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Entry version 189 (08 May 2019)
Sequence version 1 (01 May 2000)
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Protein

Gamma-aminobutyric acid type B receptor subunit 1

Gene

GABBR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054).By similarityCurated10 Publications
Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei247Agonist1
Binding sitei270Agonist1
Binding sitei287Agonist1
Binding sitei367Agonist1
Binding sitei395Agonist1
Binding sitei466Agonist1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-977444 GABA B receptor activation
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UBS5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-aminobutyric acid type B receptor subunit 1
Short name:
GABA-B receptor 1
Short name:
GABA-B-R1
Short name:
GABA-BR1
Short name:
GABABR1
Short name:
Gb1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GABBR1
Synonyms:GPRC3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4070 GABBR1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603540 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBS5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini15 – 591ExtracellularSequence analysisAdd BLAST577
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei592 – 612Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini613 – 631CytoplasmicSequence analysisAdd BLAST19
Transmembranei632 – 652Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini653 – 667ExtracellularSequence analysisAdd BLAST15
Transmembranei668 – 688Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini689 – 710CytoplasmicSequence analysisAdd BLAST22
Transmembranei711 – 731Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini732 – 768ExtracellularSequence analysisAdd BLAST37
Transmembranei769 – 789Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini790 – 804CytoplasmicSequence analysisAdd BLAST15
Transmembranei805 – 825Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini826 – 833ExtracellularSequence analysis8
Transmembranei834 – 854Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini855 – 961CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Secreted, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi182W → A: Abolishes signaling via G-proteins. Abolishes antagonist binding. 1 Publication1
Mutagenesisi230Y → A: Slightly decreases signaling via G-proteins. 1 Publication1
Mutagenesisi234Y → A: Decreases signaling via G-proteins. 1 Publication1
Mutagenesisi287H → A: Strongly reduces signaling via G-proteins. Abolishes antagonist binding. 1 Publication1
Mutagenesisi367Y → A: Strongly reduces signaling via G-proteins. No effect on antagonist binding. 1 Publication1
Mutagenesisi395W → A: Strongly reduces signaling via G-proteins. Strongly reduces antagonist binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2550

Open Targets

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OpenTargetsi
ENSG00000204681

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28484

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2064

Drug and drug target database

More...
DrugBanki
DB08891 Arbaclofen
DB08892 Arbaclofen Placarbil
DB00181 Baclofen
DB00837 Progabide
DB05010 SGS742
DB01080 Vigabatrin

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
240

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GABBR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643873

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 14Sequence analysisAdd BLAST14
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001294915 – 961Gamma-aminobutyric acid type B receptor subunit 1Add BLAST947

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 145PROSITE-ProRule annotation
Disulfide bondi131 ↔ 157PROSITE-ProRule annotation
Disulfide bondi220 ↔ 246PROSITE-ProRule annotation1 Publication
Disulfide bondi376 ↔ 410PROSITE-ProRule annotation1 Publication
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi482N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei873PhosphothreonineBy similarity1
Modified residuei930PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UBS5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBS5

PeptideAtlas

More...
PeptideAtlasi
Q9UBS5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBS5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84047
84048 [Q9UBS5-2]
84049 [Q9UBS5-3]
84050 [Q9UBS5-4]
84051 [Q9UBS5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBS5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain (PubMed:9844003, PubMed:9753614, PubMed:9872744). Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer (PubMed:9844003). Isoform 1B: Mainly expressed in Purkinje cells (PubMed:9844003). Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland (PubMed:10906333).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204681 Expressed in 206 organ(s), highest expression level in paraflocculus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBS5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBS5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050483
HPA058459

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of GABBR1 and GABBR2 (PubMed:9872316, PubMed:10773016, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Homodimers may form, but are inactive (PubMed:9872316, PubMed:15617512). Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABBR2 (PubMed:10906333). Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity). Interacts with JAKMIP1 (PubMed:14718537).By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108825, 23 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2955 GABA-B receptor complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UBS5

Database of interacting proteins

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DIPi
DIP-38394N

Protein interaction database and analysis system

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IntActi
Q9UBS5, 16 interactors

Molecular INTeraction database

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MINTi
Q9UBS5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000366233

