraflocculus
CleanExiHS_GABBR1
ExpressionAtlasiQ9UBS5 baseline and differential
GenevisibleiQ9UBS5 HS

Family and domain databases

CDDicd15291 7tmC_GABA-B-R1, 1 hit
cd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR002455 GPCR3_GABA-B
IPR017978 GPCR_3_C
IPR002456 GPCR_3_GABA_rcpt_B1
IPR028082 Peripla_BP_I
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10519 PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF53822 SSF53822, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
PS50923 SUSHI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGABR1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBS5
Secondary accession number(s): B0UXY7
, O95375, O95468, O95975, O96022, Q5STL4, Q5SUJ8, Q5SUL3, Q71SG6, Q86W60, Q9UQQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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