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1961
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MQEX-ray2.35A165-576[»]
4MQFX-ray2.22A165-576[»]
4MR7X-ray2.15A165-576[»]
4MR8X-ray2.15A165-576[»]
4MR9X-ray2.35A165-576[»]
4MRMX-ray2.86A165-576[»]
4MS1X-ray2.25A165-576[»]
4MS3X-ray2.50A165-576[»]
4MS4X-ray1.90A165-576[»]
4PASX-ray1.62A879-919[»]
6HKCNMR-A26-98[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBS5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 96Sushi 1PROSITE-ProRule annotationAdd BLAST67
Domaini98 – 159Sushi 2PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni888 – 916Interaction with ATF4By similarityAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili869 – 925Sequence analysisAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR2 (PubMed:9872744). The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably plays a role in the specificity for G-protein coupling (PubMed:9844003).2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1055 Eukaryota
ENOG410XNN1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157642

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000171607

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBS5

KEGG Orthology (KO)

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KOi
K04615

Identification of Orthologs from Complete Genome Data

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OMAi
PKICQAR

Database of Orthologous Groups

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OrthoDBi
385042at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBS5

TreeFam database of animal gene trees

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TreeFami
TF313965

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15291 7tmC_GABA-B-R1, 1 hit
cd00033 CCP, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR002455 GPCR3_GABA-B
IPR017978 GPCR_3_C
IPR002456 GPCR_3_GABA_rcpt_B1
IPR028082 Peripla_BP_I
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

The PANTHER Classification System

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PANTHERi
PTHR10519 PTHR10519, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF00084 Sushi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53822 SSF53822, 1 hit
SSF57535 SSF57535, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
PS50923 SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms corresponding to the full receptor are essentially found in the central nervous system (CNS).

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1A (identifier: Q9UBS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MLLLLLLAPL FLRPPGAGGA QTPNATSEGC QIIHPPWEGG IRYRGLTRDQ
60 70 80 90 100
VKAINFLPVD YEIEYVCRGE REVVGPKVRK CLANGSWTDM DTPSRCVRIC
110 120 130 140 150
SKSYLTLENG KVFLTGGDLP ALDGARVDFR CDPDFHLVGS SRSICSQGQW
160 170 180 190 200
STPKPHCQVN RTPHSERRAV YIGALFPMSG GWPGGQACQP AVEMALEDVN
210 220 230 240 250
SRRDILPDYE LKLIHHDSKC DPGQATKYLY ELLYNDPIKI ILMPGCSSVS
260 270 280 290 300
TLVAEAARMW NLIVLSYGSS SPALSNRQRF PTFFRTHPSA TLHNPTRVKL
310 320 330 340 350
FEKWGWKKIA TIQQTTEVFT STLDDLEERV KEAGIEITFR QSFFSDPAVP
360 370 380 390 400
VKNLKRQDAR IIVGLFYETE ARKVFCEVYK ERLFGKKYVW FLIGWYADNW
410 420 430 440 450
FKIYDPSINC TVDEMTEAVE GHITTEIVML NPANTRSISN MTSQEFVEKL
460 470 480 490 500
TKRLKRHPEE TGGFQEAPLA YDAIWALALA LNKTSGGGGR SGVRLEDFNY
510 520 530 540 550
NNQTITDQIY RAMNSSSFEG VSGHVVFDAS GSRMAWTLIE QLQGGSYKKI
560 570 580 590 600
GYYDSTKDDL SWSKTDKWIG GSPPADQTLV IKTFRFLSQK LFISVSVLSS
610 620 630 640 650
LGIVLAVVCL SFNIYNSHVR YIQNSQPNLN NLTAVGCSLA LAAVFPLGLD
660 670 680 690 700
GYHIGRNQFP FVCQARLWLL GLGFSLGYGS MFTKIWWVHT VFTKKEEKKE
710 720 730 740 750
WRKTLEPWKL YATVGLLVGM DVLTLAIWQI VDPLHRTIET FAKEEPKEDI
760 770 780 790 800
DVSILPQLEH CSSRKMNTWL GIFYGYKGLL LLLGIFLAYE TKSVSTEKIN
810 820 830 840 850
DHRAVGMAIY NVAVLCLITA PVTMILSSQQ DAAFAFASLA IVFSSYITLV
860 870 880 890 900
VLFVPKMRRL ITRGEWQSEA QDTMKTGSST NNNEEEKSRL LEKENRELEK
910 920 930 940 950
IIAEKEERVS ELRHQLQSRQ QLRSRRHPPT PPEPSGGLPR GPPEPPDRLS
960
CDGSRVHLLY K
Length:961
Mass (Da):108,320
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54E7349CD02B633F
GO
Isoform 1B (identifier: Q9UBS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: MLLLLLLAPL...PHCQVNRTPH → MGPGAPFARV...PHSRVPPHPS

Show »
Length:844
Mass (Da):95,148
Checksum:iD926376823699485
GO
Isoform 1C (identifier: Q9UBS5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-159: Missing.

Show »
Length:899
Mass (Da):101,543
Checksum:i65DD7A31D68114AE
GO
Isoform 1D (identifier: Q9UBS5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     905-961: KEERVSELRH...DGSRVHLLYK → SGGLPRGPPEPPDRLSCDGSRVHLLYK

Show »
Length:931
Mass (Da):104,665
Checksum:i6FD16A36835AAB34
GO
Isoform 1E (identifier: Q9UBS5-5) [UniParc]FASTAAdd to basket
Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     570-961: GGSPPADQTL...DGSRVHLLYK → VISRTHSPT

Note: Major isoform in almost all peripheral tissues, although containing a premature stop codon in the mRNA and thus being a potential target for nonsense-mediated mRNA decay. May act as an antagonist of GABA-B receptors, being able to disrupt the normal association between isoform 1A and GABBR2.1 Publication
Show »
Length:578
Mass (Da):65,082
Checksum:i9B15DFD4E097428F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JKF9A0A0G2JKF9_HUMAN
GABBR1
GABBR1
961Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9S4A0A140T9S4_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
899Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA42A0A140TA42_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
578Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZG6C9JZG6_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDC0F8WDC0_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAV2F8WAV2_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAS6F8WAS6_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J342C9J342_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF38F8WF38_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2L → M in Y11044 (PubMed:9753614).Curated1
Sequence conflicti21Q → H in CAA09939 (PubMed:9872316).Curated1
Sequence conflicti21Q → H in CAA09941 (PubMed:9872316).Curated1
Sequence conflicti93P → L in AAC98508 (Ref. 3) Curated1
Sequence conflicti127V → A in CAA09939 (PubMed:9872316).Curated1
Sequence conflicti322Missing in CAA09031 (PubMed:9933300).Curated1
Sequence conflicti542L → P in Y11044 (PubMed:9753614).Curated1
Sequence conflicti691V → G in Y11044 (PubMed:9753614).Curated1
Sequence conflicti905 – 934Missing in CAA09031 (PubMed:9933300).CuratedAdd BLAST30

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01014620A → V3 PublicationsCorresponds to variant dbSNP:rs1805056Ensembl.1
Natural variantiVAR_010147489G → S3 PublicationsCorresponds to variant dbSNP:rs1805057Ensembl.1
Natural variantiVAR_049279645F → L. Corresponds to variant dbSNP:rs2076489Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0020371 – 164MLLLL…NRTPH → MGPGAPFARVGWPLPLLVVM AAGVAPVWASHSPHLPRPHS RVPPHPS in isoform 1B. 3 PublicationsAdd BLAST164
Alternative sequenceiVSP_00203898 – 159Missing in isoform 1C. 2 PublicationsAdd BLAST62
Alternative sequenceiVSP_002039570 – 961GGSPP…HLLYK → VISRTHSPT in isoform 1E. CuratedAdd BLAST392
Alternative sequenceiVSP_002040905 – 961KEERV…HLLYK → SGGLPRGPPEPPDRLSCDGS RVHLLYK in isoform 1D. CuratedAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ225028 mRNA Translation: CAA12359.1
AJ225029 mRNA Translation: CAA12360.1
AJ012185 mRNA Translation: CAA09939.1
AJ012186 mRNA Translation: CAA09940.1
AF099148 mRNA Translation: AAC98508.1
Y11044 mRNA No translation available.
AJ012187 mRNA Translation: CAA09941.1
AJ010170
, AJ010171, AJ010172, AJ010173, AJ010174, AJ010175, AJ010176, AJ010177, AJ010178, AJ010179, AJ010180, AJ010181, AJ010182, AJ010183, AJ010184, AJ010185, AJ010186, AJ010187, AJ010188, AJ010189, AJ010190, AJ010191 Genomic DNA Translation: CAA09031.1
AJ012288 mRNA Translation: CAA09980.1
AF301005 mRNA Translation: AAG23962.1
AL031983 Genomic DNA Translation: CAA21453.1
AL031983 Genomic DNA Translation: CAA21454.1
AL645936 Genomic DNA No translation available.
AL662826 Genomic DNA No translation available.
BX000688 Genomic DNA No translation available.
CR388210 Genomic DNA No translation available.
CR759766 Genomic DNA No translation available.
CR759870 Genomic DNA No translation available.
CR788300 Genomic DNA No translation available.
CR936483 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03205.1
CH471081 Genomic DNA Translation: EAX03210.1
BC042598 mRNA Translation: AAH42598.1
BC050532 mRNA Translation: AAH50532.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4663.1 [Q9UBS5-1]
CCDS4664.1 [Q9UBS5-3]
CCDS4665.1 [Q9UBS5-2]

Protein sequence database of the Protein Information Resource

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PIRi
JE0356

NCBI Reference Sequences

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RefSeqi
NP_001305982.1, NM_001319053.1
NP_001461.1, NM_001470.3 [Q9UBS5-1]
NP_068703.1, NM_021903.2 [Q9UBS5-2]
NP_068704.2, NM_021904.3 [Q9UBS5-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355973; ENSP00000348248; ENSG00000204681 [Q9UBS5-2]
ENST00000376977; ENSP00000366176; ENSG00000204681 [Q9UBS5-5]
ENST00000377012; ENSP00000366211; ENSG00000204681 [Q9UBS5-2]
ENST00000377016; ENSP00000366215; ENSG00000204681 [Q9UBS5-3]
ENST00000377034; ENSP00000366233; ENSG00000204681 [Q9UBS5-1]
ENST00000383537; ENSP00000373029; ENSG00000206466 [Q9UBS5-2]
ENST00000383541; ENSP00000373033; ENSG00000206466 [Q9UBS5-3]
ENST00000383542; ENSP00000373034; ENSG00000206466 [Q9UBS5-1]
ENST00000383543; ENSP00000373035; ENSG00000206466 [Q9UBS5-2]
ENST00000383636; ENSP00000373132; ENSG00000206511 [Q9UBS5-2]
ENST00000383637; ENSP00000373133; ENSG00000206511 [Q9UBS5-3]
ENST00000383638; ENSP00000373134; ENSG00000206511 [Q9UBS5-1]
ENST00000383639; ENSP00000373135; ENSG00000206511 [Q9UBS5-2]
ENST00000414980; ENSP00000406499; ENSG00000232632 [Q9UBS5-2]
ENST00000417759; ENSP00000391572; ENSG00000237112 [Q9UBS5-2]
ENST00000419674; ENSP00000399861; ENSG00000232569 [Q9UBS5-3]
ENST00000423604; ENSP00000388035; ENSG00000232632 [Q9UBS5-1]
ENST00000425097; ENSP00000411286; ENSG00000237112 [Q9UBS5-1]
ENST00000434660; ENSP00000412167; ENSG00000232632 [Q9UBS5-3]
ENST00000438094; ENSP00000406285; ENSG00000232632 [Q9UBS5-2]
ENST00000439457; ENSP00000406066; ENSG00000232569 [Q9UBS5-1]
ENST00000443440; ENSP00000399318; ENSG00000237112 [Q9UBS5-3]
ENST00000446436; ENSP00000394528; ENSG00000237112 [Q9UBS5-2]
ENST00000448754; ENSP00000405709; ENSG00000237051 [Q9UBS5-2]
ENST00000449163; ENSP00000411263; ENSG00000232569 [Q9UBS5-2]
ENST00000452300; ENSP00000408938; ENSG00000232569 [Q9UBS5-2]
ENST00000458612; ENSP00000416903; ENSG00000237051 [Q9UBS5-2]
ENST00000494877; ENSP00000419061; ENSG00000204681 [Q9UBS5-5]
ENST00000546913; ENSP00000448999; ENSG00000232569 [Q9UBS5-1]
ENST00000547410; ENSP00000448531; ENSG00000232569 [Q9UBS5-5]
ENST00000548767; ENSP00000446983; ENSG00000232632 [Q9UBS5-5]
ENST00000551140; ENSP00000448654; ENSG00000237112 [Q9UBS5-5]
ENST00000551423; ENSP00000449342; ENSG00000206511 [Q9UBS5-5]
ENST00000552399; ENSP00000449449; ENSG00000206466 [Q9UBS5-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2550

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2550

UCSC genome browser

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UCSCi
uc003nmp.5 human [Q9UBS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225028 mRNA Translation: CAA12359.1
AJ225029 mRNA Translation: CAA12360.1
AJ012185 mRNA Translation: CAA09939.1
AJ012186 mRNA Translation: CAA09940.1
AF099148 mRNA Translation: AAC98508.1
Y11044 mRNA No translation available.
AJ012187 mRNA Translation: CAA09941.1
AJ010170
, AJ010171, AJ010172, AJ010173, AJ010174, AJ010175, AJ010176, AJ010177, AJ010178, AJ010179, AJ010180, AJ010181, AJ010182, AJ010183, AJ010184, AJ010185, AJ010186, AJ010187, AJ010188, AJ010189, AJ010190, AJ010191 Genomic DNA Translation: CAA09031.1
AJ012288 mRNA Translation: CAA09980.1
AF301005 mRNA Translation: AAG23962.1
AL031983 Genomic DNA Translation: CAA21453.1
AL031983 Genomic DNA Translation: CAA21454.1
AL645936 Genomic DNA No translation available.
AL662826 Genomic DNA No translation available.
BX000688 Genomic DNA No translation available.
CR388210 Genomic DNA No translation available.
CR759766 Genomic DNA No translation available.
CR759870 Genomic DNA No translation available.
CR788300 Genomic DNA No translation available.
CR936483 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03205.1
CH471081 Genomic DNA Translation: EAX03210.1
BC042598 mRNA Translation: AAH42598.1
BC050532 mRNA Translation: AAH50532.2
CCDSiCCDS4663.1 [Q9UBS5-1]
CCDS4664.1 [Q9UBS5-3]
CCDS4665.1 [Q9UBS5-2]
PIRiJE0356
RefSeqiNP_001305982.1, NM_001319053.1
NP_001461.1, NM_001470.3 [Q9UBS5-1]
NP_068703.1, NM_021903.2 [Q9UBS5-2]
NP_068704.2, NM_021904.3 [Q9UBS5-3]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MQEX-ray2.35A165-576[»]
4MQFX-ray2.22A165-576[»]
4MR7X-ray2.15A165-576[»]
4MR8X-ray2.15A165-576[»]
4MR9X-ray2.35A165-576[»]
4MRMX-ray2.86A165-576[»]
4MS1X-ray2.25A165-576[»]
4MS3X-ray2.50A165-576[»]
4MS4X-ray1.90A165-576[»]
4PASX-ray1.62A879-919[»]
6HKCNMR-A26-98[»]
SMRiQ9UBS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108825, 23 interactors
ComplexPortaliCPX-2955 GABA-B receptor complex
CORUMiQ9UBS5
DIPiDIP-38394N
IntActiQ9UBS5, 16 interactors
MINTiQ9UBS5
STRINGi9606.ENSP00000366233

Chemistry databases

ChEMBLiCHEMBL2064
DrugBankiDB08891 Arbaclofen
DB08892 Arbaclofen Placarbil
DB00181 Baclofen
DB00837 Progabide
DB05010 SGS742
DB01080 Vigabatrin
GuidetoPHARMACOLOGYi240

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiQ9UBS5
PhosphoSitePlusiQ9UBS5

Polymorphism and mutation databases

BioMutaiGABBR1
DMDMi12643873

Proteomic databases

jPOSTiQ9UBS5
PaxDbiQ9UBS5
PeptideAtlasiQ9UBS5
PRIDEiQ9UBS5
ProteomicsDBi84047
84048 [Q9UBS5-2]
84049 [Q9UBS5-3]
84050 [Q9UBS5-4]
84051 [Q9UBS5-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2550
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355973; ENSP00000348248; ENSG00000204681 [Q9UBS5-2]
ENST00000376977; ENSP00000366176; ENSG00000204681 [Q9UBS5-5]
ENST00000377012; ENSP00000366211; ENSG00000204681 [Q9UBS5-2]
ENST00000377016; ENSP00000366215; ENSG00000204681 [Q9UBS5-3]
ENST00000377034; ENSP00000366233; ENSG00000204681 [Q9UBS5-1]
ENST00000383537; ENSP00000373029; ENSG00000206466 [Q9UBS5-2]
ENST00000383541; ENSP00000373033; ENSG00000206466 [Q9UBS5-3]
ENST00000383542; ENSP00000373034; ENSG00000206466 [Q9UBS5-1]
ENST00000383543; ENSP00000373035; ENSG00000206466 [Q9UBS5-2]
ENST00000383636; ENSP00000373132; ENSG00000206511 [Q9UBS5-2]
ENST00000383637; ENSP00000373133; ENSG00000206511 [Q9UBS5-3]
ENST00000383638; ENSP00000373134; ENSG00000206511 [Q9UBS5-1]
ENST00000383639; ENSP00000373135; ENSG00000206511 [Q9UBS5-2]
ENST00000414980; ENSP00000406499; ENSG00000232632 [Q9UBS5-2]
ENST00000417759; ENSP00000391572; ENSG00000237112 [Q9UBS5-2]
ENST00000419674; ENSP00000399861; ENSG00000232569 [Q9UBS5-3]
ENST00000423604; ENSP00000388035; ENSG00000232632 [Q9UBS5-1]
ENST00000425097; ENSP00000411286; ENSG00000237112 [Q9UBS5-1]
ENST00000434660; ENSP00000412167; ENSG00000232632 [Q9UBS5-3]
ENST00000438094; ENSP00000406285; ENSG00000232632 [Q9UBS5-2]
ENST00000439457; ENSP00000406066; ENSG00000232569 [Q9UBS5-1]
ENST00000443440; ENSP00000399318; ENSG00000237112 [Q9UBS5-3]
ENST00000446436; ENSP00000394528; ENSG00000237112 [Q9UBS5-2]
ENST00000448754; ENSP00000405709; ENSG00000237051 [Q9UBS5-2]
ENST00000449163; ENSP00000411263; ENSG00000232569 [Q9UBS5-2]
ENST00000452300; ENSP00000408938; ENSG00000232569 [Q9UBS5-2]
ENST00000458612; ENSP00000416903; ENSG00000237051 [Q9UBS5-2]
ENST00000494877; ENSP00000419061; ENSG00000204681 [Q9UBS5-5]
ENST00000546913; ENSP00000448999; ENSG00000232569 [Q9UBS5-1]
ENST00000547410; ENSP00000448531; ENSG00000232569 [Q9UBS5-5]
ENST00000548767; ENSP00000446983; ENSG00000232632 [Q9UBS5-5]
ENST00000551140; ENSP00000448654; ENSG00000237112 [Q9UBS5-5]
ENST00000551423; ENSP00000449342; ENSG00000206511 [Q9UBS5-5]
ENST00000552399; ENSP00000449449; ENSG00000206466 [Q9UBS5-5]
GeneIDi2550
KEGGihsa:2550
UCSCiuc003nmp.5 human [Q9UBS5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2550
DisGeNETi2550

GeneCards: human genes, protein and diseases

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GeneCardsi
GABBR1
HGNCiHGNC:4070 GABBR1
HPAiHPA050483
HPA058459
MIMi603540 gene
neXtProtiNX_Q9UBS5
OpenTargetsiENSG00000204681
PharmGKBiPA28484

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1055 Eukaryota
ENOG410XNN1 LUCA
GeneTreeiENSGT00940000157642
HOGENOMiHOG000171607
InParanoidiQ9UBS5
KOiK04615
OMAiPKICQAR
OrthoDBi385042at2759
PhylomeDBiQ9UBS5
TreeFamiTF313965

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-977444 GABA B receptor activation
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SIGNORiQ9UBS5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GABBR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GABBR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2550

Protein Ontology

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PROi
PR:Q9UBS5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000204681 Expressed in 206 organ(s), highest expression level in paraflocculus
ExpressionAtlasiQ9UBS5 baseline and differential
GenevisibleiQ9UBS5 HS

Family and domain databases

CDDicd15291 7tmC_GABA-B-R1, 1 hit
cd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR002455 GPCR3_GABA-B
IPR017978 GPCR_3_C
IPR002456 GPCR_3_GABA_rcpt_B1
IPR028082 Peripla_BP_I
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10519 PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF53822 SSF53822, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
PS50923 SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGABR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBS5
Secondary accession number(s): B0UXY7
, O95375, O95468, O95975, O96022, Q5STL4, Q5SUJ8, Q5SUL3, Q71SG6, Q86W60, Q9UQQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: May 8, 2019
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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